At present, the cerebral circulation disorder is caused by various factors. According to the Ministry of Health of the Republic of Uzbekistan, 62876 cases of strokes were registered in Uzbekistan in 2019. 15% acquired lethal outcome, 10-15% returned to their previous state, 55 - 70% became disabled. Stroke is translated from the Latin language as a "stroke" which means an acute cerebral circulation disorder. Regardless of the cause of cerebral circulation disorder, the result is always the same - the death of brain neurons. The most common cause is atherosclerosis on the inner walls of blood vessels that supply the brain. They narrow the blood vessels and make them less flexible. In this case, the probability of clogging the blood vessels with blood clots increases, as a result, the blood vessels cannot supply blood to the brain.
The aim of the research: to define the modern way of prophylactics of stroke with ultra sound duplex scanner examination.
Провести анализ литературных источников, посвященных развитию повторных ишемических инсультов у больных, перенесшихCOVID-19.
Aim of the study.To assess the degree of endothelial dysfunction and renal function in experimental ischemic stroke (EIS) in rats on the dynamics of pharmacotherapy.Materials and Methods.The subject of experimental studies were 105 adult mongrel white male rats. The object of the study were the serum and urine of rats. The model of cerebral circulation reproduced by temporary clipping of the left common carotid artery. The controls were 20 intact animals. Results. The results indicate to the development of endothelial dysfunction with EIS with the activation of neoangiogenesis in experimental animals. Pharmacotherapy with suksinasol for 7 days caused reduction of the level of ET-1 with respect to the values of untreated animal group and was still significantly higher than control group of rats in 2.5 times. At the same time, the level of VEGf A (vascular endothelial growth factor A) significantly decreased respectively to untreated group of rats in 1.65 times (p<0.01), but was still higher than control values in 1.74 times (p<0.01). development of proteinuria, microalbuminuria and creatininuria in rats with EIS apparently was due to the development of hemodynamic changes in the kidney and glomerular basal membrane permeability, and due to the enhanced excretion of toxins and protein degradation products.Conclusion. The endothelial and renal dysfunctions with activation of neoangiogenesis develop on the model of EIS. Pharmacotherapy corrects the identified changes to some extent. Tivortin and choline alfosceratewere more effective, possibly, because of decrease of hemodynamic disturbances and neurotrophic effects.
The article is intended to give basic information and the role of homocysteine in the human body. The amino acid homocysteine is a product of methionine demethylation. When the level of homocysteine increases, it damages the tissue structures of the arteries, initiating the release of cytokines, cyclins and other inflammatory mediators. Its accumulation leads to loosening of the arterial walls, the formation of local defects in the endothelium, which, in turn, leads to the deposition of cholesterol and calcium on the vascular wall. Hyperhomocysteinemia as a consequence of impaired homocysteine metabolism is considered an independent risk factor for stroke in humans. The role of neuroprotective therapy in interrupting or slowing down the sequence of damaging biochemical and molecular processes that can cause irreversible ischemic brain damage is shown.
The study of the course of non-traumatic intracerebral hematomas, including in the age aspect, is one of the significant areas of modern stroke, since it allows to choose the optimal treatment tactics for each group of patients. We have studied and presented in this article the clinical manifestations and features of the course of hemorrhagic stroke in 98 patients, divided into age groups - young, middle, elderly and senile. The study revealed some differences in the course of pathology in patients of different ages.
The article provides an analysis of the literature on the process of post-stroke rehabilitation, timing and types. Neurorehabilitation is a process aimed at restoring lost or reduced function in patients with stroke. Early initiation of neurorehabilitation leads to the achievement of the necessary level of selfcare of the patient, his social, psychological, physical adaptation and finally restoration of ability to work in the post-stroke period, as well as reduction of post-stroke disability in society and improvement of patients' quality of life
Проблема инсульта имеет большую медико социальную значимость из-за их широкой распространенности, высокой частотой смертности и инвалидизации. Токсическая энцефалопатия часто возникает у людей, злоупотребляющих алкоголь. Считается, что умеренное употребление алкоголя снижает риск развития инфаркта мозга, но много пьющие люди предрасположены к ишемическим инсультам вследствие развития у них ангиопатии, кардиомиопатий, аритмий и наклонности к гиперкоагуляции. Течение и восстановление утраченных неврологических функций после перенесенного инсульта при токсической энцефалопатии зависит от сложного взаимодействия морфологических, гемодинамических, психологических и иммунологических изменений. Все эти изменения в настояшее время изучены
недостаточно.
Aphasia was first depicted by Imhotep around 3.000 B.C. in what has come to be known as the Edwin Smith careful papyrus. The early history of the investigation of aphasia unavoidably engaged upon the subject of the confinement of cortical capacity . Aphasia is an obtained issue of already flawless language capacity optional to mind harm. This definition accentuates two significant perspectives. To begin with, it focuses on the deficiency of recently obtained language. The second component of the definition concerns the word Language which ought to be isolated from both discourse and contemplations.
Выявление ранних признаков и предотвратить риски развития цереброваскулярных заболеваний у лиц старше 40 лет.
This article proposes the treatment of an acute period of ischemic stroke with Cellex, which improves speech, praxis and gnosis, which is confirmed by the results of neurophysiological studies. Thus, with mild dementia, disturbances in predominantly attention and regulatory functions were associated with clear impairments of memory, orientation, and visual-spatial function. Neuroimaging in most patients, along with focal post-stroke changes, revealed brain tissue atrophy, changes in white matter, and small focal lesions of the gray matter. It was established that a necessary condition for the verification of the syndrome of post-stroke cognitive impairment.(СI), in addition to the volume and localization of the lesion, should be signs of impaired integrative mental activity of the brain, especially disruption of regulatory functions.
Cardiovascular disease (CVD) is the leading cause of death worldwide: no other cause causes as many deaths each year as CVD.
An estimated 17,9 million people died from CVD in 2016, accounting for 31% of all deaths worldwide. 85% of these deaths were due to heart attack and stroke. Most cardiovascular diseases can be prevented by addressing risk factors such as tobacco use, unhealthy diet and obesity, physical inactivity and harmful use of alcohol through population-wide strategies [1].
In Uzbekistan, the risk of premature death (among the population aged 30-69 years) from the four major NCD groups is approximately 31%; CVD is the leading cause of death. A quarter of adults aged 18-64 and almost a third of adults aged 40-64 are at high risk of having a heart attack or stroke within the next 10 years. Men are particularly at risk for cardiovascular risk given their tobacco use and the harmful use of alcohol. In general, men tend to underuse health services; blood pressure in this population is also under-controlled [2].
we studied patients with ischemic stroke with antihypertensive medication for high arterial hypertension.
Material and methods: we studied 28 patients in the general intensive care unit of multidisciplinary TMA with acute cerebral ischemia syndrome caused by ischemic-type ACCD. The age of the patients was on average 61±7 years. There were 20 males and 8 females. The level of consciousness was assessed using the Glasgow scale. It ranged from 4 to 10 points.
Results: the given data clearly indicate a more pronounced decrease of SBP, DBP, ICP during intravenous infusion of Tahiben at the stages of the study. A significant difference in the duration of drug effects in the studied groups was noted. Thus, when using Tahiben, the target level of SBP and DBP could be maintained up to 220±54 minutes, while in the standard treatment group it was maintained for 68±8 minutes.
Conclusions: intravenous administration of Tahiben (urapidil) at the early hospital stage in patients with arterial hypertension against the background of standard baseline therapy of ACCD is an effective and safe method of urgent therapy, providing dosage BP reduction by 15-25% of the initial one.
Any pathological mechanisms are triggered by various etiological factors or biological events, therefore a large number of neurological diseases, especially of ischemic origin, with different evolution (acute, chronic) are degenerative and are reflected in the state of other vital organs [1 ,6]. The main task of eliminating cerebral ischemic catastrophes is to block ongoing pathogenetic processes in the shortest possible time, in order to maximally limit the penumbra zone in order to avoid massive death of brain cells [5, 11].
The flow model of the crushing and crushing equipment is important because it allows the stone material to slide down through the crushing chamber. The crushing or crushing characteristics were achieved by testing the rock based on spring compression during crushing under controlled conditions. The input data (CSS) includes parameters such as speed, stroke, camera geometry, distribution of transmission values and mechanical properties of the material. The performance of a traditional cone crusher, which shows the performance for ore of various products. The nominal design of the conical crushing and crushing equipment is made. At this stage, it is possible to calculate a set of nominal parameters characterizing the chopper chamber. The nominal stroke and layer thickness are determined at each point of the chamber cross section. The same material was used in modeling and field tests. After each compression test, the material was screened. Distribution of the sizes received at each check. A selection function with two variables adapted to experimental data. b) functional representation in 3D. Normalized crushing of the porphyry material under study. b) the crushing properties of quartz and porphyrite were compared.
The article talks about CSF and the occurrence of cognitive disorders in them, their diagnosis, treatment methods. In recent years, there has been an increase in cerebrovascular diseases. All patients were evaluated for the severity of stroke by NIHSS scale and the daily activity level by Bartel scale (Barthel ADL index). To exclude patients with depressive disorders from the study, a scale of de- pression assessment was used in Gamiltona (Hamilton depression rating scale, HDRS-17). Tricortin as a nootropic drug was used to improve cognitive impairment in patients who participated in the study and its effects were evaluated.
Systemic lupus erythematosus is a chronic disease with multiple defects of immune regulation. The prevalence of systemic lupus erythematosus varies from 12.5 to 40 per 100000 populations, with predominance among women of reproductive age. Nervous system impairment in systemic lupus erythematosus occurs in 25 to 83% of cases of SLE and is associated with vasculopathy, thrombosis and hemorrhages, and direct damage to brain tissues with antibodies. The article presents a summary of clinical observation