The aim of the research work. It consists in studying changes in the morphological and morphometric parameters of the wall of the gastric mucosa under conditions of polypharmacy with anti-inflammatory drugs.
The object of the scientific research is 180 white outbred male rats, 5 months of age.
The scientific novelty of the research work is as follows:
For the first time it was established that polypharmacy with anti-inflammatory drugs in 5 combinations had a different negative effect on the mucous and submucosal base, which is the structural structure of the stomach wall of white male rats;
It has been proven that structural changes in the organs of the digestive system cause profound disturbances in the processes of growth and formation of the gastric mucosa and its glandular tissue, submucosa, which is accompanied by a decrease in the total thickness of the stomach wall;
With the simultaneous use of more than 3 types of anti-inflammatory drugs, the negative effects of polypharmacy are significantly enhanced. We analyzed the rate of formation of structural and functional zones of the stomach wall, the activity of mucosal cells, the change in the shape of lymphocytes located in the submucosa, the decrease in morphological parameters;
Using the methods of modern morphological studies (organometric, histological, histomorphometric, statistical), new information was obtained directly about the morphological and morphometric parameters of the stomach wall. Changes at the tissue, cellular and intercellular levels are characterized by hypotrophic and hypoplastic changes in the structures of the stomach wall of white male rats.
Implementation of the research results. Based on the obtained scientific results on morphometric changes in the gastric mucosa under conditions of polypharmasia:
methodological recommendation was approved on the topic: "Method for determining the morphometric parameters of the gastric mucosa in polypharmasia of anti-inflammatory drugs", which allows to determine the morphometric parameters of the gastric mucosa in the conditions of polypharmacy in the experiment.
The scientific results obtained in the study of morphofunctional features and morphometric changes in the structure of the gastric mucosa under the influence of polypharmacy are used in healthcare practice, including Academician Y.Kh. Turaqulov Conclusion of the Ministry of Health of the Samarkand State Medical University. The introduction of information obtained in scientific research, the development of an algorithm for correct and timely diagnosis, pathogenetic morphometric and morphological indicators, the choice of treatment tactics made it possible to predict the development of pathological changes.
The structure and volume of the dissertation. The dissertation consists of an introduction, three chapters, conclusions, practical recommendations, a list of references and applications. The dissertation is presented on 102 pages of computer text.
The authors of the study studied the morphometric parameters of the morphofunctional state of the pituitary gland under the influence of the lipid-lowering and anti-atherosclerotic drug ladygynoside. The relative weight indices of basophilic, eosinophilic adenocytes, chromophobes and ADH stroma were calculated. Subsequent statistical processing of the data showed that daily administration of ladygynoside leads to an increase in the morphofunctional activity of adenohypophysis basophils. It has also been shown that this approach allows a fairly objective assessment of morphofunctional changes in ADH and can be recommended for using the above morphometric methods to study the morphofunctional status of other various organs.
The purpose of the study was to determine and evaluate the features of morphological changes in the liver parenchyma of 5-month-old white outbred rats under the influence of anti inflammatory drugs under conditions of polypharmacy.
The object of study for experimental studies was taken 250 white male rats weighing 200-250 g.
The scientific novelty of the research is as follows: polypharmacy of anti-inflammatory drugs negatively affects all parameters of liver structures. Under the influence of polypharmacy, there is a decrease in the absolute mass of the liver, volume and morphological parameters of the liver parenchyma. The decrease in morphometric parameters depends on the number of drugs in polypharmacy; under conditions of polypharmacy, the state of the hepatic capillaries and internal bile ducts, as well as biological membranes, was studied, as a result of which the structural structure of the liver, the development of destruction of the hepatic tissue were studied, and the morphofunctional foundations of this condition were shown.
Implementation of the research results. Based on the obtained scientific results, the morphofunctional characteristics of the liver of rats in the norm and under the influence of polypharmacy were determined:
Approved methodological recommendations: "Methodology for determining the morphometric parameters of the liver during polypharmacy of anti-inflammatory drugs" (Conclusion No. 8n-r / 265 dated 14.03.2022 of the Ministry of Health of the Republic of Uzbekistan) and "Methodology for determining the morphometric parameters of the liver during polypharmacy of anti-inflammatory drugs" (Uzbekistan, Conclusion of the Ministry of Health of the Republic of Uzbekistan No. 8 n-z 180 of 2022), electronic program No. DGU 1038 "Program for studying the comparative characteristics of morphological changes caused by polypharmacy in the liver."
The scientific results obtained in the study of morphological and functional properties and morphometric changes in the structure of the liver under the influence of polypharmacy have been introduced into the practice of the Samarkand branch of the Republican Specialized Oncological and Radiological Scientific and Practical Medical Center of the Samarkand City Medical Association (Order of the Ministry of Health of the Republic of Uzbekistan dated March 14, 2022, 8n-r / 265-No. and conclusion No. 8 n-z 180 of 2022). The implementation of the obtained research data allows developing methods for early diagnosis, treatment and prediction of organopathology by morphological parameters, improving the quality of life and reducing the number of complications.
The structure and scope of the dissertation. The structure of the dissertation consists of an introduction, three chapters, a conclusion and a list of references. The volume of the dissertation was 103 pages.
Currently, construction conditions in large cities are such that the most intensive construction work is carried out in the central part of populated areas. A distinctive feature of modern urban construction is the desire to develop underground space. This is due, on the one hand, to the attractiveness for investors to locate properties in areas with already developed engineering infrastructure and the highest concentration of population, and on the other hand, to the historical psychology of the “prestige” of real estate in central areas of cities. In this regard, the growth of cities in height was a feature of the two previous centuries - the 19th and 20th. But in the 21st century. The main feature of truly modern urban construction is the desire to develop underground space. being built into city blocks.
This study presents a comprehensive morphometric analysis of the human cadaveric pancreas in the Assamese population. The pancreas is a vital organ involved in digestion and glucose regulation, and its morphological variations can have significant clinical implications. However, limited information exists regarding the specific characteristics of the pancreas in the Assamese population. To address this knowledge gap, we conducted a detailed examination of pancreas specimens obtained from cadavers of individuals from the Assamese population. Morphometric measurements, including length, width, and thickness of the pancreas, as well as the dimensions of its various lobes, were recorded. The data obtained were statistically analyzed to determine any significant differences or similarities compared to other populations. The findings of this study contribute to a better understanding of the morphological variations of the pancreas in the Assamese population and may have implications for clinical practice and surgical interventions in this region.
This article discusses the specific features of words used as pronouns, and tries to reveal their mutual difference from pure pronouns. It should be noted thatthe original origin of words that act as pronouns is related to other words, and revealing their essence serves as the research object of this article.
This study presents an innovative approach to enhance facial recognition technology using contrastive convolutional neural networks (CNNs). The primary focus is on improving the accuracy and efficiency of face recognition systems under varying conditions. Key elements of this approach include meticulous data preparation and preprocessing, where images undergo normalization and diverse augmentation techniques to ensure quality inputs. The network architecture is designed to process pairs of face images, utilizing a common feature extractor and cascaded convolution layers for detailed feature representation. A specialized kernel generator further refines the process, emphasizing unique facial characteristics. The core of the training regimen is a contrastive loss function, optimized through gradient descent to enhance the network's discriminatory capabilities. Results from the study demonstrate a significant improvement in recognition accuracy, particularly highlighted by the superior performance of the proposed model in comparison to standard facial recognition algorithms. This research provides a comprehensive methodology that could revolutionize face recognition technology, offering more reliable and efficient solutions for various applications.
The bestowing of clinical instruction in Pakistan since antiquated to bygone eras has been a topic of exploration among a few history specialists like Mark Harrison, Deepak Kumar, Anil Kumar, Syed Ali Nadeem Rezavi, Irfan Habib and others, who had attempted to feature scattering of clinical information, illnesses, cures and progress in clinical practices. This article implies to give an outline of granting of clinical schooling in middle age India, feature the significance of Ayurvedic doctors, Unani clinical specialists hakims; pretended by a few Indian rulers in upgrading the clinical instruction; educator understudy relationship in clinical calling; two route going of doctors from Iran to Pakistanand bad habit a-versa. This article depends on top to bottom investigation of a few essential Persian verifiable records, diary and letters and all the while with a few European travel records.
Conceptual Field tests were attempted on sandy soils with three trimming frameworks at India for a very long time during 2011-2013. The trials were executed in split plot plan by relegating h2o dissolvable phosphorus composts in primary plot and suggest ed portion of phosphorus in sub-plot with three replications. The most extreme practical yield of rice, child corn and Chickpea were recorded with the utilization of . The most extreme efficient yield of progressive harvests - wheat, mustard and groundnut were recorded with the application of treatment. Practically comparable patterns were seen as far as side-reaction yield, supplement take-up and leftover soil richness status. Every one of the degrees of in compound manures were discovered to be similarly successful for grain yield, straw yield, supplement take-up, and leftover soil richness.
In the world, attention is drawn to the great importance of the period of early postnatal ontogenesis for the morphofunctional differentiation of organs and systems of the future organism, since a violation of their formation in ontogenesis is a possible reason for the development of various congenital pathologies. Our experimental studies show that by the time of birth in rabbits, the main structural components of the jejunal wall have been formed, however, in their morphometric parameters and morphological picture, they differ significantly from the jejunum of adults. The jejunum of 10 day old rabbits has morphometric and structural differences from the jejunum of newborn rabbits. The total wall thickness increases significantly, mainly due to the mucous and submucosal membranes, the villi and crypts begin to lure in shape
We have studied the morphological, morphometric parameters of the liver of white rats. Against the background of polypharmacy, when using non-steroidal anti-inflammatory drugs, it was revealed in the structure of the liver, which led to various damage to the liver parenchyma. The simultaneous use of non-steroidal anti-inflammatory drugs leads to acute or chronic liver failure in rats. The longer the therapy for chronic diseases, the more pronounced morphological changes (necrosis, fibrosis, and cholestasis).