Проблема изучения гендерных особенностей и качества жизни при ревматоидном артрите является одной из актуальных в ревматологии. Ревматоидный артрит (РА) – широко распространенное аутоиммунное заболевание неизвестной этиологии, характеризующееся хроническим эрозивным артритом (синовитом) и системным поражением внутренних органов, приводящее к снижению качества жизни и функциональных возможностей. Женский пол является фактором риска ревматоидного артрита. Женщин с РА в 2,5 раза больше, чем мужчин. Известно, что половой диморфизм РА у мужчин и женщин проявляется различиями в частоте метаболического синдрома, венозных тромбозов, развитии вовлечения в патологический процесс легких, однако не установлено влияние гендерных особенностей на клиническое течение и качество жизни пациентов с РА.
Ювенильный ревматоидный артрит – артрит неустановленной этиологии, длительностью более 6 недель, развивающийся у детей в возрасте до 16. Одним из ведущих звеньев патогенеза являются иммунопатологические процессы, развивающиеся вследствие дисрегуляции клеточного и гуморального иммунитета.
Among rheumatic diseases reactive arthritis occupies one of the leading places in terms of prevalence and it is one of the most common chronic inflammatory joint diseases. When the process is chronic, destructive processes in the joints develop up to ankylosing. This article presents the results of studies on the features of the clinical course of reactive arthritis of post-enterocolitic and urogenital forms. The study was carried out in 120 patients with an established diagnosis of reactive arthritis.
The article presents the results of a study of 189 children with juvenile idiopathic arthritis. The results of the study show that the prevalence of oligoarthritic (33.8%), polyarthritic (32.8%) and systemic (27.5%) forms of diseases is observed in the frequency of occurrence of various forms of juvenile idiopathic arthritis. In children, juvenile idiopathic arthritis can debut at any age and is characterized by varying degrees of arthritis activity, and the systemic form of the disease is characterized by the predominance of systemic manifestations, severe course of the disease and frequent relapses.
Ювенил ревматоид артрит (ЮРА) - бу бўғимнинг оғир деструктив-яллиғланиш касаллиги бўлиб, 16 ёшгача бўлган болаларда ривожланади ва ногиронликка олиб келади.ЮРА ташхиси клиник белгиларга, рентгенологик текширув маълумотлари ва лаборатор текширув натижаларига асосланиб қўйилади. Мазкур касалликнинг асосий клиник белгиси артрит ҳисобланади. Болаларда кўпроқ катта ва ўрта ўлчамдаги бўғимлар, умуртқанинг бўйин қисми, жағ бўғимлари зарарланади.
The aim of the study is to identify the frequency of hemodynamic disturbances: left ventricular (LVDV) and right ventricular (VVD) dysfunction and to study the relationship with markers of inflammation in patients with RA and secondary OA. In 38% of patients with RA and secondary OA, LVDD was detected, in 15.5% - RVD. RVD are found mainly in combination with LVDD with a predominance of the first (I) type of LVDV. It was found that in patients with RA and secondary OA, the incidence of LVDV and RVD is high; therefore, CVS damage in RA and secondary OA is ubiquitous and is closely related to the activity of the inflammatory process and traditional risk factors.
Subject of the inquiry: 116 patients with rheumatoid arthritis of the hand joints and 25 healthy subjects.
Aim of the inquiry: improvement of the diagnosis of rheumatoid arthritis of the hand joints using sonography and magnetic resonance imaging.
Methods of inquiry: X-ray, sonography, magnetic resonance imaging and magnetic resonance imaging with contrast enhancement.
The results achieved and their novelty: For the first time data were presented on the role of sonography, magnetic resonance imaging and magnetic resonance imaging with contrast enhancement in the diagnosis of rheumatoid arthritis of the hand joints. The findings have shown that sonography in hand joint rheumatoid arthritis allowed detection of changes in soft tissues, synovial capsule, joint surfaces and ligaments. Diagnostic value was given of sonography in revealing characteristic sonographic signs of rheumatoid arthritis. Magnetic resonance imaging was highly informative radiological method to detect synovitis, changes of synovial capsule and subchondral cysts. Magnetic resonance imaging with contrast enhancement reliably detected the degree of activity and severity of the rheumatoid process.
Practical value: consisted in revealing and describing characteristic sonographic and MRI signs of hand joint rheumatoid arthritis and in the developed radiological algorithm of the disease.
Degree of embed: the results of the investigation were introduced in the practice of rheumatology and radiology departments of the First Tashkent Medical Institute, in teaching process of the Radiology Chair of the First Tashkent Medical Institute.
Sphere of usage: radiology, rheumatology, traumatology and orthopedics.
Ювенильный ревматоидный артрит (ЮРА) - хроническое воспалительное заболевание суставов, неустановленной причины, длительностью более 6 недель, развивающийся у детей в возрасте не старше 16 лет. Хронические воспалительные заболевания суставов развиваются в любом возрасте. Среди них ювенильный ревматоидный артрит является одним из наиболее значимых и прогностически неблагоприятных заболеваний, приводящий к инвалидизации в детском возрасте. Заболеваемость ЮРА - от 2 до 16 человек на 100 000 детского населения в возрасте до 16 лет. Распространенность ЮРА в разных странах - от 0,05 до 0,6%.
Ревматоидный артрит - наиболее часто встречающееся патология, среди системных заболеваний. На сегодняшний день частота встречаемости ревматоидного артрита резко выросла среди детей и подростков.
Objects of inquiry: 107 women with rheumatoid arthritis in climacteric period.
Aim of inquiry: studying clinical-immunologic and roentgenologic indices in females with rheumatoid arthritis in connection with climacteric periods and perfecting therapeutic approaches.
Methods of inquiry: clinical studies, assessment of pain syndrom under visual analogous scale (VAS), determination of pro-inflammatory cytokins in blood scrum, roentgendensitometry, determination of body mass index, gravity of climacteric syndrom under modified menopausal index, determination of osteosyndrom by Ritchie and Lee test.
Results achieved and their novelty: for the first time in RA women in climacteric an interrelation between clinical laboratory RA manifestations and an expression of reproductivity disorders has been revealed. An interplay between acute phase indices, rheumatoid arthritis and Lee test and grade of severity of climatcric period has been established. An intcraggravating effect of RA and climacteric syndrom was approved. Predictive valuable factors in RA women in climacteric were determined. Osteoporosis in females with RA was began earlier before climacteric, it lasted more pronounced with lowering mineral density of bones. An advancing lowering of mineral density of bones in RA began in climacteric was shown. Dependance between a level of pro-inflammatory cytokins and duration of disease has been revealed, and less expressed regression of IL-ip indices in women with preserved menstrual function. Recommendations for strategy of RA treatment in women in climacteric taking into consideration features of a course of disease were worked out.
Practical value: rocngcnometry in females with RA, determination of TNF-a, IL-ip cytokins, modified menopausal index by Kuppermann contributed to diagnosis and prediction, management of an adequate therapy. Using of plasmapheresis and climadinon in complex therapy of rheumatoid arthritis reduced manifestations of disease and climacteric syndrom.
An implementation degree and economic efficacy: results of studies were implemented into activities of the Republican Arthrology Center, Specialized Qualified Ambulance Treatment, departments of Rheumatology, Cardiorhcumatology, 1st clinic of the Tashkent Medical Academy, in teaching process on a department of Faculty & Hospital Therapy, Oriental Medicine and Internal Diseases of the medico-preventive faculty.
A field of application: Internal Diseases, Rheumatology