All articles - Research and experimental medicine
Number of articles: 290
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STRATEGY OF EFFECTIVE APPLICATION OF DIGITAL TECHNOLOGIES IN HEALTHCARE MANAGEMENTAbstract: despite the attempts made to combat the new coronavirus intcction, its pandemic stops its development. In the cunent conditions, the introduction of digital technologies into the processes of organization by the health department is becoming particularly relevant. This is designed to maximize the effectiveness of management both in the primary link at an outpatient dental appointment and in the management of a patient in a hospital. The availability of currently implemented options opens up unique opportunities for the use of blockchain technologies, while ensuring the achievement of the most effective decisions.
Medicine and innovations -
This article discusses the main anthropometric features of male athletes who are engaged in sprinting and high jump in athletics at the Samarkand children and youth sports school, which specializes in sports and athletics. The study involved 100 cross-country runners and high jumpers. -
Macroscopic and microscopic characteristics of kidneys of white unbored rats after severe cranial injuryThis article provides information on the results of scientific studies that allow to evaluate and study the features of macroscopic and microscopic characteristics of the kidneys of 3-month-old white outbred rats with severe traumatic brain injury. Traumatic brain injury was performed using the Traffic Accident model, and rat kidneys were isolated and macroscopic and microscopic examinations were performed in the order in which anatomical parameters were established.
Doctor's Herald -
The article discuss issues of creatine use safety in pregnant women. Literature search has shown that although the use of creatine during pregnancy in humans is not yet fully understood, long-term use of this agent in adults is considered absolutely safe. Authors discourse about creatine synthesis pathways by the fetus, the mechanisms of transfer through the placental barrier. Considerable attention is paid on evidence of benefit of creatine supplementation during pregnancy for prevention and reduction of oxidative stress, fetoplacental hypoxia arising from various types gestational complications, such as fetal growth restriction, premature birth, and cases of fetal hypoxic conditions. -
THE INFLUENCE OF CONSTRUCTIVE FEATURES OF THE CAR BODY ON THE FORMATION OF DAMAGE IN CHILDREN – PEDESTRIANSIn order to study the influence of the design features of the ear body on the formation of injuries in children -pedestrians, the results of the SME and case materials of 140 children aged 6-17 years who died as a result of collisions with moving cars were analyzed. The most frequent collisions (86) were carried out by modern passenger cars of the Daewoo-uz brand. In 18 cases, collisions were made with the participation of old cars (VAZ-2106, Izh-Moskvich). In 33 cases, pedestrian children were injured in collisions with passenger and cargo vehicles, and in the remaining 4 cases, the types and brands of vehicles were not identified. In children-pedestrians who were injured from collisions with passenger cars and trucks, the volume and nature of the associated injuries were significantly higher than those caused by passenger cars. It was also found that in children injured in a collision with old cars, the severity of structural damage was less than in cases of collisions with modem cars, which was due to the structural features of the body of modem cars - the relative smoothness and less elasticity of the outer protruding parts.
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In recent years, the problem of strokes in young people, in particular, the study of biomarkers of the risk of ischemic stroke, has received great attention due to its insufficient knowledge and a steady increase in the number of cases among people of working age. We were aimed to determine the clinical significance of homocysteine as a biomarker of the risk of ischemic stroke in young people. We examined 123 patients with ischemic stroke in the acute period. The control group consisted of 50 young people without cerebrovascular pathology. The results of the study showed that the level of homocysteine has age characteristics and has a correlation with the severity of neurological deficit. The obtained data will make it possible to develop an algorithm for a differentiated approach to the prevention of cerebrovascular pathology and to reduce the risk of ischemic stroke in young people. -
RESULTS OF THE STUDY OF TRANSLOCATION OF INTESTINAL MICROBES IN DIFFERENT INTERNAL ORGANS AND SYSTEMS OF A GENETICALLY MODIFIED PRODUCT IN LABORATORY EXPERIMENTS ANIMALSOne of the important areas of socio-economic development on a global scale is the solution of food supply, food availability in accordance with rational norms of healthy nutrition, as well as achieving high quality and safety of food consumed by the population. A number of studies are being carried out in the world to assess the biomedical safety of genetically modified food products and the effect of genetically modified soybeans on mutagenic, embryotoxic, carcinogenic and gonadotoxic effects, as well as on hematological and biochemical parameters of the organism of experimental animals. The aim of the study was to study and evaluate the effect of a genetically modified product (commercial product from soybeans) on the translocation of intestinal microbes in an experiment on laboratory animals.
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The purpose of the study is to assess the environmental and hygienic impact of production factors on the health of poultry farm workers and to develop measures to improve working conditions, improve the environmental situation on the territory of farms. It is established that the unfavorable factors of the production environment of poultry farms are strenuous physical labor, neuropsychiatric stress, the impact on the human body of chemicals, bacterial and dust aerosols, fungal microflora, excrement and other products of poultry life. -
HYGIENIC JUSTIFICATION FOR THE POSSIBILITY OF USING AN INSECTICIDE ZARAGEN IN AGRICULTUREOn the basis of a special experiment, it is hygienically substantiated that, according to the parameters of acute toxicity, Zaragen belongs to substances of the 4th hazard class (low-toxic drug). (SanPiN No. 0321-15). It has a slightly irritating effect on the skin and mucous membranes of the eyes: possesses functional cumulation. Hygienic standards and regulations for the use of the drug have been developed, subject to which the pollution of the environment with this insecticide is prevented.
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Premature labor (PL) continues to be at the epicenter of obstetricians and gynecologists attention around the world. The nature of the relationship between the synthesis of placenta-specific proteins and uterine hemodynamics in threatening preterm labor was studied. The study included 150 women with a clinic of threatened preterm birth with gestational terms from 22 to 36.6 weeks (main group), who were treated in the Perinatal Center and City Maternity Complex in Bukhara. The control group consisted of 50 pregnant women with the physiological course of gestation at the same time. The revealed character of correlations between the content of gravidar proteins and the parameter of uterine hemodynamics in threatening preterm labor indicates the presence of progressive disorders in the motherplacenta-fetus system. The results of the study dictate the need for further study of the pathogenetic mechanisms of miscarriage in order to improve the existing principles of treatment. -
ROLE OF DIFFERENT ENDOSCOPIC STUDIES IN DIAGNOSTICS AND TREATMENT OF EROSIVE AND DYSPLASTIC CHANGES IN THE MUCOSA OF THE ESOPHAGUSThe development of modem medicine is reflected in all areas. This article also presents the results and the importance of using various endoscopic studies in the diagnosis and treatment of erosive and dysplastic pathologies of the esophageal mucosa, which is one of the urgent problems of medicine. Our research is based on the tactics of diagnosis and treatment of 2051 patients with gastroesophageal reflux disease complicated by various erosive pathologies of the esophageal mucosa, examined in the period 2019-2020 in the diagnostic departments of the Samarkand CMO and State Institution “RSSPMCS named after acad. V.Vakhidov".
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MORPHOLOGICAL CHANGES IN THE SPLEEN TISSUE OF LABORATORY RATS ON THE THIRD DAY AFTER A TRAUMATIC BRAIN INJURYLaboratory studies were conducted on 26 white mongrel rats of 3 months of age. This study was conducted three days after receiving a traumatic brain injury. The animals were fixed on a device made by hand in the form of a vehicle on wheels, the fixed animals were accelerated on the vehicle and hit the wooden barrier with the frontal part of the head. The speed of the vehicle was 6.7 km per hour. As a result of this experiment, two rats died on the spot. In 3-month-old rats, during the experiment, it was revealed that there were no macroscopic changes outside the organ, but there were some changes in the tissue structures of the white and red pulp of the spleen.
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STUDYING THE CARRIAGE OF PATHOGENIC STAPHYLOCOCCUS (S. AURES) IN THE MEDICAL STAFF OF THE SURGICAL DEPARTMENTS OF HOSPITALS, OBSTERTIC HOSPITALS AND INDICATORS OF ACQUIRED ADAPTABILITY IN RELATION TO DIFFERENT ANTIMICROBIAL DRUGSA survey was carried out on staphylococcal bacteriocarrier of medical personnel. The test material was taken from the nasal cavity and pharynx. Carriage of S.aureus in the nasal cavity was revealed in 24 examined. Investigated clinical strains of S.aureus allocated in the surgical departments of hospitals and obstetric hospitals in 2016-2018. in order to study their antibiotic resistance. The sensitivity was determined by the disk diffusion method on Muller-Hinton agar. Acquisition of resistance of S.aureus to lincomycin and erythromycin was revealed.
Doctor's Herald -
HYGIENIC ASPECTS OF THE KOTOFOR HERBICIDE INFLUENCE ON THE QUALITY OF SOME PLANT PRODUCTSWhen applying Kotofor's herbicide in agriculture against weeds in consumption rates of 1.0-3.0 kg/ha, there is no change in biological quality (total protein, starch, vitamins С, P) in plant products. With an increase in Kotofor's consumption rate to 4.0 kg/ha. a decrease in total protein, starch, and vitamin C in potato and watermelon tubers was revealed. Based on the foregoing, from a hygienic point of view, planting of collective farms was established with an acceptable dose of introducing kotofor into the soil for planting of crops no more than 3.0 kg/' ha.
Doctor's Herald -
COMPARATIVE MORPHOLOGICAL ANALYSIS OF THE PLACENTA IN WOMEN WITH HYPERTENSIVE CONDITIONSI his article presents a comparative analysis ot morphological and functional changes in the placenta and placental site in pregnant women with various types of hypertensive conditions. The modem ultrastructural methods for the study of the placenta in women with preeclampsia and with a physiological full-term pregnancy have been carried out.
Doctor's Herald -
TO STUDY THE PREVALENCE OF DENTOFACIAL ANOMALIES AND DEFORMITIES IN SCHOOLCHILDREN IN THE CITY OF BUKHARASummary: In 2018-2019. Between ages 6 to 18. there are 642 schoolchildren living in the city of Bukhara, den-tofacial anomalies and deformations, as well as the spread of temporomandibular diseases caused by them, were identified. Maxillofacial anomalies and deformations were observed among children in Bukhara city with a frequency of 57.5%. of which 36.4% were dentomaxillary anomalies. About 642 children were observed and 298 of them were revealed with bad habits, including 52 (8.1%) children with respiratory failure (from mouth) and 67 (10.4%) children with impaired pronunciation.
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CLINICAL AND LABORATORY FEATURES OF THE COURSE OF ENTEROVIRUS ETIOLOGY SEROUS MENINGITIS IN CHILDRENThis article examines an examination of 16 patients aged 1 to 14 years with a laboratory confirmed (cerebrospinal fluid PChR) diagnosis of enterovirus meningitis. All patients, depending on age, were divided into 3 groups. The main group of cases was made up of school children. The course of the disease in all cases is benign with a short febrile period, a short period of clinically pronounced meningeal syndrom.
Doctor's Herald -
The results of assessing the state of health and the psychophysiological state of modem teachers of leading universities in Uzbekistan are presented as the basis for the development of preventive measures to maintain their health. The factors of living conditions, working conditions that determine the state of the psycho-emotional sphere of teachers arc indicated. It is shown that for 60% of teaching staff there arc signs of psycho-emotional burnout of medium and high levels, more pronounced at the end of the school year. To reduce the negative impact of external factors on the psycho-emotional sphere of teaching staff, an integrated approach is recommended taking into account the role of social and living conditions, working conditions and personal stress resistance. -
Meaning oi dental disease on the background of somatic pathology in the scientific and practice medicine is defined by growth of their prevalence in the general population, the rapid development of complications and the need for a comprehensive approach to treatment by reference to the background therapy. Among 157 children and adolescents with rheumatism living in various regions of Bukhara, a study was made of the particular biophysical properties of oral fluid. An analysis of the results showed a decrease in the rate of saliva secretion (RSS) compared with a healthy group of children and the need to study the level of dental health taking into account the duration and form of rheumatism, basic therapy of background pathology, as well as the development of a set of dental treatment and prophylactic measures taking into account unified protocols for medical helping children with rheumatism. -
FEATURES OF DAMAGE FORMATION TO PEDESTRIANS IN THEIR COLLISION WITH MOVING MODERN CARSThe article emphasizes the relevance of studying the features of the formation of damage by pedestrians in their collision with moving modem cars produced in Uzbekistan. The examples from practical observations on this type of motor vehicle injury show the distinctive features of injuries by their nature and localization on the body of the victims. Despite the fact that in the past cases there was a classic type of collision of cars with pedestrians, the dead bodies did not reveal the so-called “characteristic injuries" for this car accident.
Doctor's Herald -
This article discusses the age-related features of the functional and physical development of young athletes involved in football and martial arts. The study involved 60 athletes (30 athletes involved in football and 30 athletes involved in martial arts between the ages of 8-15 years old. Assessment of physical development included the measurement of morphological and functional indicators (body weight, height, waist and hips, body mass indices). The obtained data on age periods are compared, and the effects of various sports on the body of children and adolescents are revealed. -
Organizational measures are being taken to introduce compulsory medical insurance in the healthcare system of the Republic of Uzbekistan, with in-depth study of the experience of socially and economically effective areas of medical insurance in the medical system of developed countries. According to a study of world experience and work analysis of hospitals, the introduction of a medical insurance system will improve the quality of medical services for patients in medical institutions, will lead to the formation of socio-economic relations in society based on the justice principles. -
This article presents review of modern literature, which is devoted to existing methods for assessing body composition, the scope of their application and the possibilities of each of them arc indicated, the effective role of monitoring the body composition of athletes is indicated, as well as the main factors affecting the ratio of the components of the body of athletes. -
Comparative study of evaluation methods of the thrombus for biosealants formationThe use of new forms of biosealants based on thrombus is perspective direction in medicine. Thrombus may be studied from the view point of natural policompositive biomaterial without any negative influence on the organism. Especially retractive thrombi faced these requirements. In connection with this fact methods of evaluation and investigation of thrombus retraction, the study of their physic-mechanical properties have been had large significance. Current research was performed with aim to compare exist indirect methods of throm- bus retraction evaluation with perspective direct methods that allow assess physic-mechanical properties of thrombi. The work was performed in cooperation with researchers of Physic-technical institute at Academy of Science RUz.
Journal problems of biology and medicine -
The review presents current data on the problem of sleep disorders in pregnant women, as well as the impact ot sleep disorders on the course of pregnancy, the development of obstetric complications and birth outcomes.
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