The purpose of the study is to determine the significance of genetic factors in the development of chronic nephritic syndrome in children and to clarify the features of the clinical course
The оbject of research were 129 children aged 4-15 years who were treated for chronic nephritis in the nephrology department of the Samarkand Regional Multidisciplinary Paediatric Medical Centre.
The scientific novelty of the study is as follows:it has been established that the severity of chronic nephritic syndrome in children is associated with clinical manifestations (gradual development, dyspepsia, abdominal pain) and an increase in the amount of Cystatin C in the blood;for the first time, it was revealed that the development of sclerotic lesions due to increased proliferation in patients with the presence of the MMP-9 (A-8202G) rs 11697325 genotypes in chronic nephritic syndrome leads to a worsening of the clinical course of the disease; established early diagnostic marker MMP-9 (A-8202G) rs 11697325 and its tissue inhibitor TIMP-2 (C536T) rs 11551797 in chronic nephritic syndrome in children in the diagnosis of the disease; for the first time, the prognostic value of the alleles of the MMP-9 (A-8202G) rs 11697325 genes and the homozygous G/G genotype in determining the risk of developing the disease in children with chronic nephritic syndrome has been proven.
Implementation of the research results. Based on scientific results of evaluation of the role of polymorphic genes of matrix metalloproteinase and its tissue inhibitors in chronic nephritic syndrome in children: methodological recommendation “The role of polymorphic genes of matrix metalloproteinase and its genetic inhibitors in the development of chronic nephritic syndrome in children” was developed and approved (reference of the Ministry of Health of the Republic of Uzbekistan No. 8n-r / 554 of 30.02.2022).
This methodological recommendation made it possible to predict the development of chronic nephritic syndrome in children and improve preventive measures; approved and developed on the basis of scientific results of research on early diagnosis and prognosis of chronic nephritic syndrome “Dynamics of clinical and laboratory parameters in nephritic syndrome in children”, (reference of the Ministry of Health of the Republic of Uzbekistan No. 8n-r / 555 of 30.02.2022).
This methodological recommendation made it possible to optimize the diagnosis and treatment tactics for various forms of nephritic syndrome in children;
The results obtained were implemented in the practice of health care, in particular, in the Republican Children's National Medical Center, in the 1st clinic of the Samarkand State Medical University, in the Samarkand Regional Children's Multidisciplinary Medical Center (conclusion No. 8 n-r/324 of 21.06.2022 of the Ministry of Health of Uzbekistan).
The application of the obtained results to practice has made it possible to reduce the frequency of recurrence of the disease in children, prevent complications of the disease, improve the quality of life of patients, diagnose and prevent the disease.
The structure and scope of the dissertation. The dissertation consists of an introduction, 4 chapters, conclusions, practical recommendations. The volume of the dissertation is 120 pages.
The concentration of the level of cytokines in saliva depends on the form of stomatitis, which is confirmed by the presence of a relationship between the concentrations of TNFα and IL-1β, and this relationship is direct and varies depending on the form of stomatitis, which indicates a violation of immunoregulatory mechanisms in chronic recurrent forms of stomatitis.
Хронический рецидивирующий афтозный стоматит (ХРАС) одно их самых частых воспалительных заболеваний слизистой оболочки полости рта, характеризующееся рецидивирующими высыпаниями афт с длительным течением и периодическими обострениями. Лечение ХРАС должно быть комплексным и индивидуально подобранным.
To evaluate the effectiveness of local treatment of erosive and ulcerative lesions of the oral mucosa using Dentor-gel (ALTEZZA pharma, Italy).
Хронический рецидивирующий афтозный стоматит (ХРАС) -- это воспаление слизистой оболочки полости рта, проявляется наличием афты округлой или овальной формы с гиперемированным ободком вокруг, поражает 20% населения. Факторами, провоцирующими ХРАС чаще являются переохлаждение, стрессовые ситуации, прием лекарственных препаратов. Расположение афт, по данным разных авторов, бывает на слизистой оболочке щеки (45,6%), переходные складки (45%), кончике и боковой поверхности языка (6,1%-14%), подъязычной области (4%-7%), верхней и нижней губе (41,2%), мягкое небо (2%) (Успенская О.А.,2015; Ибрагимова М.Х.,2019).
Хронический рецидивирующий афтозный стоматит (ХРАС) - один из самых распространенных заболеваний слизистой оболочки рта, характеризующееся выраженной воспалительной реакцией тканей с образованием эрозивно-язвенных элементов и рецидивирующим течением.
Хронический рецидивирующий афтозный стоматит (ХРАС) представляет серьезную проблему стоматологии в связи с ростом заболеваемости.