A clinical case of familial congenital cataract in two patients is presented. born from consanguineous marriage. The studies were carried out in the department of ophthalmology clinics of the Tashkent Pediatric Medical Institute. Patients underwent standard laboratory and instrumental studies, as well as ophthalmological examination , including visometry , biomicroscopy , ophthalmoscopy . The a clinical case indicates the risk of having children from a closely related marriage with congenital cataract, optic nerve hypoplasia, which can further lead to visual impairment.
Атипичный гемолитико-уремический синдром (аГУС) – ультраредкое генетически детерминированное заболевание, обусловленное неконтролируемой активацией альтернативного пути комплемента. Органом мишенью при аГУС являются почки из-за высокой чувствительности к активации и дисрегуляции комплемента за счет фенестрированной архитектуры эндотелия клубочков, отсутствия поверхностно связанных регуляторов комплемента в гломерулярной базальной мембране и высокой зависимости эндотелиальных клеток клубочков от фактора роста эндотелия сосудов. В 20% случаев у пациентов с аГУС могут диагностироваться внепочечные симптомы, которые могут быть как проявлениями, так и осложнениями заболевания.
Acute inflammatory polyradiculoneuropathy (Guillain-Barre syndrome) is a severe autoimmune disorder that affects the peripheral nervous system. A clinical case with acute inflammatory polyradiculoneuropathy in a 13-year-old girl is presented. The issue of the relationship between GBS and K19 is debatable (there was contact with sick parents, there was no clinic and diagnosis of the disease (PCR) in the child, although the child had an acute respiratory infection, possibly K19, erased or mild form).
Проведение клиническогоисследования полости рта у детей с сахарным диабетом 1типа для повышения
эффективности ранней его диагностики по стоматологическому статусу
A clinical case of EYE MANIFESTATIONS of complications is presented in a teenager who has had COVID-19. The studies were carried out in the intensive care unit and intensive care unit (ICU) of the clinic of the Tashkent Pediatric Medical institute. The patient underwent standard laboratory and instrumental studies, as well as an ophthalmological examination, including visometry, biomicroscopy, ophthalmoscopy. This clinical case showed that COVID-19 infection was complicated polymorphic ophthalmic symptoms indicating involvement in the process lacrimal gland, mucous membranes of the eyeball and eyelids, cornea of the lacrimal sac, retrobulbar tissue, while from the side of the eyes these complications are expressed in dry keratoconjunctivitis (Sjögren's syndrome).
The article presents a clinical case of intensive care of a child with the main diagnosis: Bronchiectasis, surgical sepsis (>10 points on the p SOFA scale); with complications: HDN 2 degrees, CSHF 2B degrees, protein-energy deficiency, hypercatabolism-hypermetabolism syndrome, toxic infectious encephalopathy, purulent fibrous endobronchitis; with concomitant Ehlers-Danlos syndrome. Upon admission to the intensive care unit, the child was diagnosed with BDL pulmonary form, bacterial sepsis, respiratory failure of the 2nd degree. The diagnosis was confirmed on the basis of instrumental research methods. Complex intensive therapy was carried out: respiratory and nutritional support, antibacterial and infusion therapy, sanitation bronchoscopy. Due to the defeat of more than 11 segments of the lungs - in carrying out surgical treatment was refused. A good example of the outcome of late diagnosis of bronchiectasis, which led to systemic irreversible processes, is presented.
Остеонекроз челюсти на фоне приема остеотропных материалов - серьезное побочное явление, связанное с высокими кумулятивными дозами таких препаратов как бисфосфонаты или моноклональные антитела. Остеонекроз клинически проявляется в виде обнаженного участка кости, сохраняющегося более 8 недель [1].
In the article is presented the 2-years experience of new medical technology use “Register of epilepsy” - automated information analytical system. Clinical audit experience was performed for 104 patients with epilepsy according to established medical treatment standards. Studying the results of the performed clinical audit in this review may improve the quality of medical care.
Information over is brought about evolutional development of term "premature insufficiency of ovaries"(STUMP). STUMP is a clinical syndrome, uniting the heterogeneous group of diseases, in that ovarian insufficiency can be caused by different reasons, with large probability of presented of the inherited factors. The role of immunological comes into question as one of candidates for development of STUMP. Cited data allow to examine STUMP as a result of violation immunological status
This clinical example shows the progressive nature of the course of a combined eye injury: contusion and thermochemical
burn as a result of the explosion of the “New Year’s firecracker”, which led to the development of cicatricial, degenerative
processes in the tissues of the eyeball and eyelids. After the injury, the patient underwent three stages of emergency (according
to vital indications for the eye) surgical treatment, as a result of which it was possible to preserve the structures of the eyeball
and visual functions. At the same time, the rehabilitation period has not yet been completed. These injuries, unfortunately, are
one of the causes of low vision and blindness in children and require constant monitoring and treatment.
The article presents a clinical case of Meyer-Schwickerath – Grüterichs – Weyers syndrome (oculodentodigital dysplasia syndrome). A feature of this case can be considered the predominance of pathology of the organ of vision and oral cavity. The diagnosis was made in the department, after the received treatment the stabilization of the disease was achieved.