The aim of the study was to optimize the treatment of patients with dermatological manifestations in patients who had a coronavirus infection by identifying the features of their clinical course, microelement and immune changes.
The object of the research were 138 patients who underwent a comprehensive examination and treatment in the conditions of the Samarkand
regional dermatovenerologic dispensary from June 2020 to July 2021.
The scientific novelty of the research consists of the following: for the first time, it was revealed that the most common dermatological manifestations of the post-COVID period is the high incidence of hair loss, which manifests itself in the form of the prevalence of baldness foci in the occipital and temporal regions in women and in the parietal and temporal regions in men; dermatological manifestations were also observed in the form of rashes like acrodermatitis, papulo-squamous rashes, urticarial rashes, papulo vesicular rashes and vesicular rashes like herpes. It has been established that a high risk of developing dermatological manifestations in the post-COVID period is observed in males over 40 years old, while there is an immune imbalance and a violation in the microelement status;
for the first time, based on a spectrometric study, a decrease in the level of microelements necessary for the body, such as zinc, selenium and magnesium, as well as an increase in the level of chlorine and bromine, was found in patients with
dermatological manifestations after suffering a coronavirus infection; for the first time, changes in the hematopoietic system were revealed, almost
all patients with dermatological changes who underwent coronavirus infection have anemia, severe leukocytosis and an increase in ESR, although 12 weeks have passed since the coronavirus infection.for the first time, a characterization of the morphological elements of dermatological manifestations after a coronavirus
infection (COVID-19) was given; for the first time, pathological changes in the immune status in patients with dermatological manifestations after a coronavirus infection have been proven, consisting in an increase in the fractions of immunoglobulins G, A, E, IL-1,2,6, TNF-α, a decrease in the level of T-lymphocytes by 22.2% below normal (p>0.05) and an increase in B-lymphocytes by 15%, compared with patients without dermatological manifestations; for the first time, a characteristic of morphological rashes after the coronavirus infection SARS-CoV-2 (COVID-19) was given. Implementation of research results. Based on the results obtained to
improve the diagnosis and treatment of dermatological manifestations after a coronavirus infection: the methodological recommendation “Dermatological manifestations after a coronavirus infection” was developed and approved (conclusion of the Ministry of
Health dated January 19, 2022 No. 8n-r/37). This methodological recommendation has improved the algorithm for diagnosing and treating dermatological manifestations after coronavirus infection; scientific information on improving the diagnosis and treatment of dermatological manifestations after a coronavirus infection has been introduced into practical healthcare, in particular, in the Bukhara and Andijan regional
dermatovenerological dispensaries (certificate of the Ministry of Health dated January 25, 2022 No. 8n-r/35), which made it possible to increase the effectiveness of dermatological manifestations.
The structure and scope of the dissertation. The dissertation consists of an introduction, four chapters of own research, a conclusion, practical
recommendations and a list of cited literature. The volume of the text material is 107 pages.
Any epidemic and pandemic that is a great stress or emergency leads to disruptions in the psycho-neurological system and human behavior. Psycho-emotional excitement in patients with severe Covid-19 dramatically reduces the effectiveness of non-invasive ventilation. Purpose of the study: to assess the efficacy, safety and impact on the quality of life of patients with dexmedetomidine and propofol against the background of a decrease in need for oxygen. The study included 21 patients with severe and extremely severe Covid-19. In the first group of patients with fear of death, a combination of drugs propofol + sibazone + fentanyl was used. In the second group, dexmedetomidine and promedol. Conclusions: in patients with a severe course of coronavirus infection, dexmedetomidine is more effective in reducing psycho neurological arousal and improving cognitive functions, which leads to an effective supply of oxygen and to their faster recovery.
21 patients with a severe course of COVID-19 were under observation. The study was carried out in a specialized hospital for the treatment of patients with coronavirus infection. A more detailed analysis of the ECG was carried out: the duration of the corrected QT interval, the variance of the QT interval, the Tp-Te interval and the Tp-Te/QT ratio were determined. Prolonged repolarization rates are a poor predictor of a dangerous COVID-19 outcome.
This article studies the evolution of the coronavirus epidemic into a pandemic that has become an unprecedented threat to humanity in the 21st century, its impact on the lifestyle of Chinese society, changes in China’s domestic and foreign policies due to coronavirus infection, and the results of the Chinese government’s effective struggle against the “disaster”. Moreover, the author analyzes the situation in international relations due to COVID -19, changes in international relations under the influence of the pandemic, the transformation of relations between major powers as a result of the coronavirus, a variety of methods for combating COVID -19 in different countries of the region, China’s experience in combating the pandemic and its significance for the world, and the crisis caused by the pandemic in people's lifestyles and in all sectors of the economy. What is more, the assessments and approaches of Chinese experts and specialists in combating the pandemic are examined based on their experience in overcoming the crisis. Finally, it reflects the opinions of Chinese scientists and experts about the huge changes that could happen in the world order after a pandemic.
Environmental change, climate warming, increasing population density, high migration activity and other factors are provoking the emergence and spread of new infections around the world. The emergence in December 2019 of diseases caused by a new coronavirus ("coronavirus disease 2019") has already gone down in history as not a disease of minor importance, but a disease of great magnitude engulfing the entire humanity. It is known that the most common clinical manifestation of the new infection is pneumonia and, in a large proportion of patients, respiratory distress syndrome. In our article we present a brief analysis and literature review of the epidemiological and epidemiological picture, in addition, we note the etiopathogenesis and some of the nuances of the disease.
Currently, coronavirus infection has become an important medical and social problem on a global scale, which has acquired the status of a pandemic. This article describes neurological as well as cerebral complications of coronavirus infection.
In order to maintain and strengthen the health of the population in a pandemic, the following preventive measures are being taken to prevent the spread of coronavirus infections: specific, non-specific, with the help of medicines, as well as at medical enterprises, preventive measures aimed at eliminating coronavirus infection are being considered. To prevent infection of the population with coronovirus, vaccination is mandatory.
In accordance with the Decree of the President of the Republic of Uzbekistan №5537 "On establishment of the Special Republican Commission on preparation of the Program of measures to prevent importation and spread of a new type of coronavirus in the Republic of Uzbekistan" dated January 29, 2020, and in accordance with the Ministry of Health of the Republic of Uzbekistan the list of primary prevention measures carried out by VPP in the primary health care system was developed.
The aim of our study was to study the course of diabetic polyneuropathy in patients who had undergone coronavirus infection. The analysis of the factors of the elementary element in diabetic polyneuropathy is planned. Currently, the study of the effect of coronavirus on the nervous system, including the peripheral nervous system, is the most urgent.
The study discusses some key issues regarding the impact of the COVID-19 pandemic on the international relations, the global economy. According to the author, slackening of economic relation in global economy, the falldown of Gross Domestic Product, has counted against many national economies and for global economy as a whole. In this context, it is also necessary to emphasize that the issue will negatively affect the cultural and humanitarian relations between the countries, which will also affect and slow down the pace of development of international relations after the pandemic. The situation that has developed in the world as a result of a pandemic makes it clear that the emergence of any disease, epidemic, threatens its mass spread among millions of people and not a single country or state is protected from this, and the consequences apply to absolutely all spheres of life of a human being. At present, for many states, along with political and economic problems that need urgent solutions, the construction of hospitals, their equipping and provision of medical personnel, the lack of which is especially acute in the context of the global epidemic, has become especially priority. And, in such conditions, the development of multilateral cooperation is acutely felt, actions together based on the principles of cooperation in solving priority problems. The following tasks are revealed in the article: study of the situation in the world related to the current spread of the coronavirus, the impact of the pandemic on international relations; measures taken by governments in a pandemic conditions and their effectiveness; Uzbekistan's experience in counteracting the pandemia; strengthening regional cooperation; Uzbekistan's initiatives to combat the pandemia. The general situation, connected with the spread of the pandemia is examined. The consideration is given to the measures applied by the countries’ governments in combating the coronavirus pandemia, as well as their effectiveness. The article presents the experience of Uzbekistan in combating a pandemia, initiatives to combat the crisis, as well as strengthening regional cooperation with neighboring countries at the current stage. Currently, only the beginning of regional cooperation between Central Asian states is observed. The study of the issues of spread of coronavirus, and its impact on international relations are not well-defined. Since the pandemic has spread throughout the world, there are a lot of questions for research, not only large-scale, but also local in nature. In the course of the work, the author applied a systematic approach.
In the short-term, the global spread of coronavirus infection, first identified in Wuhan, China, and known as COVID-19, is leading to a deterioration in the socio-economic situation in almost all countries. The global pandemic of coronavirus COVID-19 has not only killed many people, but it has been also damaging the global economy on an unprecedented scale since the Great Depression. The ability of COVID-19 to destroy personal life, business, industry and the
entire economy has become known to the world community. The main purpose of this article is to summarize the socio-economic impact of COVID-19 on individual aspects of the world economy and the measures taken by countries to address its consequences and analyze their importance
and role in broad economic development.
COVID-19 is the current global coronavirus pandemic caused by the SARS-CoV-2 coronavirus. The first reports of the disease outbreaks appeared in China on December 31, 2019 and the first clinical manifestations occurred earlier on December 8, 2019. On January 30, 2020, the World Health Organization declared the outbreak as a public health emergency of international concern. On March 11 it was declared a pandemic. Common symptoms include fever, cough, fatigue, shortness of breath, and anosmia (loss of smell).Complications can cause acute respiratory distress syndrome (ARDS) and pneumonia. The incubation period is usually around five days, but can range from two to fourteen days.
Aim of the research isto study of clinical and diagnostic criteria for neurological disorders and changes of laboratory parameters in patients with COVID-19.
Актуальность проблемы: в декабре 2019 года в г. Ухане, КНР, впервые была зафиксирована вспышка новой коронавирусной инфекцией COronaVIrus Disease 2019 (COVID-19), которая быстро приобрела масштабы пандемии. Стойкая активация иммунной системы при COVID-19 у пациентов высокого риска может привести к неконтролируемому усилению продукции цитокинов. На фоне цитокинового шторма возникает SARS-CoV-2-ассоциированный эндотелиит с развитием микроангиопатий как локально в легочной ткани, миокарде, органах желудочно-кишечного тракта, головном мозге, так и системно с проявлениями продуктивно-деструктивного изменение что в конечном итоге приводит к прогрессирующей полиорганной недостаточности. Наряду с потенциальным прямым вирусным поражением слизистая оболочка повышенный уровень провоспалительных цитокинов может поддерживать местное воспаление и провоцировать изъязвления и разрывы в области уже существующих патологии.