The article analyzes the essence of human rights and freedoms. Relations between people are regulated by social norms of conduct. In the system of social relations, norms of morality and law are considered the basic norms of regulation. Human rights exist in both moral and legal norms. The author of the article believes that human rights and freedom are a system of philosophical concept of the worldvision of a man's essence. At the same time it is possible to recognize that human rights is the system consisting of principles of politeness and morality and norms of law, socially regulating relations between people.
Subject of research: English and Uzbek compound words characterising appearance and character of the person in the belles-lettres texts.
Purpose of work: studying and revealing linguoculturological and gender features of compound words characterising appearance and character of the person in the literary text of the English and Uzbek languages.
Methods of research: a method of the componcntial analysis, contextual method, statistical method and method of linguocultural analysis.
The results obtained and their novelty: 1) the complex analysis of compound words expressing appearance and character of the person; has been attempted to analyse; 2) linguoculturological and gender essence of compound words characterising appearance and character of the person have been revealed; 3) a national-cultural specificity of compound words characterising appearance and character of the person has been considered; 4) compound words has been considered linguoculturcma; 5) the role of stylistic devices and metaphoric nominations of considered compound words in the research have been studied.
Practical value: results can be used in lecture courses on Lexicology, Stylistics, Comparative Typology, Linguoculturological Studies, in writing research works, text books and manuals.
Degree of embed: results of the research have been applied in the course of teaching of the following disciplines: Comparative Stylistics, Text Interpretation, Lexicology, Comparative Typology in the Uzbek State University of World Languages.
Field of application: General Linguistics, Stylistics, Comparative Linguistics, Cognitive Linguistics, Linguoculturology, Text Interpretation, Gcndcrlogy.
Topicality and demand of the subject of dissertation. Researches of human population genomic variety and scenarios of its genetic pool formation arc one of perspective directions of modem genetics. Prompt progress in this field has allowed defining the basic routes of continents settlement. However the information about Central Asian (CA) populations even on «classical» genetic markers has accidental, fragmentary character, and requires additional large-scale investigations. Besides, according to historical, archeological, paleontological and some anthropogenetic studies, given region was playing certain role in ancient moving of modem human ancestors throughout Eurasian continent. Therefore it is extremely important to summarize and perform complex assessment of new and collected data on Central Asian populations as practically there arc no multivariate analyses studies of given region as a complex population system.
In studies of human population genetic structure arc usually used various approaches allowing understanding concept of populations subdivision and character of genetic relationships between them. Among these techniques the prominent place belongs to approaches based on an assessment of genetic distances between populations with their subsequent analysis by multivariate statistics methods. For even more compelling picture of the relationships between the populations on tree diagram we composed «the genetic landscape» of area, where the description of population genetic structure is presented by equally spaced figures consistently consolidating populations according to their genetic distances from each other and thus creating a genetic landscape. This approach is not only a tool for elementary population boundary detection, but also can be effectively used for identification of borders and sizes of population as naturalistic unit.
Multigcnctic landscape is a collection of different genetic systems which arc specific to the region and ethnic groups, which have their geographical areas, their geographical, historical and cultural boundaries. Gene flows arc run through these conventional boundaries, but they arc less intense than in the limits of area. These limits arc ambiguous and fluid, but it is real. You can identify them by studying, for example, the structure of marriage migration. Therefore anthropogenesis of different populations will inevitably differ from each other. Ethnogenetic composition tends to change over time, from generation to generation, and hence there is a need to understand the structure of the genepool, not only at a given time, but also in the study of genetic processes that form and reform the gcncpooL In this regard, the studying of multigcnctic landscapes is in close contact with the demographics, medical and genetic ecology, anthropology, ethnology, archeology and history of the peoples, that is, with a range of areas, not only natural, but also the humanities knowleges.
Study of genomic diversity is important not only to address questions of origin and genetic history of different ethnic groups, but is also the basis for molecular epidemiology of hereditary and multifactor diseases. Each region is characterized by a specific set of common genetically determined diseases. To understand the causes of the prevalence of disease in different regions, and to develop approaches to their early DNA diagnosis and effective prevention, initially it is necessary to conduct population-based studies, which determine the development of the disease.
Purpose of research is to implement a comprehensive description of the structure of indigenous Central Asian populations genetic pool, examine demographic, phylogenetic and evolutionary features of Central Asian populations through the analysis of genetic variety of mtDNA, Y-chromosomal (NRY), autosomal, X-chromosomal microsatcllites and immunogcnetic variants of Helicobacter pylori (H.pylori) and hepatitis В virus (HB V).
To achieve this goal the following tasks of research is solved:
specification of immunogcnetic variants of H.pylori and HBV, allocated at the patients in Central Asian region, with the subsequent comparative phylogenetic analysis of H.pylori and HBV regional versions with those in other regions of the world;
examination of genetic variety and degree of genetic differentiation of Central Asian populations according to classical population-genetic objects -polymorphisms of mtDNA, Y-chromosomal, autosomal and X- chromosomal STRs;
assessment of the Western and East-Eurasian lines of population inheritance contribution to Central Asian populations’ genetic pool at regional, ethnic, sub-cthnic levels and in a level of elementary populations;
reviewing of character of regional populations relationships by genetic variety of mtDNA, autosomal, X-chromosomal, Y-chromosomal STRs markers in view of ethnographic, social and linguistic data;
evaluation of sex-specific genetic structure and the social organization according to polymorphisms of mtDNA, autosomal, X-chromosomal, Y-chromosomal markers in the region;
determination of ancient ways of migrations and scripts of formation of Central Asian populations according to mtDNA, autosomal, X-chromosomal, Y-chromosomal STRs markers and immunogcnetic variants of H.pylori and HBV',
evaluation of ethnogenetic position of studied Central Asian populations in the system of genetic pools of Eurasia and the world in general through comparative analysis of all studied population-genetic parameters.
Scientific novelty of dissertational research consists in the following:
for the first time was performed a study of genetic pool structure of 26 Central Asian populations from 6 ethnic groups as complete population systems using a wide range of genetic objects;
for the first time was made an assessment of informativeness of each type of genetic subjects. For the first time was received detailed characteristic of genetic pool structure of indigenous Central Asian population on the basis of variability lines of the spectrum of genetical objects;
for the first time was defined the ratio of Westem-and the East-Eurasian lines in a genepool of Central Asian population and were made an assessments of genetic variety level and genetic differentiation degree of regional populations as a whole;
for the first time phylogenetic analysis of major haplogroups of investigated genetic subjects was conducted;
for the first time the position of Central Asian population in population genetic pool system of surrounding regions and Eurasia in the whole was studied;
for the first time the evolutionary-adaptable mechanisms, necessary in the forecast of formations of multigenic pathologies in region were studied at 6 ethnoses of Central Asian.
CONCLUSION
1. H.pylori from Central Asian territory is similar to Western Europe isolates, and shaped by two ancestral populations genotype Ancestral Europe 1 (dominant) and Ancestral Europe2 and for AE1-genotype Central Asian region probably is the source. H.pylori from the territory of Central Asia form a separate cluster group: close relationship of Tadjik, Uzbek strains and Iranian isolates from the north of Iran is established. Kirghiz isolates were found to be closer to populations from territory of Siberia.
2. High diversity of HBV genotypes in Central Asia was found -4 genotypes (A, C, D, and G). Phylogenetic analysis of Central Asian genotype HBV-with options for other regions of the world showed a close relationship between the dominant genotype D (0,78), the D1-subtype with variants of the virus in Europe, the Middle East and Africa.
3. The rates of genetic affinity for STR-NRY in Kazakhs, Turkmens, Karakalpaks Turtkul at the level of the same lineage were high: 0,58 (p<0,001); 0,34 (p<0,01) and 0,77 (p<0,001), respectively. The coefficients of relationship at the level of clan for Kazakhs, Turkmens, Uzbeks and Karakalpaks from Kungrad and Turtkul were lower: 0,30 (r<0,01); 0,21 (p<0,001) and 0,40 (r<0,001); 0,07 (p<0,05) and 0,09 (p<0,05), respectively. At the level of the tribe, the indicators were negative for all Turkic populations: -0,02 (r<0,05);-0,04 (r<0,001);-0,07 (p<0,01); -0,0011 (r<0,1) and -0,10 (r<0,01), respectively.
4. The analysis of mtDNA HVS-1 showed that total rate of differentiation level for all populations was low: FST=0,013; p<0,0001. Level of diversity between groups was 0,6% (p<0,001) of the total variability. Parameter of genetic differences between Turkic and Indo-Iranian populations made 0,55% (p<0,0283) of the total genetic variability. The rate of genetic differentiation on a sub-ethnic level was significantly expressed in Indo-Iranian group (FST=0,0197;r<0,001) than among the Turkic-speaking (0,3%; p=0,10). In all populations, in general, wasn‟t detected the correlation between genetic and geographic distances at the global level on mtDNA HVS-1: r=0,00682; p=0,502.
5. Analysis of STR-NRY showed that the level of the genetic differentiation between ethnic groups was 5,6% (p<0,02); general differentiation between populations made RST=0,186 (p<0,001). Combined analysis, taking into account the language and way of life of Turkic and Indo Iranian populations, showed the general differences between the two groups – 9,1% Value of genetic differentiation when comparing the ethnos-ethnos was slightly lower than the level within ethnos: 5,6% among ethnic groups, 18,6%, and 13,7%-between populations within the ethnic group.
6. Analysis of heterozygosity (H) and the average number of pairwise differences (p) of mtDNA, were high in nomadic populations (av.H=0,99; av.p=5,29) and farmer populations (av.H=0,99; av.p=5,32). Heterozygosity (H) on Y- chromosome was lower in nomadic groups than in the agrarian – 0,86 and 0,99,respectively (p<0,01). Nomadic populations exhibit a higher level of population differentiation (RST) in comparison with farmers - 0,19 and 0,06, respectively (p<0,01). Indicators of population growth (r) were lower in nomadic populations compared with farmers - 1,004 and 1,008, respectively (p=0,056).
7. The level of genetic differentiation in all ethnic groups was higher on the Y chromosome in comparison with mtDNA. The farming populations showed no significant difference in the genetic differentiation FST (Y)=0,069 and FST (mtDNA)=0,034, while among patrilineal nomadic population the level of genetic diversity was higher in the male line of inheritance - FST(Y)=0,177 and FST (mtDNA)=0,010. Genetic diversity of population structure in patrilineal nomads on autosomal and X-linked markers were: FST (A)=0,008 (0,006-0,010) and FST (X)=0,011 (0,001-0,004) (H0: FST(A)=FST(X); H1: FST(A)>FST(X); p=0,02). In bilinear farmer populations the differences of autosomal and X-chromosomal markers were insignificant: FST (A)=0,014 (0,012-0,016) and FST (X)=0,013 (0,008-0,018 at p=0,36).
8. Analysis of mtDNA indicated that the age of expansion on the territory of Eurasia (τw) declined significantly from East to West (r=0,72; p<0,001). The age of expansion had a pronounced tendency to decrease from 30 thousand years in China to 17 thousand years in Western Europe. Age of expansion in Central Asia amounted to 26 thousand years. Results of expansion analysis on NRY also show a decrease in genetic diversity from the East to the West of Eurasia (r=0,49; p<0,001). In Central Asia this age was 16 thousand yrs. According STRs-NRYBatwing analysis of the minimal age of Uzbek population origin was 1232,71 yrs old (Ne=14088 (6765-23942); α=0,0108 (0,0065-0,0155)).
9. The apportionment of multilocus genetic variations among ethnic and linguistic groups of Central Asian populations showed that more than 98% of all variations were within the population (p<0,0001). Evaluation of the ethnic and linguistic affiliations in the observed variations showed reliable conformity - FST=0,007; p<0,0001 and FST=0,011; p<0,0001, respectively. We didn‟t find evidence of geographical isolation within each of the Turkic and Indo Iranian groups of populations (p=0,363 and p=0,772, respectively).
10. Analysis of multilocus allelic diversity (AR) and heterozygosity (He) showed differences among the Central Asian and other populations in allelic variety (χ2 =105,29; d.f.=25; p<0,0001) and heterozygosity (χ2=67,98; d.f.=25; p<0,0001). Population differentiation at multilocus analysis at populations of Central Asia is more pronounced than in the other regions of Eurasia: in European and Middle Eastern groups pairwise estimation of FST ranged from 0,011 to 0,015 and -0,008-0,021, respectively; in East-Asian groups from -0,011 to 0,046; and finally, in Central Asia these rates ranged from -0,004 to 0,056. Heterozygosity was significantly higher in the group of the Indo-Iranian populations than among Turkic-speaking (He=0,818 and He=0,787, respectively; Z=-4, 55; p<0,0001). According to multilocus analysis all 26 Central Asian populations slightly but significantly differed (FST=0,015; CI99%=0,011-0,018; p<0,01).
Bizga ma’lumki, biz ko‘rib chiqqan sud tibbiyotiga oid barcha mahalliy va xorijiy adabiyotlarda inson so‘lagi tarkibi, uning tarkibidagi (oqsil va fermentlar jinoiy ishlarni ochishdagi voqea joyida qoldirgan va dalil sifatidagi sudga oid tasdiqlavchi asosiy ko‘rsatma ekanligi, shu jihatidan so‘lak va uning dog‘larini, tarkibiy qismlarini o‘rganish sud tibbiyotida, inson hayotiga suiqasd qilish, nomusga tajovus qilish va boshqa bir qancha jinoyatlarda shaxsni aniq identifikatsiyalash zarurligini taqoza etadi. Inson aralash so‘lagining solishtirma og`irligi 1002-1007 ga teng bo‘lib, u yopishqoq suyuqlikdir. Uning tarkibida hujayra elementlari bo‘lganligi tufayli, u xira-oqish ko‘rinishga ega. Aralash so‘lak oqsillari hazm qiluvchi, himoyalovchi, ajratuvchi, bufer va boshqa bir qator vazifalarni bajaradi. Aralash so`lakda 100 dan ortiq fermentlar mavjud. Bu fermentlardan- amilazaga sud tibbiyotida alohida ahamiyat beriladi
Fiction as a type of arts possesses with its distinguishing features. The palette of the descriptive-expressive resources include the depiction processes of the nature. The author, referring to the nature, deals with the various forms of its presence in the literary work through the mythological presentation of its power and influence on the human-being, its poetic embodiment, description of animals, which have the human-beings related features, plants, as well as the landscape descriptions in the process of depicting of the local neighborhoods. At its early stages, the folklore of the Korean people possessed with the mythological power of nature, including poor landscape descriptions, which were personalized and actively lived in the lives of human-beings. The description of nature become more acceptable, losing that “beaty”, which was seen as main composition principle of description of the nature such as hyperbolizm. So, it is clearly seen a tendency to the individualization of the tractate about the nature, which influences on the heroes in their trials to comprehend properly the surrounding world, and define their own places in the natural circle. The Korean literature transfers the nature through the traditional images, such as the mountain, the pine tree, moon, and through the depiction of the seasons of the year and the time of the days. The pine tree and mountain are seen as the natural phenomenon, which feel the loneliness. These phenomenon are the subjects of the environment, which create the whole unity with the surrounding world of the human-beings. Such unclearness of the lines between the human-being and nature are the harmonious unity of a human-being and a world. Usually the depiction of the mountain, water, moon and etc. where the action takes its place. Due to the Dao’s visions it prevails the benevolent peacefulness, averting from nature from the routine life, in order to get the harmony with the nature. In the whole it is to acknowledge that the Korean prose of XVII – XVIII centuries, the authors come to the depiction of nature, without the deep details of descriptions. Factually, the nature did not play that role, which was related with the revealing process of the emotional world of story-telling. Here, it is being transferred as the “calling” phrases, it generally demonstrates the emotional background of the literary work. So, the gist based features of the Korean prose of XVII – XVIII centuries very clearly proves about the cosmologic idea of relation to the nature, including a special vision of nature and laws.
This scientific article describes the great benefit of human health in the construction of a new Uzbekistan, increasing the medical literacy of the population to preserve it, raising medical education to the level of modern requirements, in depth study of national medical values passing from ancestors to generations, and using them as a criterion of morality, as well as making sufficient investments in human continuity, interesting points were also made about the introduction of sufficient investments in ensuring the continuity of human health, scientific and practical issues of “Smart Medicine” and “Digital Medicine”
A clinical and immunological examination of 21 school children from 7 to 14 years old with dilated
cardiomyopathy (DCMP) was carried out. As a control, 20 practically healthy children of comparable age were examined. Significant changes in the studied parameters of the immune system were found in children with DCMP. A significant increase in the concentration of pro inflammatory (TNF-α and IL-18 increased by 4.2 and 3.0 times) cytokines was revealed. The number of expressing apoptosis antigen - CD95 + cells in peripheral blood rises 2.0 times.
Ўзбекистон Республикаси мустақилликга эришганидан сўнг инсон ва фуқаронинг ҳуқуқ ва эркинликларини ҳамда қонуний манфаатларини ҳимоя қилишга катта аҳамият берди. 1991 йилнинг 30 сентябрида Ўзбекистон Инсон ҳуқуқлари умумжаҳон декларациясига аъзо бўлди.
In this article It’s analyzed international and national legal documents related to personal human rights and freedom. The author shows the main international documents and their norms, and also points to their implementation in the national legislation. In the conclusion the author comes to a conclusion that it is necessary further development of the national legislation in the sphere of human rights.
The age is common risk factor for cardiovascular diseases (CVD). One of the main risk factors for ageing is biologic age of vessels or vessel ageing. Main mechanisms of vessel ageing are oxidative stress, chronic inflammation, endothelial disfunction, apoptosis of endothelial cells, demage of endothelial EPCs progenitory cells functions, replication ageing of endothelial cells, disregulation of circadian system, arterial stiffness. Understanding of the mechanisms that lead to ageing pathophyziological changes in vessels is important and necessary of for novel methods of patogenetic treatment