Type 1 diabetes mellitus is a disease in which the highest rates of premature mortality and early disability of patients are observed, which is caused by the onset of the disease at an early age, the instability of the course of type 1 diabetes and the threat of acute and chronic complications. The goals of type 1 diabetes mellitus treatment are its compensation, prevention of the risk of complications when normoglycemia is reached and stabilized.
The history of the study of hyperhomocysteinemia goes back half a century. It is interesting that the increased level of homocysteine as a factor of vascular damage was first noticed in pediatric practice. In 1969, Kilmer S. MeCully, a professor in the Department of Pathology at Harvard University, studying a rare genetic disorder manifested by homocysteinuria (increased levels of homocysteine in the urine), suggested a link between elevated serum homocysteine levels and arterial disease. Without treatment, these children usually die at an early age from myocardial infarction or cerebral strokes. During autopsy, it was found that their vessels were the same damaged and thickened as in elderly patients with cardiovascular diseases. Clinically, this disease is characterized by a marfan-like phenotype, connective tissue lesions (high growth, arachnodactyly, lens subluxation, chest deformities, heart defects), neuropsychiatric disorders, arterial thrombosis. The pathology is based on a defect in one of the metabolic enzymes of sulfur-containing methionine, mainly in the amino acid cystothionine-E-synthetase (classical tomocysteinuria). Subsequently, it was shown that moderate and mild homocysteinemia affects the vessels of various localization, leading to pathological changes in them.
This article is devoted to the issues of improving the geometric training of future mathematics teachers. Examples are given of using the method of geometric transformations when solving construction problems in order to develop graphic skills. To develop students' graphic skills, specially selected exercises are offered. When solving problems, analysis and synthesis are used together. It is substantiated that the formation of the ability to predict and anticipate the results that each individual step in the process of finding a solution to a problem will lead to is an important component of the development of geometric training of students
The authors of the article considere the experience of decentralization of government in the countries of Eastern Europe and some other countries. Also models of the development of local self-government were presented.
In the history of the world epics study, the Arab epics has long remained unexplored, and this was the reason that sometimes there impression of the absence of an epics among the Arabs. To date, epic patterns have been considered mainly as sources of interest only to historians and anthropologists. One of the unique examples of the early medieval epic stories of the Arabs is the tribal traditions, known in Arabic studies as “Ayyam al-Arab” (“Days of the Arabs”). This collection of oral and later written narratives is not only a unique historical monument, but also a valuable philological source in its broadest sense. This article is devoted to the study of the role and place of man in pre-Islamic society, his essence and dignity, positive and negative qualities, which have reflected in ”Ayyam al-Arab. For this purpose, the selection and analysis of tribal legends – “Days” was made, on the basis of which the main participants in historical events – epic heroes were identified, a classification of heroes was made, and the question of the prototype of literary heroes in Arabic literature and their influence on the formation of literary types at the subsequent stage of its development was baised.
Low hygiene of oral cavity is one of etiological factors of the development of periodontal diseases. An indicator of periodontal diseases in children with orthodontic treatment has almost reached 100%. This work reveals results of a clinical test of a drug called Ismijen. The offered way of treatment of gingivitis of orthodontic patients using Ismijen is tend to be more effective than other conventional treatments.
The article examines the problem of centralization and decentralization of the budget. Budget decentralization is interconnected with the processes of geographical decentralization and decentralization of the system of administrative decision-making. Decentralization of the system of making and executing administrative decisions implies a wider delegation of authority to local divisions of the central executive authority. The article also states that the main goal of decentralization is to create a closer relationship between the control system and the population, and this requires strengthening the financial system of local governments. The task of decentralization is to provide the regions and local governments with certain powers in the field of taxation and expenditure of funds, as well as the ability to independently determine the parameters and structure of the budget expenditures. The article substantiates the advantages and disadvantages of budget centralization. Attempts were made to cover all arguments for and against decentralization.
In the article, the author examines the work carried out by universities today to develop students' organizational skills in the process of independent learning and the problems they face
The article considers the attitude of pragmatics to linguistics, its source of research, the unification of individual elements into a single system - a system of communication, which is necessary for the conditions of speech. The structure of the discursive system and its differences from the structural (paradigmatic) system are also considered on the methodological basis of the system's multi-dimensionality, and a new concept of isosignes is introduced to graphically designate the relevant components of speech communication as a system of a particular kind. In many cases, the use of any method is usually considered a specific feature of the author's creative approach. Therefore, the form of representation of the artistic image of speech communication is proposed to be divided into 8 types. The article studies the connection between central and district relations, subordination of district elements by primary elements, unification of language and non-linguistic, internal and external factors of the RA in the SPS, employment of the centre of the system by language verbal means. Practical examples of the SPS isosaints have also been developed and given; it has been substantiated that, like other different SPS systems, the SPS has a structure of a central structure that consists of verbal and non-verbal language means of communication, as well as on each floor of this structure different other means of social character play an important role.
In this scientific article explored the questions connected with high educational system in Uzbekistan with the international experience view. There are demonstrated the structures of high education of Uzbekistan and it’s evolution and there are given some information in charts & diagrams. By learning innovative and progressive methods of education of the foreign countries there are given some suggestions and recommendations to improve and develop of intellectual potential, educational sector and academies of republic of Uzbekistan in international arena.