Systemic lupus erythematosus is a chronic disease with multiple defects of immune regulation. The prevalence of systemic lupus erythematosus varies from 12.5 to 40 per 100000 populations, with predominance among women of reproductive age. Nervous system impairment in systemic lupus erythematosus occurs in 25 to 83% of cases of SLE and is associated with vasculopathy, thrombosis and hemorrhages, and direct damage to brain tissues with antibodies. The article presents a summary of clinical observation
In the monograph, in determining the role of antiphospholipid syndrome in the origin of cerebrovascular diseases in systemic diseases of connective tissue, an algorithm for the diagnosis of antiphospholipid syndrome was developed with the combined use of immunological and clinical-neuroimaging tests for the early diagnosis of antiphospholipid syndrome in patients with neurological manifestations of systemic diseases of connective tissue. It allows early diagnosis of patients, reduction of disease in their treatment and improvement of treatment efficiency. The monograph is intended for neuropathologists and general practitioners, rheumatologists, as well as graduate and clinical residency students.
Современные цели лечения системной красной волчанки у детей многогранны и заключаются в достижении клинико лабораторной ремиссии заболевания, предотвращении поражения жизненно важных органов, своевременном выявлении и контроле сопутствующей патологии, профилактике осложнений лекарственной терапии и улучшении качества жизни
Nowadays, dependence on many types of clinical manifestations of APS has become an interdisciplinary problem that is widely studied by various medical specialties around the world: neurologist, rheumatologist, obstetriciangynecologist, dermatologist, and others. L.A. to study APS in Russia. Kalashnikov (neurologist), E.A. Nasonov (rheumatologist), T.M. Reshetnik (rheumatologist), Z.S. Barkagan (hematologist) and others made significant contributions. The first publication on the study of APS was published in 1990 in Ukraine by gynecologist Professor T.N. Demina and neurologist Professor S.K. Belonging to Evtushenko and his students [1; 143-146-p., 3, 4; 39-41-b 84-86-b.]. The results of many years of research on the neurological aspects (aspects) of AFS based on Donetsk National Medical University were presented by Professor S.K. The role of antiphospholipid antibodies in the development of cerebrovascular pathology in young people under the guidance of Evtushenko (M.F. Ivanova), "Cerebral palsy in children born to mothers with seropositive and seronegative variants of antiphospholipid syndrome" (M.A. Moskalenko in 2003). completed. In 2004, Professor S.K. Evtushenko visited Professor G. Hughes Clinic in London and got acquainted with the Lupus Journal Foundation, which publishes laboratory work, systemic connective tissue diseases, and scientific work related to APS. In recent years, the number of publications made by Ukrainian authors has increased. According to foreign and Russian authors, the incidence of APS hypercoagulability in the general population is 5% among young people [19; 513-518-b., 20; Pp. 1217, 39; Pp. 9-20]. The disease is observed in children even in newborns [17, 26; Pp. 21-25, 39; Pp. 9-20]. In the general population, APS is more often detected in women than in men (1: 5 ratio), probably due to women's predisposition to systemic connective tissue disease [6; 9-b.]. In 11.8% of cases, stroke was associated with APS among young women [20; Pp. 12-17].
Проблема помощи пациентам с трофическими венозными язвами остается актуальной медико-социальной проблемой, которая вновь обострилась на фоне пандемии COVID-19 в 2020–2021 гг. Как сейчас известно, после перенесенной вирусной инфекции COVID-19 у большинства пациентов с сердечно-сосудистыми заболеваниями наблюдается значимое обострение этих недугов. У многих пациентов после перенесенной пневмонии, ассоциированной COVID-19, отмечается формирование трофических язв слизистой оболочки полости рта. При этом трофические язвы имеют высокую резистентность к традиционной терапии, направленной на их заживление (Зудин А.М., Шаповал А.С., 2021).