In chronic experiments in laboratory animals, studied toxicological perspective new antiarrhythmic effect of N-deacetyllappaconitine for the treatment of arrhythmic states, an original herbal preparation based on Aconitum leucostonum, Ac.Septentrionale was created. During 2,5 months of intragastric administration in animals exposed to all doses of N-deacetyllappaconitine, no deviations in the parameters of the functioning of the nervous system were found, therefore, this value is the lowest effective (threshold) dose in a chronic experiment.
It is known that in chronic liver diseases, secondary immunodeficiency is formed, which is of great importance for the dental system and the entire body as a whole. Therefore, it becomes clear the importance of studying the state of the protective system of oral tissues in chronic viral liver pathology, which requires timely and constant correction. The aim of this study was to evaluate the activity of proinflammatory cytokines and cytolytic enzymes in patients with chronic viral hepatitis before tooth extraction. The level of cytokine IL-1 in patients with CVI before tooth extraction was on average 43.97±3.56 pg / ml, whereas in healthy people the studied indicator was on average 5.41 ± 0.42 pg / ml. The patients showed an increase in the level of IFN in the blood serum by an average of 6.2 times, the level of interleukin-18, belonging to the IL-1 family, was statistically significantly increased by 2.4 times in patients with CVI, compared with the control group. The features of CVH are dissociations between the levels of proinflammatory cytokines IL-1, IL-6, IL-18 and interferon. This indicates the disintegration of the inflammatory process occurring in the periodontal tissues and with the transition to a chronic course of the disease. Changes in the level of IL-1, IL-6, IL-18 and interferon in the blood serum of patients with CVI from normal parameters before tooth extraction is an indicator of the severity of the inflammatory process in the liver, as evidenced by changes in the dynamics of cytolytic enzymes.
Chronic brain ischemia (CHEM) develops due to insufficient blood circulation of the brain, is one of the most common cerebrovascular diseases, accompanied by cognitive disorders, with a decrease in concentration and cognitive activity, and emotional disorders.
The article describes a clinical case of a patient with chronic brain ischemia.
In an experimental study, the morphofunctional features of the spleen of 6-month-old white rats were studied in normal conditions and in chronic radiation sickness. The study found that in response to the action of a chronic radiation factor in the spleen of white rats, there is a decrease in structural parameters. This is reflected in the morphological parameters of the organ. As a result, the functional activity of the spleen’s lymphoid tissue decreases.
Objects of research: 447 patients, from them 68 with chronic purulent middle otitis and 379 with dry meso- and cpitympanitis.
Purpose of research: to estimate efficiency and forecasting of results of various variants of tympanoplasty.
Methods of research: common clinical investigation, voice-frequency threshold and over threshold audiometry, research of hearing in low and expanded range of frequencies, speech audiometry, ultrasound research of hearing, rontgenography of mastoid, computer tomography, otomicroscopy.
Received results and their novelty: at chronic purulent middle otitis it is proved carrying out two stage tympanoplasty - as the first stage reconstructive-sanity operations - atticoantrotomy on to the “closed” type with mastoidoplasty, and as the second stage hear improving operations. The way of laying of a transplant is developed and introduced as the “romashki”, raising efficiency of engraftment and functional results. Efficiency is revealed at carrying out myringoplasty and tympanoplasty on a “dry” car. Developed forecasting criteria, based on the objective data for planned operations.
Practical value: developed the ways of reconstructive-plastic and hear improving operations, estimation of their efficiency and forecasting expected result at patients with chronic inflammatory diseases of middle car.
Degree of embed and economic effectivity: results and conclusions of research arc introduced into practice in ENT-dcpartmcnts and polyclinics, in educational process of Tashkent medical academy.
Field of application: otorhinolaryngology.
Clinico-laboratorial part of the work is based on a survey of 96 patients with chronic generalized periodontitis (CGP). 22 people of the patients have chronic generalized periodontitis mild (HGPM), patients with chronic generalized periodontitis average degree (HGPA) and chronic generalized severe periodontitis (HGSP) 42 and 32 people respectively, combined with hypothyroidism. For objectification of the clinical research of the periodontal tissues, we used indicators such as the periodontal index, papillary-marginalalveolar index and the index of Ketze. For aexact determination of the intensity of the inflammatory process
used Schiller-Pisarev trial. To measure the depth of periodontal pockets also held X-ray examinations. It was found that a significant activation of lipid peroxidation and reduced antioxidant defense observed in patients with severe CGP on the background of hypothyroidism. It is shown that thyroid dysfunction occurs pronounced activation of the immune system, manifested by increased levels of cytokines in the serum. The highest concentration of TNF, IL-1 and IL-4 were detected in patients with moderate CGP thyroid hypofunction.
Chronic inflammatory diseases of the larynx (CIAG) are a collective concept of a fairly large number of diseases with different etiologies. Nosological forms of diseases of the larynx in this case are presented in a wide range - from functional disorders leading to respiratory failure, benign formations of the larynx to gross, long-term cicatricial stenoses that require complex reconstructive operations. The pathomorphological assessment of such a condition of the larynx is primarily associated with the presence of chronic inflammation of the mucous membrane and elements of the larynx, including the submucosal layer, as well as the muscles and cartilages of the larynx. Most often, chronic inflammation of the larynx is localized in the region of the vocal cords, the subvocal region of the larynx with the transition to the cervical trachea and is a secondary manifestation of the damaging factor.
Currently, in medicine the number of patients with burn injuries. This necessitates further improvement of local treatment methods for such patients. Although several types of wound dressings have been developed, no gold standard has yet been developed. Therefore, the development of easy-to-use, bactericidal effective and inexpensive wound coverings is relevant, taking into account the requirements for coatings.