o date, there are many unexplored aspects in the pathogenesis of cognitive impairment (CI) associated with COVID-19. It is as- sumed that many factors are involved in the development or deterioration of CI in patients who have undergone COVID-19. Such factors include the direct impact of viral infection on the nervous system, the systemic inflammatory reaction of the human body to the virus, cerebrovascular ischemia due to endothelial dysfunction or pronounced coagulopathy, ARDS in severe COVID-19, the use of artificial ventilation, drug sedation in ARDS, dysfunction of internal organs.
The absence of statistical correlation suggests that CI develops after COVID-19 as a neurological complication of the disease. A number of studies have reported impaired attention and executive functions, apathy. In this article, the authors paid special attention to the study of cognitive impairment in patients with chronic cerebral ischemia who had a coronavirus infection.
Цереброваскулярная патология является одной из самых частых коморбидных состояний у пациентов с COVID-19, обнаруживаясь приблизительно у 12% инфицированных [4]. Изучение коморбидных заболеваний среди летальных исходов COVID-19 показало, что из 2000 случаев у 228 пациентов имелась хроническая ишемия головного мозга (ХИГМ) [6].
Проводить клинико-неврологическое обследование больных с ХИМ 1-2 стадии, перенесших короновирусную болезнь.
Оценить динамики когнитивных функций на основании клинико-неврологического обследования больных с ХИМ 1-2 стадии, перенесших кароновирусную болезнь.
The article is devoted to the problems of the development of Currently used antiretroviral therapy has made HIV infection a chronic controlled infection and has prolonged life and quality of life. However, any antiretroviral drug has side effects, although not on every patient and not always the same.
To assess the current state of the side effects problem of antiretroviral therapy in HIV - infected patients based on the analysis of literature data.
The following are data on the side effects of various groups of antiretroviral drugs used in the past and now, as well as some of their representatives. Antiretroviral drugs exhibit various side effects, in particular mitochondrial toxicity caused by nucleoside reverse transcriptase inhibitors (NRTIs), causing a wide range of side effects such as lactic acidosis, hepatic steatosis, myopathy, cardiomyopathy, peripheral neuropathy, pancreatitis, and possibly lipodystrophy syndrome. In general, integrase inhibitors are well tolerated and cause minimal drug interactions
The use of older antiretroviral drugs has been associated with a variety of side effects, which include lactic acidosis, hepatic steatosis, allergic reactions, myopathy, cardiomyopathy, peripheral neuropathy, pancreatitis and lipoatrophy.These side effects are less common with newer recommended ARVs. drugs. When treating, it is necessary to consider the likelihood of side effects and the possibility of their prevention.
Определение диагностически информативного комплекса показателей эндогенной интоксикации (ЭИ) у детей с дисметаболической нефропатией.
Trauma, particularly traumatic impairment of vision organ, is one of the most common percentage in the structure of diseases. Analysis of structure of traumatic impairments of vision organ was performed among the population of Fergana valley by the using archive materials of hospitals of Andijan. Fergana and Namangan regions for period 2006- 2009yy. Patients with the gender of Male, age of pre-school and school, active working age are the most sensitive for trauma of eyes. In-time diagnostics, primary medical and special ophtalmological aid are actual in the prevention of complication of traumatic impairments of vision organ