This article is devoted to the preclinical study of the anti- atherosclerotic drug firutas on pathomorphological changes in animal organs during prolonged administration. Preclinical study of the general toxicology of the drug "Firutas" showed that it belongs to the IV class of low-toxic compounds. The drug "Firutas" does not have a cumulative and locally irritating effect. With repeated intramuscular administration to mice and rats, it does not affect the behavior and weight dynamics of animals, does not have a toxic effect on the composition of peripheral blood, kidney and liver function, as well as on the pathomorphology of animal organs and tissues. All the above data allow us to conclude that the drug does not have a toxic effect on the body of animals
This article describes the results of pathological examinations in experimental tuberculosis using the drug "Rifizostrept"
The article presents the results of a study of the efficacy and safety of the use of the drug Cytoflavin in patients with tension headache (TH). The assessment of cognitive and emotional disorders in patients with this pathology was carried out and the dynamics of the severity of these disorders after a course of therapy was traced. The study included 50 patients aged 18 to 50 years with TH. Research methods included neurological examination, assessment of cephalalgia intensity using a visual analogue scale (10-point option), determination of the level of anxiety using a self-rating scale Sh.D.Spilberger, Yu.L. Khanina; assessment of cognitive functions using the RAVLT methodology (Rey Auditory Verbal Learning Test) and the CFQ (Cognitive Failures Questionnaire), the psychophysiological test TOVA (The Test of Variables of Attention) to quantify impaired attention and impulsivity; electroencephalographic research (routine and spectral analysis). Test results after a course of cytoflavin showed that clinical improvement was observed in 62.0% of the patients included in the study. In the observed group, after completion of the course of treatment, in addition to reducing the frequency and intensity of the pain syndrome, a significant improvement in memory indices, a decrease in the level of inattention, and a decrease in reactive anxiety were also recorded. A comparative analysis of the data of electroencephalographic studies before and after the treatment showed a decrease in the manifestations of dysfunction of nonspecific regulation of the brain. Thus, the data obtained during this study allow us to recommend the use of the drug cytoflavin in the treatment of tension headache.