To study the anti-inflammatory and some other pharmaco- logical properties, toxicity of the new thiocarbamate and thiourea derivatives (codes UB-421 and BIK-15, respectively), selected after the scrinning reseaches among the compounds of this group and to ground the possibility of their using in clinic
The state of biochemical markers of inflammation in 337 patients with destructive tuberculosis with different genetic backgrounds was studied. It was found that in the indicators of inflammation – sialic acids, haptoglobin, seromucoids in patients with destructive pulmonary tuberculosis with different genetic backgrounds, there is a significant difference between individuals with different reactivity. The most profound and long-lasting changes in the activity indicators of acute-phase proteins are characteristic of patients with an unfavorable and relatively unfavorable genetic background
Оксидативный стресс, синтез вазоконстрикторов, факторов воспаления и цитокинов, подавляющие продукцию оксида азота основного вазодилататора, влияют на возникновение и развитие дисфункции эндотелия (ЭД). ЭД всегда предшествует повреждению или нарушению функционирования любого сосуда независимо от его органной локализации. Оценить функциональное состояние эндотелия можно косвенно. Для этого необходимо исследовать в крови содержание факторов воспаления, повреждающих эндотелий – С реактивного белка (CRP), провоспалительных цитокинов и др. Уровень содержания данных факторов связан со степенью выраженности ЭД. Провоспалительные цитокины способствуют синтезу эндотелина-1 (ЭТ-1), уменьшают вазодилатацию, индуцированную ацетилхолином, дестабилизируют мРНК эндотелиальной синтазы NO, вызывая ЭД.
A literature review on the problem of treatment of exudative otitis media was performed. Exudative otitis media (EMI) is one of the most actively studied diseases of the middle ear in recent decades. Particular interest in this pathology is due to the variety of clinical manifestations of the disease, the duration of the course, the laboriousness of treatment, often resistance to standard therapy for otitis media, and a tendency to relapse. Clinical signs: the presence of exudate in the tympanic cavity, the absence of signs of acute inflammation and defect of the tympanic membrane. Modern medicine is considering many options for the treatment of exudative otitis media, up to the alternative of using hearing aids for patients with contraindications to other types of treatment. On the territory of the CIS, patients are prescribed medication or surgical treatment without active observation tactics, in most European countries and the United States, a wait-and see approach is used.