The purpose of the study is to determine the significance of genetic factors in the development of chronic nephritic syndrome in children and to clarify the features of the clinical course
The оbject of research were 129 children aged 4-15 years who were treated for chronic nephritis in the nephrology department of the Samarkand Regional Multidisciplinary Paediatric Medical Centre.
The scientific novelty of the study is as follows:it has been established that the severity of chronic nephritic syndrome in children is associated with clinical manifestations (gradual development, dyspepsia, abdominal pain) and an increase in the amount of Cystatin C in the blood;for the first time, it was revealed that the development of sclerotic lesions due to increased proliferation in patients with the presence of the MMP-9 (A-8202G) rs 11697325 genotypes in chronic nephritic syndrome leads to a worsening of the clinical course of the disease; established early diagnostic marker MMP-9 (A-8202G) rs 11697325 and its tissue inhibitor TIMP-2 (C536T) rs 11551797 in chronic nephritic syndrome in children in the diagnosis of the disease; for the first time, the prognostic value of the alleles of the MMP-9 (A-8202G) rs 11697325 genes and the homozygous G/G genotype in determining the risk of developing the disease in children with chronic nephritic syndrome has been proven.
Implementation of the research results. Based on scientific results of evaluation of the role of polymorphic genes of matrix metalloproteinase and its tissue inhibitors in chronic nephritic syndrome in children: methodological recommendation “The role of polymorphic genes of matrix metalloproteinase and its genetic inhibitors in the development of chronic nephritic syndrome in children” was developed and approved (reference of the Ministry of Health of the Republic of Uzbekistan No. 8n-r / 554 of 30.02.2022).
This methodological recommendation made it possible to predict the development of chronic nephritic syndrome in children and improve preventive measures; approved and developed on the basis of scientific results of research on early diagnosis and prognosis of chronic nephritic syndrome “Dynamics of clinical and laboratory parameters in nephritic syndrome in children”, (reference of the Ministry of Health of the Republic of Uzbekistan No. 8n-r / 555 of 30.02.2022).
This methodological recommendation made it possible to optimize the diagnosis and treatment tactics for various forms of nephritic syndrome in children;
The results obtained were implemented in the practice of health care, in particular, in the Republican Children's National Medical Center, in the 1st clinic of the Samarkand State Medical University, in the Samarkand Regional Children's Multidisciplinary Medical Center (conclusion No. 8 n-r/324 of 21.06.2022 of the Ministry of Health of Uzbekistan).
The application of the obtained results to practice has made it possible to reduce the frequency of recurrence of the disease in children, prevent complications of the disease, improve the quality of life of patients, diagnose and prevent the disease.
The structure and scope of the dissertation. The dissertation consists of an introduction, 4 chapters, conclusions, practical recommendations. The volume of the dissertation is 120 pages.
The article provides an analysis of patients in terms of the frequency, causes and epidemiological features of eye injuries caused by animals in childhood for 2010 to 2021 according to the data of the clinic of the Tashkent Pediatric Medical Institute. Up to 50% of all accidents occur before the age of 15. The data presented in the analysis showed that boys aged 5–7 years are most susceptible to injury to the eye and its appendages at home during contact with pets. The high level of injuries and complications resulting from them requires an intensive study of this issue with the development and implementation of effective preventive measures.
In recent years, doctors of ultrasonic diagnostics and cancers began to pay attention to
the possibility to obtain information about the status of the cervix, especially with the aim
of assessing the prevalence of tumor process, which is especially important in planning
treatment. However, the information to date is fragmented and based on a small number
of publications. However, to date not clearly developed sonographic criteria for cervical
cancer, given the clinical course of the disease and possibilities of modern digital (digital)
ultrasonic equipment, transvaginally, color echocardiography to better identify cervical
pathology, which will improve timely, differential, and clarifying the diagnosis of cervical
cancer.
To study the characteristic features of local and systemic immunity in patients with acute purulent odontogenic ostitis of the jaw. Material and methods: The data obtained during the examination and treatment of 42 patients aged from 7 to 9 years with acute purulent odontogenic ostitis who applied to the TGSI clinic were analyzed.Results: Bacteriological study of wound discharge in patients with acute purulent odontogenic ostitis showed that staphylococcus form the basis of microflora in species ratio. These microorganisms accounted for 82% of the total number of isolated strains. Conclusions: in acute purulent odontogenic ostitis, the ability of periodontal cells to recover is not observed, but rather the development of irreversible processes occurs, which requires surgical intervention and appropriate pharmacological correction.
On the basis of the eye department of the TashPMI clinic, a retrospective study of the case
histories of 42 (84 eyes) patients with congenital cataracts was carried out. The age of the patients
ranged from 1 month to 13 years. All patients underwent a comprehensive clinical, ophthalmological, laboratory and instrumental examination and consultations of related specialists. The reasons for the late surgical treatment of children with congenital cataracts are: late diagnosis associated with clinical
forms of cataracts that are difficult to detect during external examination, the presence of concomitant somatic pathology, which is a contraindication to surgical treatment.
The lack of understanding of bilateral breast cancer is a much more complex problem for oncologists. Today the incidence of unilateral as well as bilateral breast cancer is much higher than 10 years ago, which makes this problem even more urgent. Information about the causes of bilateral breast cancer, important criteria for the development of the disease, early diagnosis of the disease and early detection of the possibility of bilateral metachronous cancer, as well as preventive measures are not fully covered in the literature, scientific studies. In this article, the authors analyze the data of the recommendations of the international scientific society and the results of large clinical trials on bilateral breast cancer. Also, important criteria in the development of metachronous and synchronous breast cancer were analyzed, the results of clinical and morphological, immunohistochemical aspects were studied. The reasons for the development and modern knowledge about the diagnosis of bilateral breast cancer have been studied. In particular, the authors reviewed and studied about 40 foreign and domestic scientific works devoted to this problem.
AIM: To analyze clinicofunctional and echobiometric indicators of the eyes in children with target refraction, pseudofacial myopia, and their mothers.
MATERIAL AND METHODS: In the eye department of the clinic of the Tashkent Pediatric Medical Institute, a correlation analysis of optical and echobiometric indicators was conducted in 30 children (30 eyes) with artifakia and their mothers (60 eyes). Visiometry, keratorefractometry, and ultrasound examination (A/В scan of the eyeball) were conducted. Children were examined 12-14 months after CC extraction with intraocular lens (I0L) implantation.
RESULTS: A strong direct correlation was determined between the optical power of lOLs in children and their mothers who were theoretically planned for I0L implantation of lOLs in the group that has achieved target refraction. This may indicate the possibility that the child has the same optical power as the mother and the optical power of lOLs in a child is the same as that in adults. No correlation was found between the optical power of the I0L in the eyes of children with pseudophakic myopia and maternal artificial lenses theoretically planned for implantation.
CONCLUSION: The direct strong correlations between the optical power of the I0L of children and the lenses of their mothers in the group with the target refraction achieved by this age make it possible to use the optical power of maternal lenses as a “guideline" when calculating the power of the I0L implanted in children to achieve the target refraction. The lack of correlation between the refractive powers of the I0L in children with pseudophakic myopia and the lenses of mothers may indicate that the SRKII formula with age-related hypocorrection is not adapted to calculate the I0L power in children at risk of excessive refractive enhancement after surgery.
To study the anti-inflammatory and some other pharmaco- logical properties, toxicity of the new thiocarbamate and thiourea derivatives (codes UB-421 and BIK-15, respectively), selected after the scrinning reseaches among the compounds of this group and to ground the possibility of their using in clinic
Caesarean section (CS) is an operative method of delivery that is widely used at the moment. According to the Ministry of Health for 2022, we registered 932.2 thousand births, which is the highest figure since independence. The total fertility rate (number of births per 1,000 inhabitants) was 26.2 – in 2022, which falls into the category of countries with a “moderately high” fertility rate. The frequency of surgical births in Uzbekistan is about 23% of all births. The purpose of the study was determined the role of the level of type XXVI collagen in the blood and its influence on the viability of the surgical scar, to improve the tactics of managing women after cesarean section. 103 pregnant women and the outcomes of their births were studied. Research and scientific work were carried out for 2020-2022. on the basis of the obstetric department of the multidisciplinary clinic of SamSMU. The average concentration of type XXVI collagen in the main group during pregnancy was 328.22±17.5 ng/ml, and after childbirth - 363.1±48.4 ng/ml, while in the comparison group there was a two-fold decrease. This shows its specificity to the organs of the reproductive system, as well as its role in assessing their condition, including the condition after a surgical scar.