The problem of diarrhea in children of different ages remains one of the topical areas of modern medicine. The study of the characteristics of the microflora in diarrhea is associated with the development of therapeutic and preventive measures for this condition. The intestinal microflora performs important functions in the child's body, including the exchange of energy substrates and the formation of intestinal immunity. At the same time, the intestinal microflora changes during the first years of life. In addition to age-related changes, gut flora changes with nutritional status, birth path, antibiotic exposure, genetic factors, and episodes of diarrhea.
Subjects of the inquiry: patients with acute intestinal obstruction.
The aim of the inquiry: improvement of treatment results of the patients with acute bowel obstruction by means of the perfection of the methods of intestinal decompression and enteral correction of metabolic disturbance of the organism with nutritive blend “Perative”.
Methods of inquiry: general clinical laboratory investigations, roentgenological studies, statistical technologies, clcctrocntcrography.
Novelty of inquiry: In complex treatment of the patients with acute bowel obstruction the improved intestinal tube has been used for intraoperative decompression of the gastrointestinal tract and it has been demonstrated of its effectiveness. The active intra- and postoperative decompression of the gastrointestinal tract, gut lavage, enteral [tube] feeding effectiveness in complex treatment of the patients with acute bowel obstruction has been proved. The necessity of addition of the complex treatment of the patients with acute bowel obstruction the enteral correction of metabolic disturbance of the organism has been proved and the balanced nutritive blend “Perative” efficacy has been defined.
Practical value: The application of the improved intestinal tube allowed accomplishing of the adequate evacuation of the toxic contents of the gastrointestinal tract and reducing of the enteric pressure. It has contributed to earlier recovery of the all gastrointestinal tract function and it has created the favourable conditions for enteral [tube] feeding. Carrying out of the enteral [tube] feeding with semi - substrate nutritive blend “Perative” has promoted to earlier replacement of the loss of power and plastic material needs. Clinical application of the developed patients management with acute bowel obstruction has promoted to the reduction of the complications rate (from 33,9% to 6,0%) and mortality (10,7% to 0%).
Degree of embed and economical effectivity: The main regulations of the dissertation have been applied in practical work of the urgent surgical department of the second clinic of the Second Tashkent State Medical Institute and it is used in process of 4-6 years students teaching in the Second Tashkent State Medical Institute.
Sphere of usage: urgent surgical help.
Established qualitative and quantitative changes in the components of the intestinal microflora in patients with acute intestinal
infections. Increased the percentage of representatives of opportunistic flora: yeast, Staphylococcus aureus, Escherichia coli laktozanegativnye, enterococci and Klebsiella. The study correcting abilities of the domestic biocorrector Bifidobakterin PL and milk products Bifilin QC, made from local strain Bifidobacterium bifidum spacecraft showed that correcting ability of both drugs were
identical
In the last decade, the role of microbiota in the pathogenesis of various diseases and in the functioning of macroorganism organs and systems has been widely discussed. Microorganisms are placed by all human organs that come into contact with the external environment. However, the most populated part of the body is the intestines with a total weight of 1.5 kg of microorganisms. On average, 1 ml of intestinal product contains up to 1 million microbes [1, 2]. The gastrointestinal tract is an open system in constant contact with the outside world, which leads to the formation of a relatively stable intestinal microbiocenosis. In addition, each person has an individual intestinal microflora that undergoes significant changes during his life.
Minimally invasive surgical interventions are widely used both in planned surgery and urgent surgery. To date, the share of acute intestinal obstruction in emergency abdominal surgery accounts for about 10% of all diseases of abdominal cavity. The use of video laparoscopy in acute adhesive intestinal obstruction contributes to early recovery of intestinal motor function, early activation of patient and reduction in bed-days.