A pre-clinical study of the general toxicity of the medication “Fitin-S” has shown that it is referred to class IV of low toxic compounds. The medication “Fitin-S” does not have aaccumulative and local irritant action. At multiple intramuscular administration to rats and rabbits it does not influence the behavior and the dynamics of animals growth, does not cause a toxic effect on the composition of peripheral blood, kidneys’ and liver’s function as well as on the pathomorphology of animals organs and tissues. There is a slowdown in the process of blood coagulation in rabbits at doses of 16 and 32 mg/kg during the whole study period. In 1 month of a recovery period all the indicators have been changing within physiological norm. All the aforementioned data allows us to make a conclusion that the medication does not cause a toxic effect on the organism of animals.
Male and female patients aged 18 years and older who gave written informed consent to participate in the study with Parkinson's disease, parkinsonism syndrome, were observed for 30 days. Patients of the main group received the drug "Pramipexol BIO" tablets of 0.25 mg. The drug was prescribed together with Madopar. Patients of the comparison group received Madopar for 30 days. The drug Pramipexole BIO 0.25 mg tablets in complex treatment with levodopa significantly expands the possibilities of anti-Parkinsonian therapy both in the early and late stages of PD and SP.
Vitrum cardio Omega-3 a preparation for preventive maintenance thromboprophilia infringements at pregnancy. Hodzhimuratova G. А.
Включение в схемы профилактики и комплексного лечения беременных с тромбофилиями лекарственного препарата Витрум кардио Омега—3 (полиненасыщенная жирная кислота) способствует снижению ингибирования агрегации тромбоцитов,
снижению артериального давления у беременной, предотвращает угрозу преждевременных родов.
The resume: Inclusion in schemes of preventive maintenance and complex treatment of pregnant women with thrombophilia medicai product Vitrum cardio Omega-3 (polynonsaturated fat acid) promotes decrease in inhibition of aggregation trombocits, to decrease in arterial pressure at the pregnant woman, prevents threat of premature birth
To identify possible SUCNR1-mediated mechanisms of the activity of the succinate-containing preparation Hyalual in the skin. Material and methods: For the study, patients were selected who were hospitalized in the department of adult oral and maxillofacial surgery in 2017-2019, of which 14 women aged 27 to 40 years and 18 men aged 25 to 44 years. We used a succinate-containing preparation Hyalual (preparation for a course procedure, injectable form; concentration of hyaluronic acid 1.1%, 1.8%, 2.2%; succinate content 1.6%), diprospan (injectable form, 1 mg/ml), saline 0.9% 1 ml). Results: Morphological studies indicate the implementation of SUCNR1-dependent mechanisms of the activity of the succinate-containing preparation Hyalual. Conclusions: The drug Hyalual has great potential for solving numerous problems of reparative medicine, cosmetology and plastic surgery, trichology.
The purpose of the study is to study the sensitivity of microbes to certain drugs in vitro! Material and Methods: to establish this research method, we have prepared 18-hour cultures of microbes - taking into account the most frequent inhabitants in the oral cavity. 1-2 ml of the studied microbes were applied to the surface of the dried nutrient medium by Mueller Hinton. The preparation sea buckthorn oil had an antibacterial effect on most microbes, although among them the most sensitive were such microbes as streptococci, proteas and pseudomonas. At the same time, the chlorhexidine drug had an effect on most microbes, but the effect was insignificant and only streptococci were the most sensitive and amounted to 18.0 ± 0.3 mm. Conclusions: the drugs used to treat sick children belonging to the group of traditional therapy have a weak antibacterial effect. At the same time, drugs from the special treatment group have a more pronounced antibacterial effect, especially on microbes of the genus streptococci.
В последнее время ведется интенсивный поиск альтернативы наркотическим аналгетикам по пути как нефармокологического воздействия, так и синтез новых препаратов лишенных недостатков наркотических аналгетиков. В этом ряду вызывают интерес препараты с агонист-антогонистическими свойствами по отношению к опиоидным препаратам. В этом отношении привлекает к себе внимание препарат Нубаин (нальбуфин) аналгезирующее свойство которого связано главным образом с агонистическим влиянием на альфа-рецепторы, но вместе с тем препарат является антогонистом гаммарецепторов, в связи с чем не оказывает выраженного эйфорического эффекта. Вместе с тем, в педиатрической анестезиологии недостаточно изучено влияние комбинированной анестезии с использованием Нубаина на состояние ЦНС, гемодинамики, гомеостаза и активности стресс-гормонов при хирургических вмешательствах.
This article presents the results of a study of the hepatoprotective properties of the herbal drug darmonal in combination with phytin compounds in experimental animals (rats) with experimental hepatitis caused by SS14 intoxication. The obtained research results showed that darmonal in combination with phytin compounds increases the synthesis of total protein and normalizes the composition of protein fractions of blood serum. Both studied drugs have a high level of hepatotropic effect. The combination of darmonal and fitin-C was the most effective. According to this effect, they were superior to the hepatoprotective drug LIV-52.
Мақолада туберкулёз микобактериялари штаммларининг қишлоқ хўжалик ҳайвонлари, паррандалар ҳамда одамлар организмида патогенлигининг таҳлилий шарҳи натижалари баён қилинган. Турли хил худудларда ички аъзолар ва тўқималарда касаллик қўзғатувчисининг патологик ўчоқлар ҳосил қилиш хусусияти, юқумлилик даражаси ҳақида тушунчалар берилган
This article is devoted to the preclinical study of the anti- atherosclerotic drug firutas on pathomorphological changes in animal organs during prolonged administration. Preclinical study of the general toxicology of the drug "Firutas" showed that it belongs to the IV class of low-toxic compounds. The drug "Firutas" does not have a cumulative and locally irritating effect. With repeated intramuscular administration to mice and rats, it does not affect the behavior and weight dynamics of animals, does not have a toxic effect on the composition of peripheral blood, kidney and liver function, as well as on the pathomorphology of animal organs and tissues. All the above data allow us to conclude that the drug does not have a toxic effect on the body of animals
Соблюдение принципов антибактериальной терапии поможет врачам эффективно и безопасно применять антибактериальные препараты, снизить развитие резистентности микробов к антибактериальным препаратам.
This article presents the results of a study of the hepatoprotective properties of the herbal drug darmonal in combination with phytin compounds in experimental animals (rats) with experimental hepatitis caused by SS14 intoxication. The obtained research results showed that darmonal in combination with phytin compounds increases the synthesis of total protein and normalizes the composition of protein fractions of blood serum. Both studied drugs have a high level of hepatotropic effect. The combination of darmonal and fitin-C was the most effective. According to this effect, they were superior to the hepatoprotective drug LIV-52.
To evaluate the effectiveness of the use of a domestic production of Vinifer in the prevention of alveolitis after the removal of impacted and dystopic teeth. Material and methods: 72 patients aged 17 to 30 years and older, who applied from district polyclinics in Tashkent and other regions of Uzbekistan in 2019-2021, were under observation. Results: When using Vinifer to prevent alveolitis, the frequency of complications after tooth extraction decreased markedly. Treatment of alveolitis with the use of powder from the Vinifer preparation has reduced the number of visits to the dental surgeon. Conclusions: In terms of therapeutic and prophylactic properties, the drug showed positive results, while not inferior to imported counterparts.