This article examines the role of property tax in the formation of the country's budget, its dynamics and rates in 2000 - 2009 and 2010 - 2021, and also developed proposals to improve the methodology for calculating this type of tax
Purpose of the study: to evaluate the results of complex therapy including retrobulbar catheterization and magnetic stimulation of the optic nerve in patients with ChASN of different genesis by studying clinical and functional features of the eye in this case.
Methods. 105 patients (155 eyes) with the diagnosis: partial optic nerve atrophy of different genesis (PAN) received conventional treatment, treatment with the method of retrobulbar catheterization, as well as with the method of retrobulbar catheterization in combination with MS for 10 days. The dynamics of OD indicators, visual field, electrophysiological studies, ophthalmoscopy and ultrasound Dopplerography were investigated.
Results. The analysis of the obtained data indicates that the effectiveness of the proposed methods of treatment depends on the degree of MN destruction, so the treatment is more effective in the 11th degree of ChASN. However, in the group of patients treated by the combined method the efficiency is equally high both at II and III degrees of ChASN.
According to the data of visual acuity dynamics in patients with II stage of Chasnosis in the course of treatment it follows that if in the group of patients treated by the traditional method the effect was observed only in 64,3% of cases, in the group of patients treated by the method of retrobulbar catheterization the efficiency was observed in 89,3%.
The dynamics of the ocular fundus state under the proposed methods of treatment due to the short period of observation (2-3 weeks) underwent the following changes: dilation of CAC vessels, reduction of capillary tortuosity, reduction of retinal edema, as well as the appearance of foveal and macular reflexes distinctness. The data of ultrasound Dopplerography indicate a significant improvement of hemodynamic parameters in the CAC in patients with ChASN of different genesis in early terms after treatment. Improvement of systolic pressure indices was noted. In each case of the examined patients the improvement of hemodynamic resistance index Ri towards normalization was revealed. Accordingly, there was a significant increase in diastolic pressure, indicating the strengthening of elastic-elastic properties of vessels under the influence of treatment.
In our opinion, the improvement of hemodynamic parameters after the course of the proposed method of treatment is associated with an increase in the volume of the microcirculatory channel in the area of direct influence on MN by retrobulbar catheterization and MS.
Purpose of the study: to study the effect of the combination of valsartan with sacubitril on myocardial remodeling in patients with coronary heart disease after revascularization. Material and research methods. The study included 320 patients with coronary artery disease who underwent coronary revascularization. On average, the concentration of creatinine was 90.08 ± 1.72 µmol / L. All patients were divided into 2 groups: patients who received valsartan (group B, 160 people), patients who received ARNI - a combination of valsartan and sacubitrile molecules (group C, 160 people). Also, all patients were divided into 2 subgroups depending on the degree of eGFR decrease by the 3rd month of observation: patients with a decrease in eGFR by the 3rd month of observation more than 20% (group 1 - 59 patients) and less than 20% (group 2 - 261 sick). In dynamics, three months later, at the end of the first and second years of follow-up after revascularization, all patients underwent an echocardiographic study (EchoCG). Research results. During the observation process, it was found that against the background of both therapy options, there was a positive dynamics of indicators characterizing myocardial remodeling. he relative dynamics of indicators between the treatment groups was comparable at all stages of observation. In the group of patients with a decrease in eGFR of more than 20% in the first 3 months against the background of standard therapy after revascularization, no significant dynamics of the geometric parameters of the heart was observed at all follow-up periods. In the group of patients who received standard therapy with the addition of sacubitrile, both in group 1 and in group 2, more favorable geometric parameters were achieved, demonstrating a decrease in the severity of pathological remodeling and the formation of CHF. Conclusion. The use of sacubitril in the treatment of patients with coronary artery disease contributes to a more pronounced positive remodeling of the heart chambers - a decrease in the size of the chambers and the LV sphericity index. The effect is more pronounced in patients with a tendency to rapidly develop CKD.
The article deals with the problems of assessing the labor market and employment of the population in the Republic of Uzbekistan. The directions and sizes of expenses for the introduction of a new system for vocational training of the unemployed and the poor and increasing their labor activity are analyzed. Since the consequences of population poverty is a limiting factor in human development. The analysis of the dynamics of the structure of labor resources, the level of participation of the population of the Republic of Uzbekistan in the labor resources by sex, the dynamics of the level of employment and unemployed in the Republic of Uzbekistan. The main conclusion of the authors is that the changing conditions of various spheres of public life require from the state a new approach to teaching young people and women, assistance in organizing their interaction with employers.
Purpose of the study: to study the effect of the combination of valsartan and sacubitril on the indices of central hemodynamics in patients with coronary heart disease (CHD) within 2 years after revascularization. Material and research methods. The study included 320 patients with coronary artery disease who underwent coronary revascularization. All patients were divided into 2 groups: patients who received valsartan (group B, 160 people), patients who received ARNI - a combination of valsartan and sacubitrile molecules (group C, 160 people). At baseline and in dynamics after three months, at the end of the first and second years of follow-up after revascularization in patients with coronary artery disease systolic the blood pressure (SBP, mm Hg), diastolic blood pressure (DBP, mm Hg), heart rate in minute, the concentration of brain natriuretic peptide (BNP) in the blood were determined. Also, during echocardiography, the stroke volume of the heart, indexed to the body surface area (SI, ml / m2), the minute index (MI, ml / m2), the mean pressure in the pulmonary artery (PA, mm Hg) were determined. Research results. In the group of patients taking valsartan (group B), the relative dynamics of BNP concentration was -10.69 ± 0.55% by the 3rd month of observation, -21.24 ± 1.03% by the end of the 1st year, and -34, 39 ± 1.64% by the end of the 2nd year of observation. The inclusion of sacubitril in the therapy scheme contributed to a greater positive effect in reducing the BNP concentration: the relative dynamics of the BNP concentration was -10.30 ± 0.52% by the 3rd month of observation, - 21.91 ± 1.00% by the end of the first year of observation, and -39.28 ± 1.67% (p <0.05 significant difference with group B). By the end of the 1st and 2nd years of observation, the use of a combination of valsartan and sacubitril contributed to a more pronounced decrease in blood pressure (p <0.01), a more pronounced dynamics of MI (p <0.05) and a decrease in pressure in РA (significantly lower baseline indicators, p <0.05 and indicator in group B, p <0.01). Conclusion. The present study revealed a positive effect of revascularization and subsequent therapy of coronary artery disease with the inclusion of sacubitrile on the BNP concentration, blood pressure and mean pressure of pulmonary artery.
In modern social studies, sociological research and study of human capital is gaining urgent importance. In this article, in the processes of social development, firstly, to determine the sociological genesis of the concept of human capital, to observe the aspects of its innovative development as a social phenomenon, and secondly, the problem of human capital as a socio-cultural phenomenon was researched. Also, conclusions on increasing social and economic empowerment through education, activating social norms and social mobility in young people, forming skills and habits, and ensuring the growth and stability of incomes are given.