The aim of the study is to development of an algorithm for managing pregnancy and childbirth by studying the functional state of the mother-placenta-fetus system in pregnant women who have undergone COVID-19 in different trimesters of pregnancy.
The object of the study was 105 pregnant women who, were treated at the Samarkand Regional Perinatal Center and a specialized maternity center for pregnant women with COVID-19
Тhe scientific novelty of the research consists of the followings: for the first time in pregnant women infected with COVID-19, a relationship was established between the course of pregnancy, childbirth, the postpartum period and the development of complications depending on the trimester and severity of the disease; a direct correlation has been established between the state of the vessels of the mother-placenta-fetus system (resistance and pulsation indices, Endothelin-1 indicators), disorders in the hemostasis system (D-dimer, platelet aggregation) and the clinical course of the disease in pregnant women who underwent COVID-19; it has been established for the first time that the developed scale for assessing risk factors for non-developing pregnancy in women infected with COVID-19 (age, BMI, obstetric history, gestation period, hemostasis system status, endothelial function and severity of the disease) can serve as a prognostic marker of the degree of risk of pregnancy complications; it was proved for the first time that the choice of effective therapy for restoring hemodynamics in the mother-placenta-fetus system, in women who underwent COVID-19 at different stages of pregnancy, leads to a decrease in the number of thrombophilic complications.
Implementation of the research results. The results of the scientific research were introduced into the practical activities of the Samarkand Regional Perinatal Center by Order No. 128/1 of 01.09.2022 and the Samarkand City Maternity Complex No. 1 by order No. 58/1 of 03.10.2022. In pregnant women who underwent COVID-19 at different periods of pregnancy, changes in the mother-placenta-fetus system were determined using simple and effective research methods, such as ultrasound and Dopplerography, and this saved 53,000 soums; obstetricians and gynecologists, as well as neonatologists and therapists, are needed to diagnose signs of complications in the echocartin, that is, it has been proven that there is no need for other highly qualified specialists for this, due to the lack of need to train new personnel, state budget funds have been saved. With early detection of disorders in the hemostasis system in pregnant women with COVID-19: the period of stay of patients in the hospital was reduced from 10.5 days to 7.5 days and the number of hospital bed days was reduced; due to the reduction of the period of stay in the hospital for several days, the number of necessary drugs was reduced (on average, drugs are used for 1 day in the amount of 130,000 soums). Examination of pregnant women infected with viral diseases using simple and effective research methods such as ultrasound and Dopplerography served to save 85,000 soums: in the early stages up to 16 (10-11 weeks. - fetometry), 19-21, 32-34, 38-40 weeks of pregnancy; due to the absence of the need to use other research methods, it was possible to reduce costs by 23.5%; early detection of changes in the hemostasis system and endothelial dysfunction using fast, budgetary and effective research methods, contributed to the prevention of possible pregnancy complications, as well as the absence of the need to use long-term and expensive research methods, and this saved 106 000 soums: the coagulogram was checked in 105 (100%) patients, time was saved and efficiency was increased; endothelin-1 was also determined in 105 (100%) patients, efficiency was increased by 78.6%.
Improving the functionality of blood circulation in the uteroplacental and fetal-placental systems, a comprehensive analysis of possible complications during pregnancy and childbirth in women who have had viral infections, improving diagnostic, preventive and prognostic measures for managing pregnancy and childbirth contributed to the birth of live, full-term and healthy newborns in women who experienced COVID-19 during pregnancy, as well as a decrease in maternal mortality and perinatal mortality, 43% of women underwent rehabilitation in the postpartum period, 23.8% of women who underwent severe COVID-19 improved their quality of life.
To introduce scientific novelty on the topic “The impact of COVID-19 on the state of hemodynamics in the mother-placenta-fetus system in pregnant women”, a letter was sent to the Ministry of Health from Samarkand State Medical University on November 9, 2022 under No. 4295 (Conclusion of the Ministry of Health No. 8 n-z / 679 of December 15, 2022).
The structure and volume of the dissertation. The content of the dissertation consists of an introduction, five chapters, conclusion, list of used references. The volume of the dissertation consists of 113 pages.
As it is known, the social status of occupation in the communication is determined, compared to the
participants-curry, relationship status, position and role in the family. Speech communication is an important tool for providing information about the social status of the participants. For example, the speech units selected by the owner, the speech etiquette forms can transport information about the social status of the speaker. In particular, the participants' concluding remarks in the life of society are received great attention in the communication culture of Uzbekistan. In this article deixis theory in linguistics, deixis of the social condition, its representatives are discussed. In communication gestural units they are mainly used to express participants' social condition. The social status of linguistics in the speech of the participants of the dialogue is pointed as social deixis, we used terminology of social condition deixis. After all, the social status (social further status) of speech participants is provided in terms of social deixis. The speech units that
express social status deixis not only explain speaker and social condition of other participants, but also inform about its subjective evaluation. Linguistic and also extralinguistic units are used to make deixis of social status in the Uzbek language. Language units of deixis of social status language include pronouns, contact units, social lexic units and some supplements. Personal pronoun organize complicated deictic character as a tool to form of social status and person's deixis. They indicate participants of the speech which makes clear individual's deixis and determine social status deixis via showing their relations and
social factors in the same time. Supplement -s which indicates grammar meaning of possession, personal
suffixes, respect does a task of clarifying social status deixis too. Also, one of active language units that could explain speech participants' social status is reference units. Reference units' have a special duty of not only grabbing attention of listener in the speech, but also defining social relationship between speech participants. Communication units are actively used as a tool of indicating speech participants' social status in our speech. Even spelling name incorrectly to the listener indicates disrespectfulness, lowness of listener's social status or using words that mean relativity with strangers’ services as a respect. In speech deictic points which have social symbol are used in lexical field too. This include socially specialized lexic units. In
the conversion of speech participants practicing certain field's representatives' special words, slangs indicate that they are in a one group and they are socially equal. Character (right) which was formed by human's job, position, adorenes identifies not only that person's duty (responsibility), but also his position along communicative act. Overall, in Uzbek language expression units of the social condition deixis are various, therefore when each of them are analysed deeply they could obviously give intriguing informations about not only pragmalinguistics, but also sociolinguistics of Uzbek linguistics' researches
We conducted a retrospective study of 75 cases of pregnancy and childbirth in women with obesity, which were divided into 2 groups: group 1 - 45 pregnant women with obesity and group 2 - 30 pregnant women with overweight. The control group consisted of 16 healthy pregnant women with normal weight growth rates. The effect of overweight and obesity in women on the course and outcome of pregnancy and childbirth was studied. In obese pregnant women, the risk of developing hypertensive conditions increases 3.5 times. Gestational hypertension was detected in 15.5%, and preeclampsia in 26.6% of obese pregnant women. Gestational pyelonephritis was detected in 20% of group 1 and in 10% of pregnant women in group 2. In women of the 1st group, in 22% of cases, the pregnancy was terminated before 12 weeks. Physiological childbirth in patients of group 1 occurred in 68.5% of cases, and in group 2, it was 80%. The study of anthropometric data of newborns showed that 28.5% had an increased body weight, and 25.7% of newborns had indicators of a large fetus.
The aim is to study the review of the literature review on autoimmune thyroiditis and violations of the reproductive function in women of fertile age
Methods. In total, 100 cases of Ait in women of fertile age with various disorders of the menstrual function (MF) and the reproductive system (PC) were studied. The average age of women was ranging from 18 to 45 years (31.5 ± 0.4).
All 100 patients were performed by a study spectrum, including the study of endocrine status (anthropometric - height, weight, waist volume, thighs, body weight index), general crystal, biochemical, hormonal (TSH, LG, FSH, prolactin, estradiol, progesterone, free thyroxine, antibodies to TPO and other - in the laboratory of radioimmune hormonal studies of the RSNPMC Endocrinology of the Ministry of Health of Ruz. In addition, they performed an ultrasound study of the brief and genital organs, an ECG, as well as a study of the quality of life on the questionnaire of The World Health Organization Quality Of Life (WHOQOL -Qol).
Research results. Depending on the body mass index (BMI), the patients were distributed into 2 groups: 1 group - patients with ait with soblinic hypothyroidism -48 (48.0%) patients, 2 groups - patients with AIT with manifestic hypothyroidism - 52 (52.0%) patients.
In the structure of violations of MC in women, the 1st groups were allowed -24.6%, secondary amenorrhea -12.5%. These patients had a history of miscarriage (12.5%), stillbirth (14.6%). Violations of reproductive function were not observed.
In the structure of violations of the MC in women, 2 groups were an olnognosorya -59.6%, the metrrahny frequency is 21.2%, secondary amenorrhea -19.2%. For this category of patients, a high frequency of violations of the reproductive system (53.9%) is characterized, of which: primary infertility was observed in 40.4% of cases, secondary infertility - 13.5% of cases. These patients had a history of miscarriage (32.8%), stillbirth (39.8%), butorous prevention of the fetus (22.7%).
Conclusions. 1) The first stage in the treatment of menstrual disorders and infertility in women with ait should be the correction of excess body weight. 2) Most often, the violation of the MC and the reproductive function was observed in patients with ait and 1 degree of obesity than with ait and normal body weight.
The article examines women's problems - the status of women in the family and society, protection of their legitimate interests, employment, protection of motherhood and childhood, increasing the status of women in society in the years of independence, protection of their rights and interests. , labor. and improving living conditions has become one of the priorities and goals of public policy, and it is scientifically based that the problem of treating women has risen to the level of public policy and strategy. The factors determining the relevance of the topic are analyzed. The article highlights the attitude towards women in the renewed Uzbekistan, the essence of the state policy in the field of guardianship, aimed at comprehensive support of women. It is known that in recent years in the field of history, social philosophy, law, economics, pedagogy, such issues as treatment of women, gender equality, protection of the rights and interests of women, ensuring their social protection and employment, participation of women in internal and external migration have been considered. The scope of special research work is expanding. Problem-chronological, comparative-analytical methods of the occurrence of socio-historical events are based on a methodological approach that allows the synthesis of objectivity, accuracy and development, linking history and modernity, ensuring the unity of theory and practice, a theoretical and methodological basis. research based on the formation of such scientific principles as interdependence, structure, development in development.
The results of a comparative study of the oral cavity of pregnant women with hypertrophic gingivitis and without inflammatory diseases of the oral cavity (ESD) were studied on the example of the Samarkand region as a risk factor for the development of hypertrophic gingivitis in pregnant women. It has been shown that during pregnancy, the negative influence of local factors of hypertrophic gingivitis significantly increases. Keywords: hypertrophic gingivitis, pregnancy, dental indicators, risk factors Despite numerous studies, the etiology of inflammatory periodontal diseases in pregnant women has not been sufficiently studied. Thus, the prevention, diagnosis and treatment of gingivitis in pregnant women remains insufficiently effective. In addition, many medications and effects cannot be used during pregnancy (or perhaps, but there is only a risk comparable to the health of a mother with gingivitis).The fruit depends on the means used). On the other hand, hypertrophic gingivitis negatively affects the course of pregnancy and increases the likelihood of perinatal complications [1,2]. In particular, periodontitis often contributes to premature birth and intrauterine infection of the fetus, since it complicates the course of pregnancy and is a focus of infection in the mother's body.[3] Many inflammatory diseases have regional peculiarities of development, course and treatment related to its iodine state, the state of ecology, the epidemiological situation and the organization of medicine, as well as the genetic characteristics of the population of this territory [4,5]. It is reasonable to assume the presence of such signs in hypertrophic gingivitis. However, at the moment there are no special publications dedicated to this disease in the Samarkand region.
This research is about the development of an important part of Chinese literature -women’s literature in XX century. In the beginning of XX century the number of women writers who wrote fiction works increased rapidly. The uneasy situations of the country such as revolutionary movements in the beginning of XX century, China-Japan war, monopole government of Mao Zedong, persecuting the democratic movements, deporting intelligent people to the “re-educating” camps and other conditions were not able to obstacle the women to enter the literature world. On the contrary, interfering of women in social-politic life of the country got stronger in the second part of the XX century. The various movements of women, journals and newspapers and societies of women were organized. The role of women in social life became more noticeable and women literature developed more. Women writers such as Bin Sin, Lin Shukhua, Lu In, Din Lin, Syao Khun, Shi Pinmey, Dzao Min, Lyui Bichen, Chjan Aylin got an important place in social-politic and moral-cultural life of the country with their works. Many of these women participated actively in literary processes and public events. In this article some of the mentioned women writers’ life and work will be discussed in detail. The women writers mentioned in this article are confessed not only in China, but also in the world’s literature. The problems risen in women’s works, the real events described by them play a significant role in gaining more knowledge about the history of China in the first half of XX century and enriching our imaginations regarding to literature processes.
Thyroid function disorders are the most common pathology of endocrine glands, which has a significant
impact on the physical and mental development of children.
Diagnosis of thyroid pathology in newborns and infants is very difficult. They are caused by peculiarities of
functional activity of the thyroid gland in newborns and infants, postnatal modifications of pituitary-thyroid
system, as well as numerous "masks" of other pathological processes, under which thyroid pathology can
hide. In addition, the formation and functional activity of the child's thyroid gland is closely related to the
health of the mother and the course of pregnancy. Transient neonatal hypothyroidism (TNH) is reversible,
and thyroid function subsequently recovers, but intellectual development disorders remain lifelong.
Unfortunately, data on the consequences of neonatal transient hypothyroidism are rather fragmentary and
contradictory. Aim. The aim of the present study was to investigate the features of mental development in children with
congenital transient hypothyroidism during the neonatal period.
Material and Methods: clinical-psychopathological, clinical-catamnestic, experimental-psychological and
statistical research methods.
Results. Based on learning and applying research methods, were first studied long-term results of neonatal
transient form of hypothyroidism to 11 years. The validity of the timely use of thyroid drugs in combination
with neuroprotective showed efficiency.
Conclusion. Given the paramount role of thyroid hormones in the formation and maturation of the nervous
system in children, the special significance of transient hypothyroidism among other endocrinopathies of
newborns and children becomes obvious, which necessitates its further study.
Economic and political situation in the world is changing rapidly and these changes generated pathway for women to running a business. Even though women headed business increasing and contribute large portion to the national economy, they have problems for balancing work family conflict for the success of their business. Research objective is to investigate the impact of work-family issues for the success of women entrepreneurs’ in Sri Lanka. Women entrepreneurs selected from the VIDATHA program, Central Province, which was initiated by the Ministry of Science, Technology and Research in mid-2000. Simple Random Sampling method used to select women entrepreneurs and sample size is 65. According to the results, Women entrepreneurs face problem with balancing a role as fulfilling parental responsibility and role as a homemaker. During the start-up pace they have problem with inadequate capital for investing their business. Further on going period they faced cash-flow problem which is difficult to manage working capital. They have barriers for investing money for their business. All the respondents’ success due to their hard work which done on behalf of their business and good family support other than the Children because most of women entrepreneurs were having children who were schooling and it is a barrier for them. Among the all respondents most of them were created/pull entrepreneurs. Moral support, financial management training, and training on commercialization is necessary for them.