We examined 43 patients with breast cancer, who, as in the previous group, underwent percutaneous transhepatic cholecystostomy, however, the bile separated through the external drainage was preliminarily purified from toxic and ballast substances using the Lignov sorbent. Subsequently, the patients took it orally.
In the first group of patients, the concentration of IL-6 in the blood serum prior to the application of percutaneous transhepatic cholecystostomy was higher than normal, averaging 152.65±16.3 pg/ml. Immediately after the application of percutaneous transhepatic cholecystostomy in bile, this indicator averaged 68.58±7.24 pg / ml. At the end of the observation, the decrease in the level of IL-6 in the blood compared to the initial one was 64.4%, and in bile-54.3 (P<0.001). In the second group of patients, after the application of percutaneous transhepatic cholecystostomy, the concentration of IL-6 in the blood serum averaged 151.52±14.2 pg / ml, and in bile - 67.43±9.14 pg/ml. The initially high concentration of IL-6 in the blood and bile after bile absorption decreased by 75.7% (36.81±4.4 pg /ml) and 73.9% (17.57±2.2 pg/ml), respectively, from the initial level. The inclusion of bile absorption in the therapeutic complex significantly changed the concentration of IL-6 in blood serum (P<0.01) and bile.
The dynamics of parameters in blood serum and bile in patients of this group indicates a significant efficiency of bile absorption. Initially high indicators of endotoxicosis, such as SMP, TNF-α, IL-6 and bilirubin, were removed from the body by bile absorption, which made it possible to remove toxic substances from the body. The study of SMPs in blood serum and bile in patients of the main group revealed a more accelerated elimination of them with bile than in the control group. An increase in the concentration of SMP in bile was accompanied by a decrease in it in the blood serum.
Cerebral injuries, complicated by subdural and intracerebral hematomas play the leading role in the structure of childhood injuries, they are the most frequently encountered injuries. The work presents a retrospective assessment of medical records of children aged 5 to 7 years who were admitted on an emergency basis with a clinic of traumatic brain injury. The paper presents the indicators of the main patterns of respiration and hemodynamics, the minimum alveolar concentration, which reflect the effectiveness of inhaled anesthesia during the operation.
Cerebral injuries, complicated by subdural and intracerebral hematomas play the leading role in the structure of childhood injuries, they are the most frequently encountered injuries. The work presents a retrospective assessment of medical records of children aged 5 to 7 years who were admitted on an emergency basis with a clinic of
traumatic brain injury. The paper presents the indicators of the main patterns of respiration and hemodynamics, the minimum alveolar concentration, which reflect the effectiveness of inhaled anesthesia during the operation.
This article examines the main directions in the study of media
language (linguistic, rhetorical, hermeneutic, psycholinguistic, linguopragmatic,
sociological, legal and cultural aspects). Particular attention is paid to semiotic and
cognitive-discursive approaches to the analysis of mass communication texts. Active
innovation processes in the sphere of convergence of various discourses into
communicative and discursive practices of the mass media, the problem of translating
media texts, as well as texts of political discourse are considered.
Chronic brain ischemia (CHEM) develops due to insufficient blood circulation of the brain, is one of the most common cerebrovascular diseases, accompanied by cognitive disorders, with a decrease in concentration and cognitive activity, and emotional disorders.
The article describes a clinical case of a patient with chronic brain ischemia.
Застой мочи, присоединившаяся инфекция, порождающая рефлюкс, приводят к развитию острого гнойного пиелонефрита. В дальнейшем нарастают признаки интоксикации, вплоть до развития инфекционно-токсического шока. Инфекция в мочевыводящих путях при наличии окклюзии усугубляет болезненный процесс, а сами инфекционные агенты, микробы могут жить в матриксе при приципстации мочевых солей.
In many aspects, the processes of regulation of the effects of opioid peptides remain unclear, but it has been shown that, due to the activation of opiate receptors, regulatory cellular reactions are involved, as well as the inhibition of adenylate cyclase and the formation of adenosine monophosphate. As a result, an increase in the supply of potassium ions and some other processes are observed. Interacting primarily with delta and mu receptors, dalargin controls the processes of pain relief and eating behavior. Dalargin mediates its effects both in the gastric mucosa and in the myocardium. The drug stabilizes blood flow and lymph flow in the area of the defect, stimulates increased production of mucus and a number of prostaglandins, these factors contribute to the regeneration of the mucosa. Interacting with receptors in the myocardium, the level of cyclic adenosine monophosphate and specific proteases decreases in cardiomyocytes, the process of glycogenesis increases, the concentration of catecholamines in the general blood flow normalizes, which improves hemodynamics and heart rate. Thus, these factors lead to accelerated scar healing.
Теоретические основы возможности и прогнозирования токсичности и опасности химических соединений начали закладываться еще за рубежом в 19- 20 веках.