In the era of COVID-19 the current direction is to study the possibility of introducing a quantitative assessment of the ECG by digital processing using the software in the real clinical practice to optimize treatment in assessing the effectiveness of drugs at the stage of patient rehabilitation. The effectiveness of the drugs used in rehabilitation was analyzed according to the methodology of our previous study, 78 patients were diagnosed acute Q-myocardial infarction in comparison with 46 patients were diagnosed stable angina II functional class. The effectiveness of the assessment of metabolic therapy at the stage of rehabilitation of patients with cardiac pathology using the drugs "Tivortin", "Tivorel" in comparison with amiodarone and bisoprolol is proved. Rehabilitation during the constellation of acute myocardial infarction and COVID-19 is complicated by a decrease of the number of admitted patients, more complicated course of the disease during constellation, non- urgent coronary interventions, a large number of complications, and a slowdown in rehabilitation measures.