В структуре черепно-мозговой травмы краниофациальная составляет 6-7%, а от всех видов сочетанной черепно-мозговой травмы – 34%. Частота переломов орбиты при КФТ чрезвычайно высока – до 98%, что связано с особенностью строения глазницы. В 66% повреждения глазницы сопровождаются повреждениями глазного яблока и его вспомогательных органов. Повреждения зрительного нерва при черепно-мозговой травме встречаются в 0,5-5% наблюдений, при краниоорбитальных повреждениях – в 11,2%. Травматическая оптическая нейропатия, тяжелые травмы глаза в 50% случаев могут явиться причиной возникновения стойкой утраты зрения. Последствия травм органа зрения, наличие выраженных косметических дефектов, а также функциональных расстройств нарушают качество жизни больного и влекут за собой стойкую утрату трудоспособности. Краниоорбитальные повреждения в 16-30% остаются не диагностированными даже после проведения компьютерной томографии пациентам с тяжелой черепно-мозговой травмы. В настоящее время остается открытым вопрос о раннем выявлении офтальмологической симптоматики краниофациальных повреждений в остром периоде черепно-мозговой травмы. Несвоевременное и неправильное их устранение может приводить к нарушениям функций органа зрения, тяжелым косметическим дефектам и гнойно-септическим осложнениям.
В структуре черепно-мозговой травмы краниофациальная составляет 6-7%, а от всех видов сочетанной черепно-мозговой травмы – 34%. Частота переломов орбиты при КФТ чрезвычайно высока – до 98%, что связано с особенностью строения глазницы. В 66% повреждения глазницы сопровождаются повреждениями глазного яблока и его вспомогательных органов. Повреждения зрительного нерва при черепно-мозговой травме встречаются в 0,5-5% наблюдений, при краниоорбитальных повреждениях – в 11,2%. Травматическая оптическая нейропатия, тяжелые травмы глаза в 50% случаев могут явиться причиной возникновения стойкой утраты зрения.
The purpose of the study is to determine the significance of genetic factors in the development of chronic nephritic syndrome in children and to clarify the features of the clinical course
The оbject of research were 129 children aged 4-15 years who were treated for chronic nephritis in the nephrology department of the Samarkand Regional Multidisciplinary Paediatric Medical Centre.
The scientific novelty of the study is as follows:it has been established that the severity of chronic nephritic syndrome in children is associated with clinical manifestations (gradual development, dyspepsia, abdominal pain) and an increase in the amount of Cystatin C in the blood;for the first time, it was revealed that the development of sclerotic lesions due to increased proliferation in patients with the presence of the MMP-9 (A-8202G) rs 11697325 genotypes in chronic nephritic syndrome leads to a worsening of the clinical course of the disease; established early diagnostic marker MMP-9 (A-8202G) rs 11697325 and its tissue inhibitor TIMP-2 (C536T) rs 11551797 in chronic nephritic syndrome in children in the diagnosis of the disease; for the first time, the prognostic value of the alleles of the MMP-9 (A-8202G) rs 11697325 genes and the homozygous G/G genotype in determining the risk of developing the disease in children with chronic nephritic syndrome has been proven.
Implementation of the research results. Based on scientific results of evaluation of the role of polymorphic genes of matrix metalloproteinase and its tissue inhibitors in chronic nephritic syndrome in children: methodological recommendation “The role of polymorphic genes of matrix metalloproteinase and its genetic inhibitors in the development of chronic nephritic syndrome in children” was developed and approved (reference of the Ministry of Health of the Republic of Uzbekistan No. 8n-r / 554 of 30.02.2022).
This methodological recommendation made it possible to predict the development of chronic nephritic syndrome in children and improve preventive measures; approved and developed on the basis of scientific results of research on early diagnosis and prognosis of chronic nephritic syndrome “Dynamics of clinical and laboratory parameters in nephritic syndrome in children”, (reference of the Ministry of Health of the Republic of Uzbekistan No. 8n-r / 555 of 30.02.2022).
This methodological recommendation made it possible to optimize the diagnosis and treatment tactics for various forms of nephritic syndrome in children;
The results obtained were implemented in the practice of health care, in particular, in the Republican Children's National Medical Center, in the 1st clinic of the Samarkand State Medical University, in the Samarkand Regional Children's Multidisciplinary Medical Center (conclusion No. 8 n-r/324 of 21.06.2022 of the Ministry of Health of Uzbekistan).
The application of the obtained results to practice has made it possible to reduce the frequency of recurrence of the disease in children, prevent complications of the disease, improve the quality of life of patients, diagnose and prevent the disease.
The structure and scope of the dissertation. The dissertation consists of an introduction, 4 chapters, conclusions, practical recommendations. The volume of the dissertation is 120 pages.
Рак вульвы относится к одной из наиболее редких форм гинекологических злокачественных опухолей и составляет примерно 6% всех злокачественных новообразований женских половых органов, чаще встречаясь у пожилых женщин. Заболеваемость РВ составляет менее половины процента глобальной заболеваемости злокачественными опухолями. В 2018 г. в мире было зарегистрировано 44 000 новых случаев рака вульвы, в то время как количество смертей составила около 15 000 случаев [1, 2, 3].
Приведенные данные литературы свидетельствуют, что на прогноз эндодонтического лечения оказывают влияние внутри- и внекорневые факторы. В дополнение к традиционному препарированию перспективно использование препаратов йода и физических факторов как при проведении первичного, так и повторного эндодонтического лечения.
Each region of the Fergana Valley is characterized by its strong management centers, the diversity of natural resources, the general agro-climatic factors, the availability and the potential for the creation of a finished product production system. For this reason, it is advisable to work out prospective directions for the deployment and development of productive forces. At the same time, it is important to fully utilize the capabilities of the main sector in the organized economic system of the region. The future development of productive forces in this area is inseparably linked with agro-industrial production and its sectoral and regional improvement. In addition, the interregional production system, which is based on the continuous growth of food production in the regions, the intensification of intersectoral communications, the expansion of the role of intensive factors, in turn, will increase the demand for complex scientific forecasts. At this stage, the scientific forecasting should reflect the activities of the food market and facilitate the expansion of foreign markets. The region's participation in the world economy opens the way for further stages of social and economic development. At the same time, the emphasis should be on the sustainable improvement of the elastic business structure, adapted to the changing competition inherent to the market economy. The main task of the food market in the Ferghana Valley in the near and long-term perspective is to increase production efficiency and bring the level of material welfare of the population to the world's leading countries on the basis of equalizing social and economic development in the regions. This, in its turn, is a very complex and urgent issue, not only with the radical changes in the economy, but also with a change in the lives of the whole society and, consequently, the acceleration of its development. In this regard, this article elaborates the forecasts of the food market in the Ferghana Valley
for 2020-2030 and its alternative scenarios. The first scenario is based on a retrospective analysis of food production in the Ferghana Valley. In the second scenario, the population's food supply is calculated based on the minimum consumer budget, while the third scenario provides the regions' food supply coefficients and supply estimates. On the basis of the analysis of the forecast parameters of the Ferghana Valley Food Market and its results, scientific-practical conclusions have been developed.
The purpose of the research is to develop measures for the protection of the Zeravshan river, which is used as an industrial and drinking water supply for the population of several regions of the Republic. Studies have established that the main source of river pollution is industrial enterprise "Navoiazot", which produces mineral fertilizers for needs of agriculture. Discharge of wastewater into the water, leads to pollution of water, and the quality does not correspond to GOST 951:2011 "Sources of centralized drinking water supply. Hygienic, technical requirements and selection rules". At the same time, harmful chemicals are found in the water of the Zeravshan river, which are 2-9 times higher than the MPC installed on them. The medium term forecast showed that by 2030 the ecological state of the Zeravshan river will not be improved, due to the fact that the production of mineral fertilizers is planned to be increased. In this regard, recommendations on the protection of the Zeravshan river have been developed, which will help to improve the monitoring of the state of the water body and improve the conditions of water use of the population
This article is devoted to topical issues of scientific strategic forecasting of legislation in the private legal sphere. In the article, based on public objective realities and landmarks, the conclusions on the unification of the experience of foreign countries and the country's legislative acts in the field of private law are substantiated.
Perinatal lesions of the central nervous system unites a large group of brain lesions that are different due to the cause and origin, arising during pregnancy, childbirth and in the first days of a child's life. Severe forms of perinatal lesions of the central nervous system are observed in 1.5–10% of term infants and in 60–70% of premature infants. Purpose of the study: conducting immunochemical screening in order to identify a predisposition to pathology of the central nervous system and internal organs in low birth weight infants.
This article substantiates the content of the medium-term fiscal policy and the objective need for its implementation. The organizational and economic foundations of medium-term forecasting of income and expenditure of the state budget of the Republic of Uzbekistan are analyzed.
Clinical and functional assessment of the results of complex treatment of optic glaucoma neuropathy using tanakan in the form of endonasal electrophoresis in combination with electrical stimulation according to optical coherence tomography of the eye and ultrasound Doppler mapping. Material and methods: 43 patients (74 eyes) with glaucomatous optic neuropathy aged from 58 to 76 years were examined. Results: The used method effectively delays the development of optic nerve atrophy and, along with the improvement of visual functions, lengthens the positive effect of the main treatment, which was confirmed by a significant improvement in hemodynamic parameters ac-cording to the ultrasound Doppler study. Conclusions: The proposed method will improve the efficiency of treatment of patients with compensated open-angle glaucoma and improve the vision prognosis and the quality of rehabilitation measures.