Clinico-laboratorial part of the work is based on a survey of 96 patients with chronic generalized periodontitis (CGP). 22 people of the patients have chronic generalized periodontitis mild (HGPM), patients with chronic generalized periodontitis average degree (HGPA) and chronic generalized severe periodontitis (HGSP) 42 and 32 people respectively, combined with hypothyroidism. For objectification of the clinical research of the periodontal tissues, we used indicators such as the periodontal index, papillary-marginalalveolar index and the index of Ketze. For aexact determination of the intensity of the inflammatory process
used Schiller-Pisarev trial. To measure the depth of periodontal pockets also held X-ray examinations. It was found that a significant activation of lipid peroxidation and reduced antioxidant defense observed in patients with severe CGP on the background of hypothyroidism. It is shown that thyroid dysfunction occurs pronounced activation of the immune system, manifested by increased levels of cytokines in the serum. The highest concentration of TNF, IL-1 and IL-4 were detected in patients with moderate CGP thyroid hypofunction.
The influence of stimusol (extract radix Glycyrrhiza+mumie) on lipid peroxidation processes and
synthesis of gall m the liver at chronic toxic hepatitis were researched. It was determined that stimusol during
chronic poisoning with heliotrine made antioxidant and choleretic action. Normalize of gall contains. It didn't
give up to famous, silibor by hepatoprotector action
The article highlights the assessment of cognitive impairment in chronic cerebral ischemia and the treatment of these disorders. A study of the cognitive sphere of 40 patients with chronic cerebral ischemia (CHCI) of stage 1-2 was carried out. It was found that active systematic metabolic therapy in patients with Mexidol ® can reduce the severity of cognitive impairment, anxiety and depression.
Urticaria is an allergic disease characterized by the appearance of blisters on the skin and mucous membranes. The disease can be caused by external factors (temperature, mechanical, chemical) or internal (diseases of internal organs, disorders of the nervous system). [1, 2]. Allergies can be caused by toxins, bacteria, and undigested food. In the diagnosis of the disease, anamnestic data, dermography and various skin allergological tests are used. There are acute (up to 6 weeks) and chronic (more than 6 weeks) urticaria. The latter is characterized by daily or frequent symptoms (blistering, itching, angioedema for 6 weeks or more [3, 4]. During life, 0.5-1% of the entire population of people suffers from chronic urticaria. At the same time, if acute urticaria is usually associated with the action of exogenous factors and allergens (food, medicines, insect bites, etc).
Tonsillitis is a common and frequent disease in childhood, divided into acute tonsillitis and chronic tonsillitis. Acute tonsillitis is caused by pathogens invading the tonsils. Symptoms: fever, cough, sore throat, fever in severe cases, difficulty swallowing, and examination reveals the tonsils are hyperemic, swollen and festering. The tonsils have acute attacks more than 4 times a year, which can be diagnosed as chronic tonsillitis, mostly caused by pathogens in the fossa of the tonsils. On examination, hypertrophy, hyperemia or secretion of the tonsils and enlargement of the submandibular lymph nodes can be seen.
This research aimed to study the nature of pathomorphological changes in the kidney in chronic alcoholism in rats. In the present study, we have studied experimentally the nature of pathomorphological changes in the kidneys in chronic alcoholism in rats. The longer the intoxication is, the more the kidneys are damaged and homeostatic shifts are more pronounced in young animals. In an experiment on rats, it was found that taking ethanol orally has a short-term effect on kidney tissue and affects water-salt metabolism. Histologically, there are foci of acute inflammation of nephrocytes, spasm of small arterioles, and on the 15th day, atrophic changes in the renal parenchyma. Long-term alcohol intoxication (AIM) leads to persistent morphological disorders of the nephron, which are manifested in changes in the shape and size of the glomerulus, partial sclerosis of loops, vacuolar dystrophy of endothelial cells and partial vacuolar dystrophy of the tubular epithelium, especially the distal part.