No. 1 (2007)

Subjects of the inquiry: “Asos-ul-baloga” by Makhmud Zamakhshari
Aim of the inquiry: to investigate “Asos-ul-baloga” by the side of soursc studies. To show the role of the work in Arabic lexicography, its influence on next Arabic dictionaries.
Methods of the inquiry: Dcscriptional, statistical and historical-comparative methods have been used in the work.
The results achieved and their novelty: It’s the first time that “Asos-ul-baloga” was studied from the point of view of source study. It was determined the manuscript and cditional copies that were kept in the world fonds. “Asos-ul-baloga” was carried on constitutive analyses. The sources which were based on “Asos-ul-baloga” were found and they analysed.
Practical value: This work will help to new scientific search studying the scientific legacy of Makhmud Zamakhshari and to analyse his lexicography. The dissertation will be the main source of educational programms for Literary Sourse Studies and Manuscript Studies, the history of Arabic lexicography in Higher Educational Institutions, preparing lectures on it special courses for students.
Degree of embed and economic effectivity: 13 articles were published on the results.
Sphere of usage: sourse studies, Arabic sourse studies, manuscript studies, linguisty, the history of Arabic linguisty, Arabic lexicography.

Subjects of the inquiry: The work is devoted to studing to inverse problem by S'-function of scattering theory and by the spectral function for Dirac’s operator.
Aim of the inquiry: To study the inverse spectral problem for Dirac’s operator.
Method of the inquiry: In the work are used the methods of functional analysis, spectral theory of linear operators, the theory of functions of complex variable and theory differential equations.
The results achieved and their novelty: The main results of this work are new and consist of the following:
1) the regularized trace formulas for Dirac’s operator with peculiarity in the potential is calculated by Lax’s method;
2) the inverse scattering problem for Dirac’s operator is studied by following conditions:
(a) p(x), q(x) sufficiently quickly tends to zero as x—>oo, where xe[a,oo), a e R';
(b) spectrum of the problem Dy = Лу, yf(a) = 0 (-oo<x<a) is discrete;
3) Dirac operator with mass which has a countable number of eigenvalues in the continuous spectrum is constructed and for the constructed operator the sufficient conditions to belong coefficients p(x), <?(x) to the space Z/’(0,=o) are found;
4) the position’s dependence of eigenvalues in the continuous spectrum Dirac’s operator with mass from the common boundary condition is studied.
Practical value: the work have theoretical character.
Degree of embed and economic effectivity: on the basis of the received results a special course will be read for the students of the magistracy.
Sphere of usage: the obtained results may be used in spectral theory of linear operators, in mathematical physics for integration of nonlinear equation as well as quantum mechanics and other areas of natural subjects.

Subjects of the inquiry: a process of preparation future engineers-teachers in the system of the vocational training using imitation model devices.
Aim of the inquiry: to create scientifically-methodical base and experimental motivational in improvement of training future engineer-teachers using imitation model devices in the system of the vocational training.
Method of the inquiry: theoretical analysis of the scientific-pedagogical literature and normative documents, questionnaire, expert estimations, pedagogical experiment, mathematical-statistic processing of result.
The results achieved and their novelty: is worked out scientific-methodical bases improvement training future engineer-teacher with using imitation model device in system of the vocational training including: is determined place and importance imitation model device in training student; it is designed didactic, methodical and specificationses on designing and using imitation model device in scholastic process - as didactic facilities of increasing of the training student; it is designed scientifically-methodical bases designing and using imitation model device in scholastic process and on this base are created complex imitation model device; experimental is motivated increasing to efficiency of the training student.
The practical importance: on result of the study is designed scholastic-methodical allowance "Using imitation model device in training engineer-teacher" and methodical allowance "Methods of the undertaking the laboratory work on device and theories of the transport facilities" and are used in scholastic process..
Degree of embed and economic effectiveness: designed imitating model device and scholastic-methodical recommendations were approved and used in Dzhizak state pedagogical institute and Dzhizak polytechnic institute, Guliston state university..
Sphere of usage: results of the study can be are used in improvement of the training engineer-teacher in system of the high vocational train ing.

Subjects of the inquiry: patients with ITSW were 7781 people, persons from risk groups were 7573 people, 1573 people were from CSW and so on, in all addressing for five years were 408902 people.
Aim of the inquiry. Study reasons causing unfavorable epidemiologic situation by ITSW in Astana city for proving, working out and introduction of innovational, medical-social and organizational managing technologies in complex prophylaxis and control.
Methods of inquiry: informational-analytical, social-hygienic, expert evaluation, chronometry, economical analysis, mathematical modeling, statistical.
The results ahieved and their novelty: On the base of social demographic characteristics of population in Astana city it was taken epidemiological characteristics of ITSW’s spreadness in different social-dcmographic and professional groups of urban population in age sexual aspect. In realization of tasks on fighting with ITSW’s epidemy the opinion of Astana city’s population was researched. Regularities of influence for behavioral and social factors on epidemic process at ITSW were determined. Recommendations on improvement of organization for primary and secondary prophylaxy, effective managing and organizational decisions in struggle with ITSW were proved in formed social-economical conditions of fast developing city.
Practical value. For supply of real dcrmatovenerological aid to population of Astana city, it is necessary 0,25 rate of doctor-dcrmatovenerologist to 10 thousand of population4 by center of dermatology and prophylaxis of ITSW of Astana city special medical-social and organizational-managing technologies of prophylaxis ITSW were worked out, that were oriented to risk groups, introducing from 2001, that can be used for managing of given pathology.
Degree of embed and economic effictivity. Approaches in study of peculiarities for development of cpidcmy were worked out, and, suggested methods of primary and secondary prophylaxis were used in centers of dermatology and prophylaxis of country and showed high social, economical and medical efficacy.
Sphere of usage: Dermatovenerology, public health and health care

Object of research. Mountain forests of South-West Tian-Shan.
Purpose of work. Development of theoretical positions, practical recommendations on protection, preservation, rational use of forest resources and steady development of forests of South - West Tian-Shan taking into account their ecological adaptablcness, and estimation of up-to-date condition.
Method of research: field, reconnoitered. Routing ecological inspections of mountain forests arc put in the bases of field - reconnoitered researches, also mapping, comparative, analyzing and other methods.
Received results and their novelty include detailed and all-round analysis of forest florae of South -West Tian-Shan. It was investigated features of formation and distribution, established the laws of high- altitude distribution and sectors both forest flora as a whole, and forest types. Also it was investigated degrees of depression of large forests and their reasons.
Practical importance of w ork. Results of researches arc directed on protection and multiplication of forest riches of republic, rational use of forest resources, and focused on expansion of knowledge of scientists, students and pupils.
Degree of introduction and economic efficiency. The given dissertations arc applied in the organization of forest husbandry works. It makes interest for experts in the field of forestry, forest husbandry, ecology, bio-geography, botany, also serve as a valuable material for creation of the state programs in the field of protection and rational use of objects of flora.

Objects of research: onc-cylindcr high-speed diesel, piston, socket, insulated ceramic parts.
Aim of research: working out and practical realization of the scientific bases of creating transport diesel with lowered heat losses under heat insulated ceramic parts.
Research methods: theoretical and experimental research methods have been used in this work. Theoretical research is established on both three-dimensional model of the heatstressed state of a socket and piston and one-zonned and multizonncd models of the diesel working process.
Experimental research has been carried out on one-cylinder highspeed diesel 96x120 mm size and engine-free heat stand on the basis of the modem foreign and domestic measuring devices.
Received results and their novelty:
- technology of making heat insulated parts from silicon nitride for the main parts of the diesel foreseeing synthesis of the powder, pulverization and preparation of the mix, pressing and mechanical treatment has been developed; the optimal chemical composition of the powder Si3N4-Si С-ХгОг-УгОз on the basis of silicon nitride with high physical and mechanical characteristics has been worked out; setting of the heat insulated parts made from that powder composition on the piston and socket enabled to lower their common temperature level and give more even temperature field;
- three-dimensional models for investigation of the heatstressed state of the main and heat insulated sockets and pistons accounting real thermal limit conditions from the side of working body have been made;
- onczonncd model and algorithm of the calculation of the diesel working process foreseeing change of the momentary factor of air excess depending on the law of fuel feed and used as the basics for defining the speed of heat discrimination have been developed;
- experimental calculation method of defining speed of head discrimination in the combustion chamber of the highspeed diesel, founded on usage of the real indicator diagrams got experimentally, has been elaborated;
- semiempirieal formulae for the calculation of the local tangcncial speed of the whirling movement of the charge depending on the running cylinder radius and frequency of the crankshaft rotation has been received;
- multizonncd model of the working process in the diesels with the direct injection enabling to get meanings of the local nonstationary temperatures of the gases in the cylinder and to define the meanings of the zonal and total concentrations of the nitrogen oxide depending on regime and construction factors has been worked out.
Practical meaning:
- complex examination of the modelling the working process and heatstressed state of the piston engines presents an instrument having practical meaning for estimation of the possibilities and perspectives of the engines with the decreased heat losses;
- calculation theoretical bases of the designing diesels with the decreased branching of the heat from the working body, conversion of the serial diesels on the engines with the decreased heat losses have been developed;
- algorithms and programmers enabling to realize mathematical models and to solve the tasks of designing, finalization and modernization with the sufficient precision both for the serial and perspective diesels with the decreased heat losses have been worked out;
- method of experimental research of the heatstressed state of the piston has been developed; experimental unit with the automated measuring complex for examining of the working process of the highspeed diesels has been elaborated.
Inculcation and economic efficiency.
- developed technology of making heat insulated parts from silicon nitride for the main parts of the diesel, calculation experimental methods of investigation of the working process of the diesel, cylinder-piston group and practical recommendations on the choice of tuning and constructive parameters when designing and creating diesels with decreased branching of the heat from the working body have been taken for inculcation in CShS “UzDAEWOOAuto” and SLL“Autobilc Plant of Samarkand”, ShC “Uzavtosanoat”;
- the results of the thesis arc used in the teaching process at the Tashkent Automobile and Road Construction Institute and Moscow Automobile and Highways Institute when delivering lectures on “Theory and Construction of ICE”.
Field of applying: automobile construction, engine construction, scientific research.

The subject of the research: peculiarities, the tendency of the development of national self-awareness of Uzbek nation and the problems existing in this process in the conditions of independence.
The aim of the research analysis of peculiarities, tendencies of development of national self-awareness in the conditions of independence, the defining of the factors influencing on it and working out scientific substantiated conclusions, proposals for the development of the national self-awareness of the youth.
Methods of the research: social-philosophical analysis, historicity, comparative analysis, consistency, analysis and synthesis, conclusion.
The results achieved and their novelty: the term “national self-awareness” developed theoretically with consideration of peculiarities of appearing national development in the period of independence; made up analysis of the meaning “nations” as the real subject in the system of social mutual relations; given the definition of the concept national spiritual legacy; compared position of national self-awareness in the conditions of independence; revealed its place of the national spiritual legacy as one of the important basis of national development; revealed the meanings of historical personalities in the development of national self-awareness, defined factors, influencing of the development of national self-awareness, on decreasing degree of optimism in the development of national self-awareness, arc shown and substantiated factors scientifically, influencing on his overcoming positively.
The practical value: the research worked out conclusions and proposals promote further analysis of the dinamics of the development of the national self-awareness and the creation of the theoretical basis in overcoming problems in this direction.
The degree of embed: materials of the research can be used in teaching social-humanities in the system of education and in upbringing activities competent state and social organizations.
Sphere of usage: the scientific and theoretical conclusions of the research can be used in the system of education, in the activity of state and humanitarian organizations in perfecting educational work and international relations.

Subject of the inquiry: 78 patients with chronic sensouncural deafness on background of hypertension and complicated with discirculatory encephalopathy and 20 healthy persons.
Aim of inquiry: to assess the effectiveness of klcxan in complex therapy of the patients with sensoncural deafness of vessel genesis
Methods of inquiry: clinic- laboratory, functional and biochemical
Achieved results and their novelty: For the first time there was performed purposeful investigation of the 78 patients with chronic sensoncural deafness the background of the discirculatory encephalopathy of first and second stages. There was revealed the correlation between the level of hearing disorder disturbances of cerebral hcmodinamics and duration of vessel pathology. For the first time there was based the expediency on the fact of including of low- molecular anticoagulant klcxan in the complex therapy of deafness.
Practical value: There was proved the importance of investigation of the hemostasis system, rcohology and lipid system according to the biochemical data with the purpose of determination of disbalanses in microcirculation system with the follow adequate its correction at the patients with sensoncural deafness of the vessel genesis. There was determinated the necessity of using the duplex scanning of the extracranial vessels for assessment of cerebral hcmodinamics. There was proved that using of klcxan in complex therapy improved hearing function and prevent the progressive hearing decreasing.
Introduction degree and economic efficiency: The results of investigation were introduced in medical practice of First and Second clinics of Tashkent Medical Academy and ENT department of Andijan State Medical Institute. The materials of investigations arc used in the educational process of ENT and Neurology Departments of Tashkent Medical Academy.
Field of application: otorhinolaryngology

Subjects of research: medical staff of RMOC of the Ferghana region, population of the region, fertile age female, pregnant women, patients with IDA, ferro medications.
Purpose of work: organization of the haemoglobin enhancement of the population at the primary branch, analysis of treatment and prophylaxis of IDA, study of condition of provision with ferro medications, creation of effective, inexpensive and convenient system of its provision.
Methods of research: clinical, morphological, statistical.
Achieved results and their novelty: For the first time there was conducted a training of medical staff of the primary branch on treatment and rational nutrition for the purpose of haemoglobin enhancement of the population, the acquired knowledge was applied in practice. There was stated decrease of anaemia among the population in 5 years to 10,2 %. By means of evidentiary medicine indicators of IDA among fertile age and pregnant females were studied. Among fertile age females anaemia in its severe and medium-severe forms was reduced in 3.4 times, while in light form increased in 4.6 times. Among pregnant women anaemia in its severe and medium-severe forms was decreased in 1.5 times, while in light form increased in 4.6 times. For the first time there was studied prophylaxis, outpatient and inpatient treatment by means of ferro medications in practice of medical staff at the primary branch and problems were identified. The rational usage of ferro medications along with the national drug policy, condition of its provision and volume were studied. On the basis of experience of the medical staff at the primary branch there were determined indicators such as cffectiveness/cost/sidc effect of ferro medications. The degree of their optimal application and their significance at preparing a drug fonnular was determined.
Practical significance: 90 % of patients with IDA arc treated by the medical staff at the primary branch. Therefore, training of the medical staff and study of achieved results application in practice is actual. The study of comprehensive complex treatment of IDA by means of ferro medications in drugstores and application in practice of achieved results arc the requirement of the modem drug policy. The study of provision, cost and distribution as well as degree of their effectiveness at the level of the primary branch increases effectiveness of pharmacotherapy. It assists in applying in practice of the drug formular.
Degree of application and economical effectiveness: Training of medical staff of the primary branch increases effectiveness of IDA treatment. The study of indicators such as effectiveness/cost/ side effects at pharmacotherapy assists to optimal drug selection as well as procurement of effective, high quality and inexpensive ferro medications on tender basis. It produces economic effectiveness at conducting of trcatmcnt-and-prophylactic measures in treatment of IDA.
Field of application: The primary branch of healthcare system.

Objects of inquiry: One hundred and three patients with gonarthrosis.
Aim of inquiry was: to study an efficacy of preparation Solcoseril in complex therapy of gonarthrosis’ patients.
Methods of inquiry: clinical studies, estimation of pain syndrome under tests of Leken, WOMAC, Likert and functional dynamic tests, determination of a level of anti-inflammatory cytokins in blood scrum, body mass index, arthrosonog-raphy.
Results achieved and their novelty: For the first time a role of antiinflammatory cytokins in development, course and progression of gonarthrosis was studied. Clinico-functional and arthrosonography efficacy of using of Solcoseril in complex therapy of gonarthrosis was also substantiated.
Practical value: Arthrosonography performed in gonarthrosis’ patients, determination of IL-ip and TNF-a cytokins contributed to diagnosis and determination an efficacy of the therapy carried out. Application of Solcoseril in complex therapy perfected quality of life of patients.
An implementation degree and its economic efficacy: results of investigations were implemented into activity of the Republican Arthrology Center, Specialized Qualified Ambulance Treatment, departments of Rheumatology, Cardi-orhcumatology, the 1st clinic of the Tashkent Medical Academy, training process on department of Faculty & Hospital Therapy, Oriental Medicine and Internal Diseases of the medico-preventive faculty.
A field of using: Internal Diseases, Rheumatology.

Subjects of the inquiry: nonlinear evolution equations with self-consistent source.
Aim of the inquiry: To deduce the scattering data of spectral problem connected with nonlinear evolution equations with self-consistent source.
Method of the inquiry: used research methods include the methods of mathematical physics, theory differential equations, the theory of functions of complex variables, spectral theory of differential and difference operators.
I hc results achieved and their novelty: The main results of this work are new and consist of the following:
1) the law of changing on t of spectral data of Stunn-Liouville operator with potential which is the solution of general Korteweg - de Vries equation with source in the class of ‘rapidly decreasing’ functions is deduced;
2) the evolutions of scattering data of Sturm-Liouville operator with potential which is the solution of general Korteweg - de Vries equation in the class of “steplike” functions is defined;
3) the integration of general Korteweg - de Vries equation with source from “steplike” initial data is studied;
4) the inverse scattering method is used to solve various nonlinear evolution equations with self -consistent source in the case the simple eigenvalues of corresponding spectral problems;
5) it is shown that the inverse scattering method may be used for integration of sin-Gordon equation with self-consistent source in the case the multiple eigenvalues of Dirac’s operator;
6) the solution of Toda lattice with self-consistent source is expressed in terms of the inverse scattering method for the discrete Sturm-Liouville operator.
Practical value: the work has a theoretical character.
Degree of embed and economic cffcctivity: a special course will be read for post-graduate students on the basis of the received results.
Sphere of usage: the obtained results may be used in mathematical physics for integration of nonlinear evolution equations.

Subject of the inquiry: An old irrigated typical sierozem soil, an irrigated meadow alluvial soil, cotton crop, labeled and non-labeled nitrogen fertilizer, manure, furrow irrigation, drip irrigation, polyethylene film, mulch.
Aim of the inquiry: Regulation of transformation processes of soil and fertilizer nitrogen in accordance with requirements of cotton plant in the belt of irrigated sierozem soils.
Method of inquiry: Field, lyzimeter and pot experiments with cotton were conducted in accordance with “Methods of field experimentation with irrigated cotton” (Uzbekistan Cotton Growing Research Institute, 1973, 1981). Chemical analyses of soil and plant samples were performed according to "Methods of agrochemical analyses of soil and plants" (Uzbekistan Cotton Growing Research Institute, 1963, 1977). Relative growth rate of cotton stem and dry mass accumulation were determined as suggested by D. 13. South (1991). Relative growth rate of nitrogen productivity was calculated according to P. Poorter (1989). Data were subjected to analysis of variance using PROC GLM procedures in SAS (SAS Institute, 2003).
The results achieved and their novelty: The qualitative data on soil nitrate content as well as the N-total concentrations in cotton leaves allowed for the differentiation and thus improvement of the nitrogen fertilizer application norms and timing for cotton growth.
Fertilizer nitrogen recovery in cotton was determined by l?N methods both for cotton grown with a mulch of polyethylene film and combined with various timings of nitrogen application, different nitrogen quantities and under different irrigation modes including drip and furrow irrigation.
The impact of nitrogen quantities applied during planting on the germination of cotton seeds and stand establishment was researched. The content and dynamic of all soil mineral nitrogen forms were investigated. In addition, estimated was the quantitative ratio of available soil NPK throughout the cotton vegetation period, the relative growth rate of nitrogen productivity, cotton growth and development, and cotton yield depending of the nitrogen application timing while cotton was grown w ith the use of polyethylene film.
Mineralization and immobilization processes of nitrogen in the soil and the fertilizer nitrogen l5N balance was investigated under various ratios of manure carbon and with different brands of fertilizer nitrogen. Results showed that the optimal C:N ratio was obtained with the combination of cow-dung carbon + nitrogen of mineral fertilizer + manure applied, which was reflected in an improved availability of plants nutrients content in the soil, which in turn increased cotton yield and the quality of the cotton lint.
The transformation of mineral forms of soil nitrogen, NPK uptake and dry mass accumulation by plants, as well as cotton yield quantities and quality were investigated subject to various nitrogen rates and application timing combined with different irrigation technologies, irrigation methods and modes.
Practical value: Based on the results following implications options could be elaborated:
- A method for a refined use of nitrogen fertilizers application both in terms of quantities and timing on cotton which is based on the nitrate content in the soil (for automorphyc soils only) and on the nitrogen concentration in plant leaves which is applicable for all soil types;
- nitrogen fertilizer application methods for various irrigation technologies used in cotton production (alternate irrigation during whole vegetation);
- efficient method of a combined application of nitrogen fertilizer and manure on cotton, which lowered the use of nitrogen fertilizer rate by 30% and concurrently increased the scope of usage for organic fertilizer;
- nitrogen fertilizer application timing on cotton when cotton is grown with the use of polyethylene film.
Degree of embed and economic efficiency: The results of the investigations formed the scientific basis for the development of “Practical recommendations in agriculture: soil, water, fertilizer” (in Russian, MAWR, Tashkent, 1996. - 108 p.), “Recommendations on production of high and qualitative cotton yield in Tashkent Province” (in Uzbek, UzSPCA, Tashkent, 1996. - 16 p.), Recommendations on the use of mineral and organic fertilizer in cotton growing” (in Uzbek, UzSPCA, Tashkent, 2003. - 24 p.). Practical recommendations as presented in this thesis were included in various provinces of the country but on a total area of 80,000 hectares. Hence this would lead to a net profit varying from 48,826 to 215,981 sums ha'1 caused by the recommendations
Sphere of usage: Farmers units specialized in cotton production in the belt of the irrigated sierozem soils.

Subject of the inquiry: steering wheel of self-driven energetic vehicle means.
Aim of the inquiry: the aim of this inquiry is to rise the stability of the motion and conducting of self-driven means by rational choice of transmission ratio of the steering wheel.
Methods of inquiry : the analytical and experimental research methods are used in the work based on methods of automatic regulation theory.
The results achieved and their novelty: the character of the influence of the transmission ratio quantity on the sensitiveness of the machines the control and stability of the motion are used
The mathematical models for calculation of parameters of the motion of selfdriven energetic means with hydro-huged characters of the steering wheel and the choice of mounting coordinates of carried out hydrocylinders are worked out.
Practical value: the recommendations on the choice of transmission ratio of steering wheel and mounting coordinates of carried-out hydrocylinders rising stability of the motion and improving conduction of self-driven energetic means are worked out.
Mathematical models allowing to realize rational choice of parameters of steering wheel on the stage of project are created.
Degree of embed and economic effectiveness: recommendations on the choice of the quantity of transmission ratio of steering wheel and calculated definition of rational parameters of mounting hydrocylinders of the wheel implement are accepted for the usage in SSC (GAO) "Tashkent Tractor Plant".
Sphere of usage: tractor and agricultural machine-building.

Objects of research: 92 immature rats with term of 30-40 days. 108 patients with asiderotic an anemia: men - 13 (12%), women - 95 (88%); middle age - 39,9 years. The control group was made by 17 healthy persons.
The purpose of work: Increase of efficiency of treatment of patients asiderotic [iron-deficiency] anemia by an induction of synthesis and a metabolism a theme in a liver.
Methods of research: clinical, biochemical, morphological, tool.
The received results and their novelty: Activization of the initial stages of synthesis is established on models alimentary asiderotic [iron-deficiency] anemia in mitochondrial and microsomal-cytosol fractions of a liver a theme, on a background to inhibit its final stage. Correction of a level malonic dialdehyde and activity of enzymes superoxide dismutase (SOD) and catalase (CAT) is revealed as a result of application of a combination of preparations maltofcr and neosclcn in mitochondrial and microsomal-cytosol fractions of a liver of experimental animals. For the first time we analyse parameters of ions of tri valent, bivalent iron both dif-feritin in mitochondrial and microsomal-cytosol fractions of a liver of experimental animals. The morphological picture of a liver at alimentary iron deficiency is submitted an anemia and correction of the revealed infringements by preparations maltofcr and ncosclcn. For the first time on the big clinico-expcrimcntal material efficiency of application of a combination of preparations maltofer and neoselen is shown.
The practical importance: Application of a combination of preparations maltofer and neoselen on a clinico-experimental material restores activity of enzymes of synthesis and disintegration a theme in hepatocyte’s, improves ferroki-nctic, hematologic parameters and promotes improvement of a functional condition of a liver. The received positive results in clinical researches have found acknowledgement (confirmation) on an experimental material that allows to recommend the given circuit of treatment железодефицитной to an anemia in clinical and outpatient conditions.
Degree of introduction and economic efficiency: Results of research are introduced into practice гематологического, therapeutic branches, and as for doctors of an initial link.
Scope: hematology, therapy.

Subject of the inquiry: 97 patients with ankylosing spondylitis, 20 healthy volunteers.
Aim of the inquiry: to assess metabolic activity of erythrocytes and peculiarities of fcrrokinctics in using Fhlogcnzymc in the complex therapy of patients with AS. Methods of research: functional-metabolic process erythrocytes and ferrokinctics (scrum iron, ferritin, saturation of transferrin with iron) lipid peroxidation and antioxidant system.
The results achieved and their novelty: For the first time purposeful complex study was conducted of metabolic process parameters in erythrocytes and fcrrokinctics, lipid peroxidation and antioxidant system processes, Willebrand factor, atherogenicity in relation to the clinical course of the disease. Functional-metabolic disorders in erythrocytes in fcrrokinctics determined systemic changes in blood, with their extent associating with severity of the clinical course of AS. For the first time it was found that the use of Fhlogcnzymc in the complex treatment improved clinical course of the disease. The shortening of clinical recovery period was associated with normalization of parameters characterizing functional metabolic activity in crythrocytea and ferrokinctics. Systemic enzyme therapy was proved to increase the effect of conventional therapy by a directed improvement of functional metabolic processes in erythrocytes, energetic activity and ferrokinctics which allowed inclusion of systemic enzyme therapy preparations for hemic hypoxia in patients with AS.
Practical value: Use of Fhlogcnzymc in the complex treatment of AS increased the efficacy of therapy, decreased the rate of drug side-effects, allowed us to decrease the doses of basic preparations and non-stcroid anti-inflammatory. Changes of laboratory parameters in Fhlogcnzymc using included more significant decrease of acute phase indices, increase of hemoglobin and erythrocyte concentration in the peripheral blood.
Degree of inculcate and economic efficiency: conclusions and practical recommendations were introduced into the practice of departments of rheumatology, nephrology of the third clinic of the Tashkent Medical Academy and into teaching process of departments of faculty and hospital therapy, folk medicine, internal diseases of the stomatological faculty and clinical pharmacology of the Tashkent Medical Academy.
Sphere of usage: rheumatology, therapy.

Subject of the inquiry: 994 women, delivered by operative way under subarachnoid anaesthesia for period since 1998 to 2004. In addition, 16 women’s corpses of fertile age, died from accident and during pregnancy, were examined.
Aim of inquiry: Increase of safety of combined subarachnoid anaesthesia during surgical delivery by finding out and estimating the risk factors, determining the groups of risk on the base of prognostic index, development of the algorithm of rational choice of the anaesthesia method.
Method of inquiry: Retrospective analysis and statistical processing of the clinical observations, produced in the analysis of the patient’s history, protocols of anaesthesia and cards of intensive care, as well as morphological and dura mater of the died women histochemical examinations.
The results achieved and their novelty: Complications and side effects of different variants of combined subarachnoid anaesthesia of the pregnant women were detail studied and classified; the anatomico-physiological factors, promoting the development of the neurological complications of subarachnoid anaesthesia were revealed; new prognostic indexeses of the risk of development complications and side effects afterf subarachnoid anaesthesia in pregnant women , as well as severity complications indexes were developed; the algorithm of the choice of the anaesthesia method in pregnant women was developed, allowing to reduce frequency and severity of anaesthesia complications and to improve the quality of anaesthesia.
The main advantages of developed indexes arc using simple clinical data and the absence of need in using the special methods of the examination or special equipment.
Practical value: Developed complex introduced into clinical practice and practical recommendations on prognosis, preventive maintenance and treatment of the complications of combined subarachnoid anaesthesia, allowed the 1,5 times as much reduction of the frequency and severity of the complications and their outcomes, improvement in the quality of anaesthesia 3,5 times as much. Due to its accessibility and simplicity, the technique can be used in all types of hospitals including central district hospitals.
Degree of embed and economic effectivity: The technique can be used in all obstetric clinics, including republican, regional, district hospitals.
Sphere of usage: medicine, anesthesiology.

Objects of inquiry: 107 women with rheumatoid arthritis in climacteric period.
Aim of inquiry: studying clinical-immunologic and roentgenologic indices in females with rheumatoid arthritis in connection with climacteric periods and perfecting therapeutic approaches.
Methods of inquiry: clinical studies, assessment of pain syndrom under visual analogous scale (VAS), determination of pro-inflammatory cytokins in blood scrum, roentgendensitometry, determination of body mass index, gravity of climacteric syndrom under modified menopausal index, determination of osteosyndrom by Ritchie and Lee test.
Results achieved and their novelty: for the first time in RA women in climacteric an interrelation between clinical laboratory RA manifestations and an expression of reproductivity disorders has been revealed. An interplay between acute phase indices, rheumatoid arthritis and Lee test and grade of severity of climatcric period has been established. An intcraggravating effect of RA and climacteric syndrom was approved. Predictive valuable factors in RA women in climacteric were determined. Osteoporosis in females with RA was began earlier before climacteric, it lasted more pronounced with lowering mineral density of bones. An advancing lowering of mineral density of bones in RA began in climacteric was shown. Dependance between a level of pro-inflammatory cytokins and duration of disease has been revealed, and less expressed regression of IL-ip indices in women with preserved menstrual function. Recommendations for strategy of RA treatment in women in climacteric taking into consideration features of a course of disease were worked out.
Practical value: rocngcnometry in females with RA, determination of TNF-a, IL-ip cytokins, modified menopausal index by Kuppermann contributed to diagnosis and prediction, management of an adequate therapy. Using of plasmapheresis and climadinon in complex therapy of rheumatoid arthritis reduced manifestations of disease and climacteric syndrom.
An implementation degree and economic efficacy: results of studies were implemented into activities of the Republican Arthrology Center, Specialized Qualified Ambulance Treatment, departments of Rheumatology, Cardiorhcumatology, 1st clinic of the Tashkent Medical Academy, in teaching process on a department of Faculty & Hospital Therapy, Oriental Medicine and Internal Diseases of the medico-preventive faculty.
A field of application: Internal Diseases, Rheumatology

Subjects of the inquiry: the patients with nonspecific ulcerative colitis
Aim of the inquiry: an improvement of the results of the treatment of patients with nonspecific ulcerative colitis by the perfection of diagnosis and a choice of the scope of surgical intervention.
Method of inquiry: clinical, laboratory, instrumental, surgical and statistical.
The results achieved and their novelty: algorhythm of diagnosis and choice of the method of treatment of the patients with non-specific ulcerative colitis has been developed. Indications to intraoperative colonofibroscopy for the choice of the method and scope of the operation in complicated forms of non-specific ulcerative colitis have been formulated for the first time. Its efficiency has been proven. Intraoperative colonofibroscopy gives a possibility to determine borders of the inflammatory-ulcerative process exactly and provides threefold decrease of the postoperative complications and significantly more often positive outcomes of the operation (88,5% of the cases). A quantitative scale for evaluation of the severity of various forms of non-specific ulcerative colitis was offered. It permits to obtain more objective information.
Practical value: the developed algorhythm of diagnosis of nonspecific ulcerative colitis, including intraoperative colonofibroscopy, considerably improves results of surgical treatment, decreasing the number of postoperative complications and resulting in good outcomes more frequently. Use of quantitative scale for evaluation of the severity of various clinical forms of nonspecific ulcerative colitis provides an adequate estimation of the patient’s state
Degree of embed: the developed scheme of diagnosis in the form of algorhythm and an offered method of a choice of a scope of operation -intraoperative colonofibroscopy - in nonspecific ulccrus colitis is introduced into practice of work of the Research Center of Coloproctology of the Ministry of Public Health of the Republic of Uzbekistan. Results of the research arc included in the course of lectures at the department of surgery for doctors of general practice of Tashkent Medical Academy.
Sphere of usage: coloproctology and gastroenterology.

Subjects of the research: 1066 patients with peritonitis.
Purpose of the research: improvement of the results of treatment of the patients with peritonitis by determination of the prognostic significance of clinical-metabolic parameters in the estimation of severity of patients condition, flow and outcome of the disease.
Methods used in the research: clinical, microbiological, biochemical methods of investigation, mathematical statistics and mathematical modeling.
Results obtained and their novelty
1. The prognostic significance of clinical-anamnestic, microbiological, laboratorial- instrumental and metabolic data has been determined on the basis of the correlational interrelation between metabolic parameters and bacterial contamination in patients with peritonitis
2. When the actions of NIDE (UIDI) RC and GI are studied in clinical conditions it is shown, that their combined application during the operation and postoperative periods considerably decreases the culture growth in peritoneal exudates and improves metabolic parameters.
3. On the basis of the method of mathematical modeling, programs arc proposed to estimate the severity of patient s condition and predictability of flow, the outcome of disease in the patients with peritonitis.
Practical significance
1. The special features of the disturbance of metabolic parameters dependent on the bacterial contamination have been established, which makes it possible to reveal the patients with high risk of development of complications.
2. It is proven that the application of the infra-R emitters in combination with the traditional treatment in patients peritonitis contributes to more favorable flow of the disease and to reduction of postoperative complications and lethality.
3. Two programs have been created with the methods of mathematical modeling which allow: 1) To estimate severity of the patients condition on the basis of clinical-anamnestic, laboratorial- instrumental, metabolic and microbiological data;
2) To predict the complications of the disease; 3) To predict the healing of the postoperative wound; 4) To identify the indications for NIDE (UIDI) applications.
Level of induction: method of application of narrow-spectrum infrared distant emitters in peritonitis is used in surgical department of the Clinical Hospital of Emergencies and Casualties, Г' Municipal Clinic Hospital and in Central Military Clinical Hospital named after P.F. Borovskiy.
Region application: Surgery.

Subjects of the inquiry: 103 patients with rheumatoid arthritis, 20 healthy individuals.
Aim of the inquiry: To study therapeutic effect of low frequency physical factors on the cytokines and the processes of lipid peroxidation and to confirm scientifically the efficacy of their use based on the their effect on the clinical laboratory findings.
Methods of investigation: Clinical and laboratory investigations, immunological analyses of the blood scrum cytokine levels and synovial fluid, biochemical examinations of the lipid peroxidation and antioxidant system indicators, phospholipase-A2 activity, nonspecific phosphatases and free oxyprolinc in the blood serum of patients.
The results achieved and their novelty: There was studied clinical efficacy of ultraphonophoresis with benzketozon during treatment and rehabilitation of the patients with rheumatoid arthritis. It was proved that disbalance between inflammatory and anti-inflammatory cytokines as well as lipid peroxidation activation activity in the erythrocyte membranes and blood scrum destabilized cellular membrane structures, increase in phospholipase-A2 activity and, consequently, stimulating prostaglandines, inflammation mediators, synthesis. There was shown that complex therapy with inclusion of low frequency physical factors, particularly ultraphonophoresis with benzketozon, gave marked positive effect normalizing interrelation ship between inflammatory and anti-inflammatory cytokines reducing activity of phospholipase-A2, lipid peroxidation products and rising the levels of antioxidant system indicators.
Practical value: There has been shown rationality of inclusion of the physical-pharmacological method ultraphonophoresis with benzketozon into clinical practice. The differential indicators developed for application of low-frequency physical methods of therapy for rehabilitation of the patients with rheumatoid arthritis allow prolongation of the remission, improvement of the patients life quality.
Degree of embed and economic effectivity: The practical recommendation and guidelines have been applied in the clinical practice of the out-patient special course of arthrological treatment in the Republican Rhcumatological Center, Clinical Hospital N 1, Central Hospital of Zangiota district of Tashkent province. Sphere of usage: Rheumatology, physiotherapy.

Subject of the inquiry: rabbits, visceral-ischemic shock, metabolism, mitochondria, suktsinasol, suktsivil.
Aim of the inquiry: to study effect of new hemocorrectors such as suktsinasol and suktsivil on the basic pathogenetic mechanisms of visceral-ischemic shock.
Methods of inquiry: physiological, biochemical, biophysical, statistical.
The results achieved and their novelty: A complete evaluation of indices in hemodynamics is given in VIS including AAB and toxemia, functional changes in liver, indices of carbohydrate-phosphoric metabolism. A number of research methods have been studied which gave the opportunity to have a distinct understanding about metabolic status of the organism. Efficiency of a new polyfunctional hemocorrection - suktsinasol on hemodynamic and metabolic indices of VIS have been studied for the first time. The effect of a new polyfunctional hemocorrector Suktsivil on the hemodynamical and metabolic indices of VIS have been studied. A comparative analysis of effective blood substitutes during infusion for VIS in experiment has been carried out.
Practical value: We have determined hypothesis about disorder of energetic metabolism in liver cells in VIS. We have proved efficiency of using new complex blood substitutes sulktsinasol and suktsivil as supply of rich energetic compounds (sulktsinasol) and corrector of electronic and transport function of mitochondria in liver in emergency complicated by hypoxia and toxemia.
Degree of embed and economical efficiency: Obtained results concerning effective new substitutes suktsinasol and sukrsivil for VIS can be recommended for combined treatment of VIS in medicine new blood substitutes can restore hemodynamics, acid-alkaline balance, metabolism, reduce toxemia.
Sphere of usage: medicine.

Subject of the inquiry: diets for nutrition in the families and kindergardens, biological active addition to the food, animals, children.
Aim of the inquiry: elaboration of effective methods of rationalization of diet for nutrition of studying-educational institutions with usage of biological active additions for food.
Methods of inquiry: hygienic, medical- biological, toxicological, biochemical, chemical and statistical.
The results achieved and their novelty: According to the results of hygienic and toxicological explorations of biological active addition “ Biovit” was selected as the most successful, which made compensation of the deficit of vitamin C, A, B6, B12; folium acid, calcium, magnesium; irreplaceable aminoacids in daily diet of children, who attends kindergardens. It was estimated the increase of biological value of nutritional diet, increase of nitrogen’s balance, secretion of nitrogen, assimilation of the protein and improvement of biochemical index of nitrogenical components of the urine and sufficiency in vitamin C among children. The methodological approach was established to the basis of using biological active additions and estimation their effect in kindergardens.
Practical value: The results of research, which was appvouba by Sanitary rules and norms Republik of Uzbekistan, 2 methodical recommendations, method of avaluation of nutrition’s condition was elaborated and approved for practical health care according to research works;
Degree of embed and economic effectivity: the introduction on the Republic level has public cultural, general prophylactic, social and ecological hygienic role in the safety of the health of population.
Sphere of usage: in prophylactic medicine and hygienic practice, in study of medical Universities.

Object of research: formation process of elements of graphic literacy at children of the senior and preparatory groups of children's preschool institutions.
The purpose of work: to develop pedagogical system to the doctrine of elements of graphic literacy of senior and preparatory groups pupils.
Methods of research: the theoretical analysis, individual, group oral and written conversations, questioning, experiment, innovative and interactive methods, the mathematic -statistical analysis.
Novelty of research: the problem formation of elements of graphic literacy at children of the senior preschool age is first developed in a scientific way by proceeding and opening features of Uzbekistan. The theoretical and practical basis, pedagogical system and system of problems tasks included into it is developed; scientifically proved technique of elements formation of graphic literacy at children of the senior preschool age is developed.
Network of introduction and economic efficiency: the point of research and pedagogical system developed on ins basis, methodical recommendations and workbooks’ will help teachers and chiefs of graphic activity courses in formation of graphic literacy elements at children.
The practical importance: an essence research and on the basis of it’s the developed pedagogical system, methodical recommendations and the grant will help teachers and heads of a circle on graphic activity in formation at children of elements of graphic activity. Ideas stated in dissertational work is possible to use in teaching lessons of graphic activity in pedagogical High schools and colleges. Proceeding from conclusions the developed methodical recommendations will help to organize and increase the efficiency of lessons of graphic activity.
Scope: conclusions and the basic ideas of the dissertation can be used at faculties of preschool education of High schools, professional colleges whey teaching «Pedagogics of preschool age", at the organization of lessons heat are included into the in that are included into the group of graphic activity in children's preschool institutions.

To study the anti-inflammatory and some other pharmaco- logical properties, toxicity of the new thiocarbamate and thiourea derivatives (codes UB-421 and BIK-15, respectively), selected after the scrinning reseaches among the compounds of this group and to ground the possibility of their using in clinic

Objects of research: 1st group (control) - 8 dogs, which apply traditional intensive therapy at craniocereberal trauma without hypothermia. 2 st group - 8 dogs, which apply drug treatment with external craniocerebral hypothermia. 3 st group -8 dogs, which apply drug treatment with perfusion method of hypothermia. At 286 patients with heavy craniocerebral trauma, efficiency hyperventilation on a background of various methods CCH is investigated depending on type of infringement of a cerebral blood flow.
Purpose: to optimize results of protection and reanimation of a brain at a severe craniocereberal trauma by perfection of a method craniocerebral hypothermia and the differentiated choice of a mode of artificial ventilation easy.
Methods: the cerebral blood flow parameters estimated by transcranial Dop-plcrography datas. Also was definite saturation of arterial (SataO2) and venous (SaI. vjO2) blood oxygen, cerebral blood flow (arteriovenous difference O2), a level of lactate in peripheral blood and in liquor, parameters of intensity.
Results and novelty: by complex study was proved that perfusion method of the craniocerebral hypothermia is an effective and adequate method of protection of a brain caused by hypoxia and secondary damages at severe craniocerebral trauma. It is established, that at carrying out perfusion CCH the important factor of protection of a brain from hypoxia and secondary damages to which the death of animals at severe craniocerebral trauma, is preservation on a limit of physiological norm of functioning erythrocytes owing to adaptable decrease in processes the lipid peroxidation, preservation at high enough level of activity of enzymes antioxidant system, reactions peroxide hemolysis erythrocytes and which can serve as criteria of an estimation of the forecast of efficiency of spent treatment, an outcome of disease.
Practical value: it is developed and pathogenetic efficiency of a perfusion method of the CCH is proved at severe craniocerebral trauma. The algorithm of differential use hyperventilation at patients with severe craniocerebral trauma is developed depending on type of cerebral blood supply disturbance and a degree of development intracranial hypertension.
Inclusion of a method perfusion method of the CCH increase efficiency of protection of a brain from hypoxia and secondary damages reduces frequency of lethal outcomes at severe craniocerebral trauma.
Introduction and economic efficiency: results of research are introduced in practice of the Republican science centre of neurosurgery Health Ministry of the Republic of Uzbekistan and department of anesthesiology and resuscitation of 2-clinic of the Tashkent medical academy.
Field of application: resuscitation and neurosurgery.