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The real intellectuals have always left a deep mark on the spiritual life of their people. They even laid down their life on this way. Especially, in the former Soviet state, where was ruled under a totalitarian regime, these nationalist, truthful intellectuals were brutally banned. The history of the whole nation has been rewritten. In the words of the famous German philosopher K. Jaspers, the twentieth century was "the most enlightened and bloodiest century in human history." The policy of repression had a profound effect, especially on the social sciences. The course "Brief History of the CPSU (b)", which was based on the decisions of the party congresses, was served as the main methodological guidelines for the study of history.
Those who thought a little differently and more freely, were exiled to the GULAGs or shot with the label "enemy of the nation." The greats of Uzbek intellectuals such as Abdurauf Fitrat, Abdulla Qodiri, Munavvar Qori, Otajon KHashim, Bolat Soliev, Cholpon, Usmon Nosir and others were declared "enemies of the nation" on various political charges and slanders, and thrown into the mill of repression. The real nationalist intellectuals were turned into "enemies of the nation." Fear and dread reigned in the society. The domination of a single ideology regulated science and literature. "Velikorus" chauvinism and atheism climaxed. The members of the "the Ungodly Society " multiplied, and the Communists were proud of their atheism. Under the mask of pseudo-internationalism - proletarian internationalism, the regions and streets of Uzbekistan were named Kirov, Kuibyshev, Orjanikivze, Frunze. If we look at the roots of the terrible tragedies of the repressions that took place at that time, various aspects of the anatomy of the Totalitarian regime are revealed. In this regime, dictatorship, repression, terror prevailed, instead of democracy.
The article provides a review of the literature on the study of a new class of drug ARNI (angiotensin receptor neprilysin inhibitor) LCZ696 - thе combines a molecule of valsartan and an inhibitor of neprilysin sacubitrile in a molar ratio of 1: 1. The results of experimental and clinical studies on the use of ARNI in cardiovascular pathology are presented. The nephrological aspects of ARNI use in patients with chronic heart failure are also shown.
Ежегодно, во всем мире среди населения различного возраста отмечается регистрация более 100 миллионов случаев бронхо - легочными заболеваниями, таким как: острый, рецидивирующий и хронический бронхит, пневмонии. По статистическим данным высокий рост заболевания пневмонии отмечается среди детей дошкольного и школьного возраста, но и у взрослого населения.
The article presents the results of three-year experiments on testing insecticides in the fight against the codling moth and ticks. The best among the tested drugs were: insectoacaricide Bifenfos, 42% k.e. at a rate of consumption of 1.5 l/ha,
SUMMARY
The main industry in the economy of the Republic of Uzbekistan is agriculture. Modern technologies for the production of agricultural products, based on the widespread use of pesticides and mineral fertilizers, made it possible to largely solve the problem of providing the population with food, and, at the same time, gave rise to numerous environmental, medical and environmental problems, problems of ecologically pure and biologically valuable food, rehabilitation land, restoration of their fertility. Therefore, the arrival of new classes of pesticides with different mechanisms of action, high selectivity and low toxicity for warm-blooded animals is very modern.
Currently, the development and application of new plant protection products that are non-toxic to humans and animals is of global importance. Priority studies are aimed at creating plant protection products based on microorganisms and their metabolites, as well as the search for substances of plant origin with potential pesticidal activity, but at the same time, studies based on the development of pesticides based on chemical compounds that have high efficiency, selectivity to objects of use and rapid degradation in the environment.
Significant funds were allocated for the solution of these goals, support was provided to horticultural farmers and the result has borne fruit. Horticultural products from Uzbekistan are in demand on the world market. At present, the export of food, fruit and vegetable products totaled about $ 5 billion. Over the past three years, the volume of exported agricultural products has more than tripled. Our country sends to 80 countries of the world more than 180 types of selected fruits and vegetables and products made from them. Uzbekistan is among the top ten countries in the world - leaders in terms of exports of apricots, plums, grapes, nuts, cabbage and many other types of fruits and vegetables [9].
In the 21st century, in solving the food problem, FAO experts recognized the concept of integrated plant protection as the leading one [8].
To maintain the potential for environmental resilience of plants, including their resistance to pathogens, the use of pesticides should be minimized. Particularly dangerous for plants are organophosphate insectoacaricides, which can block the work of important redox enzymes responsible for environmental resistance, including pathogens.
Шаҳарлар йирик савдо марказлари сифатида ҳам муҳим аҳамият касб этган. XVIII асрнинг иккинчи ярми – ХХ аср бошларида шаҳар аҳолиси асосий қисмининг асосий машғулоти савдо-сотиқ эди. Воҳадаги энг йирик савдо шаҳри бўлган Қарши бутун Бухоро амирлигининг савдо алоқаларида катта ўрин тутган. Қарши шаҳри катта карвон йўлининг чорраҳасида жойлашганлиги туфайли бу йўл орқали шаҳар шарқ ва ғарб, жануб ва шимолий ўлкалар ва мамлакатлар билан доимий алоқада бўлган. Қарши шаҳри Бухоро воҳасини Шаҳрисабз ва Ҳисор билан боғлаб турувчи Бухоро амирлигидаги муҳим аҳамиятга эга шаҳар ҳисобланади.
The article examines theory and practice of the issue of the culture of using the Internet in dissemination of mass information. The creation of an international code of the Internet user is proposed.
SUMMARY
What is information? What role does it play in the life of the person? It is important to understand this point. Information is as crucial to him as food. It forms his second, spiritual life. There can be no social personality without social information. And a person is, first of all, a social being.
There are four links in communication process: source - information - channel - audience. In this article, we will consider all four parts with a special emphasis on the third one, the channel.
First of all, it is necessary that there is information itself, i.e. have something to say to others. It is a spiritual component that unites people. Secondly, there must be a desire to tell someone it. People often cannot keep any information in themselves and, like the legend of King Midas, feel an urgent need to tell someone it. Thirdly, there will always be people willing to listen to it. The need for information is an inescapable state of a person. Moreover, its absence can lead a person to moral degradation. No wonder one of the most difficult tests for astronauts is sensory deprivation, and in order to become applicants, one must pass this difficult exam. Sensory deprivation is an ability to survive a complete (emphasize - complete) lack of information for as long as possible or simply not to be moved by it. It is not as easy for a person as it seems at the first glance when there is absolutely no information. A complete lack of information seems to be a rest only in first minutes and hours - from the wife, mother-in-law, neighbor and friend. In a day or two person in this state, will feel anxiety and after another three or four days, irreversible changes may begin in his psyche. Hence there is a conclusion - the need for information is one of the most important qualities of an individual. Only thanks to it he preserves himself as a person.
Another link is information channel. This channel will be information space of the Internet in our dimension. It is a new and most important modern dimension of the global communication network. Finally, it is necessary to respect mass media as a value, sociological category, i.e. t is necessary to appreciate educational, pedagogical, aesthetic value of information.
Инсон туғилганидан бошлаб изланади. Изланаверади, изланаверади. Қадамлар секинлашади, сочларга оқ оралайди, тўкилади...Аммо умр сўнггида топгани бир ҳовуч ҳам чиқмайди. Сабаби? Сабаби минг битта. Чунки бу ҳаёт.Ҳаёт йўлида топганларимизнинг барчасида ҳикмат бор. Яхшиликлар бор. Яхши инсонлар бор.Ана шундай яхши инсонлардан бири Профессор Ўктам Маҳмасобирович Мавлонов
Purpose of the study: to study the effect of the combination of valsartan with sacubitril on myocardial remodeling in patients with coronary heart disease after revascularization. Material and research methods. The study included 320 patients with coronary artery disease who underwent coronary revascularization. On average, the concentration of creatinine was 90.08 ± 1.72 µmol / L. All patients were divided into 2 groups: patients who received valsartan (group B, 160 people), patients who received ARNI - a combination of valsartan and sacubitrile molecules (group C, 160 people). Also, all patients were divided into 2 subgroups depending on the degree of eGFR decrease by the 3rd month of observation: patients with a decrease in eGFR by the 3rd month of observation more than 20% (group 1 - 59 patients) and less than 20% (group 2 - 261 sick). In dynamics, three months later, at the end of the first and second years of follow-up after revascularization, all patients underwent an echocardiographic study (EchoCG). Research results. During the observation process, it was found that against the background of both therapy options, there was a positive dynamics of indicators characterizing myocardial remodeling. he relative dynamics of indicators between the treatment groups was comparable at all stages of observation. In the group of patients with a decrease in eGFR of more than 20% in the first 3 months against the background of standard therapy after revascularization, no significant dynamics of the geometric parameters of the heart was observed at all follow-up periods. In the group of patients who received standard therapy with the addition of sacubitrile, both in group 1 and in group 2, more favorable geometric parameters were achieved, demonstrating a decrease in the severity of pathological remodeling and the formation of CHF. Conclusion. The use of sacubitril in the treatment of patients with coronary artery disease contributes to a more pronounced positive remodeling of the heart chambers - a decrease in the size of the chambers and the LV sphericity index. The effect is more pronounced in patients with a tendency to rapidly develop CKD.
Purpose of the study. Determination of the clinical and pathogenetic characteristics of COVID-19 in the early rehabilitation period according to retrospective analysis
Material and research methods. A retrospective analysis of the case histories of 128 patients who underwent COVID-19 and persistent symptoms of the disease was carried out. The number and frequency of underlying diseases and clinical manifestations of various pathological syndromes were determined.
The results of the analysis of case histories of patients showed that 44 patients suffered moderate severity of COVID 19, 45 patients - severe, 39 - extremely severe. 40 patients were diagnosed with a lesion of 25% of the lungs or less (CT 1), in 43 patients - more than 25 to 50% of the lung volume (CT-2), in 32 patients - more than 50 to 75% (CT-3) and in 13 patients - more than 75% (CT-4). On average, the number of background pathologies was 4.53 ± 2.20. The average number of background diseases was significantly higher in patients of the older age group (p <0.001). In patients with severe and extremely severe infections diabetes and obesity were more common (p <0.05 for both comparisons). In the group of patients with moderate severity of infection, chronic viral hepatitis was more common (p <0.05). Clinical syndromes pathogenetically associated with an autoimmune inflammatory reaction were observed in 99 patients (77.34%), cell dystrophy - in 123 patients (96.09%), coagulopathy - in 73 patients (57.03%), fibrosis - in 44 patients (34.38%). Conclusion. According to the data of retrospective analysis, the average number of background diseases was significantly higher in patients of the older age group. Diabetes and obesity were more common in patients with severe and extremely severe COVID-19. In patients with moderate severity of infection, chronic viral hepatitis was more common. The pathogenetic syndrome of an autoimmune inflammatory reaction was observed in 77.34% of patients, cell dystrophy syndromes in 96.09%, coagulopathic in 57.03% and fibrosis in 34.38% of patients.
The article analyzes the shadow economy in certain areas of economic activity. The object of research is the sphere of trade and services. In order to create favorable conditions for the development of entrepreneurship, it is proposed to introduce modern information technologies into the settlement system in the field of trade and services