Tajribalar og'irligi 150-170 g bo'lgan oq oq kalamushlarda o'tkazildi.Hayvonlarning birinchi tajriba guruhiga har kuni intraagastral ravishda Maurik (2,8 mg / kg) 30 kun davomida yuborildi. Hayvonlarning ikkinchi tajriba guruhi sxema bo'yicha geliotrin (5 mg / kg) oldi. Hayvonlarning nazorat guruhiga steril fiziologik eritma yuborildi. Dalak va mezenterial limfa tugunlari morfometrik va elektron mikroskopik usullar yordamida tekshirildi. Surunkali intoksikatsiya dinamikasida ksenobiotiklarning (geliotrin va fozalon) immunogenez organlarining T ga bog'liq zonalariga ta'sirchan ta'sirchanligi qayd etildi, bu proliferatsiya havzasining pasayishi bilan vayron qiluvchi jarayonlarning ko'payishi sifatida namoyon bo'ladi. hujayralar.
Xulosa: surunkali intoksikatsiya tanadagi immunogenez jarayonlarining buzilishiga olib keladi, ularning namoyon bo'lishlaridan biri immunitetning periferik organlarining T ga bog'liq zonalaridagi tarkibiy va funktsional o'zgarishlardir.
It is known that in chronic liver diseases, secondary immunodeficiency is formed, which is of great importance for the dental system and the entire body as a whole. Therefore, it becomes clear the importance of studying the state of the protective system of oral tissues in chronic viral liver pathology, which requires timely and constant correction. The aim of this study was to evaluate the activity of proinflammatory cytokines and cytolytic enzymes in patients with chronic viral hepatitis before tooth extraction. The level of cytokine IL-1 in patients with CVI before tooth extraction was on average 43.97±3.56 pg / ml, whereas in healthy people the studied indicator was on average 5.41 ± 0.42 pg / ml. The patients showed an increase in the level of IFN in the blood serum by an average of 6.2 times, the level of interleukin-18, belonging to the IL-1 family, was statistically significantly increased by 2.4 times in patients with CVI, compared with the control group. The features of CVH are dissociations between the levels of proinflammatory cytokines IL-1, IL-6, IL-18 and interferon. This indicates the disintegration of the inflammatory process occurring in the periodontal tissues and with the transition to a chronic course of the disease. Changes in the level of IL-1, IL-6, IL-18 and interferon in the blood serum of patients with CVI from normal parameters before tooth extraction is an indicator of the severity of the inflammatory process in the liver, as evidenced by changes in the dynamics of cytolytic enzymes.
The problem of pulmonary hypertension (PH) is very essential for a large number of clinical conditions. It naturally occurs in many internal diseases, especially in patients with valvular heart disease, chronic lung pathology, vasculitis with vascular lesions of the pulmonary circle, pulmonary embolism, heart defects and many others. Increased blood pressure within the pulmonary artery (PA) is a natural step in the progression of chronic heart failure.
Surunkali toksik gepatitda stimusolning (radix Glycyrrhiza+mumie ekstrakti) lipid peroksidlanish jarayonlariga va jigarda o't sinteziga ta'siri o'rganildi. Geliotrin bilan surunkali zaharlanish paytida stimulyator antioksidant va xoleretik ta'sir ko'rsatishi aniqlandi. O't pufagini normalizatsiya qiladi. Gepatoprotektor harakati bilan mashhur, silibordan voz kechmadi.