Chronic recurrent aphthous stomatitis (stomatitis chronica aphtosa recidiva) is a chronic inflammatory disease of the oral mucosa of an infectious-allergic nature, characterized by periodic remissions and frequent exacerbations. Morphological elements on the oral mucosa are the so-called "ulcerative formations", that is, apht characterized by periodic remissions and partial exacerbations with a rash of aphtha. According to the latest publications of domestic and foreign authors, HRAS is usually considered as a polyetiological disease that plays a role in the formation and the nature of the course of the pathological process. The factor causing chronic aphthous stomatitis is staphylococcal infection, adenovirus, allergies, immune disorders, as well as diseases of organs and systems. First of all, it is a local effect aimed at reducing pain that makes it difficult to eat up to forced starvation, as well as at the speedy regeneration of the defect. Secondly, it is the regulation of the body's immunocompetent systems and a decrease in the level of bacterial allergies. In addition, the identification and treatment of background diseases with the involvement of specialists of different profiles (Lukinykh L.M., 2004; Savkina G.D., 2005; Drobotko JI.H., 2008).
In this article, the reforms implemented in the health care system of the Republic of Uzbekistan. Also, the information about the work carried out in the health care system of Fergana region during 1996-2015 and their effective results in restoring the health of the population was analyzed.
This article is devoted to the preclinical study of the anti- atherosclerotic drug firutas on pathomorphological changes in animal organs during prolonged administration. Preclinical study of the general toxicology of the drug "Firutas" showed that it belongs to the IV class of low-toxic compounds. The drug "Firutas" does not have a cumulative and locally irritating effect. With repeated intramuscular administration to mice and rats, it does not affect the behavior and weight dynamics of animals, does not have a toxic effect on the composition of peripheral blood, kidney and liver function, as well as on the pathomorphology of animal organs and tissues. All the above data allow us to conclude that the drug does not have a toxic effect on the body of animals
This article presents the results of a study of the hepatoprotective properties of the herbal drug darmonal in combination with phytin compounds in experimental animals (rats) with experimental hepatitis caused by SS14 intoxication. The obtained research results showed that darmonal in combination with phytin compounds increases the synthesis of total protein and normalizes the composition of protein fractions of blood serum. Both studied drugs have a high level of hepatotropic effect. The combination of darmonal and fitin-C was the most effective. According to this effect, they were superior to the hepatoprotective drug LIV-52.
Monografiyada ta’lim xizmatlari raqobatbardoshligini oshirishda marketing tadqiqotlarini amalga oshirishni nazariy-uslubiy asoslari tadqiq etilgan. Ta’lim xizmatlari marketingining nazariy asoslari, ta’lim xizmatlari bozorida iqtisodiy munosabatlar tizimi, ta’lim xizmatlari bozorini marketing strategiyasini rejalashtirishda raqobat muhitining o‘rni O‘zbekistonda oliy ta’lim tizimini rivojlantirishning marketing strategiyalaridan foydalanishni hozirgi holati tahlili, oliy ta’lim raqobatbardoshligini oshirishning marketing strategiyalari samaradorligini baholash, O‘zbekistonda oliy ta’lim tizimini rivojlantirishning marketing strategiyasi va uni amal qilish mexanizmi, Jahon oliy ta’lim tizimini isloh qilishning marketing modellari va ulardan foydalanish imkoniyatlari bo‘yicha ilimiy taklif va amaliy tavsiyalar shakllantirilgan.
Monografiya ta’lim sohasida faoliyat olib boruvchi mutaxassislar, magistrantlar, ilmiy tadqiqotchilar, doktorantlar va keng kitobxonlar jamoasi uchun mo‘ljallangan.
The article is about lexico-semantic features and evolution of noun as an independent grammatical category in Sindhi. Opinions of scientists on this matter L. A. Barhudarova and R. P. Egorova are also discussedin it.
Trinatrium salt of glycyrrhizic acid (Glycytrinate) with strong anti-ulcerous activity combined with anti-inflammatory effect was synthesized on the basis of glycyrrhizic acid. According to the parameters of acute toxicity in experiments on white mice and rats with per oral administration Glycytrinate was included to the group of little toxic substances. And according to the assessment of anti-ulcerous activity on the models of rats’ gastric mucous membrane destruction caused by indo metasin, ortophen, and reserpin glycytrinate has an expressed antiulcer effect. The mechanism of glycytrinate’s antiulcer effect is linked with its antioxidant property and suppression of the secretory function of gastric glands.
In experimental toxic hepatitis caused by the hepatotropic poison carbon tetrachloride, a decrease in bile synthesis, bile-releasing function of the liver was revealed. There was a decrease in the composition of bilirubin, cholesterol and bile acids in the bile. In the treatment of experimental hepatitis with cobalt and silibor fiat, cholestasis decreased, the chemical composition of bile improved, as the content of bilirubin, cholesterol and total bile acids increased.
Alkaloids differ in their physiological effects: some of them weaken or stimulate the nervous system, others paralyze nerve endings, dilate or narrow blood vessels, and others are considered to have an analgesic effect. It is studied using methods such as chromatography, spectroscopy, and continues to get high results in these methods. The advantage of this method is that in the study of alkaloids, the additives contained in alkaloids are considered extremely necessary for the study of organic and meningeal substances, as well as for the analysis of biological objects. The chromatography method is widely used in the study of detection, isolation of compounds contained in alkaloids. On the other hand, the spectroscopy method is studied by exposing light to alkaloids. The chemical composition of alkaloids is studied by ultraviolet light and some reagents.
The search for new sources of highiy active drugs based on iocai raw materials is an urgent task of modern science, it is known that iicorice root is widely used in various sectors of the economy, the main component of it is glycyrrhizic acid. The presence of anti-inflammatory activity, iow toxicity and iack serious side effects make new synthetic derivative of glycyrrhizic acid promising for medicine compounds.
The purpose of the study. To study the antiulcer activity glycerinate on an experimental model of neurogenic uicers caused by 24-hour immobilization of animals and to identity the mechanism of antiulcer activity.