The purpose of the study was to determine and evaluate the features of morphological changes in the liver parenchyma of 5-month-old white outbred rats under the influence of anti inflammatory drugs under conditions of polypharmacy.
The object of study for experimental studies was taken 250 white male rats weighing 200-250 g.
The scientific novelty of the research is as follows: polypharmacy of anti-inflammatory drugs negatively affects all parameters of liver structures. Under the influence of polypharmacy, there is a decrease in the absolute mass of the liver, volume and morphological parameters of the liver parenchyma. The decrease in morphometric parameters depends on the number of drugs in polypharmacy; under conditions of polypharmacy, the state of the hepatic capillaries and internal bile ducts, as well as biological membranes, was studied, as a result of which the structural structure of the liver, the development of destruction of the hepatic tissue were studied, and the morphofunctional foundations of this condition were shown.
Implementation of the research results. Based on the obtained scientific results, the morphofunctional characteristics of the liver of rats in the norm and under the influence of polypharmacy were determined:
Approved methodological recommendations: "Methodology for determining the morphometric parameters of the liver during polypharmacy of anti-inflammatory drugs" (Conclusion No. 8n-r / 265 dated 14.03.2022 of the Ministry of Health of the Republic of Uzbekistan) and "Methodology for determining the morphometric parameters of the liver during polypharmacy of anti-inflammatory drugs" (Uzbekistan, Conclusion of the Ministry of Health of the Republic of Uzbekistan No. 8 n-z 180 of 2022), electronic program No. DGU 1038 "Program for studying the comparative characteristics of morphological changes caused by polypharmacy in the liver."
The scientific results obtained in the study of morphological and functional properties and morphometric changes in the structure of the liver under the influence of polypharmacy have been introduced into the practice of the Samarkand branch of the Republican Specialized Oncological and Radiological Scientific and Practical Medical Center of the Samarkand City Medical Association (Order of the Ministry of Health of the Republic of Uzbekistan dated March 14, 2022, 8n-r / 265-No. and conclusion No. 8 n-z 180 of 2022). The implementation of the obtained research data allows developing methods for early diagnosis, treatment and prediction of organopathology by morphological parameters, improving the quality of life and reducing the number of complications.
The structure and scope of the dissertation. The structure of the dissertation consists of an introduction, three chapters, a conclusion and a list of references. The volume of the dissertation was 103 pages.
The aim of the research work. It consists in studying changes in the morphological and morphometric parameters of the wall of the gastric mucosa under conditions of polypharmacy with anti-inflammatory drugs.
The object of the scientific research is 180 white outbred male rats, 5 months of age.
The scientific novelty of the research work is as follows:
For the first time it was established that polypharmacy with anti-inflammatory drugs in 5 combinations had a different negative effect on the mucous and submucosal base, which is the structural structure of the stomach wall of white male rats;
It has been proven that structural changes in the organs of the digestive system cause profound disturbances in the processes of growth and formation of the gastric mucosa and its glandular tissue, submucosa, which is accompanied by a decrease in the total thickness of the stomach wall;
With the simultaneous use of more than 3 types of anti-inflammatory drugs, the negative effects of polypharmacy are significantly enhanced. We analyzed the rate of formation of structural and functional zones of the stomach wall, the activity of mucosal cells, the change in the shape of lymphocytes located in the submucosa, the decrease in morphological parameters;
Using the methods of modern morphological studies (organometric, histological, histomorphometric, statistical), new information was obtained directly about the morphological and morphometric parameters of the stomach wall. Changes at the tissue, cellular and intercellular levels are characterized by hypotrophic and hypoplastic changes in the structures of the stomach wall of white male rats.
Implementation of the research results. Based on the obtained scientific results on morphometric changes in the gastric mucosa under conditions of polypharmasia:
methodological recommendation was approved on the topic: "Method for determining the morphometric parameters of the gastric mucosa in polypharmasia of anti-inflammatory drugs", which allows to determine the morphometric parameters of the gastric mucosa in the conditions of polypharmacy in the experiment.
The scientific results obtained in the study of morphofunctional features and morphometric changes in the structure of the gastric mucosa under the influence of polypharmacy are used in healthcare practice, including Academician Y.Kh. Turaqulov Conclusion of the Ministry of Health of the Samarkand State Medical University. The introduction of information obtained in scientific research, the development of an algorithm for correct and timely diagnosis, pathogenetic morphometric and morphological indicators, the choice of treatment tactics made it possible to predict the development of pathological changes.
The structure and volume of the dissertation. The dissertation consists of an introduction, three chapters, conclusions, practical recommendations, a list of references and applications. The dissertation is presented on 102 pages of computer text.
Designing divisions are compelled to raise new ways to deal with stay cutthroat. Henceforth, orderly development is fundamental for progress. One approach to address idea age is the examination of capacities and their division into sub-capacities, for which a few guideline arrangements can be planned or taken from lists. Those singular arrangements can be joined with the assistance of morphological boxes to acquire alleged generally speaking arrangements. Albeit broadly distributed, this technique isn't grounded in mechanical application and frequently abused in scholarly community: it doesn't forestall awful choices. The huge number of conceivable generally arrangements coming about because of combinatorial blast is as yet not reasonable. A writing survey is directed to comprehend the underlying point of morphological examinations. Two repudiating headings can be noticed: the quest for arrangements either towards development potential or towards specialized plausibility. Both accompany disadvantages. To beat these deficiencies, another strategy is introduced meaning to help engineers. It is established on the speculation that considering setting data decreases the general exertion. This prompts an iterative methodology with progressively proving utilizations of low-intricacy morphological boxes. Numerical ideas like pareto-effectiveness are incorporated to streamline the variety coming about because of blend.
Morphological analysis is a fundamental task in natural language processing that involves breaking down words into their constituent morphemes to understand their grammatical structure and meaning. However, when morphological analysis is applied to English language sentences by Hindi language users, noise issues arise due to the syntactic and structural differences between the two languages. This study addresses these noise issues and proposes techniques to improve the accuracy of morphological analysis for English sentences processed by Hindi language users. By exploring methods to handle word order variations, phrasal differences, and other syntactic disparities, this research aims to enhance the effectiveness of morphological analysis tools for bilingual users and facilitate their comprehension of English language sentences.
The linguistic systems are involved in language contact situations, it is supposed toanalyze of lexical, morphological and syntactic borrowings which are acceptance of linguistic elements from one language to another
This article discusses morphological structure of mountain soils. The mountainous regions of the Republic of Uzbekistan are located mainly in Tashkent, Surkhandarya, Samarkand, Jizzakh, Syrdarya, Fergana Valley and Navoi regions, and differ from each other in their greenery, charm and structure. Mountain soils are distributed sequentially according to the law of vertical zoning, depending on the altitude above sea level. The soil cover in these regions is characterized by their development (evolution), genesis, agrochemical, agrophysical properties and, most importantly, morphological structure. Each region has its own natural factors, which directly affect the development and morphological structure of the soil cover.
The paper analyzes some aspects of using social-politic terms in Japanese, ways of inter-preting through analyzing some semantic specialties of terms. Recently, in the textual materials of the Japanese mass media, words written by the Japanese phonetic alphabet katakana, used for the written fixation of vocabulary of foreign origin, began to appear more and more. In itself, this phenomenon is not new - similar vocabulary in Japanese and has its own historical roots and specific use. Translation of the borrowed vocabulary involves the use of several methods, three of which we will consider in more detail in the framework of this article. The first way of transfer: borrowing. The simplest method of transfer is borrowing, which allows filling a gap, usually of a metalinguistic nature (new technique, unknown concepts). Borrowing would not even be such a way of translation, which we might be interested if the translator did not need it at times to create a stylistic effect. The second way of translation: calculating. Calculation is borrowing a special kind: we borrow from a foreign language one or another of the syntagmas and literally translate the elements that make up it. We thus obtain either the expression of the expression, and we use the syntactic structures of the translation language, introducing new expressive elements into it. The third way of translation: literal translation. A literal translation, or translation "word for word", means a transition from the source language to the translation language, which leads to the creation of a correct and idiomatic text, while the translator observes only the observance of the compulsory norms of the language. Since the process of assimilation of foreign-language elements begins from the moment they are introduced into the language by translators, it is appropriate to say a few words about the technology of translating specifically foreign names. When translating words and expressions with an incomprehensible associative meaning, as well as translating the names of realities, transcription, less often transliteration, calculating and explanatory translation (the transfer of the meaning of a foreign word or word combination with the means of the native language without preserving the motivation and form) can be applied. When calculating, transcribing and transliteration, sometimes you need to resort to comments. Can also be applied reception, which is a kind of explanatory translation and calculating-replacement of associative meaning.
Language is a dynamic entity that constantly evolves, adapting to changing societal and cultural influences. The borrowing of foreign words, or loanwords, is a common phenomenon in linguistics. This article explores the presence and adaptation of English sports terms in the Karakalpak language, a turkic language spoken in Uzbekistan. The study examines the mechanisms of borrowing, phonological and morphological adaptations, and the implications of these borrowings for the Karakalpak language and its speakers. By delving into the impact of globalization and sports on language, this research sheds light on the dynamic nature of linguistic evolution and cross-cultural exchange.
The article considers the issues of public debt management, the importance of economic growth and reduction of debt servicing costs. The conditions of observance of debt management, the negative impact of public debt on the economy, the issues of borrowing, the effectiveness of borrowing, sources of debt coverage, the impact of borrowing on the socio-economic development of the state are studied.
The article considers the issues of public debt management, the importance of economic growth and reduction of debt servicing costs. The conditions of observance of debt management, the negative impact of public debt on the economy, the issues of borrowing, the effectiveness of borrowing, sources of debt coverage, the impact of borrowing on the socio-economic development of the state are studied.
The nutritional nature of mammals, which has developed during a long evolution, leads to adaptive - morphological changes in their digestive tract and its immune structures, although the general laws of their structural organization are identical. The literature has data on the study of the immune structures of the small intestine under normal conditions and under the influence of certain factors. In the structure of immune structures there are numerous parallelisms, however, in each class of vertebrates, complication of this organization is achieved independently. The small intestine is an important section of the digestive tube, where the final chemical processing of the chyme and the absorption of nutrients into the body take place. However, the comparative morphology of the immune structures of the small intestine in mammals with different nutrition patterns remains poorly understood.
The research highlights the morphological, semantic and mutual translation problems of modern English and Uzbek imitative words. Imitative words in the Uzbek language refer to a separate group of words between independent and non-independent groups of words at the morphological level. In English linguistics, onomatopoeic words and independent words formed by imitation are called onomatopoeia. In the morphological layer, independent words formed from imitation, according to their grammatical features, belong to one of the existing independent groups of words. Also, the disadvantages of translating imitative words from Uzbek to English, from English to Uzbek, including imitative words can be omitted in the translation text or expressed by transliteration.
For the first time on a large clinical material, the results of the study of clinical and morphological features and prognostic factors of clear cell ovarian cancer and mixed malignant neoplasms of the ovaries with a mandatory clear cell component are presented.
Based on a comparative analysis of pure and mixed forms of clear cell neoplasms of the ovaries, their morphological signs and features of the clinical course of the disease were established.
The factors of prognosis of malignant clear-cell neoplasms of the ovaries were revealed: the stage of the disease, the volume of surgery, the degree of tumor differentiation and the degree of cellular anaplasia.
Clinically, neurotrophic disorders manifest themselves most often in acute brain diseases (strokes, injuries, meningoencephalitis, etc.), accompanied by the involvement of the hypothalamus - pituitary gland, brain stem, sympathetic and vagus nerves [3]. At the same time, the greatest functional and morphological disorders are observed in the gastrointestinal tract (ulcers, erosion, hemorrhages), lungs (edema, pneumonia) and pancreas (transient hyperglycemia) [1, p. 529] and liver (4, p. 170] Despite the fact that the main theater of action is expressed in a local catastrophe of the brain and neurological disorders, most researchers and practitioners do not pay due attention to the essential role of the "main laboratory" of the body - the morphofunctional state of the liver [7, p. 876].