Viral hepatitis C (HCV) is one of the most important problems of modern medicine. According to WHO statistics, there are between 500 and 700 million HCV carriers worldwide. The aim of the study was to study the clinical and immunological features of the course of chronic viral hepatitis C, depending on the genotype of the virus, and to assess the diagnostic and prognostic value of immunological disorders. The clinical and laboratory features of the course of chronic viral hepatitis C depending on the genotype of the virus, the immunological features of the course of chronic viral hepatitis C depending on the genotype of the virus were studied, the diagnostic and prognostic value of immunological indicators as objective criteria for assessing the severity of the disease and the prognosis of the disease was determined. We examined 83 patients with chronic viral hepatitis, 35-50 years old with chronic viral hepatitis C, and 20 practically healthy individuals of the same age and gender.
Purpose of the study: to study the effect of the combination of valsartan and sacubitril on the indices of central hemodynamics in patients with coronary heart disease (CHD) within 2 years after revascularization. Material and research methods. The study included 320 patients with coronary artery disease who underwent coronary revascularization. All patients were divided into 2 groups: patients who received valsartan (group B, 160 people), patients who received ARNI - a combination of valsartan and sacubitrile molecules (group C, 160 people). At baseline and in dynamics after three months, at the end of the first and second years of follow-up after revascularization in patients with coronary artery disease systolic the blood pressure (SBP, mm Hg), diastolic blood pressure (DBP, mm Hg), heart rate in minute, the concentration of brain natriuretic peptide (BNP) in the blood were determined. Also, during echocardiography, the stroke volume of the heart, indexed to the body surface area (SI, ml / m2), the minute index (MI, ml / m2), the mean pressure in the pulmonary artery (PA, mm Hg) were determined. Research results. In the group of patients taking valsartan (group B), the relative dynamics of BNP concentration was -10.69 ± 0.55% by the 3rd month of observation, -21.24 ± 1.03% by the end of the 1st year, and -34, 39 ± 1.64% by the end of the 2nd year of observation. The inclusion of sacubitril in the therapy scheme contributed to a greater positive effect in reducing the BNP concentration: the relative dynamics of the BNP concentration was -10.30 ± 0.52% by the 3rd month of observation, - 21.91 ± 1.00% by the end of the first year of observation, and -39.28 ± 1.67% (p <0.05 significant difference with group B). By the end of the 1st and 2nd years of observation, the use of a combination of valsartan and sacubitril contributed to a more pronounced decrease in blood pressure (p <0.01), a more pronounced dynamics of MI (p <0.05) and a decrease in pressure in РA (significantly lower baseline indicators, p <0.05 and indicator in group B, p <0.01). Conclusion. The present study revealed a positive effect of revascularization and subsequent therapy of coronary artery disease with the inclusion of sacubitrile on the BNP concentration, blood pressure and mean pressure of pulmonary artery.
This article analyzes the degree of researches of the scientific heritage of Abu Isa Tirmidhi in Western countries, such as Germany, France, the United Kingdom. And at the same time the article provides information about the reasons for the emergence of interest in the scientific heritage of Abu Isa Tirmidhi and its results based on scientific literatures.
The article notes that although representatives of the social and humanitarian sciences have not yet sufficiently studied the processes of formation and development of diplomacy of the Central Asian states and territories, subordinate to them, as well as the history of the development of the Uzbek diplomacy, a comprehensive study of various periods in the history of the problem and issues of international cooperation mainly began in the years independence. The author on the basis of the problem-chronological method conditionally subdivides the conducted research into several directions.
Явилось изучение функционального состояния жевательных мышц у больных до и после зубного протезирования с опорой на дентальные имплантаты методом электромиографии
The influence of stimusol (extract radix Glycyrrhiza+mumie) on lipid peroxidation processes and synthesis of gall in the liver at chronic toxic hepatitiswere researched. It was determined that stimusol during chronic poisoning with heliotrine made antioxidant and choleretic action. Normalize of gall contains. It didn’t give up to famous, silibor by hepatoprotector action.
The search for new constructions of contracts not described in the legislation is connected with the continuous search for participants of agreements of simplified and mutually beneficial contract terms. This article describes the course of the emergence of unnamed contracts with the analysis of the typology and structure of such agreements. In addition, the article attaches special importance to modern types of non-named contracts. Also, the article analyzes the application of the law analogy to unnamed treaties. The opinions of foreign and domestic scientists on this issue have been studied. It is noted that the study of the issue of correct and legally well-written unnamed contracts is one of the priority branches of civil law not only in Uzbekistan but throughout the world.
Optimal choice of treatment of patients with POAG according to peculiarities of condition of anterior chamber angle. Patients with initial stage of glaucoma may be prescribed monotherapy or combination of antiglaucomatous drugs and make preliminary prognosis.In patients with opened angle with slight pigmentation or without pigmentation and subatrophy of iris root Travatan turned out to be the most efficient treatment choice.In patients with opened angle with evident endo- and exopigmentationDuotrav was most effective antiglaucomatous drug. In patients with rostral profile of angle Fotil Forte combined with Travatan was the most effective choice.In most evident pigmentation of angle laser trabeculoplasty is recommended as additional method of glaucoma treatment.
The article includes data from a literature analysis on aspects of allergopathology in children, which are important for physicians, especially pediatricians, and the study of this problem remains an open question.
This article is devoted to the student's independent work. Independent work is the primary form of self-education. Self-educational activity of a student, especially based on modern teaching technologies, plays a leading role in the development of their cognitive activity, readiness for self-improvement, contributes to the development of creative skills, initiative, the ability to rationally organize their time. The study of this problem will reveal the organization and conduct of independent work and its role in improving the quality of training of doctors.
Инглиз тилини амалий мақсадда эгаллаш нафақат ундан келгусида касбий фаолиятда фойдаланиш, балки талабанинг умумий маданияти, тафаккурини ривожланиб боришига имкон яратади. Бунинг учун олий таълим муассасаларида инглиз тили дарсларини самарадорлигини янада ошириш, дарсларда талабаларни мутахассисликка оид соҳавий манбалардан мунтазам бохабар этиб боришни тақозо этади. Талабалар ихтисосликка оид матнлар билан ишлашни билиши керак, чунки ихтисосликка оид матнларда расмий белгилар, соҳавий атамалар кўпроқ учрайди