The aim of the study was to study the risk factors for congenital heart defects in newborns. 374 newborns with congenital heart defects were examined. When determining the significance, according to the questionnaire with a codifier of 42 features, modifying risk factors for the development of congenital heart defects were identified by socio-hygienic, medico-biological, the influence of intrauterine infections, taking medications by the mother during pregnancy, and obstetric and gynecological indicators.