The aim of the research work. It consists in studying changes in the morphological and morphometric parameters of the wall of the gastric mucosa under conditions of polypharmacy with anti-inflammatory drugs.
The object of the scientific research is 180 white outbred male rats, 5 months of age.
The scientific novelty of the research work is as follows:
For the first time it was established that polypharmacy with anti-inflammatory drugs in 5 combinations had a different negative effect on the mucous and submucosal base, which is the structural structure of the stomach wall of white male rats;
It has been proven that structural changes in the organs of the digestive system cause profound disturbances in the processes of growth and formation of the gastric mucosa and its glandular tissue, submucosa, which is accompanied by a decrease in the total thickness of the stomach wall;
With the simultaneous use of more than 3 types of anti-inflammatory drugs, the negative effects of polypharmacy are significantly enhanced. We analyzed the rate of formation of structural and functional zones of the stomach wall, the activity of mucosal cells, the change in the shape of lymphocytes located in the submucosa, the decrease in morphological parameters;
Using the methods of modern morphological studies (organometric, histological, histomorphometric, statistical), new information was obtained directly about the morphological and morphometric parameters of the stomach wall. Changes at the tissue, cellular and intercellular levels are characterized by hypotrophic and hypoplastic changes in the structures of the stomach wall of white male rats.
Implementation of the research results. Based on the obtained scientific results on morphometric changes in the gastric mucosa under conditions of polypharmasia:
methodological recommendation was approved on the topic: "Method for determining the morphometric parameters of the gastric mucosa in polypharmasia of anti-inflammatory drugs", which allows to determine the morphometric parameters of the gastric mucosa in the conditions of polypharmacy in the experiment.
The scientific results obtained in the study of morphofunctional features and morphometric changes in the structure of the gastric mucosa under the influence of polypharmacy are used in healthcare practice, including Academician Y.Kh. Turaqulov Conclusion of the Ministry of Health of the Samarkand State Medical University. The introduction of information obtained in scientific research, the development of an algorithm for correct and timely diagnosis, pathogenetic morphometric and morphological indicators, the choice of treatment tactics made it possible to predict the development of pathological changes.
The structure and volume of the dissertation. The dissertation consists of an introduction, three chapters, conclusions, practical recommendations, a list of references and applications. The dissertation is presented on 102 pages of computer text.
The purpose of the study was to determine and evaluate the features of morphological changes in the liver parenchyma of 5-month-old white outbred rats under the influence of anti inflammatory drugs under conditions of polypharmacy.
The object of study for experimental studies was taken 250 white male rats weighing 200-250 g.
The scientific novelty of the research is as follows: polypharmacy of anti-inflammatory drugs negatively affects all parameters of liver structures. Under the influence of polypharmacy, there is a decrease in the absolute mass of the liver, volume and morphological parameters of the liver parenchyma. The decrease in morphometric parameters depends on the number of drugs in polypharmacy; under conditions of polypharmacy, the state of the hepatic capillaries and internal bile ducts, as well as biological membranes, was studied, as a result of which the structural structure of the liver, the development of destruction of the hepatic tissue were studied, and the morphofunctional foundations of this condition were shown.
Implementation of the research results. Based on the obtained scientific results, the morphofunctional characteristics of the liver of rats in the norm and under the influence of polypharmacy were determined:
Approved methodological recommendations: "Methodology for determining the morphometric parameters of the liver during polypharmacy of anti-inflammatory drugs" (Conclusion No. 8n-r / 265 dated 14.03.2022 of the Ministry of Health of the Republic of Uzbekistan) and "Methodology for determining the morphometric parameters of the liver during polypharmacy of anti-inflammatory drugs" (Uzbekistan, Conclusion of the Ministry of Health of the Republic of Uzbekistan No. 8 n-z 180 of 2022), electronic program No. DGU 1038 "Program for studying the comparative characteristics of morphological changes caused by polypharmacy in the liver."
The scientific results obtained in the study of morphological and functional properties and morphometric changes in the structure of the liver under the influence of polypharmacy have been introduced into the practice of the Samarkand branch of the Republican Specialized Oncological and Radiological Scientific and Practical Medical Center of the Samarkand City Medical Association (Order of the Ministry of Health of the Republic of Uzbekistan dated March 14, 2022, 8n-r / 265-No. and conclusion No. 8 n-z 180 of 2022). The implementation of the obtained research data allows developing methods for early diagnosis, treatment and prediction of organopathology by morphological parameters, improving the quality of life and reducing the number of complications.
The structure and scope of the dissertation. The structure of the dissertation consists of an introduction, three chapters, a conclusion and a list of references. The volume of the dissertation was 103 pages.
In the article, the individual conditions for the readiness of qualified boxers to achieve a high result of competition activity are studied. Correlational analysis results reveal the relationship between boxers' personal characteristics in increasing overall performance of competition activities in situations with and without confounding factors.
This article discusses about phraseological units (FU) and the proverbial phraseologisms (PF) in the French, Russian and Uzbek languages, their symbols and features, as well as the definitions of the various linguists and the personal opinion of the author for each determination. According to the results of our studies symbols and features belonging to the phraseology, is also applied to the proverbial phraseology.
In the world, attention is drawn to the great importance of the period of early postnatal ontogenesis for the morphofunctional differentiation of organs and systems of the future organism, since a violation of their formation in ontogenesis is a possible reason for the development of various congenital pathologies. Our experimental studies show that by the time of birth in rabbits, the main structural components of the jejunal wall have been formed, however, in their morphometric parameters and morphological picture, they differ significantly from the jejunum of adults. The jejunum of 10 day old rabbits has morphometric and structural differences from the jejunum of newborn rabbits. The total wall thickness increases significantly, mainly due to the mucous and submucosal membranes, the villi and crypts begin to lure in shape
The article discusses the essence and main new trends of the regional foreign policy of Uzbekistan in modern conditions. New trends in regional cooperation in the foreign policy of Uzbekistan revealed from the second half of 2016. Based on the analysis of the works of Uzbek political scientists, researchers, as well as specialists, the continuity of forms, methods, and mechanisms for ensuring stability in the Central Asian region is analyzed. It is obvious that all countries equally face the threats of terrorism, religious extremism, transnational crime and drug trafficking, the main emphasis relies on the fact that today the prospects for development stability are inextricably linked with the peace in Afghanistan. It can be seen that Uzbekistan has been resolving regional tensions on all issues, which over the years have accumulated with neighboring countries and there is a real opportunity to discuss problems, develop joint projects identified on the agenda for the region as a whole. The analysis made it possible to establish that in modern conditions, the main trend in the formation and development of regional development institutions is the course towards the integration of functions, structural ties, areas of activity, etc., both at the regional and interregional levels. The article analyzes that regional security is provided by various structures, with diverging and overlapping areas of responsibility, however, in the current conditions, specialized structures, for example, military-political blocs, are beginning to gradually transform into universal structures. Accordingly, the international legal base of regional systems is becoming more complicated, a multilevel set of norms appears. The article shows that regional institutions in Central Asia are being formed to solve regional problems. These processes testify to the degree of development of regional consciousness that such characteristics as mutual accounting and respect for interests, mutual openness and political trust have become inherent in the interstate relations of Central Asian countries. The above processes are only at the initial stage and require constant study.
Тучные клетки отличаются мультифункциональностью, то есть выполняют важные функции, существенно влияющие на формирование регуляции гомеостаза, микроциркуляции, фибриллогенеза и др. Изучение возрастных особенностей реактивности тучных клеток имеет большое теоретическое и прикладное значение.