В обзорной статье представлена современная концепция механизмов антиоксидантного и антигипоксического действия оригинального препарата Мексидол® (2-этил-6-метил-3-гидроксипиридина сукцинат).
The article talks about CSF and the occurrence of cognitive disorders in them, their diagnosis, treatment methods. In recent years, there has been an increase in cerebrovascular diseases. All patients were evaluated for the severity of stroke by NIHSS scale and the daily activity level by Bartel scale (Barthel ADL index). To exclude patients with depressive disorders from the study, a scale of de- pression assessment was used in Gamiltona (Hamilton depression rating scale, HDRS-17). Tricortin as a nootropic drug was used to improve cognitive impairment in patients who participated in the study and its effects were evaluated.
Transient-ischemic attacks (TIA) as precursors of cerebral strokes occupy an important place among all forms of cerebrovascular insufficiency. With regard to the epidemiology of transient ischemic attacks (TIA), most countries do not have accurate data. So, in the uS, they carry up to 5 million adult citizens per year, with many TIAs remaining undiagnosed. These episodes of sudden and short-term neurological deficit were considered benign and harmless for a long time. Most general practitioners and patients incorrectly or insufficiently understand the nature and significance of TIA, perhaps this can explain the small interest of doctors, and the lack of statistical data on this nosological unit. Transient ischemic attacks (TIA) are defined clinically as rapidly occurring focal and less commonly diffuse (cerebral) dysfunctions of the brain that are caused by local ischemia and disappear within one day. Over the past two decades, many views on TIA have changed significantly, approaches to the diagnosis and treatment of patients have become much more intense and more aggressive. Current knowledge of TIA is of great importance both for the proper organization of patient care and for educational programs among the population, the importance of which cannot be overestimated.
Subject of the inquiry: 298 patients with finn deformations of the larynx and trachea
Aim of the inquiry: early rehabilitation of patients with firm deformations of the larynx and trachea path optimization and creating clinical and pathogenic methods of complex treatment.
Methods of the inquiry: clinical examination, special examination: LOR-examination, endoscopy of air ways, X-ray, CT, MRI of larynx, trachea and bronchus, bacterial examination of larynx and trachea wounds; morphological examination, biochemical methods of examination: lipid peroxidation, antioxidant enzymes, activity of hepatic monooxygenase system (MOS); biophysical methods of examination: исследование electric damage of erythrocytes’ membrane (EDEM), blood viscosity (BV) and blood shift velocity (BSV); cytological examination.
The results achieved and their novelty: In patients with firm deformations of the larynx and trachea, firstly basing on complex investigation clinical and structural-functional parameters revealed pathomorphological changes in neck tissues as chronic inflammation with productive component. Despite, revealed disrupt balance of process lipid peroxidation and antioxidant system, hydroxylic function of liver, decrease of electoral penetrability of erythrocytes’ membrane and aggravate of hemorheology. With this, level of expression of changes depends on clinic form and load disease, correlate with stage of wound healing and after restore of functions of the larynx and trachea gradually becoming normal. Presented classification of the firm deformations of the larynx and trachea, permitting complexly counting etiologic factor and morphological variant of the damage of laryngotracheal tract. In scheme of the pathogenic complex conservative therapy before and after reconstructive operations included medicine, influencing on Hemodynamic, with ability membranotrope action, systemic enzymotherapy, immunostimulators, and correction of the tissue metabolism by laser. Created private and modified methods of reconstructive laryngotracheoplasty in case of cicatricle stenosis of glottic and subglottic parts, bilateral paralyses of the larynx, cicatricle deformations of pharyngolarynx, combination deformations and defects of the larynx and trachea, permitting single stage restore laryngotracheal ways.
Practical value: The investigation of pathogenic mechanism of developing of the firm deformations of the larynx and trachea on data of changes of main functional and metabolic processes will permit not only activating and improving of pathogenic therapy, and forecasting variant of development and course of postoperative period after reconstructive operations.
Use of proposed methods of complex conservative and surgical treatment of the firm deformations of the larynx and trachea allowed to provide whole volume of restoring means in more short time and with less quantity of stage operations, preoperative preparing till 3 days, hospital stay till 14-20 days, surgical operations in 1.9 time.
Degree of embed and economical effectivity: The results of investigation intruded in treatment practice of the First and Second Tashkent Medical Institutes, LOR-clinics of Samarqand territorial children hospital, territorial hospital of Karshi. Materials of the investigation using in study process of LOR - cathedra First Tashkent Medical Institutes during lectures and practice tutorials with students, magistracies, and clinic ordinators. Determined main economic effect in use of proposed complex therapy in connection with reduce of term of treatment and hospital stay (on an average 10 days) and taking off or decreased disability on 67% patients.
Sphere of usage: otorhinolaryngology, surgery, reanimation
The aim of the study was to assess the effectiveness of the use functional food products aimed at reducing the content of table salt in the body. According to the research results, a positive trend towards an increase in the level of sodium excretion in urine was revealed in students who received functional food products made from local products rich in potassium and low in sodium, developed by us in the standard "Products of functional nutrition NUMA".
Изучить предикторы формирования факторов риска у больных параноидной шизофрении,перенесших нарушение мозгового кровообращения.