In patients with type 2 diabetes mellitus who have had COVID-19, in various forms of this disease, clinical symptoms depend on various manifestations in the oral cavity. Based on the world literature data, the authors came to the conclusion that the problem of the pathology of the organs and tissues of the oral cavity in COVID-19, in contrast to the concomitant disease, has not been studied enough and requires further scientific research.
В хирургической стоматологии дентальная имплантация с наращиванием костной ткани у больных сахарным диабетом занимает особое место. Это одна из немногих отраслей, наряду с тканьевой инженерией, где мы можем говорить о репаративной регенерации - самовосстановлении организма в условиях, созданных врачом хирургом-имплантологом
The aim of the work was to optimize the methods of early detection of NAFLD. Materials and methods: A total of 582 patients with type 2 diabetes mellitus were examined. The average age of the surveyed was 48.1 ± 11.6 years, 68% of the surveyed were women. All patients were calculated using the FIB-4 scale, NAFLD score, BMI. Results: significant factors determining the risk of developing NAS are fasting hyperglycemia (above 6.1 mmol / L), female sex, total cholesterol level above 5.2 mmol / L, HDL below 1.2 mmol / L for women, VLDL above 0.55 mmol / L, TG above 1.7 mmol /L, ferritin above 400 mmol / L for men, NAFLD score above 2 points, BMI above 25 kg / m2. The factors are listed as their contribution to the risk of developing NAS increases. Conclusions: To prevent the development and progression of steatosis, it is important to achieve target values of glycemia and lipid spectrum indicators, as well as achieve weight loss.
Периодическая научная литература заполнена информацией об осложнениях КОВИД-19. Этот вирус практически поражает все важные системы организма и вызывает различные осложнения, связанные с образованием тромбов и соединительной ткани и вторичных воспалительных процессов. Об осложнениях данной инфекции в челюстно-лицевой области практически нет информации. Однако в последнее время в нашу клинику начали обращаться пациенты с патологическими изменениями тканей средней зоны лица после перенесенной инфекции КОВИД-19. В клинической картине в отличие от банальной инфекции челюстей преобладал некроз костной и окружающих мягких тканей. Почти все они принадлежали старшей возрастной группе с такой сопутствующей патологией, как сахарный диабет.
Purpose of the study. Determination of the clinical and pathogenetic characteristics of COVID-19 in the early rehabilitation period according to retrospective analysis
Material and research methods. A retrospective analysis of the case histories of 128 patients who underwent COVID-19 and persistent symptoms of the disease was carried out. The number and frequency of underlying diseases and clinical manifestations of various pathological syndromes were determined.
The results of the analysis of case histories of patients showed that 44 patients suffered moderate severity of COVID 19, 45 patients - severe, 39 - extremely severe. 40 patients were diagnosed with a lesion of 25% of the lungs or less (CT 1), in 43 patients - more than 25 to 50% of the lung volume (CT-2), in 32 patients - more than 50 to 75% (CT-3) and in 13 patients - more than 75% (CT-4). On average, the number of background pathologies was 4.53 ± 2.20. The average number of background diseases was significantly higher in patients of the older age group (p <0.001). In patients with severe and extremely severe infections diabetes and obesity were more common (p <0.05 for both comparisons). In the group of patients with moderate severity of infection, chronic viral hepatitis was more common (p <0.05). Clinical syndromes pathogenetically associated with an autoimmune inflammatory reaction were observed in 99 patients (77.34%), cell dystrophy - in 123 patients (96.09%), coagulopathy - in 73 patients (57.03%), fibrosis - in 44 patients (34.38%). Conclusion. According to the data of retrospective analysis, the average number of background diseases was significantly higher in patients of the older age group. Diabetes and obesity were more common in patients with severe and extremely severe COVID-19. In patients with moderate severity of infection, chronic viral hepatitis was more common. The pathogenetic syndrome of an autoimmune inflammatory reaction was observed in 77.34% of patients, cell dystrophy syndromes in 96.09%, coagulopathic in 57.03% and fibrosis in 34.38% of patients.
The history of the study of hyperhomocysteinemia goes back half a century. It is interesting that the increased level of homocysteine as a factor of vascular damage was first noticed in pediatric practice. In 1969, Kilmer S. MeCully, a professor in the Department of Pathology at Harvard University, studying a rare genetic disorder manifested by homocysteinuria (increased levels of homocysteine in the urine), suggested a link between elevated serum homocysteine levels and arterial disease. Without treatment, these children usually die at an early age from myocardial infarction or cerebral strokes. During autopsy, it was found that their vessels were the same damaged and thickened as in elderly patients with cardiovascular diseases. Clinically, this disease is characterized by a marfan-like phenotype, connective tissue lesions (high growth, arachnodactyly, lens subluxation, chest deformities, heart defects), neuropsychiatric disorders, arterial thrombosis. The pathology is based on a defect in one of the metabolic enzymes of sulfur-containing methionine, mainly in the amino acid cystothionine-E-synthetase (classical tomocysteinuria). Subsequently, it was shown that moderate and mild homocysteinemia affects the vessels of various localization, leading to pathological changes in them.
Бугунги кунда адентия оғиз бўшлиғи патологиялари орасида энг кенг тарқалган бўлиб, унинг патогенезини ўрганишда оғиз суюқлигининг биохимик тахлили юқори информативликка эга. Бироқ адентияда ва турли туман тиш протезлари билан тиш қатори бутунлигини тиклашдан сўнг оғиз суюқлиги метаболизм кўрсаткичлари ва физик химиявий параметрларини ўрганишга бағишланган тадқиқотлар сони чегараланган. Оғиз бўшлиғи, тиш – жағ тизими ва аралаш сўлакни хосил қилувчи асосий компонентларни қондан рекрецияловчи ва ишлаб чиқарувчи сўлак безларининг анатомик ва функционал бирлиги оғиз суюқлигининг стоматологик патологияда ҳам, ҚД каби соматик патологияда ҳам кузатиладиган сезиларли даражадаги физико – химиявий ўзгаришларига шароит яратади [Камилов Х.П., 2002; Литвинова М.Г., Басов А.А., Быков И.М., 2012]
Time at your disposal: 3 minutes for the talk. Cumulative 5 minutes discussion will be held after 5 presentations Your presentation must be in English, the official language of the Congress. Only PowerPoint or Keynote files are accepted. If your presentation include video please prepare 2 slides explaining the procedure used. Video file should be in .mp4 format.
За последние годы по данным обращаемости имеется явная тенденция к увеличению числа больных несахарным диабетом (НД) - как у взрослых (от 9,0 до 11,0), так и у детей (от 2,2 до 3,3 случаев) на 100 000 населения. Высокая частота встречаемости синдрома НД при различных соматических патологиях и опухолевых поражениях гипоталамо-гипофизарной области (30-50%, несвоевременный учет и отсроченная диагностика различных его форм обуславливает высокую частоту сердечно - сосудистых (кардиомиопатии, аритмии), нефрологических (пиелонефриты, ХПН) и эндокринных (задержка физического, полового развития и др.). Отсутствие данных об истинной распространенности НД усугубляет прогнозирование осложнений заболевания и бесперебойное обеспечение больных НД препаратами антидиуретического гормона.
Purpose of the study. Based on a retrospective analysis, to determine prognostic markers for the progression of fibrosis of the pulmonary parenchyma and the development of unfavorable endpoints in patients with postcovid syndrome.
Material and research methods. The material of the study was the case histories of 128 patients who underwent COVID-19 and are in early medical rehabilitation. A retrospective analysis of the data of case histories and their statistical processing were carried out.
Research results. Patients with progressive pulmonary fibrosis were more comorbid (p<0.001). BA (p <0.05), CIPD (p <0.05), obesity and steatohepatitis (p <0.001) and thromboembolic events within a month after discharge from the infectious hospital (p <0.001) were significantly more frequent in them. Thromboembolic events occurred in 66 patients (51.56%), 12 patients died (9.38%), the combined endpoint (death + thromboembolism) occurred in 70 patients (54.69%). The risk of adverse endpoints is significantly higher in patients with severe and extremely severe COVID-19. In these patients, the average number of background pathologies was significantly higher (p <0.001), among which COPD (p <0.001), type 2 diabetes (p <0.05), obesity and steatohepatitis (p <0.001), Parkinson's syndrome ( p <0.05). Also, the group of patients with the development of thromboembolism and deaths was distinguished by more pronounced lung damage (p <0.05), a higher incidence of severe and extremely severe infections (chi square = 6.98, p <0.01).
Conclusion. Retrospective analysis showed that the risk of progression of fibrosis of the pulmonary parenchyma in patients with COVID-19 increases in the presence of AD by 1.83 times (p<0.05), CIBD - 2.46 times (p <0.05), obesity and steatohepatitis - 7.22 times (p <0.001), the development of thromboembolic events during the first month - 9.39 times (p <0.001). The risk of developing a combined unfavorable endpoint (death and thromboembolic events) COVID-19 increases 1.63 times in severe and extremely severe disease, 2.33 times in the presence of COPD (p <0.001), 1.63 times - in the presence of type 2 diabetes (p <0.05), 3.64 times - in the presence of obesity and steatohepatitis (p <0.001).
В последние годы наблюдается драматический рост случаев сахарного диабета 2-го типа, ожирения, метаболического синдрома, хронических заболеваний почек, а также их различных сочетаний, отмечающихся у каждого второго жителя планеты. Ежегодный уровень смертности от ХБП оценивается приблизительно в 1 млн. случаев во всемирном масштабе. Условия, которые вызывают или ускоряют ХБП, включают сердечно-сосудистые заболевания, кроме того, различного рода факторы нередко оказывают существенное воздействие на процессы патогенеза, а также – развитие ХБП.
To investigate the variations in blood glucose levels, hemodynamic effects and patient anxiety scores during tooth extraction in patients with type 2 diabetes mellitus T2DM and coronary disease under local anesthesia with 2% lidocaine with or without epinephrine
Diabetes is a major cause of chronic kidney disease (CKD). Poor blood sugar control accelerates the progression of CKD to terminal renal failure. Chronic kidney disease is also an important co-morbidity of diabetes. Impaired renal function further increases the risk of cardiovascular events in diabetic patients and ultimately carries a severe social and economic burden. Altered fibroblast growth factor 23 (FGF-23) and Klotho levels are considered the earliest biochemical abnormality of chronic kidney disease, the mineral and bone disease syndrome.
To study hepatic encephalopathy caused by endogenous intoxication in patients with diabetes mellitus (DM) complicated by necrotic soft tissue lesion (PNSTL) and ways of their correction.
Diabet ko'p yillik o'rganishlar va yangi zamonaviy davolash usullariga qaramay, kasallik, ayniqsa sanoati rivojlangan mamlakatlarda rivojlanib bormoqda. JSST ma’lumotlariga ko'ra, so'nggi o'n yilliklar ichida qandli diabet bilan ogrigan bemorlar soni ikki barobarga oshgan va 160 millionga teng bo'lib, 2025 yilga borib ikki barobar ko'payishi taxmin qilinmoqda. Qandli diabetning katta ijtimoiy aamiyati shundaki, mikro va makroangiopatiyalarning qon- tomir asoratlari tufayli erta nogironlik va o'limga olib keladi. Kasallik bilan bogliq xarajatlarning doimiy o'sishi sogliqni saqlash uchun ogir yuk bo'lib kelmoqda. Qandli diabetning eksperimental modellari nafaqat kasallikning patofizilogiyasini tushunish uchun balki turli dori darmonlarning antidiabetik ta’sir mexanizmini xam qo'llash uchun qimmatli ma’lumotlarni olish imkonini beradi.
Согласно современной точке зрения воспалительные заболевания пародонта относятся к инфекционным хроническим воспалительным заболеваниям, поэтому нормализация микрофлоры полости рта является неотъемлемым условием их рациональной терапии
Вопрос поражений хрусталика при сахарном диабете давно привлекает внимание офтальмологов. По данным разных авторов, поражение хрусталика наб-сдаетея у 2-62% больных диабетом и занимает второе месте по частоте поражения органа зрения. Учитывая данные отечественной и зарубежной литературы о поражениях хрусталика как об одной из причин слепоты при сахарном диабете, или провели изучение распространенности катаракты на основе клинико-эпидемиологического обследования 600 вольных сахарным диабетом. Возраст обследуемых больных колебался от 16 до 80 лет, мужчин было 273, женщин 327.