Subject of the inquiry: 97 patients with ankylosing spondylitis, 20 healthy volunteers.
Aim of the inquiry: to assess metabolic activity of erythrocytes and peculiarities of fcrrokinctics in using Fhlogcnzymc in the complex therapy of patients with AS. Methods of research: functional-metabolic process erythrocytes and ferrokinctics (scrum iron, ferritin, saturation of transferrin with iron) lipid peroxidation and antioxidant system.
The results achieved and their novelty: For the first time purposeful complex study was conducted of metabolic process parameters in erythrocytes and fcrrokinctics, lipid peroxidation and antioxidant system processes, Willebrand factor, atherogenicity in relation to the clinical course of the disease. Functional-metabolic disorders in erythrocytes in fcrrokinctics determined systemic changes in blood, with their extent associating with severity of the clinical course of AS. For the first time it was found that the use of Fhlogcnzymc in the complex treatment improved clinical course of the disease. The shortening of clinical recovery period was associated with normalization of parameters characterizing functional metabolic activity in crythrocytea and ferrokinctics. Systemic enzyme therapy was proved to increase the effect of conventional therapy by a directed improvement of functional metabolic processes in erythrocytes, energetic activity and ferrokinctics which allowed inclusion of systemic enzyme therapy preparations for hemic hypoxia in patients with AS.
Practical value: Use of Fhlogcnzymc in the complex treatment of AS increased the efficacy of therapy, decreased the rate of drug side-effects, allowed us to decrease the doses of basic preparations and non-stcroid anti-inflammatory. Changes of laboratory parameters in Fhlogcnzymc using included more significant decrease of acute phase indices, increase of hemoglobin and erythrocyte concentration in the peripheral blood.
Degree of inculcate and economic efficiency: conclusions and practical recommendations were introduced into the practice of departments of rheumatology, nephrology of the third clinic of the Tashkent Medical Academy and into teaching process of departments of faculty and hospital therapy, folk medicine, internal diseases of the stomatological faculty and clinical pharmacology of the Tashkent Medical Academy.
Sphere of usage: rheumatology, therapy.
The search for new sources of highiy active drugs based on iocai raw materials is an urgent task of modern science, it is known that iicorice root is widely used in various sectors of the economy, the main component of it is glycyrrhizic acid. The presence of anti-inflammatory activity, iow toxicity and iack serious side effects make new synthetic derivative of glycyrrhizic acid promising for medicine compounds.
The purpose of the study. To study the antiulcer activity glycerinate on an experimental model of neurogenic uicers caused by 24-hour immobilization of animals and to identity the mechanism of antiulcer activity.
COVID-19 - это инфекционное заболевание, вызываемое коронавирусом SARS-CoV-2, являющийся респираторным патогеном. ВОЗ впервые узнала об этом новом вирусе 31 декабря 2019 года из случаев заражения в Ухане, Китайская Народная Республика (ВОЗ). По данным литературы, витамины С, Д, цинк и другие микро- и макроэлементы оказывают существенное влияние на работу иммунной системы. В частности, известно, что витамин Д стимулирует активность макрофагов, индуцирует дифференциацию [созревание] иммунных клеток, повышает пролиферацию моноцитов, увеличивает активность Т регуляторных клеток, которые регулируют силу и продолжительность иммунного ответа, снижает выработку провоспалительных цитокинов, увеличивает синтез антимикробных пептидов. Огромное количество доказательств in vitro и ex vivo свидетельствует об активации рецептора к витамину D на моноцитах, макрофагах, дендритных клетках и лимфоцитах, что важно для контроля как врожденного, так и приобретенного иммунитета.
The influence of dannonal on the functional condition of liver has been studied in toxic hepatitis. It was determined that dannonal increased content of protiens and improved detoxication function of liver by decreasing activity of cytolitic enzymes ALT and AST, decreasing cholestatic markers - APh and GGT. Dannonal showing hepatoprotective action improves function of liver and do not resign to other hepatoprotector - LIV-52.
Increasing the motivation for cognitive activity in the learning process is also necessary in particular because it explains the intensity of the chosen professional activity, the activity in achieving the result and the goal of the activity, which is called to help people.