The article provides a review of the literature devoted to modern data, as well as the impact of genetic predisposition on the development of pneumonia in children. It is known that timely, innovative diagnosis, treatment and prevention of pneumonia in children today is one of the most pressing problems in pediatrics. Timely identification of the etiological cause of pneumonia, treatment is carried out only by early diagnosis, adequate assessment of the severity of the patient's condition, reasonable choice of treatment with antibiotics, taking into account the background disease, age and weight of the child.
This article presents the results of the study of changes observed in the mucosa and submucosa of the bronchial wall after inducing experimental pneumonia in rabbits. The investigation was carried out on 24 adult rabbits weighing 2-2,5 kg. The experimental rabbits were examined 3, 15, 30 days after induction of pneumonia. Data from 6-7 rabbits in each period were analysed.
Pneumonia is a serious public health problem due to its high prevalence, especially among young children. The urgency of this problem is also determined by the constant growth of antibiotic-resistant strains of key pathogens of community-acquired pneumonia.
Pulmonary pleural complications in children with pneumonia occur at different stages of the disease, which does not dictate the need to analyze predisposing and premorbid factors that influence the risk of developing complications in pneumonia in children.
This scientific article presents the pathomorphological specific changes in viral atypical pneumonia that develop in children with immunodeficiency. Histological examination of lung tissue in 36 patients with atypical pneumonia, carried out by autopsy in April-November 2020 at ROAC RUz. The results of the morphological study showed that, first, there are strong dicirculatory and hemorrhagic changes in the lung tissue, then pathomorphological changes in the pulmonary epithelium, if the process continues for a long time, the development of proliferative inflammation in the lungs. The proliferation of fibroblasts in the bronchi, blood vessels and interstitial tissue.
Despite numerous studies in the field of pediatric pulmonology, the problems of acute and complicated pneumonia in young children still remain relevant. With this pathology, taking into account the phase of the disease, and its clinical forms (complicated, uncomplicated), the study of isoform lactate dehydrogenase (LDH) in the blood of children with complicated pneumonia is of great scientific and practical interest.
This article presents an analysis of the features of the clinical manifestations of pneumonia with a typical and atypical course. When prescribing antibiotic therapy in children with community-acquired pneumonia, it is necessary to take into account the etiological factor and the severity of the condition.