Young apple trees that are planted in areas with limited water resources face challenges in their early growth stages. Insufficient intake of moisture often stunts the growth of the young tree and impacts its subsequent growth. In this study, we observed the interaction of semi-vigorous Marubakaido (Ma) (Malus prunifolia
„Ringo‟) and dwarfing Jm7 („Marubakaido‟ × M.9) rootstocks, water treatments (50% and 70% soil water content) and soil treatments (water retention substances) on young „Miyabi Fuji‟ apple trees and how this interaction impacts their growth under dry climactic conditions. The development of shoots, stems and roots was analyzed. The results showed that the interaction of rootstock and water and soil treatments had
a significant impact on total shoot length (p < 0.01), as did the interaction of rootstock and soil treatment on the length of the top three shoots (p< 0.05) and trunk fresh weight (p < 0.05). In addition, it was found that the interaction of water and soil treatments impacted shoot fresh weight (p < 0.05). This study revealed that the growth of young apple trees in areas with limited water resources can be aided by providing a 70% and 50% saturation of water and soil retention treatments for young trees that have been grafted onto semi-vigorous Ma and dwarfing Jm7 rootstocks. Growers in these areas should think about which rootstock to use, what soil water retention treatments that can be introduced into the soil as well the amount of water that should be applied.
There is no clear distinction between metonymy and metaphor. Specifying metaphor-metonymy interaction is a difficult task, particularly differentiating the two cognitive mechanisms from each other. There are a wide variety of opinion. In this paper we look mainly at two important issue, (i) what causes this interaction between metaphor and metonymy and (ii) how these two distinctly different processes blend. In Cognitive Linguistics metaphor and metonymy have both been explicitly recognized as central to a theory of knowledge organization. Metaphor and metonymy have both been described by Lakoff and his co-workers as mappings between conceptual domains. By means of metaphor we understand and reason about one conceptual domain in terms of another. Metonymy is a multilevel cognitive mechanism that can operate at the grammatical, lexical, syntactic, phonological, and discursive levels. According to cognitive linguists, metonymy is not merely a figure of speech; it is also a way of thinking and conceptualizing. Cognitive linguists, distinguish between metaphor and metonymy in terms of the number of domains involved. If the source and target belong to the same superordinate domain, we have a metonymy. If the source and target belong to two different superordinate domains, then we have a metaphor.
Данная статья исследует межкультурные связи и взаимодействие в литературе зарубежных стран .В статье анализируются влияние литературных традиций разных стран на культуру и литературные процессы, феномены перевода и интертекстуальности. Контекстуальный анализ раскрывает взаимодействие между социокультурными факторами и развитием литературы. Роль литературы в межкультурном диалоге и ее вклад в межкультурное понимание также подчеркиваются.
The scientific article explores the issues of literary connections and the interaction of cultures of Western and Eastern literature, which in the process of intercultural communication reproduced the exchange of cultural and literary values. The author emphasizes that mutual exchange had a positive impact on the processes in the development of interacting cultures, which are reflected in their literature. The main goal of the work is to describe the interaction and mutual influence of contacting literatures. The objective of the study is to analyze the features of interliterary connections of contacting cultures.
Interaction in society involves interaction between people that might be identified as intercultural
communication. Spontaneous communication where speakers might be of various intercultural origin the interaction has to be flexible in language skills i.e. take into account the language ,thinking, traditions , intellection and beliefs.
Modern learning and teaching a language suggests concentration not only on language acquisition, accuracy and fluency as well as the massage sent by each member of the conversation ,i.e. the cultural origin of co-speakers. Using a technology of working with video tasks in the classroom is one of the beneficial approaches to develop communicative
skills in EFL learners.
Learning from the design and implementation of the innovative playful learning approaches to improve children’s readiness for primary education in Uzbekistan.
In the article, literary works are explored as a means to reveal intercultural communication facts in artistic form, emphasizing the intricate interplay of cultures within the narrative. This approach allows for a comprehensive understanding of the complexities of multicultural interactions, highlighting the nuances that enrich the characters' experiences and contribute to a deeper cultural awareness.
Studies of countries and regions suggest that there is no single main factor in the competitiveness of innovation systems. Every success story - the US, Japan, Switzerland, Finland, Israel - has come about through the combined action of a unique set of facts. Not only talented inventors and great scientific discoveries determine innovative results. Engineering education and financial resources, interaction within clusters and technological infrastructure, the attractiveness of the country for foreign scientists and engineers and proper public administration, the scope of commercialization and the demand for new products - literally everything that makes up the country's innovation system is important for its competitiveness. We identify six "components" of the competitiveness of innovative systems.
Topicality and demand of the subject of dissertation. Bronchial asthma (BA) is one of the most common and serious diseases, which in the world suffer from 3 to 12% of the child population of the globe. Proportion of adolescents with asthma, is one third of all children with this disease. High prevalence of asthma in the numbers of teenagers, characteristics of the disease, age-related aspects of the functioning of the endocrine and immune systems of teenagers that cause difficulties which arise in the course of the diagnostic process, highlight the need to find innovative approaches to diagnosis and treatment of this disease.
It is known that the key immune mechanisms in the pathogenesis of the vast majority of AD cases is real and indisputable fact. Currently, considerable interest to researchers involved in the pathogenesis of positions of allergic diseases, especially asthma, along with IL-4 and IL-13 causes a number of other (IL-6, IL-8, IL-10, IL-5, INF-a and INF-y) immunoregulatory cytokines.
Genetic predisposition plays an important role in the development of allergic diseases. Currently available data on the relationship with asthma and associated with disease symptoms polymorphism approximately 150 genes. Important role as the main contender for the predisposition to asthma gene is a gene encoding flchain of high affinity receptor IgE. Interaction elevated levels of antigen-specific IgE with FceRip plays a central role in the pathogenesis of allergic asthma. Particularly attractive candidate gene asthma is also one of the enzyme genes biotransformation - GSTirl, encoding glutathione S-transferase and л1 express almost exclusively in the pulmonary tissue. This gene is located at the locus 11 ql 3, for which repeatedly shown clutch with atopic symptoms. Accumulated in the literature say about the relationship of gene polymorphism FceRI, GSTnl with different allergic diseases.
From this perspective, the study of immunological and genetic mechanisms of the pathogenesis of this disease for the construction of rational treatment and prevention emphasizes the relevance of this thesis research.
From the earliest days of independence, the country has successfully implemented state programs aimed at reforming the health care system. As a result, the targeted implementation of organizational health and research activities aimed at effective diagnosis, prevention and treatment of asthma among adolescents, with some success in the treatment of this disease in the country. However, now the problem of early diagnosis and the development of effective programs for treatment and prevention among adolescents with asthma remain one of the most important issues of modern health care. This research work was carried out in the framework of the tasks set by the Resolution of the Cabinet of Ministers of the Republic of Uzbekistan "On additional measures to improve the health of women and the younger generation," dated 25.01.2002 for the №32. In this regard, the need to deepen the information received about the state of cellular and humoral immunity among adolescents, asking pathogenetic informative immunogcnctic studies in asthma arc one of the important criteria demand the dissertation topic.
Purpose of research is study the immunological and genetic mechanisms of the pathogenesis of asthma in adolescents and form the basis of this plan rational diagnostic and therapeutic measures in this pathology.
In To achieve this goal the following tasks of research is solved:
to establish the clinical course of asthma in the population of adolescents living in the Samarkand region, in the early stages of the pathological process in the bronchopulmonary system.
explore the features of the state of cellular and humoral immunity, as well as activation markers in asthma in adolescence by determining the immunophenotype of lymphocytes in the peripheral blood.
to examine the level of production of immunorcgulatory cytokine interleukin-6 and interfcron-y and install them pathogenetic informative in asthma among adolescents.
to determine the features of distribution of allele and genotype frequencies of polymorphic variants of genes and FceRip GSTnl population Uzbek people with asthma, compared with the healthy part of the population.
examine the clinical and immunological aspects effectiveness of therapies using drugs and polioksidony tsikloferon in patients with asthma in adolescence.
on the basis of studies to develop a multivariate model of formation of bronchial asthma and develop an optimal algorithm for the diagnosis, treatment, prevention in adolescents with this pathological condition.
Scientific novelty of dissertational research consists in the following:
proposed introduction to the work of doctors teen clinics layered approach testing can significantly improve the detection rate of asthma in adolescence and optimize treatment and preventive measures in high-risk groups;
first defined the peculiar characteristics of the quantitative parameters of the immune status of patients with asthma in the cohort of adolescence and the corresponding proposed regulations and guidance documents for the healthy part of the adolescent population;
for the first time presents a comprehensive assessment of the cytokine profile of blood serum in bronchial asthma in adolescents. Specific features of products immunorcgulatory cytokines IL-6 and INF-y and their pathogenetic and regulatory information content in asthma among adolescents;
first analyzed the distribution of alleles and genotypes of polymorphic gene variants and gene FceRip GSTirl among patients with different phenotypic variants of AD and healthy individuals of Uzbek nationality, which resulted in the identified markers of increased risk or, conversely, resistance to the development of asthma in adolescents Uzbek ethnicity;
algorithms for phase diagnosis, treatment and prevention of asthma in adolescence in terms of disclosure of important moments of the pathogenesis of the disease, allowing to build a rational sequence of diagnostic search, aimed at verifying the diagnosis and expedient construction of preventive measures.
Conclusion
1. Set the frequency of occurrence of the disease and the structure of "asthma" in the arid zone among teens. Said pathology is recorded in 9,6% of the population surveyed adolescents, while the disease is more common among females. In the structure of the disease prevails periodical exposure and mild persistent form.
2. Identified by clinical features of asthma among adolescents living in the arid zone, indicate a high frequency of lesions of the bronchial tree association with allergic processes in other organs and tissues: in 73,9% of the AR, 53,7% with AK. 16,6% with BA and 14% with urticaria/angiocdcma.
3. Found that in the study population of patients with asthma adolescence occur expressed disturbances of the immune status, manifested deficit indicators as cell (CD3‘, CD4+, CD8 , CD16+), and humoral immunity (CD19 , IgA, IgG, IgM) and activation markers (CD23+, CD95). The immune status of patients with asthma in young people, adolescence has distinctive features, the depth of detected violations immunoreactivity was most pronounced in the younger age group.
4. In patients with bronchial asthma in adolescence revealed distinct changes in cell-cell interactions in the immune system: a significant increase in the content of Th2-cclls secreted IL-6 is a regulator of maturation of antibodies and immunoglobulin production itself, and vice versa reducing regulator activity of Th 1-cell cytokine INF-y.
5. It was found that the contents of cytokines IL-6, INF-y and in the peripheral blood is in communication with one pathogenic disease. It is shown that the lowest level of INF-y production in the scrum is characteristic of allergic clinical pathogenic variant asthma in adolescence. Adolescents suffering from predominantly infectious form of asthma, there is a sharp trend towards increased production of IL-6 in peripheral blood.
6. Revealed that markers of increased risk of allergic forms of asthma in adolescents Uzbek ethnicity arc genotype FceRip-109T/T allele FceRip-109T, low-risk markers - FcsRip-109C/C and allele Fc£Rip-109C. A high degree of cohesion genotype FcsRip-109T/T allele and FcsRip-109T with hereditary burden of asthma in the Uzbek population.
7. Among females ethnic Uzbek Association revealed lie-105 allele and genotype Ilc-105/Ilc-105 polymorphic gene locus GSTkI at high risk for asthma. Revealed that the genotype associated with the development Ilc-105/Ilc-105 allergic form of asthma in adolescents Uzbek population.
8. Complex therapy with adolescents’ patients with asthma ciklofcron and polyoxidonium, providing immunocorrective effect, enhances the clinical efficacy of basic therapy. In the study of prophylactic efficacy of immunomodulators positive indicators prevailed in the group of patients receiving polioksidony, necessitating its inclusion in the priority scheme of integrated treatment and prevention of asthma in adolescents.
В статье анализируются средства взаимодействия предметно-логического и контекстуального значений в метафоре. Троп возникает в результате контекстуальной модификации. Появление нового смысла лексических единиц происходит тогда, когда соединяются семантически несовместимые элементы высказывания