Стоматологическая мембрана — специальная пленка, которая используется в стоматологической практике в качестве барьерного и фиксирующего материала в процедурах по имплантации зубов. Применение мембраны позволяет успешно бороться с атрофией кости, препятствуя ее потере, что в свою очередь создает благоприятные условия для проведения имплантации зубов.
Simblefaron is a scar fusion of the posterior conjunctival surface of the eyelid with the eyeball. It often develops as a complication of thermal burns of the eyes. Eye burns are severe damage to the organ of vision and occupy a significant share (6.9-30.5%) in the structure of eye injuries. The results of the study showed that the stage-by-stage surgical plastic surgery of the anterior segment of the eye performed by us, which consists in a combination of plastics of the fornix with flaps from the automucosal cavity of the mouth (lips) and transplantation of the amniotic membrane onto the surface of the cornea and conjunctiva with the capture of the limbal zone, allows you to eliminate the defect of the cornea and maintain its transparency and also contributes to the restoration of the conjunctival arches, which can significantly reduce the likelihood of developing complications of burn injury and shorten the rehabilitation period, improve the functional results of treatment.
The purpose of the study is to determine the significance of genetic factors in the development of chronic nephritic syndrome in children and to clarify the features of the clinical course
The оbject of research were 129 children aged 4-15 years who were treated for chronic nephritis in the nephrology department of the Samarkand Regional Multidisciplinary Paediatric Medical Centre.
The scientific novelty of the study is as follows:it has been established that the severity of chronic nephritic syndrome in children is associated with clinical manifestations (gradual development, dyspepsia, abdominal pain) and an increase in the amount of Cystatin C in the blood;for the first time, it was revealed that the development of sclerotic lesions due to increased proliferation in patients with the presence of the MMP-9 (A-8202G) rs 11697325 genotypes in chronic nephritic syndrome leads to a worsening of the clinical course of the disease; established early diagnostic marker MMP-9 (A-8202G) rs 11697325 and its tissue inhibitor TIMP-2 (C536T) rs 11551797 in chronic nephritic syndrome in children in the diagnosis of the disease; for the first time, the prognostic value of the alleles of the MMP-9 (A-8202G) rs 11697325 genes and the homozygous G/G genotype in determining the risk of developing the disease in children with chronic nephritic syndrome has been proven.
Implementation of the research results. Based on scientific results of evaluation of the role of polymorphic genes of matrix metalloproteinase and its tissue inhibitors in chronic nephritic syndrome in children: methodological recommendation “The role of polymorphic genes of matrix metalloproteinase and its genetic inhibitors in the development of chronic nephritic syndrome in children” was developed and approved (reference of the Ministry of Health of the Republic of Uzbekistan No. 8n-r / 554 of 30.02.2022).
This methodological recommendation made it possible to predict the development of chronic nephritic syndrome in children and improve preventive measures; approved and developed on the basis of scientific results of research on early diagnosis and prognosis of chronic nephritic syndrome “Dynamics of clinical and laboratory parameters in nephritic syndrome in children”, (reference of the Ministry of Health of the Republic of Uzbekistan No. 8n-r / 555 of 30.02.2022).
This methodological recommendation made it possible to optimize the diagnosis and treatment tactics for various forms of nephritic syndrome in children;
The results obtained were implemented in the practice of health care, in particular, in the Republican Children's National Medical Center, in the 1st clinic of the Samarkand State Medical University, in the Samarkand Regional Children's Multidisciplinary Medical Center (conclusion No. 8 n-r/324 of 21.06.2022 of the Ministry of Health of Uzbekistan).
The application of the obtained results to practice has made it possible to reduce the frequency of recurrence of the disease in children, prevent complications of the disease, improve the quality of life of patients, diagnose and prevent the disease.
The structure and scope of the dissertation. The dissertation consists of an introduction, 4 chapters, conclusions, practical recommendations. The volume of the dissertation is 120 pages.
The aim of the research work is determination of the prospects for the use of a domestic agent for the prevention of adhesion formation in thoraco-abdominal surgery on the basis of experimental and morphological studies.
Research objectives were white outbred rats in the amount of 62 individuals, in two experimental studies on the abdominal and pleural cavities, in each series of experiments the studies were carried out in 2 comparative groups, control and main. Experiments on the formation of adhesions in the abdominal and pleural cavities were carried out on the basis of the Republican Specialized Scientific and Practical Medical Center of Surgery named after acad. V.Vakhidov in the Department of Experimental Surgery for the period from 2019 to 2020.
The scientific novelty of the research consists of the followings: it is proved according to the data of experimental research that when modeling the adhesion process in the abdominal cavity, the local application of an anti-adhesion coating made of cellulose derivatives reduces the processes of adhesiogenesis and the development of changes in architectonics, bends and narrowings of the intestinal lumen; it was found in an experimental study that when modeling the adhesion process in the chest cavity, the local use of an anti-adhesion implant provides a significant decrease in the risk of adhesiogenesis in the form of the formation of coarse adhesions or planar adhesions; it was determined that when blood serum was applied over a powder implant, the quality of adhesion and the uniformity of its distribution on the surface of the experimental defect of the peritoneum or lung did not change, but, in contrast to activation by blood (to ensure a hemostatic effect), it was not accompanied by the development of cellular inflammation due to the resorption of thrombotic masses; it was found that the formation of a gel film over the area of damage to the peritoneum in the absence of cellular elements of blood makes it possible to achieve biodegradation of the coating without a pronounced cellular-inflammatory reaction, providing cicatricial replacement of defects with a significant reduction in the risk of developing a massive adhesive process; the morphostructural features of the formation of the adhesive process when using an anti-adhesive coating, characterized by regression in the dynamics of the number of connective tissue cells of the inflammatory infiltrate with scarring of the defect zone without the development of adhesive conglomerates with the surrounding tissues, have been determined.
Introduction of the research results. According to the results of a scientific study on a comparative analysis of the use of a domestic agent for the prevention of adhesion formation in thoraco-abdominal surgery: methodological recommendations were developed: "New technologies for the prevention of adhesions in thoraco-abdominal surgery" (certificate of the Ministry of Health No. 08-09/10055 of August 12, 2021). The proposed recommendations for performing surgical interventions on the organs of the abdominal and thoracic cavities will allow for sparing local hemostasis, as well as prevent the formation of a coarse adhesive process in the abdominal cavity.
The obtained scientific results on a comparative analysis of the use of the domestic remedy for the prevention of adhesion formation in thoraco-abdominal surgery have been introduced into the practical activities of health care, including in the Republican Specialized Scientific and Practical Medical Center for Surgery named after V.I. Academician V. Vakhidov, surgical departments of the clinics of the Andijan and Samarkand State Medical Institutes (certificate of the Ministry of Health No. 08-09/10055 of August 12, 2021). Based on the proposed results of experimental studies, it was shown that the use of an anti-adhesive coating made of cellulose derivatives made it possible to reduce the risk of adhesion formation from 60% to 20%, bowel deformation without manifestations of obstruction from 33.3% to 13.3% and the possibility of acute adhesive intestinal obstruction from 6.7% to 0%.
Structure and scope of the dissertation. The dissertation consists of an introduction, four chapters, conclusions, practical recommendations and a list of cited literature. The volume of work is 113 pages.
The oral cavity is an open biological system in which there is a constant balance between pathogenic factors, such as viruses, bacteria, and the body’s defense forces. However, due to the proliferation and rapid development of microorganisms and viruses, as well as the weakening of general and especially local immune defense factors, such an important balance is often attacked.
Due to the spread of the new coronavirus infection, the number of oral mucosal diseases caused by COVID-19 is constantly increasing. The task for the dentist is to make a timely diagnosis, identify the pathology and start rational pharmacotherapy in order to prevent the development of pathology and the development of dental diseases into more severe forms.
Важное патогенетическое значение в инициации и прогрессировании БА имеет микроциркуляторный блок, составными компонентами которого является гемореологические изменения крови. Главную роль в формировании реологических свойств крови играют эритроциты. Деформируемость эритроцитов имеет решающие значение в регуляции вязкости крови, оказывает существенное влияние на эффективность кровотока на уровне микрососудистого русла и обусловливает способность эритроцитов к транспорту веществ. Основным источником информации об электрическом заряде поверхностной мембраны циркулирующих в крови эритроцитов является метод микроэлектрофареза, основанный на прямо
пропорциональной зависимости между величиной заряда и скоростью его перемещения в постоянном электрическом поле. Данные морфофункционального состояния мембран эритроцитов большую роль играют в плане решения задач ранней диагностики и профилактики многих заболеваний в том числе бронхиальной астмы.
Inflammatory diseases of the cornea are one of the most common causes of blindness worldwide. In recent years, many modern methods of treating diseases of the cornea have appeared, including, in addition to traditional conservative methods, modern surgical methods, such as autoconjunctival plasty, amniotic membrane transplantation, therapeutic keratoplasty, corneal covering with a corneoscleral flap, microdiathermocoagulation, and corneal crosslinking. A promising direction in the treatment of corneal pathology is stem cell therapy and cell therapy.
Aim of the study.To assess the degree of endothelial dysfunction and renal function in experimental ischemic stroke (EIS) in rats on the dynamics of pharmacotherapy.Materials and Methods.The subject of experimental studies were 105 adult mongrel white male rats. The object of the study were the serum and urine of rats. The model of cerebral circulation reproduced by temporary clipping of the left common carotid artery. The controls were 20 intact animals. Results. The results indicate to the development of endothelial dysfunction with EIS with the activation of neoangiogenesis in experimental animals. Pharmacotherapy with suksinasol for 7 days caused reduction of the level of ET-1 with respect to the values of untreated animal group and was still significantly higher than control group of rats in 2.5 times. At the same time, the level of VEGf A (vascular endothelial growth factor A) significantly decreased respectively to untreated group of rats in 1.65 times (p<0.01), but was still higher than control values in 1.74 times (p<0.01). development of proteinuria, microalbuminuria and creatininuria in rats with EIS apparently was due to the development of hemodynamic changes in the kidney and glomerular basal membrane permeability, and due to the enhanced excretion of toxins and protein degradation products.Conclusion. The endothelial and renal dysfunctions with activation of neoangiogenesis develop on the model of EIS. Pharmacotherapy corrects the identified changes to some extent. Tivortin and choline alfosceratewere more effective, possibly, because of decrease of hemodynamic disturbances and neurotrophic effects.
This article presents the results of a study of the main hydrodynamic and mass transfer characteristics of a microbubble apparatus on model systems aimed at elucidating the possibility of using microbubble processes to conduct mass transfer processes between biogas and liquid.