The analytical article determines the formation of trends, the main directions, prerequisites and factors that influence on the Uzbek-Japanese cooperation. The condition and prospects of its development are also revealed. An analytical study based on a systematic approach, where Uzbek-Japanese cooperation is considered as interconnected elements of modern international relations. This approach allowed to perceive the internal laws of the development of international relations of the Asian continent in which Uzbekistan is the leading element in Central Asia and Japan in the East. The application of the logical-historical approach gave a chance to disclose the content, nature and of dynamics of development of bilateral relations. Depicted the condition and practical action, Japan's interests in expanding cooperation. Relations in the spheres of trade, economy, the cultural and humanitarian contribute to the transformation of Central Asia into a stable developed economic space. In order to achieve the goals and objectives, the author thoroughly analytically processed the facts, events, processes, as well as the speeches of leaders, politicians who have effect on bilateral relations between Uzbekistan and Japan. The content of agreements, treaties, memorandums signed between the two countries is analyzed. The results of an analytical study show that, firstly, Japan is a strategic partner of Uzbekistan. This determines the priority and role in the relationships. There exist historical bilateral ties which have geopolitical and geostrategic meanings in international relationships in the Asian region. Secondly, bilateral cooperation is developing gradually and growing into a new stable stage which contributing to the emergence of a new level of relationships. The effective use of untouched potential of Japan, which contribute to the social and economic development of Central Asian states, will further contribute to the integration of the region into the system of trade, economic and transport of the world. In addition, these processes require systematic and strategic researches that identify and determine the prospects for the development of bilateral and multilateral relationships between Uzbekistan and Japan.
The purpose of the study was to determine and evaluate the features of morphological changes in the liver parenchyma of 5-month-old white outbred rats under the influence of anti inflammatory drugs under conditions of polypharmacy.
The object of study for experimental studies was taken 250 white male rats weighing 200-250 g.
The scientific novelty of the research is as follows: polypharmacy of anti-inflammatory drugs negatively affects all parameters of liver structures. Under the influence of polypharmacy, there is a decrease in the absolute mass of the liver, volume and morphological parameters of the liver parenchyma. The decrease in morphometric parameters depends on the number of drugs in polypharmacy; under conditions of polypharmacy, the state of the hepatic capillaries and internal bile ducts, as well as biological membranes, was studied, as a result of which the structural structure of the liver, the development of destruction of the hepatic tissue were studied, and the morphofunctional foundations of this condition were shown.
Implementation of the research results. Based on the obtained scientific results, the morphofunctional characteristics of the liver of rats in the norm and under the influence of polypharmacy were determined:
Approved methodological recommendations: "Methodology for determining the morphometric parameters of the liver during polypharmacy of anti-inflammatory drugs" (Conclusion No. 8n-r / 265 dated 14.03.2022 of the Ministry of Health of the Republic of Uzbekistan) and "Methodology for determining the morphometric parameters of the liver during polypharmacy of anti-inflammatory drugs" (Uzbekistan, Conclusion of the Ministry of Health of the Republic of Uzbekistan No. 8 n-z 180 of 2022), electronic program No. DGU 1038 "Program for studying the comparative characteristics of morphological changes caused by polypharmacy in the liver."
The scientific results obtained in the study of morphological and functional properties and morphometric changes in the structure of the liver under the influence of polypharmacy have been introduced into the practice of the Samarkand branch of the Republican Specialized Oncological and Radiological Scientific and Practical Medical Center of the Samarkand City Medical Association (Order of the Ministry of Health of the Republic of Uzbekistan dated March 14, 2022, 8n-r / 265-No. and conclusion No. 8 n-z 180 of 2022). The implementation of the obtained research data allows developing methods for early diagnosis, treatment and prediction of organopathology by morphological parameters, improving the quality of life and reducing the number of complications.
The structure and scope of the dissertation. The structure of the dissertation consists of an introduction, three chapters, a conclusion and a list of references. The volume of the dissertation was 103 pages.
This article provides a detailed description of the problems of increasing the efficiency of the training system of highly qualified boxers and increasing their sports results, the factors determining their individual activity style are analyzed, and individual programs for increasing the reliability of the competitive activity of boxers with different characteristics are proposed.
In the literature, in the process of a new creative approach to the mythological image, the plot, of course, lies the religious worldview and the oral tradition of the people. In the literary process, the creative approach to myths has been unique in each period. In modern Arabic prose (the second half and the end of the twentieth century), especially in storytelling, new artistic researches have emerged in mythological images and plots, legends from religious sacred sources, and creative approaches to stories about the lives of prophets. In Egyptian literature, this trend is also called " رايت ةيروطسلأا " "mythological current". In the stories of this story, fantastic, mysterious, strange elements are included in the text of the work and blend with the real reality. In modern Arabic literature, Najib Mahfouz, Yusuf Idris, Diya al Sharqavi, George Salim, Munir Uteiba, Zakaria Tamer, Abdurahman Majid ar-Rubeyi, Muhammad Shalan, Ibrahim Aslan, and a number of other writers have written mythological and religious references to books. As a result, they created their own works with a unique style. In this article, the Egyptian writer Munir Uteiba's story "Warning" is characterized by its intertextuality, which uses the ancient myths of the Indian people to reveal the modern image of man, its moral and spiritual flaws and flaws. Keywords and phrases: creative process, myth, mythology, folklore, myth, mythology, mythological current, intertextuality, mythological image.
This article provides analytical information on the use of 3D technologies in the education system, the introduction of digital technologies and the possible results to improve the quality of teaching through an individual approach to students using 3D resources.
In this article analyzed the individual measures to prevent the victimization of violent crime against the person. It also includes the opinions of scientists on the issue, given appropriate suggestions and recommendations
This article widely covers students of higher medical education and their individual psychological characteristics, including the influence and characteristics of reflexive components in the implementation of individual capabilities.
Ушбу мақолада бошланғич синф ўқитувчиларда рефлексив кўникмаларни шакллантириш жараёнларини ташкил этиш ва бошқариш функциялари ахборотларни таҳлил қилиш ҳамда ҳамкорликдаги фаолиятда субъект муносабатларига устуворлик бериш асосида такомиллаштириш тўғрисида айтиб ўтилган.
The review article analyzes the diagnostic approach to cardiac surgery in children with congenital heart disease. Various methods of behavior of inhalation anesthesia with an assessment of prognosis, using a set of diagnostic measures, are described.
Topicality and demand of the subject of dissertation. Researches of human population genomic variety and scenarios of its genetic pool formation arc one of perspective directions of modem genetics. Prompt progress in this field has allowed defining the basic routes of continents settlement. However the information about Central Asian (CA) populations even on «classical» genetic markers has accidental, fragmentary character, and requires additional large-scale investigations. Besides, according to historical, archeological, paleontological and some anthropogenetic studies, given region was playing certain role in ancient moving of modem human ancestors throughout Eurasian continent. Therefore it is extremely important to summarize and perform complex assessment of new and collected data on Central Asian populations as practically there arc no multivariate analyses studies of given region as a complex population system.
In studies of human population genetic structure arc usually used various approaches allowing understanding concept of populations subdivision and character of genetic relationships between them. Among these techniques the prominent place belongs to approaches based on an assessment of genetic distances between populations with their subsequent analysis by multivariate statistics methods. For even more compelling picture of the relationships between the populations on tree diagram we composed «the genetic landscape» of area, where the description of population genetic structure is presented by equally spaced figures consistently consolidating populations according to their genetic distances from each other and thus creating a genetic landscape. This approach is not only a tool for elementary population boundary detection, but also can be effectively used for identification of borders and sizes of population as naturalistic unit.
Multigcnctic landscape is a collection of different genetic systems which arc specific to the region and ethnic groups, which have their geographical areas, their geographical, historical and cultural boundaries. Gene flows arc run through these conventional boundaries, but they arc less intense than in the limits of area. These limits arc ambiguous and fluid, but it is real. You can identify them by studying, for example, the structure of marriage migration. Therefore anthropogenesis of different populations will inevitably differ from each other. Ethnogenetic composition tends to change over time, from generation to generation, and hence there is a need to understand the structure of the genepool, not only at a given time, but also in the study of genetic processes that form and reform the gcncpooL In this regard, the studying of multigcnctic landscapes is in close contact with the demographics, medical and genetic ecology, anthropology, ethnology, archeology and history of the peoples, that is, with a range of areas, not only natural, but also the humanities knowleges.
Study of genomic diversity is important not only to address questions of origin and genetic history of different ethnic groups, but is also the basis for molecular epidemiology of hereditary and multifactor diseases. Each region is characterized by a specific set of common genetically determined diseases. To understand the causes of the prevalence of disease in different regions, and to develop approaches to their early DNA diagnosis and effective prevention, initially it is necessary to conduct population-based studies, which determine the development of the disease.
Purpose of research is to implement a comprehensive description of the structure of indigenous Central Asian populations genetic pool, examine demographic, phylogenetic and evolutionary features of Central Asian populations through the analysis of genetic variety of mtDNA, Y-chromosomal (NRY), autosomal, X-chromosomal microsatcllites and immunogcnetic variants of Helicobacter pylori (H.pylori) and hepatitis В virus (HB V).
To achieve this goal the following tasks of research is solved:
specification of immunogcnetic variants of H.pylori and HBV, allocated at the patients in Central Asian region, with the subsequent comparative phylogenetic analysis of H.pylori and HBV regional versions with those in other regions of the world;
examination of genetic variety and degree of genetic differentiation of Central Asian populations according to classical population-genetic objects -polymorphisms of mtDNA, Y-chromosomal, autosomal and X- chromosomal STRs;
assessment of the Western and East-Eurasian lines of population inheritance contribution to Central Asian populations’ genetic pool at regional, ethnic, sub-cthnic levels and in a level of elementary populations;
reviewing of character of regional populations relationships by genetic variety of mtDNA, autosomal, X-chromosomal, Y-chromosomal STRs markers in view of ethnographic, social and linguistic data;
evaluation of sex-specific genetic structure and the social organization according to polymorphisms of mtDNA, autosomal, X-chromosomal, Y-chromosomal markers in the region;
determination of ancient ways of migrations and scripts of formation of Central Asian populations according to mtDNA, autosomal, X-chromosomal, Y-chromosomal STRs markers and immunogcnetic variants of H.pylori and HBV',
evaluation of ethnogenetic position of studied Central Asian populations in the system of genetic pools of Eurasia and the world in general through comparative analysis of all studied population-genetic parameters.
Scientific novelty of dissertational research consists in the following:
for the first time was performed a study of genetic pool structure of 26 Central Asian populations from 6 ethnic groups as complete population systems using a wide range of genetic objects;
for the first time was made an assessment of informativeness of each type of genetic subjects. For the first time was received detailed characteristic of genetic pool structure of indigenous Central Asian population on the basis of variability lines of the spectrum of genetical objects;
for the first time was defined the ratio of Westem-and the East-Eurasian lines in a genepool of Central Asian population and were made an assessments of genetic variety level and genetic differentiation degree of regional populations as a whole;
for the first time phylogenetic analysis of major haplogroups of investigated genetic subjects was conducted;
for the first time the position of Central Asian population in population genetic pool system of surrounding regions and Eurasia in the whole was studied;
for the first time the evolutionary-adaptable mechanisms, necessary in the forecast of formations of multigenic pathologies in region were studied at 6 ethnoses of Central Asian.
CONCLUSION
1. H.pylori from Central Asian territory is similar to Western Europe isolates, and shaped by two ancestral populations genotype Ancestral Europe 1 (dominant) and Ancestral Europe2 and for AE1-genotype Central Asian region probably is the source. H.pylori from the territory of Central Asia form a separate cluster group: close relationship of Tadjik, Uzbek strains and Iranian isolates from the north of Iran is established. Kirghiz isolates were found to be closer to populations from territory of Siberia.
2. High diversity of HBV genotypes in Central Asia was found -4 genotypes (A, C, D, and G). Phylogenetic analysis of Central Asian genotype HBV-with options for other regions of the world showed a close relationship between the dominant genotype D (0,78), the D1-subtype with variants of the virus in Europe, the Middle East and Africa.
3. The rates of genetic affinity for STR-NRY in Kazakhs, Turkmens, Karakalpaks Turtkul at the level of the same lineage were high: 0,58 (p<0,001); 0,34 (p<0,01) and 0,77 (p<0,001), respectively. The coefficients of relationship at the level of clan for Kazakhs, Turkmens, Uzbeks and Karakalpaks from Kungrad and Turtkul were lower: 0,30 (r<0,01); 0,21 (p<0,001) and 0,40 (r<0,001); 0,07 (p<0,05) and 0,09 (p<0,05), respectively. At the level of the tribe, the indicators were negative for all Turkic populations: -0,02 (r<0,05);-0,04 (r<0,001);-0,07 (p<0,01); -0,0011 (r<0,1) and -0,10 (r<0,01), respectively.
4. The analysis of mtDNA HVS-1 showed that total rate of differentiation level for all populations was low: FST=0,013; p<0,0001. Level of diversity between groups was 0,6% (p<0,001) of the total variability. Parameter of genetic differences between Turkic and Indo-Iranian populations made 0,55% (p<0,0283) of the total genetic variability. The rate of genetic differentiation on a sub-ethnic level was significantly expressed in Indo-Iranian group (FST=0,0197;r<0,001) than among the Turkic-speaking (0,3%; p=0,10). In all populations, in general, wasn‟t detected the correlation between genetic and geographic distances at the global level on mtDNA HVS-1: r=0,00682; p=0,502.
5. Analysis of STR-NRY showed that the level of the genetic differentiation between ethnic groups was 5,6% (p<0,02); general differentiation between populations made RST=0,186 (p<0,001). Combined analysis, taking into account the language and way of life of Turkic and Indo Iranian populations, showed the general differences between the two groups – 9,1% Value of genetic differentiation when comparing the ethnos-ethnos was slightly lower than the level within ethnos: 5,6% among ethnic groups, 18,6%, and 13,7%-between populations within the ethnic group.
6. Analysis of heterozygosity (H) and the average number of pairwise differences (p) of mtDNA, were high in nomadic populations (av.H=0,99; av.p=5,29) and farmer populations (av.H=0,99; av.p=5,32). Heterozygosity (H) on Y- chromosome was lower in nomadic groups than in the agrarian – 0,86 and 0,99,respectively (p<0,01). Nomadic populations exhibit a higher level of population differentiation (RST) in comparison with farmers - 0,19 and 0,06, respectively (p<0,01). Indicators of population growth (r) were lower in nomadic populations compared with farmers - 1,004 and 1,008, respectively (p=0,056).
7. The level of genetic differentiation in all ethnic groups was higher on the Y chromosome in comparison with mtDNA. The farming populations showed no significant difference in the genetic differentiation FST (Y)=0,069 and FST (mtDNA)=0,034, while among patrilineal nomadic population the level of genetic diversity was higher in the male line of inheritance - FST(Y)=0,177 and FST (mtDNA)=0,010. Genetic diversity of population structure in patrilineal nomads on autosomal and X-linked markers were: FST (A)=0,008 (0,006-0,010) and FST (X)=0,011 (0,001-0,004) (H0: FST(A)=FST(X); H1: FST(A)>FST(X); p=0,02). In bilinear farmer populations the differences of autosomal and X-chromosomal markers were insignificant: FST (A)=0,014 (0,012-0,016) and FST (X)=0,013 (0,008-0,018 at p=0,36).
8. Analysis of mtDNA indicated that the age of expansion on the territory of Eurasia (τw) declined significantly from East to West (r=0,72; p<0,001). The age of expansion had a pronounced tendency to decrease from 30 thousand years in China to 17 thousand years in Western Europe. Age of expansion in Central Asia amounted to 26 thousand years. Results of expansion analysis on NRY also show a decrease in genetic diversity from the East to the West of Eurasia (r=0,49; p<0,001). In Central Asia this age was 16 thousand yrs. According STRs-NRYBatwing analysis of the minimal age of Uzbek population origin was 1232,71 yrs old (Ne=14088 (6765-23942); α=0,0108 (0,0065-0,0155)).
9. The apportionment of multilocus genetic variations among ethnic and linguistic groups of Central Asian populations showed that more than 98% of all variations were within the population (p<0,0001). Evaluation of the ethnic and linguistic affiliations in the observed variations showed reliable conformity - FST=0,007; p<0,0001 and FST=0,011; p<0,0001, respectively. We didn‟t find evidence of geographical isolation within each of the Turkic and Indo Iranian groups of populations (p=0,363 and p=0,772, respectively).
10. Analysis of multilocus allelic diversity (AR) and heterozygosity (He) showed differences among the Central Asian and other populations in allelic variety (χ2 =105,29; d.f.=25; p<0,0001) and heterozygosity (χ2=67,98; d.f.=25; p<0,0001). Population differentiation at multilocus analysis at populations of Central Asia is more pronounced than in the other regions of Eurasia: in European and Middle Eastern groups pairwise estimation of FST ranged from 0,011 to 0,015 and -0,008-0,021, respectively; in East-Asian groups from -0,011 to 0,046; and finally, in Central Asia these rates ranged from -0,004 to 0,056. Heterozygosity was significantly higher in the group of the Indo-Iranian populations than among Turkic-speaking (He=0,818 and He=0,787, respectively; Z=-4, 55; p<0,0001). According to multilocus analysis all 26 Central Asian populations slightly but significantly differed (FST=0,015; CI99%=0,011-0,018; p<0,01).
They related opinions about lexicology in linguistics to the study of word meaning. “... linguistic analysis of translation covers linguistic and speech factors. An integrated, structural-functional approach to the study of translation is in line with the development trend of modern linguistics, which is characterized by its refusal to limit its subject to the field of "internal linguistics" and considers language as a "form of activity." The thing in the universe, the event, the behavior are reflected as a concept in human thinking. They expressed the concept through the integrity of meaning and the form of action. Language represents being. Existence and language are inextricably linked. It is on the basis of these two concepts and a number of approaches to their relationship have emerged. Some linguists believe that language and being are inextricably linked, and that language represents the objective world. Some argue that language and being are separate concepts. They don't talk about animals, or they don't have mythical expressions, such as mermaids or giants in textiles, but they are expressed in language.
This article focuses on the methodological approach to the development of the philosophy of medicine, the methodological problems of medicine and the reforms carried out in the field of medicine today, as well as the philosophical issues of training qualified personnel in the field of medicine.
In the modern world, the principles of secular society dominate, on the one hand, and on the other, the process of the initial revival of religious consciousness, one of the ancient sources of popular culture. That is why religion has become a social institution on the agenda of many issues related to the role and status of modern society. Issues such as secularism, which implies the free, independent and independent activity of the spheres of public life. In this sense, this article is devoted to the analysis of this complex and controversial social process and its relevance. In the article, the term “secularization” occurs in terms of history and logic: the linguistic meaning of a word, its comparative and critical analysis of its definitions by various authors. At the same time, the objective and subjective factors behind the secularization process were uncovered. Specific examples of the sociocultural life of the West and the East are studied in detail and the content of the term "secularization" is defined. Particular attention is paid to the analysis of the views of modern philosophers on this issue, the analysis of theoretical views proposed by various academic schools. General and specific aspects of the description and approach are highlighted, the author’s own views on them are described and definitions of the concept of “secularization” are developed. Based on recent studies, general theoretical conclusions are given. As it is known, the secularization paradigms in the modern world are gradually changing. In this sense, secularization is not a feature of all societies. It should be noted that in the process of change, religious issues are at the center of public debate and, in some cases, at the center of controversy. However, secularization remains the core of the modern world, although religion is likely to occupy a huge space. Based on the above analysis, we can say that the processes of secularization are not based on a specific standard in different societies, and in each society there is a certain limit. Based on historical analysis, modern definition and description, secularization is a complex social process associated with the role of religion in society, and can be replaced by changing the order of religious traditions based on rational principles based on the principle of secularism.