HISTOMORPHOMETRY OF THE ADENOHYPOPHYSIS AND THYROID GLAND UNDER THE INFLUENCE OF LADIGINOZID IN EXPERIMENT

The effect of ladyginoside on histomorphometry of the adenohypophysis and thyroid gland in the experiment was estimated. Ladyginoside is a sum of triterpene glycosides obtained from the roots of the native plant Ladiginia Bucharica in the laboratory of glycosides of the Institute of Chemistry of Plant Substances, Academy of Sciences of Uzbekistan (Head - Corresponding Member of the Academy of Sciences of Uzbekistan, Professor N.K. Abubakirov). Previously conducted comprehensive studies have proven the hypolipidemic and antiatherosclerotic properties of ladyginoside. The search for antiatherosclerotic substances is an urgent problem, since cardiovascular diseases, which are often based on vascular atherosclerosis, remain the leading cause of mortality in the world. The studies on experimental animals considered a possible way of implementation of antiatherosclerotic action of ladylginoside mediated through adenohypophysis and thyroid gland. As a result of the study it was found that ladylginoside causes changes in the histomorphomctric parameters of the adenohypophysis and thyroid gland, indicating an increase in the function of these endocrine organs. The experimental study established that, in addition to the possible direct effect of ladylginoside on the thyroid gland after its absorption and further biotransformation in the body, a likely mechanism of action of the drug through the "pituitary-thyroid" system was determined.