This article examines the specific features of the formation of a realistic method of narration, as well as the beginning of the development of a realistic direction in a new type of fiction in Saudi literature. By means of the analysis, the features of the poetics of the Saudi realistic short story in the second half of the twentieth century are considered. The specific features of the formation of the realistic method of narration and the time intervals of its formation depend, in many ways, on the historical conditions in which artistic creativity develops in each society. National-historical circumstances also determine the uneven development of realism in different countries. In Egypt, near the Arabian Peninsula, the realistic method of narration began to take shape at the beginning of the first half of the twentieth century, when most of the Arabian States were not even covered by the educational movement. Already in the first collection of Muhammad Teymur - one of the founders of the short story genre in Egypt "What the eyes see" (1917-1918), the main features of realism are shown, "showing life in its contrasts". The beginning of the development of a realistic direction in the new type of fiction in Saudi literature was laid at the stage of Enlightenment. The struggle with the inherited old norms of life and consciousness for the authors of educational literature resulted in a protest against the forms of new oppression associated with the preservation and maintenance of medieval traditions and ideas in modern society, and, therefore, in many works of Saudi enlighteners, despite their inherent features of sentimentalism and romanticism, the beginnings of realistic trends can be traced.
The article highlights the variety of linguistic features of military terminology on the example of the combat regulations of the US Army "Ranger Textbook". The morphological and syntactic features of military documents were analyzed. It presents the distinctive features of the Charter. The concept of military terminology has also been considered.
The article analyzes the features of videoconferencing as a form of mutual legal assistance in criminal cases and the need for its The article analyzes the features of videoconferencing as a form of mutual legal assistance in criminal cases and the need for its use. The author explores the international and national legal framework for using video conferencing tools as innovative technologies. As a result of the study, gaps in the legislation on the use of videoconferences in matters of international cooperation in criminal matters were identified. In addition, the experience, advantages and disadvantages of foreign countries in using this form of mutual legal assistance are considered, and the relevant practice is studied in detail. Current article is enriched with real life examples. As a result, the features of the use of videoconferencing in mutual legal assistance in criminal cases, as well as the consequences and conveniences of using these tools in pandemic situation were identified, and proposals were developed to amend the relevant legislationuse. The author explores the international and national legal framework for using video conferencing tools as innovative technologies. As a result of the study, gaps in the legislation on the use of videoconferences in matters of international cooperation in criminal matters were identified. In addition, the experience, advantages and disadvantages of foreign countries in using this form of mutual legal assistance are considered, and the relevant practice is studied in detail. Current article is enriched with real life examples. As a result, the features of the use of videoconferencing in mutual legal assistance in criminal cases, as well as the consequences and conveniences of using these tools in pandemic situation were identified, and proposals were developed to amend the relevant legislation
Topicality and demand of the subject of dissertation. Bronchial asthma (BA) is one of the most common and serious diseases, which in the world suffer from 3 to 12% of the child population of the globe. Proportion of adolescents with asthma, is one third of all children with this disease. High prevalence of asthma in the numbers of teenagers, characteristics of the disease, age-related aspects of the functioning of the endocrine and immune systems of teenagers that cause difficulties which arise in the course of the diagnostic process, highlight the need to find innovative approaches to diagnosis and treatment of this disease.
It is known that the key immune mechanisms in the pathogenesis of the vast majority of AD cases is real and indisputable fact. Currently, considerable interest to researchers involved in the pathogenesis of positions of allergic diseases, especially asthma, along with IL-4 and IL-13 causes a number of other (IL-6, IL-8, IL-10, IL-5, INF-a and INF-y) immunoregulatory cytokines.
Genetic predisposition plays an important role in the development of allergic diseases. Currently available data on the relationship with asthma and associated with disease symptoms polymorphism approximately 150 genes. Important role as the main contender for the predisposition to asthma gene is a gene encoding flchain of high affinity receptor IgE. Interaction elevated levels of antigen-specific IgE with FceRip plays a central role in the pathogenesis of allergic asthma. Particularly attractive candidate gene asthma is also one of the enzyme genes biotransformation - GSTirl, encoding glutathione S-transferase and л1 express almost exclusively in the pulmonary tissue. This gene is located at the locus 11 ql 3, for which repeatedly shown clutch with atopic symptoms. Accumulated in the literature say about the relationship of gene polymorphism FceRI, GSTnl with different allergic diseases.
From this perspective, the study of immunological and genetic mechanisms of the pathogenesis of this disease for the construction of rational treatment and prevention emphasizes the relevance of this thesis research.
From the earliest days of independence, the country has successfully implemented state programs aimed at reforming the health care system. As a result, the targeted implementation of organizational health and research activities aimed at effective diagnosis, prevention and treatment of asthma among adolescents, with some success in the treatment of this disease in the country. However, now the problem of early diagnosis and the development of effective programs for treatment and prevention among adolescents with asthma remain one of the most important issues of modern health care. This research work was carried out in the framework of the tasks set by the Resolution of the Cabinet of Ministers of the Republic of Uzbekistan "On additional measures to improve the health of women and the younger generation," dated 25.01.2002 for the №32. In this regard, the need to deepen the information received about the state of cellular and humoral immunity among adolescents, asking pathogenetic informative immunogcnctic studies in asthma arc one of the important criteria demand the dissertation topic.
Purpose of research is study the immunological and genetic mechanisms of the pathogenesis of asthma in adolescents and form the basis of this plan rational diagnostic and therapeutic measures in this pathology.
In To achieve this goal the following tasks of research is solved:
to establish the clinical course of asthma in the population of adolescents living in the Samarkand region, in the early stages of the pathological process in the bronchopulmonary system.
explore the features of the state of cellular and humoral immunity, as well as activation markers in asthma in adolescence by determining the immunophenotype of lymphocytes in the peripheral blood.
to examine the level of production of immunorcgulatory cytokine interleukin-6 and interfcron-y and install them pathogenetic informative in asthma among adolescents.
to determine the features of distribution of allele and genotype frequencies of polymorphic variants of genes and FceRip GSTnl population Uzbek people with asthma, compared with the healthy part of the population.
examine the clinical and immunological aspects effectiveness of therapies using drugs and polioksidony tsikloferon in patients with asthma in adolescence.
on the basis of studies to develop a multivariate model of formation of bronchial asthma and develop an optimal algorithm for the diagnosis, treatment, prevention in adolescents with this pathological condition.
Scientific novelty of dissertational research consists in the following:
proposed introduction to the work of doctors teen clinics layered approach testing can significantly improve the detection rate of asthma in adolescence and optimize treatment and preventive measures in high-risk groups;
first defined the peculiar characteristics of the quantitative parameters of the immune status of patients with asthma in the cohort of adolescence and the corresponding proposed regulations and guidance documents for the healthy part of the adolescent population;
for the first time presents a comprehensive assessment of the cytokine profile of blood serum in bronchial asthma in adolescents. Specific features of products immunorcgulatory cytokines IL-6 and INF-y and their pathogenetic and regulatory information content in asthma among adolescents;
first analyzed the distribution of alleles and genotypes of polymorphic gene variants and gene FceRip GSTirl among patients with different phenotypic variants of AD and healthy individuals of Uzbek nationality, which resulted in the identified markers of increased risk or, conversely, resistance to the development of asthma in adolescents Uzbek ethnicity;
algorithms for phase diagnosis, treatment and prevention of asthma in adolescence in terms of disclosure of important moments of the pathogenesis of the disease, allowing to build a rational sequence of diagnostic search, aimed at verifying the diagnosis and expedient construction of preventive measures.
Conclusion
1. Set the frequency of occurrence of the disease and the structure of "asthma" in the arid zone among teens. Said pathology is recorded in 9,6% of the population surveyed adolescents, while the disease is more common among females. In the structure of the disease prevails periodical exposure and mild persistent form.
2. Identified by clinical features of asthma among adolescents living in the arid zone, indicate a high frequency of lesions of the bronchial tree association with allergic processes in other organs and tissues: in 73,9% of the AR, 53,7% with AK. 16,6% with BA and 14% with urticaria/angiocdcma.
3. Found that in the study population of patients with asthma adolescence occur expressed disturbances of the immune status, manifested deficit indicators as cell (CD3‘, CD4+, CD8 , CD16+), and humoral immunity (CD19 , IgA, IgG, IgM) and activation markers (CD23+, CD95). The immune status of patients with asthma in young people, adolescence has distinctive features, the depth of detected violations immunoreactivity was most pronounced in the younger age group.
4. In patients with bronchial asthma in adolescence revealed distinct changes in cell-cell interactions in the immune system: a significant increase in the content of Th2-cclls secreted IL-6 is a regulator of maturation of antibodies and immunoglobulin production itself, and vice versa reducing regulator activity of Th 1-cell cytokine INF-y.
5. It was found that the contents of cytokines IL-6, INF-y and in the peripheral blood is in communication with one pathogenic disease. It is shown that the lowest level of INF-y production in the scrum is characteristic of allergic clinical pathogenic variant asthma in adolescence. Adolescents suffering from predominantly infectious form of asthma, there is a sharp trend towards increased production of IL-6 in peripheral blood.
6. Revealed that markers of increased risk of allergic forms of asthma in adolescents Uzbek ethnicity arc genotype FceRip-109T/T allele FceRip-109T, low-risk markers - FcsRip-109C/C and allele Fc£Rip-109C. A high degree of cohesion genotype FcsRip-109T/T allele and FcsRip-109T with hereditary burden of asthma in the Uzbek population.
7. Among females ethnic Uzbek Association revealed lie-105 allele and genotype Ilc-105/Ilc-105 polymorphic gene locus GSTkI at high risk for asthma. Revealed that the genotype associated with the development Ilc-105/Ilc-105 allergic form of asthma in adolescents Uzbek population.
8. Complex therapy with adolescents’ patients with asthma ciklofcron and polyoxidonium, providing immunocorrective effect, enhances the clinical efficacy of basic therapy. In the study of prophylactic efficacy of immunomodulators positive indicators prevailed in the group of patients receiving polioksidony, necessitating its inclusion in the priority scheme of integrated treatment and prevention of asthma in adolescents.
This article examines the features of the genre “travelogue” in modern Arabic short stories. “Travelogue” is one of the oldest and most varied genres. During the many thousands of years of human history, and especially after the appearance of written literature, thousands of works on the subject of travel were created in the languages of the peoples of the world. The genesis of the genre is the result of the synthesis of the traditions of folklore and written literature, where works of folklore (e.g., fairy tales) were created and in written literature (e.g., ancient travel notes), in the center of which there is a traveler-narrator. As genre compositional features of travelogue, you can point out that the focus is on the image of the traveler-narrator and the presence of the fact of travel (changing in space and time movement in a certain direction), and it is noteworthy that the traveler-narrator stands in the status of an observer and compares what he saw in a foreign land with the situation in his native country. Although these main features of the genre were preserved, a number of other manifestations of travelogue appeared in the course of the development of literature. If in Uzbek classical literature the works describing the impressions of travel are called “sayokhatnoma”, then in Arabic literature this genre is called “rihla”. Studying modern Arabic fiction, you can trace how writers create works in the genre of travelogue, combining elements of the genre with the genre of the short story. A number of modern and contemporary Arab writers, such as Muhammad al-Muwaylihi, Sunallah Ibrahim, Jamal al-Ghitani, and Abdurahman Majid al-Rubeyi, used features of the travelogue genre in their short stories and novels. Among them can be the Syrian writer Abdus-Kalam Al-Ujayli (1918-2006), whose travel collections, such as Journey to Europe and The Call to Travel, consist of short stories that reflect the peculiarities of the travelogue genre. The collections Journey to Europe, Call to Travel comprise 22 short stories about travelling. Abdus-Salam al-Ujaili depicted with high artistry the greatness of his motherland Syria, where he was born and raised, showed its beautiful nature, the way of life, occupations, religion of the population, as well as he gave a description of some cities, their history, and shared hois impressins of unspeakable Paris after a trip to Europe.
In this paper the issues like preprocessing of medical data, reclassification of the training sets and determining the importance of classes, formation of reference tables, selection of an informative features set that differentiate between class objects, formed by medical professionals are discussed and solved. Mainly in the most studied references [5-8, 11-13] the Fisher's criterion is used to obtain solutions to problems/tasks. Also for solving problems, the algorithms for an estimate calculation as well as the related software programs are used. For all cases, algorithms and software programs are suggested.
The study consists of two important steps. The first step is to build a reference table, based on the importance of the features and objects as well as their contribution to the classes [1-4, 9, 10]; the second step is concerned with the choice of the most useful characteristic features set to be investigated. This corresponds to solving the issue of selection of set of informative features from a given table, their visualization, and the determination of the contribution of the features set to the formation of classes [1-13].
Article is devoted to the legal nature and features of adoption and represents the review of the working family legislation on this question, and also offers recommendations on application of the legislation on adoption. In given article it is analyzed theoretical opinions of national scientists, and also scientific foreign countries concerning the legal nature and features of adoption. In article the legal nature and features of adoption is considered, analyzed distinctive features parental relations and adoptions, connecting the the points of view with theoretical and practical sights of scientists the author represents the points of view on these questions.
Historical and cultural issues dominate in modern research. While purely literary issues receive insufficient attention. However, it should be noted that until now the image of the character beloved by the people - the image of the rogue -ayyar has not been studied at all, just as the world of human of the literature of the Arab middle ages as a whole has not been studied. No attempt was made to determine its national and epochal features. One of the characteristic features of laughter in syrah is focus on the laughing man himself. Laughing most often laughs at himself, at this conclusions and failures, the heroes of sirah - the epigones of the main character – surprisingly combine the features of an ordinary person, not shining with beauty, not educated, end ideal, heroic features. He is brave and courageous, faithful to friends and generous with enemies, resourceful, smart, tireless and noble in spirit. The characteristic features of other medieval works, such as rogue romance or the rogue novel, are vivid depiction of the life of various layers of urban society of that time, a small number of fantastic elements that are so rich, an ironic attitude to the image, bordering on cynicism, and the associated denial of didactics. In the rogue novel there is no place for meekness and patience, dexterity, as well as cunning, assertiveness and strength, are considered virtue. The true hero here is the in who manages to play the most deft joke with the opponent, outsmart himself. Roguish literature played a large role is the development of Arabic narrative prose, which received new opportunities by expanding thematic and artistic boundaries the combination of elements of humor, science fiction and caricature, parody-satirical and fantastic - utopian tendencies made it possible to correlate the ayyar narratives with the global tradition of folk culture.
In modern abdominal surgery, one of the current areas for research continues to be the improvement of various options for plastic surgery of postoperative hernias. More than 2,100,000 operations for ventral hernia are performed annually in the world, and 42% of them are postoperative hernias. In recent years, there has been a clear trend toward the expanded use of various types of biological meshes in hernioplasty. “A pooled analysis of seven PCSTAR studies for incisional hernias using retromuscular mesh showed a hernia recurrence rate of 5.7%”[1]. The use of standard surgical interventions such as alloplasty in the onlay position does not solve the problem of early postoperative complications: seroma discharge, mesh migration, adhesive disease, high frequency of hernia recurrence, etc. At the same time, hernia repair with local tissue creates the problem of increased intra-abdominal pressure and late complications in the form of recurrent hernias. “An increase in postoperative intra-abdominal pressure leads to multiple organ failure, then abdominal compartment syndrome, and even death.” [2]. Currently, there is no consensus on the surgical approach for giant postoperative abdominal wall hernias, and therefore the need to continue to develop new technologies and improve There is no doubt about the tactics. In world practice, at present, the most relevant studies continue to be studies aimed at studying the morphological and functional aspects of recurrent postoperative ventral hernias; electron microscopy reveals ultrastructural destructive changes in skin cells, aponeurosis and muscles, which indicates morphofunctional insufficiency of abdominal wall tissues; issues of cell engineering are discussed new innovative materials, experimental studies are being carried out on animals testing the biotechnical properties, texture and elasticity of new polymers, research is being conducted on open approaches with division of the posterior component with the release of the transverse abdominis muscle and a retrograde mesh, robotic operations have begun. Modern aspects of the development of domestic healthcare include many measures aimed at improving the results of treatment of patients with postoperative ventral hernias and associated pathological conditions through the introduction of modern principles of intensive care and surgical tactics. The development strategy of New Uzbekistan for 2022-2026 in seven priority areas includes tasks to improve the quality of provision of qualified medical services to the population[3]. The implementation of these tasks, including by optimizing tactical and technical approaches to the choice of hernioplasty method, as well as the development of methods for the prevention of purulent-inflammatory complications in the field of alloplastic material, is one of the current areas of abdominal surgery and medicine in general, due to the high medical and social the significance of this pathology.
This dissertation research to a certain extent serves to fulfill the tasks approved by the Decree of the President of the Republic of Uzbekistan “On comprehensive measures to radically improve the healthcare system of the Republic of Uzbekistan” No. UP-5590 dated December 17, 2018, the Resolutions of the President of the Republic of Uzbekistan “On measures to transform the surgical service, improving the quality and expanding the scale of surgical operations in the regions" for No. PP-5254 dated October 4, 2021 and "On additional measures to ensure public health by further increasing the efficiency of medical prevention work" for No. PP-4891 dated November 12, 2020, and as well as other regulatory documents adopted in this area. Compliance of the research with the priority directions of development of science and technology of the republic. The dissertation research was carried out in accordance with the priority direction of development of science and technology of the VI Republic “Medicine and Pharmacology”. Review of foreign scientific research on the topic of the dissertation.[4] Research work aimed at improving the quality of therapeutic and preventive care for patients with ventral hernias, carried out by many leading scientific centers and higher educational institutions in the world, including the Department of Surgical and Perioperative Sciences, Umeå University, Umeå (Sweden), Department of Surgery, Kingston General Hospital, 76 Stuart Street, Kingston (Sweden). nada), Department of Surgery, Helsinki University Hospital, Helsinki ( Finland), Service de chirurgie digestive et oncologique, CHU d'Amiens (France), Department of Biostatistics and Epidemiology, University of Oklahoma Health Sciences Center, Tulsa (USA), Department of Surgery, Howard University College of Medicine, Washington (USA) , Yong Loo Lin School of Medicine, National University of Singapore (Singapore), Department of Surgery, Michigan Medicine, Ann Arbor, MI, USA; University of Calgary, Calgary (Canada), Division of Plastic Surgery, Perelman School of Medicine at the University of Pennsylvania, University of Pennsylvania Health System, Philadelphia (USA), Brigham and Women's/Faulkner Hospital, Harvard Medical School, Boston (USA) , Department of Surgical Sciences, Uppsala University Hospital, Uppsala (Sweden), Department of Surgery, University of Texas Health Sciences Center at Houston, Houston (USA), Department of Surgery, Erasmus University Medical Center Rotterdam, Rotterdam (Netherlands), Department of Preventive Medicine and Public Health, Faculty of Medicine, Fukuoka University, Fukuoka (Japan), National Medical Research Center for Surgery named after A.V. Vishnevsky" (Russia), Republican Scientific Center for Emergency Medical Care (Uzbekistan), Tashkent Medical Academy (Uzbekistan), Republican Specialized Scientific and Practical Medical Center for Surgery named after Academician V. Vakhidov (Uzbekistan).
As a result of studies conducted around the world to increase the effectiveness of alloplasty for postoperative ventral hernias and reduce the risk of complications in the postoperative period, a number of scientific results were obtained, including: it was determined that patients who underwent reconstruction of the abdominal wall have an increased risk of postoperative respiratory failure, understanding the epidemiology of this complication can improve prevention (the Division of Plastic and Reconstructive Surgery, Department of Surgery, Oregon Health & Science University, USA); It has been proven that the larger the hernia, the higher the risk of early surgical complications, including such as respiratory decompensation, since hernias often increase in size over time, delaying surgery can lead to an increase in the size of the hernia and, therefore, a greater risk of complications (CentreforDigestiveDiseases, KarolinskaUniversityHospital, Stockholm, Sweden); it has been shown that the ratio of the hernia volume to the volume of the abdominal cavity <20% is an independent factor in tension-free closure, which justifies the interest in preoperative volumetry to adapt the tactics of surgical care (Servicedechirurgiegénérale, digestiveetendocrinienne, CHU LyonSud, HospicescivilsdeLyon, France); It has been determined that in patients undergoing elective laparoscopic hernia repair, predictors of mortality are older age and certain concomitant diseases: congestive heart failure, pulmonary circulatory disorders, coagulopathy, liver disease, metastatic cancer, neurological disorders and paralysis (Department of Surgery, College of Medicine, University of Oklahoma, Tulsa , USA); Older age, ascites, preoperative renal and pulmonary insufficiency have been found to be independent predictors of 30-day mortality, and in the presence of these risk factors, conservative treatment should be seriously considered (Department of Surgery, University of Kentucky College of Medicine, Lexington, USA); The American College of Surgeons (ACS) Universal Surgical Risk Calculator has been shown to accurately predict thirty-day outcomes, including major complications: venous thromboembolism, medical morbidity, surgical site infection, unplanned reoperation, mortality, and length of hospital stay (Department of Plastic Surgery, Brown University and Rhode Island Hospital, Providence, USA). At the present time in the world, the most relevant research in surgery continues to be the development of new methods of hernioplasty for large and giant ventral hernias, each of which has its own pros and cons depending on the complexity of implementation, the risk of postoperative complications and relapse, large randomized clinical trials are being conducted, comparing existing methods of traditional hernioplasty with laparoscopic access and robotic surgery, which has become increasingly widespread in the last 10 years, a search is being made for new synthetic and biological materials developed for the production and use of composite meshes that have the necessary strength and the ability to prevent fatal local complications in a contaminated environment. However, despite technical advances in this field, no modern hernia repair method or prosthesis meets all the requirements. One of the key problems is that existing synthetic endoprostheses do not have sufficient elasticity, resistance to infection, high mechanical strength and integrity over a long period of time. Further research into these clinical aspects will undoubtedly improve the current understanding of the capabilities of biocompatible endoprostheses and will make it possible to develop an optimal method for their placement during allohernioplasty. The degree of knowledge of the problem. The current period of development of abdominal surgery is characterized by an emphasis on the problems of the effectiveness of introducing new installation methods and techniques for attaching bioprostheses, options for various suture materials to determine the most promising directions for the development of these technologies [5]. Researchers led by BittnerR.[6] (2019) state that a giant postoperative abdominal wall hernia, the maximum diameter of which exceeds 12 cm or the ratio of the volume of the hernial sac to the abdominal cavity more than 20%, is difficult to treat, with a high recurrence rate and a large number of complications. One of the most challenging problems is that after the hernia contents return to the abdominal cavity, postoperative intra-abdominal pressure will increase, leading to multiple organ failure, then abdominal compartment syndrome (ACS), and even death. There is currently no agreement on the surgical approach for these giant incisional abdominal wall hernias. To prevent recurrences, some articles recommend placing the hernia mesh in the sublayer position and or linings (KirkpatrickAW.)[7]. According to CornetteB.[8], to prevent recurrence, it is recommended to place the hernia mesh in a sublayer or underlay position, and to achieve better mesh expansion, a component separation technique (CST) may be a suitable solution, but with a significant risk of complications and recurrence. JensenKK, et al. believe that truly successful giant hernia repair requires effective bridging or augmentation that will prevent recurrence with an acceptable risk of complications[9]. Another pressing issue in abdominal surgery is that patients with incisional hernias are extremely difficult to treat due to a number of factors including obesity, previous hernia repair, previous mesh placement, domain loss, and other variables.
The approach to patients with incisional hernias has changed significantly over the past 20 years due to both advances in mesh technology and surgical approaches. Key factors for successful outcome include modification of risk factors preoperatively, such as smoking cessation and weight loss, selection of mesh appropriate for the type of hernia and planned mesh location, and wide mesh coverage beyond the hernia defect. New techniques such as transabdominal muscle release and component separation with retrograde mesh placement and robotic approaches to abdominal wall hernia are increasingly being used in these patients[10]. Recent years have seen an increase in the number of biological meshes available for abdominal wall hernia repair. Biological meshes typically consist of materials obtained from humans, pigs, or cattle. The rationale for using biological meshes is that they can act as a scaffold for the growth of natural tissues. In addition, there are absorbable synthetic meshes that have properties similar to those of biological meshes, but with theoretically less risk because they are not derived from animal or human material. The choice of mesh for a ventral hernia depends on many factors, which include both the properties of the mesh and its location, for example, whether it should be placed intraperitoneally, preperitoneally, or retrorectus. BaierKF[11](2021) believes that the guiding principle should be to avoid placing uncoated polypropylene mesh in an intraperitoneal location where it may be in direct contact with internal organs. In addition, the type of hernia defect is another risk factor, such as whether the wound is clean or dirty, and whether the repair is performed with a bridge or abutment. Lightweight or biologic meshes to bridge the defect should be avoided due to increased recurrence rates. Holihan JL [12] (2016), Hodgkinson JD [13] (2018) believe that the principle of anatomical restoration to achieve a reliable, tension-free repair with reinforced mesh reduces the incidence of early postoperative complications and late recurrence of hernia compared with bridging mesh. The analysis of the literature concerning the theoretical aspects and clinical experience of using technologies for improving modern synthetic and biological prostheses that can provide a better plastic effect, as well as methods for preventing recurrence of ventral hernias, indicates that this is one of the priority areas in modern abdominal surgery. An unresolved issue remains the choice of the optimal endoprosthesis, which is highly effective and meets international standards for such properties as biological inertness and mechanical strength, as well as the method of positioning the mesh in relation to the layers of the abdominal wall. Considering that many of the allohernioplasty methods used today are not without drawbacks, the current direction is the development of new methods of repair for giant ventral hernias and methods for the prevention of postoperative complications in conditions of a contaminated wound, with justification of their effectiveness in a clinical experimental study. The connection between the dissertation research and the research plans of the research institution where the dissertation was completed. The dissertation research was carried out within the framework of the research work plan of the State Institution “RSNPMCH named after. acad. V. Vakhidov" under the project AL-422105574 "Development of new biocompatible mesh implants made of composite materials for reconstructive surgery of abdominal and diaphragmatic hernias" (2022-2024).
The purpose of the study is to improve the results of surgical treatment of large and giant postoperative ventral hernias by introducing new laser technologies and improving the tactical and technical aspects of surgical treatment. Objectives of the study: to study the structure of immediate complications after various types of prosthetic plastic surgery; to clarify the influence of obesity factors, primary or repeat hernioplasty on the incidence of immediate and long-term complications; to evaluate the role of the immediate complicated course of the postoperative period in the incidence of long-term complications of hernioplasty; to improve the technical aspects of alloplasty for large and giant postoperative ventral hernias (POVH); to improve the technique of photodynamic therapy (PDT) of the wound surface after prosthetic plastic surgery; to study in an experiment the effectiveness of using the proposed technique of alloplasty and PDT; evaluate the morphological features of the condition of tissues during prosthetic plastic surgery using the proposed method; in a comparative aspect, evaluate the clinical effectiveness of the proposed alloplasty options in the immediate and long-term periods. The object of the study was the results of allohernioplasty in 448 patients with extensive (large) and giant POVH, who were operated on at the surgical department of the 1st clinic of the Samarkand State Medical Institute in the period from 2012 to 2021, as well as experimental animals on which the effectiveness was assessed developed a technique for prosthetic repair of postoperative ventral hernias and applied the technique of photodynamic therapy.
The subject of the study is to analyze the effectiveness of the developed alloplasty of postoperative ventral hernias and intraoperative photodynamic therapy in abdominal surgery in experiments and in the clinic. Research methods. To achieve the goal of the study and solve the assigned problems, general clinical, instrumental, biotechnological, experimental, histomorphological, microbiological and statistical research methods were used. The scientific novelty of the study is as follows: it was established that the need for extensive tissue mobilization and, as a consequence, the intersection of lymphatic capillaries during implantation of the prosthesis in the onlay position, as well as the lack of sufficient resorption function of the hernial sac in the inlay position causes a high risk of the formation of clinically significant seromas; It was determined that with prosthetic hernioplasty, along with the volume of the defect, the type of plastic surgery and the degree of obesity, the most significant predictor of the risk of developing immediate complications is the factor of re-intervention in case of recurrent hernia with the presence of a “dormant infection” hidden in the remaining ligature granulomas or scar tissue; the structure and clinical features of the course of long-term complications of hernioplasty for giant and extensive hernias were clarified, taking into account the results of the immediate postoperative period, as well as the option of fixing the prosthesis, primary or repeated hernioplasty and the degree of obesity; the method of surgery for large hernias of the anterior abdominal wall has been improved, characterized by a combination of factors such as the formation of tension-free prosthetic repair, preservation of local resorptive function to prevent the development of fluid accumulations and reducing the risk of infection; the method of preventing the development or progression of wound infection during alloplasty of ventral hernias has been improved, aimed at enhancing the antibacterial effect and stimulating reparative activity through the photosensitizing and photodynamic effect of low-energy laser radiation; It was determined in an experimental model of prosthetic plastic surgery that the proposed method of fixing the prosthesis in combination with the use of the effect of photodynamic therapy through laser radiation helps to enhance reparative processes with a reduced risk of wound complications; It has been proven that all methods of antiseptic exposure and laser stimulation of the wound surface after prosthetic plastic surgery enhance preventive measures against the development of local infection, but are ineffective in the case of an already developed purulent-inflammatory process against the background of the use of alloplastic material. The practical results of the study are as follows: it has been determined that the implantation of synthetic materials for giant and extensive hernias is accompanied by a significant number of wound complications caused by both the surgical technique itself and the reaction of surrounding tissues to a foreign body, requiring improvement of tactical and technical approaches when performing hernioplasty; it was clarified that scar-degenerative changes in the tissues of the aponeurosis in giant and extensive hernias are a predisposing factor to the occurrence of post-prosthetic hernias, especially when implanting the prosthesis in the “inlay” position and, accordingly, require increasing the efficiency of their fixation and engraftment, as well as reducing the risk of developing local complications; it was determined based on the data of an experimental study that the proposed method of alloplasty for large ventral hernias makes it possible to achieve adequate reconstruction of the anterior abdominal wall, reduce the incidence of infection in the wound, and also use a smaller size of prosthetic material; it was determined that the proposed method of tension-free repair of large hernias of the anterior abdominal wall with strengthening of the aponeurosis with a mesh implant allows maintaining physiology, reducing the number of complications, shortening treatment time and reducing the risk of hernia recurrence; It has been determined that the proposed method for preventing the development or progression of wound infection during alloplasty of ventral hernias can reduce the frequency of suppuration, shorten the treatment time and the likelihood of relapse; It has been proven that the use of the proposed tactical and technical aspects of prosthetic repair for postoperative ventral hernias can reduce the incidence of specific complications, reduce rehabilitation time and the risk of hernia recurrence. Reliability of the research results. The reliability of the results is justified by the use of objective criteria for assessing the condition of patients, modern methods of diagnosis and treatment, the correct application of methodological approaches and sets of statistical analysis, methods for solving the problems discussed in the dissertation are based on modern scientific and practical concepts and approaches to the diagnosis and surgical treatment of patients with giant postoperative hernias. Scientific and practical significance of the research results. The results obtained make a significant contribution to the expansion of irradiation of existing ideas about the structure and clinical features of complications of hernioplasty for giant and extensive ventral hernias by identifying the morphological features of the development of a purulent-inflammatory process against the background of the use of alloplastic material, studying predictors of the risk of developing immediate complications, mechanisms for enhancing reparative processes through the use of an improved method of fixing the prosthesis in together using the effect of photodynamic therapy through laser radiation, which made it possible to enhance the antibacterial effect and improve the wound healing process. The practical significance of the study is that, based on the results obtained, the tactical and technical aspects of prosthetic hernioplasty have been optimized, the features of methods of antiseptic exposure and laser stimulation of the wound surface after prosthetic repair have been revealed, enhancing preventive measures for the development of local infection, and the method of surgery for large anterior abdominal hernias has been improved walls, characterized by a combination of factors such as the formation of tension-free prosthetic plasty, preservation of local resorptive function to prevent the development of fluid accumulations, thereby reducing the risk of developing postoperative complications, reducing the frequency of unsatisfactory results, length of hospitalization and the likelihood of relapse. Implementation of research results. According to the results of a scientific study to optimize the tactical and technical aspects of surgical treatment of large and giant postoperative ventral hernias: the “method for plastic surgery of giant hernias of the anterior abdominal wall” has been improved (invention patent No. IAP 2022 0148 dated April 18, 2022). The proposed method of tension-free repair of large hernias of the anterior abdominal wall with strengthening of the aponeurosis with a mesh implant made it possible to reduce the number of complications, shorten the treatment time and reduce the risk of hernia recurrence; the “method for preventing the progression of infection during alloplasty of infected hernias” has been improved (certificate of the Ministry of Health No. 08-32071 dated October 17, 2022). The proposed method made it possible to reduce the frequency of wound purulent-inflammatory complications and shorten the period of rehabilitation of patients after allohernioplasty; methodological recommendations “Tactical and technical aspects of prosthetic repair for large and giant postoperative ventral hernias” have been developed (certificate of the Ministry of Health No. 08-32071 dated October 17, 2022) . The developed recommendations made it possible to optimize the tactical and technical aspects of allohernioplasty in patients with large and giant postoperative ventral hernias; The scientific results obtained were introduced into the practical activities of healthcare, in particular, in the departments of surgery of the Khorezm and Andijan regional multidisciplinary medical centers, the clinic of the Samarkand State Medical University (certificate of the Ministry of Health No. 08-32071 dated October 17, 2022). Improving the tactical and technical aspects of prosthetic repair for postoperative ventral hernias has made it possible to reduce the incidence of specific immediate complications from 40.9% to 15.6%, to reduce rehabilitation time from 8.6±2.7 to 7.1±1.5 days, and also reduce the likelihood of long-term complications from 11.7% to 3.1%. Approbation of research results. The results of this study were discussed at 8 scientific and practical conferences, including 5 international and 3 republican ones. Publication of research results. 26 scientific works have been published on the topic of the dissertation, including 9 journal articles, 4 of which in republican and 5 in foreign journals recommended by the Higher Attestation Commission of the Republic of Uzbekistan for publication of the main scientific results of doctoral dissertations. Structure and scope of the dissertation. The dissertation consists of an introduction, seven chapters, a conclusion, conclusions, practical recommendations and a list of cited literature. The volume of work is 200 pages.
It was established that children tolerate COVID-19 much easier. Researchers note the prevalence of asymptomatic and mild forms of the disease in children. According to laboratory studies, severe lymphopenia was extremely rare in children.
It has been shown that COVID-19 in children has a significantly more favorable outcome. The noted features of the clinical and laboratory course of COVID-19 in pediatric patients are probably associated with a number of factors, including age-related features of the immune response (primarily innate immunity), healthier airways (not exposed to tobacco smoke, frequent respiratory infections ), as well as age-related features of the functioning of angiotensin-converting enzyme-2, used by coronaviruses as a cell receptor.
The authors pay special attention to the fact that children, as the category of patients with the highest level of asymptomatic and mild course of the disease, constitute the main transmissible potential for the continuation of the pandemic
The aim of this paper is to examine linguistic features and translation strategies used by advertisers to draw and hold consumers’ attention, make them remember advertisements and encourage them to buy advertised products. This article discusses the approaches advertisers, using the advertising discourse, manipulate consumers’ opinions, preference and behavior. The results of the analysis of the most important linguistic features as well as marketing strategies for addressing consumers used in TV commercials. Translating advertising texts is a complicated task, which involves a number of challenges, strategies, methods, as well as the effective use of translation techniques. The translation of the advertisement should be in the language that is understandable to the public, concise and simple, without deviating from the original.
This article deals with kanazoshi prose, which had a great influence on the creative work of many literary figures of the last quarter of the 17thcentury, as well as its place in the development of medieval Japanese literature.The aim of the work is to analyze the genre features, the development trends of kanazoshi prose, and also the task is to identify its narrative and plotless genres, reveal the factors that influence the formation of each genre and establish their poetic features through the analysis. Cultural and historical, comparative historical methods of analysis are used to achieve the goals and accomplish the tasks mentioned above.At first, the characteristic features of the plotless genres of kanazoshi” - religious and moral treatises, war chronicles are revealed drawing on the analysis of the selected examples such as “Kiyomizu monogatari”, “Gion monogatari”, “Ukigumo monogatari”. Then, narrative genres of Japanese prose of the 17 th century are characterized by the examples of the works of Suzuki Shosan, who promoted the ideas of Buddhist teachings through his novels such as “Ninin bikuni”, “Sichinin bikuni”, and also Asai Ryoi, who became famous for his fantastic stories “Otogi boko”, “Jigokuo mite yomigaeri”, “Inuhariko” which were created under the influence of Chinese literature. In particular, new principles of comprehension the reality is revealed through analyzing such works as “Tsuyudono monogatari”, “Zeraku monogatari” relating to the traditional genre of love stories of medieval Japanese literature reveal. The idea of the practical importance of kanazoshi genres such as “hyobanki” va “meishoki” which were arose from the historical conditions and poetic needs of the period of Japanese lifeis being promoted in the article. Based on the example of “Chikusai monogatari” and “Naniwa monogatari” poetic features of the above-mentioned genres are described. Also, the article provides reflections on the conditions for the formation of the genre of Japanese literature of the 17th century “rakugo” - short funny stories, as well as parodies of classical works that became popular in that period.
In recent years, various levels of research in the field of linguistics have been carried out, based on the lexical-semantic and grammatical features of the language. In particular, effective work is being done to study the linguistic features of artistic sources on folklore. In subsequent years, scientific papers and studies appeared on the linguistic features of proverbs, phraseologies, as well as wishes and applause (applause-curses). They are studied by folklorists as cultural units. In particular, research was conducted on the names of epics, fairy tales, wedding ceremonies, the linguistic features of wedding songs, the lexical and semantic analysis of Uzbek folk riddles. It seems that there is not enough information about the work done or ongoing in the above areas related to the cultural life of the peoples of the East. This article is dedicated to Turkish wishes and applause, as well as the participation and art of colors in their linguistic landscape. There are aspects that should be considered when studying wishes and applause. These cultural units are characteristic of oral discourse, although they are found in both formal and formal literature. Naturally, in order to conduct research on such a subject, it is necessary to know the way of thinking of these people. The word applause comes from the ancient Turkic language and means praise, honor, wish good wishes. The participation of flowers in Turkish wishes and applause is aimed at revealing the meanings and artistic image of these flowers in terminology. In fact, everything around us is made up of different colors. Colors are an important tool for distinguishing things from each other. You can see the place and meanings of white in desires, the positive and negative meanings of black and the use of green in life as blessings and blessings. In addition, the article provides examples of synonyms for red and white.
This article examines the history of singing art with the birth of mankind, the influence of the song genre on the spiritual and moral state of peoples, the dynamics of the process of transferring singing art from generation to generation over the centuries. In addition, the genres of songs have a long history and have been passed down from generation to generation for centuries. The origins, stages of development and features of the song genre "Alla" are discussed. Many aspects are analyzed, such as the fact that the genre of Alla's singing is based on folklore, the uniqueness of this type of song, its narration in simple and understandable language. The article systematically describes the history of the song genre, its artistic features, philosophical and spiritual features. The stages of the genre of the song "Alla", the features of each stage, the role of children in the spiritual and aesthetic education of the cradle are scientifically substantiated. The text of the article summarizes the opinions of various experts in the field of the song genre "Alla". In conclusion, the article reveals the importance of the development of the song genre in the conditions of new thinking, the relationship between mother and child. Approaches to the question of the genre of the song differ, and it was analyzed that discussions on this issue continued both during the years of Soviet power and during the years of independence. It is shown that the height of a person's spirituality can be an important factor in raising a child at the level of the song genre that mothers sing, rocking the cradle at birth. It is revealed that in the genres of Alla songs it has become a tradition to pamper a child and compare him with powerful forces and historical figures. Alla song genre takes into account the influence of Asian and European natural factors. The importance of the mother's level, the pleasantness of the sound of the words used instead of them, and so on as the songs of God reach the baby in the cradle. At the end of the article, scientifically based recommendations are given for further popularization and improvement of the song genre.
Objects of researches were the professional sportsmen who are training in the sportcomplexes of Tashkent, experimental animals. A subject of researches: optimisation of a nutrition of professional sportsmen and protection of their health at the strengthened physical, mental and thermal influence.
The work purpose: development of scientific bases of a balanced diet of professional sportsmen in the conditions of the republic Uzbekistan.
Research methods: hygienic, medical and biologic, biochemical, chemical, statistical methods of researches and questioning are used.
The received results and their novelty: are defined requirements for the basic food substances and energy of professional sportsmen RUz depending on professional skill, puberty groups, kinds of sports, climatic conditions and national features of a food defined which have not been defined earlier. Factors of physical activity (FFA) for separate kinds of activity of sportsmen are established. Power expenses of sportsmen by sports kinds, features and professional skill on the basis of daily average timing are revealed. Features of a condition of an actual food and a drinking mode of members Olympic and the national teams of Uzbekistan connected with national habits in a food and a hot climate are studied. Are revealed additional necessity to the basic food of ways of correction micronutrient structure of food in the conditions of high physical and mental loading. Have been developed toxicological passports of BAS for sportsmen. Has been estimated efficiency of actions for rationalisation of a food of professional sportsmen.
Practical value of the work. National daily average norms of a food for professional sportsmen by all kinds of sports with the account of puberty features and level of professional skill confirmed MH RUz (SanPi Ni are developed and confirmed: № 0126-01; № 0140-03; № 0139-03).
Degree of introduction and their economic value: results of researches are introduced in GDSES MH RUz, in Committee on physical training and sports RUz and are used at catering services by national teams on wrestling kurash, to free-style wrestling, boxing, weightlifting, swimming, other kinds sports, and also in sports colleges of the republic.
Sphere of usage: nutrition hygiene, physical culture and sports.
The article is devoted to the lexical-semantic and cognitive analysis of the features of using certain socio-political terms in promoting the Chinese economic and strategic initiative “One Belt, One Way”. The topic also analyzes the factors affecting changes in the layer of the lexical component, analyzes the differences of a socio-political language (hereinafter OPJ) from an ordinary language, reveals the main functions of socio-political terminology (hereinafter OPT). The study of the semantic-comparative phenomena of the ORT of a QW using descriptive methods of description, features of the socio-political discourse in Chinese, used by us as a subject of a translation object containing a rich layer of vocabulary with background information. After the appearance of the Chinese initiative “One Belt, One Way” and the official distribution of the “Concept and Action Plan for the Joint Construction of Two Belts”, i.e. “The Economic Belt of the Silk Road” and “The Sea Silk Road of the 21st Century”, various assessments and opinions began to appear in the world press on the essence, purpose, guidelines and objectives of this initiative. A number of countries took this initiative passively and even negatively, seeing in it a new threat of “Chinese expansion”. Needless to say, the semantics of the terms within the framework of this initiative has also undergone some changes in terms of their perception by recipient languages. This article analyzes the opinions of a number of Chinese sinologists, political scientists, such as Chinese scientists Shan Hupin, Gong Ting, who in their scientific works analyze the main reasons for the negative perception of the “One Belt, One Way” initiative and come to a common opinion that The reason for doubt was the misinterpretation of some documents and an inaccurate, inadequate understanding of its content, and the incorrect use of social and political terms. In this regard, Chinese scientists propose a number of recommendations on the use of socio-political terminology. Namely, in order to promote the ideas and plans for the concept of the “One Belt, One Way” initiative, the use of mainly “soft” terms and voca-bulary is suggested. It is recommended in publications to avoid the idea that China, ostensibly, intends to chase the role of the project leader and achieve the role of managing the sphere of influence in regional issues. In this regard, Chinese experts consider it necessary to firmly adhere to the principles of joint discussion, joint construction and sharing of the benefits of the Chinese initiative. The research materials show the richness of the lexical layer of the Chinese language, the broad possibilities of transmitting thought using various social and political terms, transforming not only the tone, but also the cognitive paradigm of the text. These lexical and semantic features of Chinese socio-political terminology should be taken into account when translating articles, materials of negotiations, speeches, reports and speeches.
There are two types of affixing – prefixing and suffixing in modern Chinese. Suffix words are formed by adding a semantic morpheme and a suffix. It should be noted that in modern Chinese the number of morphemes acting as suffixes in the formation of nouns is not much. However, they stand out for their productivity. The suffixes 子 “zi” and 儿 “er” in modern Chinese are considered one of such suffix morphemes. This article is devoted to the study of the features of the formation of nouns by 子 “zi” and 儿 “er” suffixes in modern Chinese. For the purpose of disclosure of the goal, the author refers to various sources, reveals common and characteristic features only corresponding to the suffix, explores the grammatical features of the lexical units formed by the 子 “zi” and 儿 “er” suffixes and presents conclusion on this topic, justifying each of them with corresponding examples. It was revealed that two, three and four-syllable words are formed by these suffixes; the nouns are formed by combination of 子 “zi” and 儿 “er” with certain verbs, adjectives, countable words, numerals; several constructions including these suffixes were identified. There are many similar features in using the suffixes 子 “zi” and 儿 “er”, which are described in this article. However, there are also significant differences, for example, the suffix 子 “zi” combined with nominal roots with the meaning of objectivity forms words with abstract concepts. And the suffix 儿 “er” sometimes forms words with a dismissive, derogatory meaning and words with the suffix 子 “zi” acquire a caressing shade. According to the study, it was revealed that in Chinese, affixing words are mainly formed by means of suffixing, the degree of use of prefixing is limited. With the help of suffixing a large number of nouns and verbs, as well as adverbs are formed. With the help of prefixation, only ordinal numerals and a limited number of nouns are formed.
This study examines the views of foreign and local scholars about the specific features of budget rules in ensuring macroeconomic stability, the essence of budget rules, their specific features and its impact on macroeconomic conditions are explained. The main purpose of the research is to highlight the theoritical background of the specific features of budget rules in ensuring macroeconomic stability.
The target article presents the semantic features of euphemisms in English and Uzbek languages by the
help of comparative analysis. The concept “euphemism” has not been studied thoroughly in Uzbek language
yet. Especially, while classifying euphemisms according to their semantic and structural features, we will
face up to some challenges in both languages. Therefore, we try to support some valid information by
comparing this phenomenon according to its semantic features