The purpose of the study was to determine and evaluate the features of morphological changes in the liver parenchyma of 5-month-old white outbred rats under the influence of anti inflammatory drugs under conditions of polypharmacy.
The object of study for experimental studies was taken 250 white male rats weighing 200-250 g.
The scientific novelty of the research is as follows: polypharmacy of anti-inflammatory drugs negatively affects all parameters of liver structures. Under the influence of polypharmacy, there is a decrease in the absolute mass of the liver, volume and morphological parameters of the liver parenchyma. The decrease in morphometric parameters depends on the number of drugs in polypharmacy; under conditions of polypharmacy, the state of the hepatic capillaries and internal bile ducts, as well as biological membranes, was studied, as a result of which the structural structure of the liver, the development of destruction of the hepatic tissue were studied, and the morphofunctional foundations of this condition were shown.
Implementation of the research results. Based on the obtained scientific results, the morphofunctional characteristics of the liver of rats in the norm and under the influence of polypharmacy were determined:
Approved methodological recommendations: "Methodology for determining the morphometric parameters of the liver during polypharmacy of anti-inflammatory drugs" (Conclusion No. 8n-r / 265 dated 14.03.2022 of the Ministry of Health of the Republic of Uzbekistan) and "Methodology for determining the morphometric parameters of the liver during polypharmacy of anti-inflammatory drugs" (Uzbekistan, Conclusion of the Ministry of Health of the Republic of Uzbekistan No. 8 n-z 180 of 2022), electronic program No. DGU 1038 "Program for studying the comparative characteristics of morphological changes caused by polypharmacy in the liver."
The scientific results obtained in the study of morphological and functional properties and morphometric changes in the structure of the liver under the influence of polypharmacy have been introduced into the practice of the Samarkand branch of the Republican Specialized Oncological and Radiological Scientific and Practical Medical Center of the Samarkand City Medical Association (Order of the Ministry of Health of the Republic of Uzbekistan dated March 14, 2022, 8n-r / 265-No. and conclusion No. 8 n-z 180 of 2022). The implementation of the obtained research data allows developing methods for early diagnosis, treatment and prediction of organopathology by morphological parameters, improving the quality of life and reducing the number of complications.
The structure and scope of the dissertation. The structure of the dissertation consists of an introduction, three chapters, a conclusion and a list of references. The volume of the dissertation was 103 pages.
To evaluate the effectiveness of the method of autologous bone grafting to increase the volume of bone tissue in atrophy of the alveolar ridge.
The popularity of orthopedic treatment using the method of dental implantation causes the interest of researchers to study the integration of implants in bone tissue. Analysis of the literature shows that the improvement of research technology and interdisciplinary approach to the study of the phenomenon of osteointegration of dental implants has led to a change in traditional concept in recent years. This article summarizes information about the physiological processes and cellular interactions occurring on the border "implant-bone tissue" in various stages of integration. The results of studies indicate the need for revision notions of bio inertness of titanium implants and consideration of the integration process in the immunological aspect.
Soft tissue deficiency in atrophy of the alveolar ridge creates difficulties for performing guided bone regeneration (GBR), the success of which to a certain extent depends on the closure of the wound without tension. The study examined the effect of the method of preliminary expansion of soft tissues on the subsequent processes of bone remodeling by histological examination of biopsies after NCR with the use of osteoplastic materials of various origins.
На современном этапе оотносительно недавним и мало разработанным вопросом является взаимосвязь ожирения и метаболизма костной ткани, в первую очередь с позиции обеспеченности витамином Д. Все имеющиесяя данные по этой проблеме противоречивы, немногочисленны и выполнены в основном взрослой популяции пациентов. В связи с этим мы поставили перед собой цель: изучить особенности формирования остеопенических расстройств при дефиците витамина Д на фоне ожирения и избыточной массы тела у детей
Today, in our Republic, most of the baking oils are margarines prepared on the basis of food salami. These margarines do not meet the standards of trans acid content (more than 2%). The research paper presents the results of hydrogenation of cotton palmitin in the presence of a regenerated catalyst, the melting temperature of which is less than 59 °C and the iodine number of no more than 6, and the preparation of a recipe for margarine with reduced trans acid content, which is used in baking based on it.
The tutorial provides brief information about various implant systems, their advantages and disadvantages, methods of surgical intervention, mechanisms for integrating implants in tissues. Modern views on the mechanisms of reparative bone regeneration, the structure and main characteristics of bone tissue are briefly presented. Describes possible complications of odontoplasty, techniques of their elimination and prevention. Biomechanical principles of orthopedic treatment of dental defects using implants are considered. The manual is prepared in accordance with the training program for specialists in the discipline "Surgical dentistry". The textbook contains the main questions of dental implantology. It at the present level presents the fundamental topics of dental implantology including osseointegration, of the morphological basis of dental implantation. Indications, contraindications, planning and surgical stages of installing plate and screw implants, complications arising during and after dental implantation, as well as their prevention and treatment are described in detail. The tutorial contains test tasks and situational tasks for monitoring the development of knowledge with reference standards of answers, as well as illustrative materials. The text of the manual contains illustrative material, final questions for each of the sections.
Experimental radionuclide studies of the dynamics of reparative regeneration of lamellar bone tissue in artificially modeled defects of various sizes in the nasofrontal region of the upper jaw
The tutorial provides brief information about various implant systems, their advantages and disadvantages, methods of surgical intervention, mechanisms for integrating implants in tissues. Modern views on the mechanisms of reparative bone regeneration, the structure and main characteristics of bone tissue are briefly presented. Describes possible complications of odontoplasty, techniques of their elimination and prevention. Biomechanical principles of orthopedic treatment of dental defects using implants are considered. The manual is prepared in accordance with the training program for specialists in the discipline "Surgical dentistry". The textbook contains the main questions of dental implantology. It at the present level presents the fundamental topics of dental implantology including osseointegration, of the morphological basis of dental implantation. Indications, contraindications, planning and surgical stages of installing plate and screw implants, complications arising during and after dental implantation, as well as their prevention and treatment are described in detail. The tutorial contains test tasks and situational tasks for monitoring the development of knowledge with reference standards of answers, as well as illustrative materials. The text of the manual contains illustrative material, final questions for each of the sections.