The purpose of the study was to determine and evaluate the features of morphological changes in the liver parenchyma of 5-month-old white outbred rats under the influence of anti inflammatory drugs under conditions of polypharmacy.
The object of study for experimental studies was taken 250 white male rats weighing 200-250 g.
The scientific novelty of the research is as follows: polypharmacy of anti-inflammatory drugs negatively affects all parameters of liver structures. Under the influence of polypharmacy, there is a decrease in the absolute mass of the liver, volume and morphological parameters of the liver parenchyma. The decrease in morphometric parameters depends on the number of drugs in polypharmacy; under conditions of polypharmacy, the state of the hepatic capillaries and internal bile ducts, as well as biological membranes, was studied, as a result of which the structural structure of the liver, the development of destruction of the hepatic tissue were studied, and the morphofunctional foundations of this condition were shown.
Implementation of the research results. Based on the obtained scientific results, the morphofunctional characteristics of the liver of rats in the norm and under the influence of polypharmacy were determined:
Approved methodological recommendations: "Methodology for determining the morphometric parameters of the liver during polypharmacy of anti-inflammatory drugs" (Conclusion No. 8n-r / 265 dated 14.03.2022 of the Ministry of Health of the Republic of Uzbekistan) and "Methodology for determining the morphometric parameters of the liver during polypharmacy of anti-inflammatory drugs" (Uzbekistan, Conclusion of the Ministry of Health of the Republic of Uzbekistan No. 8 n-z 180 of 2022), electronic program No. DGU 1038 "Program for studying the comparative characteristics of morphological changes caused by polypharmacy in the liver."
The scientific results obtained in the study of morphological and functional properties and morphometric changes in the structure of the liver under the influence of polypharmacy have been introduced into the practice of the Samarkand branch of the Republican Specialized Oncological and Radiological Scientific and Practical Medical Center of the Samarkand City Medical Association (Order of the Ministry of Health of the Republic of Uzbekistan dated March 14, 2022, 8n-r / 265-No. and conclusion No. 8 n-z 180 of 2022). The implementation of the obtained research data allows developing methods for early diagnosis, treatment and prediction of organopathology by morphological parameters, improving the quality of life and reducing the number of complications.
The structure and scope of the dissertation. The structure of the dissertation consists of an introduction, three chapters, a conclusion and a list of references. The volume of the dissertation was 103 pages.
It has now been proven that when peripheral nerves are damaged in the spinal cord, cytokines are produced (interleukin-1, interleukin-6, tumor necrosis factor alpha), which contribute to the persistence of pain. Blocking cytokines reduces pain. With the development of this area of research, new prospects are associated in the development of drugs for the treatment of chronic neuropathic pain. According to V.P. Zueva (1981), in almost 60% of patients with purulent-inflammatory diseases of the maxillofacial region, pathological changes in the immune system are detected. Mild and moderate severity of the purulent process (usually abscesses) cause moderate changes in the immune system. In severe phlegmon, inhibition of immunity occurs, especially pronounced in putrefactive necrotic forms, which necessitates studies of the immunobiological reactivity of the body. Thus, a dynamic assessment of the immune status in patients with purulent-inflammatory diseases of the maxillofacial and the selection of adequate methods of immunocorrection seems to be necessary. In our opinion, the study of the characteristics of changes in the nervous system, psychoemotional sphere and related disorders of neuroendocrine regulation in patients with acute odontogenic periostitis of the jaw will help expand the range of pathogenetically substantiated methods of treatment, increase the effectiveness of therapy and prevention of complications.
Доказано что в подавляющем большинстве случаев патологические процессы в полости рта особенно при вирусных инфекциях, как правило сопровождаются дисбиотическими изменениями в микрофлоре ротовой жидкости, что в свою очередь приводит к нарушению состояния показателя системы иммунитета. Микрофлора полости рта рассматривается как первичная мишень для любого фактора, который прямо или опосредованно влияет на адгезию и колонизационную резистентность резидентной, транзиторной и добавочной микрофлоры. Проблема лечения заболеваний слизистой оболочки полости рта у детей – это одна из актуальных задач практической стоматологии.
The article analyzes the poems written in the traditional form of creativity of Barik Shafei, identifies the problems of their form, content and art, their place in the poet's work and in the literature of this period. The article examines the state of literature in the Dari language at the beginning of the twentieth century, the place of traditional genres in lyric poetry, such as gazelle, rubai and qasida, as well as the changes that took place in poetry in the Dari language at that time. Also, questions of content are clarified first, and then changes in forms. The research is based on theoretical research methods. In the work of Barik Shafei, despite the change in content, there are poems of the traditional form. In the poet's poems, the subject of love of the lyrical hero is mainly socio-political themes. In these poems, the traditional romantic spirit is now shifted towards caring for the Motherland and the life of the people, their fate. There have also been changes in the means of artistic depiction in poetry. In particular, we can see in poems that such pictorial means and techniques as "shham", "shu'la" and "parvona" do not have the same meaning as in traditional poems. Also, according to the rhymed form of the gazelle "Khar kadar" ("No matter how much"), it refers to the type of gazelle in which the first line is repeated in the last line. The content is different from that of traditional poetry. In the gazelle, the poet from time immemorial expounds his complaints. In the poems of Barik Shafei, these images expanded their semantic volume in accordance with the theme and tone. The poet has renewed the word by reinventing it, but we see that the layers of meaning have not completely disappeared, but the meanings are gradually preserved in them.
This article covers the concept of digital economy, technological changes inherent in the digital economy, reforms in the development of this sector in the country, changes in GDP, changes in the field of digitalization in the regions, the author puts forward practical recommendations.
This article studies the evolution of the coronavirus epidemic into a pandemic that has become an unprecedented threat to humanity in the 21st century, its impact on the lifestyle of Chinese society, changes in China’s domestic and foreign policies due to coronavirus infection, and the results of the Chinese government’s effective struggle against the “disaster”. Moreover, the author analyzes the situation in international relations due to COVID -19, changes in international relations under the influence of the pandemic, the transformation of relations between major powers as a result of the coronavirus, a variety of methods for combating COVID -19 in different countries of the region, China’s experience in combating the pandemic and its significance for the world, and the crisis caused by the pandemic in people's lifestyles and in all sectors of the economy. What is more, the assessments and approaches of Chinese experts and specialists in combating the pandemic are examined based on their experience in overcoming the crisis. Finally, it reflects the opinions of Chinese scientists and experts about the huge changes that could happen in the world order after a pandemic.
The present article discusses the formation of models and the practical significance of Arabic verse using 'ariid meters. This article analyzes the peculiar iray Mahmud al-ZamakhsharVs work (1075-1144) Al-Qistas al-MustaUm fi "Ilm al- ‘Ariid analyzes meter for the first time. Phrased as feet, the eight original feet are classified and divided into two groups in the work Al-Qistas. Zamakhshari made branches offeet from each of these origins without dividing the changes of the feet on zihaf and ‘ilia. This occurs as a result of losing one consonant, orjuzv, from the foot structure or the dropping and the adding of a consonant or juzv in the composition of the foot, as well as elision of the unvowelled consonants or dropping the sdkin from the composition of the foot. Each of these changes are classified, and the formation of the feet, the process of branching out of the S original feet formed into a total of 71 feet is clearly described in the period treatise.
In addition, this paper provides a comparative analysis of the commonality and differences in the composition of the formation of the feet in the works of scientists living in Ma wara’ al-nahr: Abu Abdullah al-Khwarizmi(d. 997), AbuNasr ibn Hammad Jawhari (940-1007), Abu Hafs Nasafi(1068-1142) and Yusuf al-Sakkaki (1160-1229). As a result, Abu Abdullah al-Khwarizmi and Abu Hafs Nasafi analyze 8 feet, Yiisuf al-Sakkakl 10 feet, and Abu Nasr Jawhari 7 feet. However, the changes in the feet are divided into ziha:f and ‘ilia in all of these works.
The conclusion states that the study in the established order of the origin feet by the classification given by Mahmud al-Zamakhshari and each of their branches offeet will make it possible to accurately and easily determine the meter of bytes in the 'ariid system.