Simblefaron is a scar fusion of the posterior conjunctival surface of the eyelid with the eyeball. It often develops as a complication of thermal burns of the eyes. Eye burns are severe damage to the organ of vision and occupy a significant share (6.9-30.5%) in the structure of eye injuries. The results of the study showed that the stage-by-stage surgical plastic surgery of the anterior segment of the eye performed by us, which consists in a combination of plastics of the fornix with flaps from the automucosal cavity of the mouth (lips) and transplantation of the amniotic membrane onto the surface of the cornea and conjunctiva with the capture of the limbal zone, allows you to eliminate the defect of the cornea and maintain its transparency and also contributes to the restoration of the conjunctival arches, which can significantly reduce the likelihood of developing complications of burn injury and shorten the rehabilitation period, improve the functional results of treatment.
Determine the indicators of intraocular pressure (IOP) tonometry, taking into account the parameters of the central thickness of the cornea (CTC) in children with congenital infantile glaucoma (CIG). Clinical studies were conducted in the eye department of the Tashkent Pediatric Medical Institute`s clinic. A total of 14 patients (26 eyes) aged 3 to 10 years with a diagnosis of CG were examined. All patients underwent basic ophthalmologic examination prior to surgical and conservative treatment. In addition to basic methods, the axial length of the eyeball was determined, and the CTC was determined on an automatic non-contact tonometer - Reichert pachymeter (USA). An analysis of the data showed: IOP in 39% of cases was considered subnormal, after correction taking into account the CTC in 11% of cases, the IOP was high. This group (11% of cases) was composed of children with a “thin” cornea at the terminal stage of CIG and high myopia. The correct interpretation of IOP indicators will help in choosing an adequate treatment and monitoring the glaucoma process. The used indicator of the central nervous system has practical significance in the interpretation of tonometry according to Maklakov 5 gr.
The purpose of the study is to determine the significance of genetic factors in the development of chronic nephritic syndrome in children and to clarify the features of the clinical course
The оbject of research were 129 children aged 4-15 years who were treated for chronic nephritis in the nephrology department of the Samarkand Regional Multidisciplinary Paediatric Medical Centre.
The scientific novelty of the study is as follows:it has been established that the severity of chronic nephritic syndrome in children is associated with clinical manifestations (gradual development, dyspepsia, abdominal pain) and an increase in the amount of Cystatin C in the blood;for the first time, it was revealed that the development of sclerotic lesions due to increased proliferation in patients with the presence of the MMP-9 (A-8202G) rs 11697325 genotypes in chronic nephritic syndrome leads to a worsening of the clinical course of the disease; established early diagnostic marker MMP-9 (A-8202G) rs 11697325 and its tissue inhibitor TIMP-2 (C536T) rs 11551797 in chronic nephritic syndrome in children in the diagnosis of the disease; for the first time, the prognostic value of the alleles of the MMP-9 (A-8202G) rs 11697325 genes and the homozygous G/G genotype in determining the risk of developing the disease in children with chronic nephritic syndrome has been proven.
Implementation of the research results. Based on scientific results of evaluation of the role of polymorphic genes of matrix metalloproteinase and its tissue inhibitors in chronic nephritic syndrome in children: methodological recommendation “The role of polymorphic genes of matrix metalloproteinase and its genetic inhibitors in the development of chronic nephritic syndrome in children” was developed and approved (reference of the Ministry of Health of the Republic of Uzbekistan No. 8n-r / 554 of 30.02.2022).
This methodological recommendation made it possible to predict the development of chronic nephritic syndrome in children and improve preventive measures; approved and developed on the basis of scientific results of research on early diagnosis and prognosis of chronic nephritic syndrome “Dynamics of clinical and laboratory parameters in nephritic syndrome in children”, (reference of the Ministry of Health of the Republic of Uzbekistan No. 8n-r / 555 of 30.02.2022).
This methodological recommendation made it possible to optimize the diagnosis and treatment tactics for various forms of nephritic syndrome in children;
The results obtained were implemented in the practice of health care, in particular, in the Republican Children's National Medical Center, in the 1st clinic of the Samarkand State Medical University, in the Samarkand Regional Children's Multidisciplinary Medical Center (conclusion No. 8 n-r/324 of 21.06.2022 of the Ministry of Health of Uzbekistan).
The application of the obtained results to practice has made it possible to reduce the frequency of recurrence of the disease in children, prevent complications of the disease, improve the quality of life of patients, diagnose and prevent the disease.
The structure and scope of the dissertation. The dissertation consists of an introduction, 4 chapters, conclusions, practical recommendations. The volume of the dissertation is 120 pages.
Determine the indicators of intraocular pressure (IOP) tonometry, taking into account the parameters of the central thickness of the cornea (CTC) in children with congenital infantile glaucoma (CIG). Clinical studies were conducted in the eye department of the Tashkent Pediatric Medical Institute's clinic. A total of 14 patients (26 eyes) aged 3 to 10 years with a diagnosis of CG were examined. All patients underwent basic ophthalmologic examination prior to surgical and conservative treatment. In addition to basic methods, the axial length of the eyeball was determined, and the CTC was determined on an automatic non-contact tonometer - Reichert pachymeter (USA). An analysis of the data showed: IOP in 39% of cases was considered subnormal, after correction taking into account the CTC in 11% of cases, the IOP was high. This group (11% of cases) was composed of children with a “thin” cornea at the terminal stage of CIG and high myopia. The correct interpretation of IOP indicators will help in choosing an adequate treatment and monitoring the glaucoma process. The used indicator of the central nervous system has practical significance in the interpretation of tonometry according to Maklakov 5 gr.
The purpose of the study was to determine and evaluate the features of morphological changes in the liver parenchyma of 5-month-old white outbred rats under the influence of anti inflammatory drugs under conditions of polypharmacy.
The object of study for experimental studies was taken 250 white male rats weighing 200-250 g.
The scientific novelty of the research is as follows: polypharmacy of anti-inflammatory drugs negatively affects all parameters of liver structures. Under the influence of polypharmacy, there is a decrease in the absolute mass of the liver, volume and morphological parameters of the liver parenchyma. The decrease in morphometric parameters depends on the number of drugs in polypharmacy; under conditions of polypharmacy, the state of the hepatic capillaries and internal bile ducts, as well as biological membranes, was studied, as a result of which the structural structure of the liver, the development of destruction of the hepatic tissue were studied, and the morphofunctional foundations of this condition were shown.
Implementation of the research results. Based on the obtained scientific results, the morphofunctional characteristics of the liver of rats in the norm and under the influence of polypharmacy were determined:
Approved methodological recommendations: "Methodology for determining the morphometric parameters of the liver during polypharmacy of anti-inflammatory drugs" (Conclusion No. 8n-r / 265 dated 14.03.2022 of the Ministry of Health of the Republic of Uzbekistan) and "Methodology for determining the morphometric parameters of the liver during polypharmacy of anti-inflammatory drugs" (Uzbekistan, Conclusion of the Ministry of Health of the Republic of Uzbekistan No. 8 n-z 180 of 2022), electronic program No. DGU 1038 "Program for studying the comparative characteristics of morphological changes caused by polypharmacy in the liver."
The scientific results obtained in the study of morphological and functional properties and morphometric changes in the structure of the liver under the influence of polypharmacy have been introduced into the practice of the Samarkand branch of the Republican Specialized Oncological and Radiological Scientific and Practical Medical Center of the Samarkand City Medical Association (Order of the Ministry of Health of the Republic of Uzbekistan dated March 14, 2022, 8n-r / 265-No. and conclusion No. 8 n-z 180 of 2022). The implementation of the obtained research data allows developing methods for early diagnosis, treatment and prediction of organopathology by morphological parameters, improving the quality of life and reducing the number of complications.
The structure and scope of the dissertation. The structure of the dissertation consists of an introduction, three chapters, a conclusion and a list of references. The volume of the dissertation was 103 pages.
Стоматологическая мембрана — специальная пленка, которая используется в стоматологической практике в качестве барьерного и фиксирующего материала в процедурах по имплантации зубов. Применение мембраны позволяет успешно бороться с атрофией кости, препятствуя ее потере, что в свою очередь создает благоприятные условия для проведения имплантации зубов.
The oral cavity is an open biological system in which there is a constant balance between pathogenic factors, such as viruses, bacteria, and the body’s defense forces. However, due to the proliferation and rapid development of microorganisms and viruses, as well as the weakening of general and especially local immune defense factors, such an important balance is often attacked.
Due to the spread of the new coronavirus infection, the number of oral mucosal diseases caused by COVID-19 is constantly increasing. The task for the dentist is to make a timely diagnosis, identify the pathology and start rational pharmacotherapy in order to prevent the development of pathology and the development of dental diseases into more severe forms.
The study involved 76 patients with children (46 boys and 30 girls) aged from 9 to 15 years, 34 of them - with allergic conjunctivitis and rhinosinusitis, 24 - with chronic recurrent obstructive bronchitis (preasthma), 18 - with asthma. Duration of illness ranged from a few months to 5 years examination. To clarify the rheological properties of blood there were determined electrical breakdown of the membrane, the electrophoretic mobility, the zeta potential of the membrane of erythrocytes and blood viscosity. The extent and intensity of the rheological properties of blood disorders in association with other clinical and laboratory data has prognostic significance in the development of respiratory allergies in children.
Subjects of the inquiry: 103 patients with rheumatoid arthritis, 20 healthy individuals.
Aim of the inquiry: To study therapeutic effect of low frequency physical factors on the cytokines and the processes of lipid peroxidation and to confirm scientifically the efficacy of their use based on the their effect on the clinical laboratory findings.
Methods of investigation: Clinical and laboratory investigations, immunological analyses of the blood scrum cytokine levels and synovial fluid, biochemical examinations of the lipid peroxidation and antioxidant system indicators, phospholipase-A2 activity, nonspecific phosphatases and free oxyprolinc in the blood serum of patients.
The results achieved and their novelty: There was studied clinical efficacy of ultraphonophoresis with benzketozon during treatment and rehabilitation of the patients with rheumatoid arthritis. It was proved that disbalance between inflammatory and anti-inflammatory cytokines as well as lipid peroxidation activation activity in the erythrocyte membranes and blood scrum destabilized cellular membrane structures, increase in phospholipase-A2 activity and, consequently, stimulating prostaglandines, inflammation mediators, synthesis. There was shown that complex therapy with inclusion of low frequency physical factors, particularly ultraphonophoresis with benzketozon, gave marked positive effect normalizing interrelation ship between inflammatory and anti-inflammatory cytokines reducing activity of phospholipase-A2, lipid peroxidation products and rising the levels of antioxidant system indicators.
Practical value: There has been shown rationality of inclusion of the physical-pharmacological method ultraphonophoresis with benzketozon into clinical practice. The differential indicators developed for application of low-frequency physical methods of therapy for rehabilitation of the patients with rheumatoid arthritis allow prolongation of the remission, improvement of the patients life quality.
Degree of embed and economic effectivity: The practical recommendation and guidelines have been applied in the clinical practice of the out-patient special course of arthrological treatment in the Republican Rhcumatological Center, Clinical Hospital N 1, Central Hospital of Zangiota district of Tashkent province. Sphere of usage: Rheumatology, physiotherapy.
Inflammatory diseases of the cornea are one of the most common causes of blindness worldwide. In recent years, many modern methods of treating diseases of the cornea have appeared, including, in addition to traditional conservative methods, modern surgical methods, such as autoconjunctival plasty, amniotic membrane transplantation, therapeutic keratoplasty, corneal covering with a corneoscleral flap, microdiathermocoagulation, and corneal crosslinking. A promising direction in the treatment of corneal pathology is stem cell therapy and cell therapy.
Иммун тизим организмдаги ҳар қандай функционал ва метаболик ўзгаришларга аутоантитаначаларнинг миқдорий ўзгаришлари орқали аниқ жавоб беради [27]. Организмда барча орган ва тўқималарга мембрана, ядроли, цитолазматик, шунингдек, биорегулятор молекулалар, хроматиннинг цис-регулятор элементларига, ўсиш омиллари рецепторларига антигенларга аутоантитаначалар мавжуд, улар ёрдамида иммун система кўпайиш ва генетик жиҳатдан аниқланган функцияларни, шу жумладан нишон-ҳужайраларнинг митотик фаоллигини тартибга солиши мумкин [34]. Аутоантитаначалар тўплами бачадон ичида шаклланади ва турли ёшдаги соғлом шахсларда ўхшаш бўлади, аниқланган баъзи фарқлар иммун-метаболик индивидуалликни акс эттиради