One of the most dangerous diseases that threaten human life is heart disease. One way to analyze heart disease is by doing echocardiography. Echocardiographic test results can indicate whether the patient's heart is normal or not by identifying the area of the heart cavity. Therefore, many studies have emerged to analyze the heart. Therefore, I am motivated to develop a system by inputting four points of view of the heart, namely 2 parasternal views (long axis and short axis) and 2 apical views (two chambers and four chambers) with the aim of this study being able to segment the heart cavity area. This research is part of a large project that aims to analyze the condition of the heart with 4 input points of view of the heart and the project is divided into several sections. For this research, it focuses on the process of echocardiographic image segmentation to obtain images of the heart cavity with 4 input points of view of the heart using the Deep Learning method by using the Convolutional layers.
The aim of the study was to study the clinical and diagnostic significance of natriuretic peptide
(BNP) in heart failure (HF) in children with congenital heart defects.
Methods. The study included 24 children under 3 years of age with HF. All patients had HF
secondary to congenital heart disease and clinical data, echocardiographic parameters were collected. A comparative analysis of the data indicating significant changes in BNP with characteristic changes on the echocardiogram characterizing the signs of heart failure in children was carried out. Study results: analysis of NT-proBNP values and type of heart disease associated with HF. In our
cohort, median NT-proBNP was highest in patients with cyanotic heart disease (248.0 fmol/ml), followed by patients with dilated cardiomyopathy (193.3 fmol/ml). The lowest median value of NT-proBNP was recorded in patients with acyano- tic heart disease.
Conclusion. In patients with HF, BNP and echocardiography can provide diagnostic and
prognostic information. The highest BNP values were reported in patients with lower LVEF, but were not statistically significant. The combination of all these data may offer the best tools for optimizing the treatment of heart failure in children.
Врожденные пороки сердца по частоте встречаемости в РБ занимают 2-е место после врожденных пороков ЦНС. Тетрада Фалло составляет 7% от всех врожденных пороков сердца в нашей стране (данные за 2012 год)
The congenital pathology of heart and the main vessels is the actual problem demanding supervision and treatment since a birth of the child and throughout the subsequent life. Carrying out of timely diagnostics and the subsequent dispensaire supervision of the pediatrist, the cardiologist with regular inspection is necessary. Appointment of treatment taking into account a kind of defect and degree of warm insufficiency, presence of an accompanying pathology promote improvement of a condition of the child, adaptation and immunity increase, improve quality of a life and possibility of carrying out of operative correction of defect.
It is shown the results of the investigation on the new methods of noninvasing diagnosing of Ischemic Heart disease in this paper. This method is based on analyzes of expirating air. The results of investigation showed the possibility of the surface ionizating detector in diagnosis of Ischemic Heart disease. It was revealed the statisticly importance of difference in containing the amines in expirating air of patients ill w ith Ischemic Heart disease and healthy people. The advantage of this method concludes whole harmless, expressive ness and canceling the operative intervention and possibilities of mass testing, and cheap price of observation. The difference in eliminating the amines with expirating air can be stable marker for early diagnosing of the preinfarctive state
This work provides information on the most reliable anamnestic and clinical and instrumental data on cardiac conduction disorders in children. Heart rhythm and conduction disturbances occupy one of the leading places in the structure of cardiovascular pathology in children. Atrioventricular block is a slowdown or cessation of impulses from the atria to the ventricles. Disturbances in the rhythm and conduction of the heart of any degree alter the quality of life. The disease affects the physical condition of the child. To prevent complications, timely diagnosis and treatment is required.
Purpose of the study: to study the effect of the combination of valsartan with sacubitril on myocardial remodeling in patients with coronary heart disease after revascularization. Material and research methods. The study included 320 patients with coronary artery disease who underwent coronary revascularization. On average, the concentration of creatinine was 90.08 ± 1.72 µmol / L. All patients were divided into 2 groups: patients who received valsartan (group B, 160 people), patients who received ARNI - a combination of valsartan and sacubitrile molecules (group C, 160 people). Also, all patients were divided into 2 subgroups depending on the degree of eGFR decrease by the 3rd month of observation: patients with a decrease in eGFR by the 3rd month of observation more than 20% (group 1 - 59 patients) and less than 20% (group 2 - 261 sick). In dynamics, three months later, at the end of the first and second years of follow-up after revascularization, all patients underwent an echocardiographic study (EchoCG). Research results. During the observation process, it was found that against the background of both therapy options, there was a positive dynamics of indicators characterizing myocardial remodeling. he relative dynamics of indicators between the treatment groups was comparable at all stages of observation. In the group of patients with a decrease in eGFR of more than 20% in the first 3 months against the background of standard therapy after revascularization, no significant dynamics of the geometric parameters of the heart was observed at all follow-up periods. In the group of patients who received standard therapy with the addition of sacubitrile, both in group 1 and in group 2, more favorable geometric parameters were achieved, demonstrating a decrease in the severity of pathological remodeling and the formation of CHF. Conclusion. The use of sacubitril in the treatment of patients with coronary artery disease contributes to a more pronounced positive remodeling of the heart chambers - a decrease in the size of the chambers and the LV sphericity index. The effect is more pronounced in patients with a tendency to rapidly develop CKD.
An assessment of the complex treatment and prevention of dental caries, periodontal soft tissue diseases in children with heart defects is given. The expediency of the use of dental therapeutic and preventive measures developed against the background of the treatment of the underlying disease in children with heart defects is substantiated.
Современные данные об исходах и структуре сердечных поражений у детей, имевших в катамнезе врожденные пороки сердца (ВПС), в литературе представлено мало.
Физикальные методы обследования органов дыхательной системы у детей с острыми пневмониями при сложных врожденных пороках (ВПС) сердца до сих пор актуальны, так как являются информативными при постановки клинического диагноза.
Abstract. In ischemic heart disease (CHD), progressive disorders of the hemostasis system are corrected with shorter and longer antiplatelet therapy. However, recent studies have consistently demonstrated the development of up to 25% of all possible side effects and complications of anticoagulant and antiplatelet therapy.
Purpose of the study: to study the effect and complication of anticoagulant therapy on the state of the gastroduodenal zone in patients with ischemic heart disease.
Material and methods: 146 patients with ischemic heart disease (CHD), were examined, among them there were 12 (8.22%) patients with acute myocardial infarction (MI), 68 (46.57%) with progressive intense angina pectoris (PNS), intense angina pectoris (NS , functional class III-IV) - 66 (45.20%) people. The average age of the patients was 56.3 ± 2.4 years.
Results and its discussion: in the present study, the “ulcerative” history was assessed and whether there was a complication (bleeding, penetration or perforation). Detailing the data of the anamnesis made it possible to establish that the "ulcerative" anamnesis was detected only in 22.60% of cases. In other cases, as the duration of the course of the disease increases and, accordingly, the duration of the use of antiplatelet agents and anticoagulants, there is a directly proportional relationship to the increase in the frequency of gastropathy.
Purpose of the study: to study the effect of the combination of valsartan and sacubitril on the indices of central hemodynamics in patients with coronary heart disease (CHD) within 2 years after revascularization. Material and research methods. The study included 320 patients with coronary artery disease who underwent coronary revascularization. All patients were divided into 2 groups: patients who received valsartan (group B, 160 people), patients who received ARNI - a combination of valsartan and sacubitrile molecules (group C, 160 people). At baseline and in dynamics after three months, at the end of the first and second years of follow-up after revascularization in patients with coronary artery disease systolic the blood pressure (SBP, mm Hg), diastolic blood pressure (DBP, mm Hg), heart rate in minute, the concentration of brain natriuretic peptide (BNP) in the blood were determined. Also, during echocardiography, the stroke volume of the heart, indexed to the body surface area (SI, ml / m2), the minute index (MI, ml / m2), the mean pressure in the pulmonary artery (PA, mm Hg) were determined. Research results. In the group of patients taking valsartan (group B), the relative dynamics of BNP concentration was -10.69 ± 0.55% by the 3rd month of observation, -21.24 ± 1.03% by the end of the 1st year, and -34, 39 ± 1.64% by the end of the 2nd year of observation. The inclusion of sacubitril in the therapy scheme contributed to a greater positive effect in reducing the BNP concentration: the relative dynamics of the BNP concentration was -10.30 ± 0.52% by the 3rd month of observation, - 21.91 ± 1.00% by the end of the first year of observation, and -39.28 ± 1.67% (p <0.05 significant difference with group B). By the end of the 1st and 2nd years of observation, the use of a combination of valsartan and sacubitril contributed to a more pronounced decrease in blood pressure (p <0.01), a more pronounced dynamics of MI (p <0.05) and a decrease in pressure in РA (significantly lower baseline indicators, p <0.05 and indicator in group B, p <0.01). Conclusion. The present study revealed a positive effect of revascularization and subsequent therapy of coronary artery disease with the inclusion of sacubitrile on the BNP concentration, blood pressure and mean pressure of pulmonary artery.