the modern approach of antenatal care in pregnant women with rhesus-immunization means a timely diagnosis of the mutability of the rhesus (Rh) of the fetus through the blood of the mother, the detection of the anaemic syndrome and weight level of the fetus, the use of minimally invasive methods (diagnostic, therapeutic), as well as prevention of the development of immunization in pregnant women. The problem of rhesus-sensibilization in developed countries is rare, and only in immigrants.
Objective: to examine and analyze the literature data of foreign and local authors on the relevance, prevalence, use of non-invasive methods of Rh-sensibilization prevention of hemolytic disease of the fetus.
Search strategy: the search for information contained information such as regulatory documents, diagnostic protocols, and the conduct of RH-controversial pregnancy. Also in the databases Google Scholar, the Cochrane Library, PubMed, Library ru full-text scientific articles were used.
Inclusion criteria: randomized, cohort study data, systematic reviews, diagnostic protocols, and Rh-conflict pregnancy.
Exception criteria: practice, report, newspaper publications, articles describing theses.
Results: studies have shown that the prophylactic purpose and administration of anti-D-immunoglobulin, which is used during 28-30 weeks of pregnancy, significantly reduces the development of immunization after childbirth. Conclusion: due to the wide application of anti-D-immunoglobulin in pregnant women and family planning, it will be possible to reduce the frequency of immunization, but the goal will be achieved only if a clear Complex prevention of Rh-immunization is developed, in which the appearance of hemolytic disease of the fetus occurs. Nevertheless, the diagnosis and treatment of hemolytic disease remains an urgent problem and requires the use of new possibilities of modern medicine in the field of genetics, ultrasound diagnostics, invasive and non-invasive methods.
In order to study the significance of molecular genetic methods and endoscopy in the diagnosis of genital tuberculosis, 389 infertile women were examined. Studies have shown that laparoscopy of the endometrium and ovaries is one of the most necessary methods of examining diagnostic patients. Studies of the biopsy of the cervical canal, endometrium, molecular genetic examination of menstrual blood, caseous secretions for the presence of Mycobacterium tuberculosis increases the effectiveness of early diagnosis of reproductive disorders associated with genital tuberculosis.
Delayed diagnosis and treatment of chronic odontogenic sinusitis in patients with Covid-19 disease leads to osteomyelitis of the upper jaw, in addition to one type of clinical course of sinusitis even after surgery. Timely diagnosis and treatment of odontogenic sinusitis during a pandemic is of great importance for the rapid recovery of the general condition of patients, prevention of osteomyelitis of the upper jaw and other complications
The aim of the study was to optimize the treatment of patients with dermatological manifestations in patients who had a coronavirus infection by identifying the features of their clinical course, microelement and immune changes.
The object of the research were 138 patients who underwent a comprehensive examination and treatment in the conditions of the Samarkand
regional dermatovenerologic dispensary from June 2020 to July 2021.
The scientific novelty of the research consists of the following: for the first time, it was revealed that the most common dermatological manifestations of the post-COVID period is the high incidence of hair loss, which manifests itself in the form of the prevalence of baldness foci in the occipital and temporal regions in women and in the parietal and temporal regions in men; dermatological manifestations were also observed in the form of rashes like acrodermatitis, papulo-squamous rashes, urticarial rashes, papulo vesicular rashes and vesicular rashes like herpes. It has been established that a high risk of developing dermatological manifestations in the post-COVID period is observed in males over 40 years old, while there is an immune imbalance and a violation in the microelement status;
for the first time, based on a spectrometric study, a decrease in the level of microelements necessary for the body, such as zinc, selenium and magnesium, as well as an increase in the level of chlorine and bromine, was found in patients with
dermatological manifestations after suffering a coronavirus infection; for the first time, changes in the hematopoietic system were revealed, almost
all patients with dermatological changes who underwent coronavirus infection have anemia, severe leukocytosis and an increase in ESR, although 12 weeks have passed since the coronavirus infection.for the first time, a characterization of the morphological elements of dermatological manifestations after a coronavirus
infection (COVID-19) was given; for the first time, pathological changes in the immune status in patients with dermatological manifestations after a coronavirus infection have been proven, consisting in an increase in the fractions of immunoglobulins G, A, E, IL-1,2,6, TNF-α, a decrease in the level of T-lymphocytes by 22.2% below normal (p>0.05) and an increase in B-lymphocytes by 15%, compared with patients without dermatological manifestations; for the first time, a characteristic of morphological rashes after the coronavirus infection SARS-CoV-2 (COVID-19) was given. Implementation of research results. Based on the results obtained to
improve the diagnosis and treatment of dermatological manifestations after a coronavirus infection: the methodological recommendation “Dermatological manifestations after a coronavirus infection” was developed and approved (conclusion of the Ministry of
Health dated January 19, 2022 No. 8n-r/37). This methodological recommendation has improved the algorithm for diagnosing and treating dermatological manifestations after coronavirus infection; scientific information on improving the diagnosis and treatment of dermatological manifestations after a coronavirus infection has been introduced into practical healthcare, in particular, in the Bukhara and Andijan regional
dermatovenerological dispensaries (certificate of the Ministry of Health dated January 25, 2022 No. 8n-r/35), which made it possible to increase the effectiveness of dermatological manifestations.
The structure and scope of the dissertation. The dissertation consists of an introduction, four chapters of own research, a conclusion, practical
recommendations and a list of cited literature. The volume of the text material is 107 pages.
The question of modern possibilities of complex diagnostics of thyroid nodules is considered. Despite the large number of studies conducted, it is not always possible to correctly establish an accurate morphological diagnosis of thyroid nodules, which indicates the need to improve existing and search for new, more informative diagnostic methods. In this regard, reports on the use of measurements of tissue pressure in the thyroid gland for the differential diagnosis of various pathologies of this organ are very promising.
In the literature review, according to publications of recent years, the state of surgical treatment of obliterating atherosclerosis does not meet the requirements of the time. Currently, all research is aimed at improving the early diagnosis of the disease and their timely treatment by improving the quality and efficiency of surgical intervention.
However, despite a large number of works devoted to diagnosis and prognosis of treatment, there are still many unresolved issues. The accumulated experience indicates the need to standardize the preoperative examination of patients in order to predict the outcome of treatment.
One of the important aspects of this problem is the development of modern tactics and approaches to surgical treatment. Along with them, it is necessary to evaluate the results of treatment, analyze the quality and determine the effectiveness of traditional operations in modern angiosurgery. It should be noted that today there are a considerable number of new methods of treating atherosclerosis obliterans for early and effective diagnosis, prevention and therapy of the disease.
However, some issues are insufficiently studied or contradictory and require further research.
The purpose of the study is to determine the significance of genetic factors in the development of chronic nephritic syndrome in children and to clarify the features of the clinical course
The оbject of research were 129 children aged 4-15 years who were treated for chronic nephritis in the nephrology department of the Samarkand Regional Multidisciplinary Paediatric Medical Centre.
The scientific novelty of the study is as follows:it has been established that the severity of chronic nephritic syndrome in children is associated with clinical manifestations (gradual development, dyspepsia, abdominal pain) and an increase in the amount of Cystatin C in the blood;for the first time, it was revealed that the development of sclerotic lesions due to increased proliferation in patients with the presence of the MMP-9 (A-8202G) rs 11697325 genotypes in chronic nephritic syndrome leads to a worsening of the clinical course of the disease; established early diagnostic marker MMP-9 (A-8202G) rs 11697325 and its tissue inhibitor TIMP-2 (C536T) rs 11551797 in chronic nephritic syndrome in children in the diagnosis of the disease; for the first time, the prognostic value of the alleles of the MMP-9 (A-8202G) rs 11697325 genes and the homozygous G/G genotype in determining the risk of developing the disease in children with chronic nephritic syndrome has been proven.
Implementation of the research results. Based on scientific results of evaluation of the role of polymorphic genes of matrix metalloproteinase and its tissue inhibitors in chronic nephritic syndrome in children: methodological recommendation “The role of polymorphic genes of matrix metalloproteinase and its genetic inhibitors in the development of chronic nephritic syndrome in children” was developed and approved (reference of the Ministry of Health of the Republic of Uzbekistan No. 8n-r / 554 of 30.02.2022).
This methodological recommendation made it possible to predict the development of chronic nephritic syndrome in children and improve preventive measures; approved and developed on the basis of scientific results of research on early diagnosis and prognosis of chronic nephritic syndrome “Dynamics of clinical and laboratory parameters in nephritic syndrome in children”, (reference of the Ministry of Health of the Republic of Uzbekistan No. 8n-r / 555 of 30.02.2022).
This methodological recommendation made it possible to optimize the diagnosis and treatment tactics for various forms of nephritic syndrome in children;
The results obtained were implemented in the practice of health care, in particular, in the Republican Children's National Medical Center, in the 1st clinic of the Samarkand State Medical University, in the Samarkand Regional Children's Multidisciplinary Medical Center (conclusion No. 8 n-r/324 of 21.06.2022 of the Ministry of Health of Uzbekistan).
The application of the obtained results to practice has made it possible to reduce the frequency of recurrence of the disease in children, prevent complications of the disease, improve the quality of life of patients, diagnose and prevent the disease.
The structure and scope of the dissertation. The dissertation consists of an introduction, 4 chapters, conclusions, practical recommendations. The volume of the dissertation is 120 pages.
The materials of rendering aid to 78 patients with fractures of the scaphoid bone in different periods after the injury were analyzed. The patients underwent treatment in the Republican Specialized Scientific and Practical Medical Center of Traumatology and Orthopedics in the department "Hand and foot surgery" 2019-2021. In the process of diagnosis, 14 patients were diagnosed between the years 2019-2021 , with modern methods of clinical examination, early diagnostic weight loss and primary medical treatment, and in suspected cases, CSCT and MRT examinations have clarified the diagnosis.