Тадқиқот мақсади тажрибада ҳайвонлари йўғон ичаги микрофлораси вакилларининг ошқозоничак трактидан организм ички муҳитига ўтишининг (бактериал транслокация) микробиологик жиҳатларини ўрганиш бўлди.Экспериментал тадқиқотлар 2-3 ойлик, 18-25 грамм оғирликдаги оқ, зотсиз сичқонларда (n=115), динамикада ўтказилди. Тажрибаларда қуйидаги микроорганизмлар авлодлари штаммларидан фойдаланилди: Escherichia spр, Proteus spр, Enterobacter spр, Staphylococcus spр, Streptococcus spр, Enterococcus spр, Salmonella spр, Schigella spр. Культуралар идентификацияси Bergey's (1997) бўйича олиб борилди. Корреляцион таҳлил натижалари шуни кўрсатдики, бактерияларнинг организм ички муҳитига (қон) ўтиши (транслокация) уларнинг йўғон ичакдаги концентрациясига тўғри ва кучли боғлиқликка эга (ρ=0,85).
The goal was to assess the microbial landscape of peripheral blood and peritoneal fluid of laboratory animals in experimental intestinal obstruction. It was found that in the case of experimental obstruction of the small and large intestines, few microorganisms were sown in the peripheral blood, and there were no noticeable changes in the microbial landscape depending on the time of obturation. In both models, microorganisms were seeded in the peritoneal fluid by an order of magnitude greater than in the blood, and the microbial landscape was diverse.
The aim was to study the germination of microorganisms in the mesenteric lymph nodes, liver, spleen, lungs, peripheral and portal blood, peritoneal exudate to assess the intensity of bacterial translocation (BT). It was established that in experimental acute obstruction of the small and large intestines, the intensity of BT or the percentage of germination of microorganisms from the extraintestinal organs of animals was most pronounced in mesenteric lymph nodes and the liver. The intensity of BT was directly proportional to the duration of the experiment.
Целью исследования было изучение микробиологических аспектов переноса (бактериальной транслокации) представителей кишечной микрофлоры животных из желудочно-кишечного тракта во внутреннюю среду организма.
This article presents a brief review of sepsis/SS, reflecting the unresolved issues of pediatric sepsis and the results of our own study of surgical sepsis in children. Optimization of diagnostics and schemes of pathogenetic intensive therapy of surgical sepsis in children based on clinical and laboratory criteria and
bacteriological monitoring. Research period - 2018-2020. The subject of the study (n=73) was children with surgical pathology (widespread peritonitis, bacterial destruction of the lungs, post-traumatic brain hematomas, trauma to the abdominal organs, etc.). Studies have shown the effectiveness of complex intensive care in 86.3% of cases. Mortality was stated in 13.7% of cases. Patients with severe surgical pathology died: fecal, widespread peritonitis, severe TBI + coma with irreversible neurological disorders, urosepsis against the background of chronic renal failure, after repeated surgical interventions, due to the development of refractory SS.
Бактериальная/грибковая коинфекция - в настоящее время рассматривается как важнейшее осложнение COVID-19 в полости рта [2]. Предполагается, что росту грибковых инфекций у пациентов, страдающих COVID-19 и госпитализированных в отделение интенсивной терапии способствует использование антибиотиков и кортикостероидов широкого спектра действия, интубация и фоновая соматическая патология, на этом фоне у пациентов обнаруживаются лимфоцитопения, цитокиновые штормы, которые приводят к ослаблению иммунитета, может позволить Candida проявлять факторы патогенности [1,6,11].
BACKGROUND: Sepsis is one of the leading causes of hospital mortality in children. a decisive role in improving the results of treatment of this group of patients belongs to early diagnosis and pathogenetic therapy. AIM: this study optimizes the diagnosis and intensive care of surgical sepsis in children based on clinical and laboratory criteria and bacteriological monitoring.
MATERIALS AND METHODS: the study period is 2018–2020. the study subjects were children (n = 73) with surgical pathology (diffuse purulent peritonitis, bacterial destruction of the lungs, post-traumatic brain hematomas, injuries of the abdominal organs, and others). clinical and laboratory parameters were analyzed, and microbiological monitoring was performed to determine antibiotic sensitivity.
RESULTS: Patients who developed sepsis had a pronounced hypermetabolic syndrome, which was manifested by tachycardia and tachypnea, hyperthermia, low levels of albumin, and total protein in the blood. Protein catabolism in patients was accompanied by a decrease in globulins (IgG) synthesis and the development of a secondary immunodeficiency state. Both gram-positive and gram-negative microorganisms were involved in developing surgical sepsis in children, increasing the proportion of the latter. Given the high proportion of multi-resistant flora, empirical combined de-escalation antibiotic therapy (aBt) with broad-spectrum antibiotics was prescribed. this was followed by its revision based on microbiological monitoring and clinical and laboratory data of the patient with sepsis. Studies have shown the effectiveness of complex intensive care in 86.3% of cases. Mortality occurred in 13.7% of cases. Patients with severe surgical pathology died: fecal, generalized peritonitis, severe traumatic brain injury + coma with irreversible neurological disorders, and urosepsis against the background of chronic renal failure after repeated surgical interventions.
CONCLUSIONS: early diagnosis of sepsis, rational aBt under the control of microbiological monitoring, non-aggressive infusion therapy, and active sanitation of the surgical infection focus contributed to a decrease in mortality in this category of patients.
Diabetes mellitus is a common endocrine disease, which belongs to the risk factors for the development of changes in periodontal tissues. The presence of diabetes mellitus in patients can cause the development of structural and functional changes in the maxillofacial area, and also increase the risk of changes in the tissues of the parodontium. At the same time, the nature of these changes and the degree of influence of diabetes mellitus on the state of the tissues of the parodon are 46 insufficiently studied. In this regard, it is necessary to pay great attention to this problem in order to provide timely assistance to these patients in order to avoid rather serious complications
Purpose of the study. Evaluation of the effectiveness of early diagnosis and intensive care of surgical sepsis that developed against the background of bacterial destruction of the lungs in children based on a comprehensive analysis of clinical, laboratory, bacteriological criteria and the pSOFA scale. Materials and methods. The study period is 2019. - March 2021 The object of the study (n=24) were children with surgical pathology (bacterial destruction of the lungs). Results. The effectiveness of complex intensive therapy for surgical sepsis was noted in 91.6% of cases. In 2 cases, young children died as a result of delayed diagnosis and admission with BDL, pulmonary-pleural-mediastinal form, due to the development of refractory septic shock.
Klinik amaliyotda stomatologlar ko'pincha endodont va parodont to’qimalarining birlashgan zararlanishiga duch kelishadi. Ushbu holatlar endodontoperodontal shikastlanishlar (EPSH) deb ataladi va endodont va parodontdagi yallig'lanish va destruktiv o'zgarishlar bilan kechadigan parodontal kasallikning kombinirlangan shikastlanishini anglatadi. Ushbu murakkab patologiya shifokor uchun diagnostika nuqtai nazaridan muhim muammolarni keltirib chiqaradi va ularning klinik ko'rinishlari, endodontiya va parodontologiyada diagnostika va davolash tamoyillari to'g'risida keng bilim va tushunishni talab qiladi. Parodontal to'qimalarda yallig'lanish jarayoni tishlarning pulpasiga sezilarli ta'sir ko'rsatadi: II darajali umumiy parodontit bilan pulpada qaytarilmas o'zgarishlar tishlarning 54-56 foizida aniqlangan. Parodont, pulpa va periodontdagi surunkali yallig'lanish odontogen o'chog’i sifatida qaraladi, bu esa o'z navbatida surunkali stomatogen o'choqning tarkibiy elementi hisoblanadi. Ushbu muammolarni hal qilish bu sohadagi tadqiqotchilar uchun dolzarb hisoblanadi.
Optimization of diagnostics and schemes of pathogenetic intensive therapy of surgical sepsis in children based on clinical and laboratory criteria and bacteriological monitoring.Materials and methods: The research period is 2018-2020. The object of the study (n=73) – children with surgical pathology (widespread peritonitis, bacterial destruction of the lungs, post-traumatic brain hematomas, abdominal trauma, etc.). Research methods: microbiological monitoring to determine the sensitivity of the micro-organism to antibiotics was carried out before and at the stages of treatment (sputum, urine, wound, bron-choalveolar lavage, tracheal aspirate, blood, contents from drainages, wound surface). Determination of the sensitivity of the isolated strains to antibiotics was carried out by the disk-diffusion method. To determine predictors of sepsis in surgical patients, clinical (mean arterial pressure (mAP), heart rate (HR), respiratory rate (RR), SpO 2 , etc. and laboratory parameters on days 1–2 (up to 48 hours) of sepsis identification, days 4 and 8 of intensive therapy. Procalcitonin was determined by immuno-fluorescence on a Triage® MeterPro analyzer (Biosite Diagnostics, USA). Blood gases and electrolytes were analyzed using a Stat Profile CCX analyzer (Nova Biomedical, USA). Results: studies have shown the effectiveness of complex intensive care in 86.3 % of cases. Mortality was found in 13.7 % of cases. Patients with severe surgical pathology died: widespread peritonitis, severe TBI + coma with irreversible neurological disorders, urosepsis against the background of chronic renal failure, after repeated surgical interventions, due to the development of refractory septic shock (SS).
Conclusions. Early diagnosis of sepsis, rational early ABT under the control of microbiological monitoring, non-aggressive infusion therapy with early prescription of vasopressors (SS) with constant monitoring of the child's main life support organs contribute to an improvement in sepsis outcomes and a decrease in mortality
Эндодонто-пародонтальные поражение - это совокупность поражения пульпы и тканей пародонта.В современной стоматологии данное поражение является серьезной проблемой, так как требует от врачастоматолога определенных знаний не только в области эндодонтии, но и в области пародонтологии.