All processes in the wound occur due to the activation of complex enzyme-catalytic systems and the effective healing of the wound strictly depends on the prescribed differential treatment depending on the stage of the wound process. The process of wound healing in a short time is possible if the prescribed measures and prescribed drugs correspond to the physiological stages of the wound process. The evaluation of the effectiveness of treatment in the postoperative period in 40 patients with chronic dacryocystitis was determined as the goal of our study. After endonasal endoscopic dacryocystorhinostomy, a gel-type anti-adhesin drug was injected into the lacrimal duct every 2 hours and the cytological composition of smears of the nasal mucosa was examined to evaluate the course of reparative processes in surgical wounds. The study showed that the effectiveness of postoperative treatment of patients with chronic dacryocystitis increased in the main group of patients using antiadhesin, which led to better healing of wounds and epithelization by the 7th day, whereas in the comparative group this process occurred only on the 14-17th day.
Nilufar Khushvakova, Fozil Nurmuhamedov, Anvar Boltayev
The main goal of functional endoscopic sinus surgery is to reconstruct the ostiomeatal complex zone and restore ventilation and drainage of the affected sinuses through physiological pathways. Under the control of an endoscope, a thorough maximum removal of purulent and polypous tissue was performed from the cells and walls from which the polypous tissue originated.
The use of citoflavin is effective in the treatment of patients with CHF for preventive therapy in order to maintain the stability of auditory thresholds in the absence of a mutation of the А1555 G mitochondrial gene, the presence of which is a factor in the progression of hearing loss, which requires electroacoustic correction with a plan for future cochlear implantation. In the group
with standard treatment, no statistically significant changes were found, however, it should be noted that monotherapy is preferable both from an economic point of view and a medical position, when the use of several drugs is an expensive and time-consuming process that does not always entail a positive result. As a result of the research, it was shown that complex treatment with the preparation of cytoflavin leads to an improvement in cerebral circulation and coronary blood flow, activates metabolic processes in the central nervous system, contributes to a more pronounced regression of neurological symptoms in the main group 2 to 3 times compared to the control group.
The study involved 30 patients, 17 of them are the main group and received postoperative immunostimulant derinat whose action figures normalized local and general immunity of patients with polypous etmoidita and also reduce the number of relapses. Significantly low levels of IgA after treatment
increased to control values, the reduced level of IgG was normalized, and the high level of IgM was significantly decreased to the benchmark
Chronic hypertrophic rhinitis lead to the breakdown of the normal functioning of the body because of a violation of respiratory function, leading to circulator}' and tissue hypoxia, biochemical disturbances, including lipid metabolism and activity of the antioxidant system, which is accompanied by the development of the inflammatory reaction of the nasal mucosa; breach of natural immunity, as well as organic lesions of the paranasal sinuses, pharynx, larynx, lower respiratory tract. The examination and treatment of patients with chronic hypertrophic rhinitis who after surgical treatment along with conventional treatment included medication elfunat (ethylmethylhydroxypyridine succinate). Use of the drug has contributed elftinat: reduction of postoperative inflammatory reaction region and improve the activity of reparative tissue of the nose, the normalization of blood lipid peroxidation system and morpho-functional restoration layer of nasal mucosa.
Cleft lip and palate (CLP) take 86.9% of all congenital face malformations. Often the conductive hearing
loss develops due to the otitis media with effusion in children with this pathology. There are not enough data
about the state of the middle ear and hearing function in children with CLP in different periods of childhood.
The aim of the study was to evaluate these indicators in children operated on for CLP in the first year of life in
different periods of childhood. As a result of a comprehensive survey of 28 children it was found that the prob-lem with the middle ear was preserved in that group of patients, despite the early stages of surgical treatment
of the congenital malformation and the courses of the conservative therapy aimed at restoring the function of
the auditory tube. It was made a conclusion about the necessity for the dynamic observation by a physician oto-
laryngologist of such patients in different periods of childhood, even in the absence of complaints from the
middle ear and good results in the study of the state of the tympanic cavity and hearing at the time of another
scheduled inspection
Subjective noise can be regarded as a phantomauditory perception. In some cases.the perception of the perception of the ear shumaassotsiiruetsya with negative emotions.such as fear of hearning loss or brain diseases wich leads to focus attention on these sumtoms. Subconsciously generate negative emotions limbicheskuyui involvesthe sympathetic ervous sustem in a state of constant anxiety.
N Khushvakova, A Khayitov, M Nasretdinova, A Boltaev, Sh Salimova
It has been carried out the comparable analyses of the traditional treatment and local use of antiseptic solution in combination with ozone in patients who suffered from purulent otitis media against the background of chronic leucosis. There were 62 patients at the age from 1 to 14 years old under the observation. The combined use of ozonotherapy and local use of antiseptic solution could give us the opportunity to increase the treatment effectiveness in a significant degree, reduce length of hospitalization
and reduce the drugs
N Khamrakulova, N Khushvakova, G Davronova, F Ahmedova
Applying antihistamine in complex therapy exudative otitis media with an allergic rhinitis antilecotreins and topic intranasalglucocorticosteroids has show them to b reliable clinic effect which degenerated in the de-velopment of hearing decreasing symptoms and improving life style. Under our supervision there were 67 chil-dren with exudative otitis media by age from 3 to 18 year , 39 from them wereboys, and 28 were girl. Using in complex therapy with exudative otitis media with an allergic rhinitis intranasal glucocorticosteroid showing highly clinic effect, which shows reliable mucociliar transport function mucous membrane
In this paper the experience with submucosal vasotomy as a method of treatment of bilateral chronic hypertrophic rhinitis in 35 patients. We describe a technique of anesthesia and surgical technique. The analysis of the results of different surgical options, the causes of complications. The authors conclude that the technique described in the article vasotomy submucosa, is more effective in chronic hypertrophic rhinitis.
The state of the immune status of chronic rhinopharyngitis in various forms. The signs of tension humoral immunity namely sIgA, IgA, IgM, IgG. When immunoassay after the course with Amizon almost all patients show increased levels of IgA to normal values in the case of bluetongue form of inflammation - 2.02 mg / dL ( at p <0.05 ), to the upper limit of normal . In the control group there was
an increase of this index to a lesser extent to 1.37 mg / dL ( at p <0.05 ). The study of the secretory immunoglobulin A in the saliva showed that after 1 month of treatment was 1,97 ± 0,12 g / l (at p < 0.05).
The search for new conservative approaches in the treatment of exudative sinusitis is one of the urgent problems of modern rhinology. One of the existing methods of treating exudative sinusitis is at present a ra-tional combination of general measures of influence on the body with local treatment. In this regard, we pro-pose the use of medical ozone in the treatment of exudative haymarites as an independent agent and in combi-nation with ampicillin. A comparative analysis of the efficacy level of ampicillin in combination with O3 shows the advantages of this technique and its mechanism. The results of treatment of 100 patients are suggested. All patients underwent puncture, catheterization of VPC with subsequent washing and administration of drugs. Despite this, in patients 1 - group 15% of patients, 2 - group 6.66% of patients, 3 - group of 40% of patients had a short-term effect with subsequent relapse of the disease.
N Khushvakova, I Shamatov, N Khamrakulova, Sh Usmanov
Проведён анализ эффективности внутривенной озонотерапии с препаратом кавинтона при лечении нейросенсорной тугоухости сосудистого генеза, обусловленной хронической недостаточностью мозгового кровообращения в вертебробазилярном бассейне у 15 пациентов. Отмечен положительный терапевтический эффектположительная динамика по данным дополнительных методов обследования: снижение порогов слуха в диапозоне высоких частот (тональная аудиограмма), улучшение церебральной гемодинамики (компьютерная реоэнцефалография), улучшение слуховой афферентации приимущественно на стволовом уровне слухового анализатора (коротко латентные слуховые вызванные потенциалы головного мозга)
N Khushvaktova, N Tajieva, F Khamrakulova, D Nasyrova
Treatment of patients whlth chronic suppurative otitis media whlth the use of the drug In children mlramldez.samarkand state medical Institute a comparative analysis of traditional treatments ana topical drug Mlramldez In patients whlth chronic suppurative otitis medla.We observed 56patlents,aged from 0 to 18 years. Combined topical application allows the drug Mlramldez greatly enchance the effectiveness of the treatment to reduce the time of hospitazatlon and reduce the comsumptlon of drugs. This method of treatment is a modern highly effective and safe.
N Khushvakova, N Khamrakulova, M Vohidov, F Holikova
The problem of the treatment of patients with chronic hypertrophic rhinitis remains relevant at the mo-ment. The number of this disease is increasing. We want to offer a method of treatment of chronic hyper-trophic rhinitis using a surgical technique vasotomy submucosa. Difference of this method from the rest is that it does not violate the integrity of the nasal mucosa. The paper presents the results of treatment of 30 patients. All patients were performed surgery using glucocorticosteroids. However, when comparing clari-fied at impact survey of complaints in the 1st group the occasional shortness of nasal breathing paid attention 8.3% of patients, while in the 2nd group of patients was 14.8%. Mucus from the nose disturbed patients in group 1 and 10.4% of patients in group 2 14.8%. We came to the conclusion that the improvement of exist-ing and introduction of new surgical techniques using glucocorticosteroids gives good results and can be ap-plied.
N Khushvakova, N Khamrakulova, Sh Kaisarov, S Egamov
The condition of endogen intoxication during the treatment with topical steroids for allergic rhinitis has been studied insufficiently. Nasonex (mometasone furoate) was used during the study which is able to inhibit release of mediators of allergic reactions. Under the influence of Nasonex content of MDA decreased to 42.6%, the activity of catalyses plasma increased to 60.0%, a decline of ratio MDA/CА 80.4%, decreased concentration MSM254 and MSM280 45, 0 and 35.5%, respectively, significantly moved them closer to the healthy group
The paper presents data on the definition of methods for the study of ear noise in various pathologies. Their occurrence is explained by the dysfunction of peripheral and Central parts of the sound analyzer under the influence of unfavorable factors. The sequence of the appearance of noise and hearing loss depended on the nature of the disease. Most patients were concerned about noise II and III degrees of tolerance, which violated the quality of their lives and reduced their ability to work. An increase in the percentage of registration with the UAE is reliably proved tinnitus
Одной из наиболее сложных форм хронического рино- синусита, как в плане клинического течения, так и в плане лечения, является полипозный риносинусит( ПРС).
В Узбекистане 14,7% населения страдают хроническим риносинуситом. За последние 10 лет заболеваемость выросла в 2 раза.
M Nasretdinova, N Khushvaktova, D Negmatov, A Boltaev, A Khayitov
IVe studied the changes of Immunological parameters of children with recurrent exudative otitis media (REOM) that are associated with impaired Immunogenesis regulation. The results showed that during the Intensification of the clinical sympatoms in children with primary exudative otitis media was reveled violations of Immunareactlvitly, which were expressed by a decrease In cell - mediated Immunity (CLE.CD8), dislmmunoglobulinemiya exhibiting Increased levelsoflgM, decrease levelsoflmAandthe Increase ofcomplementary activities. In cases of recurrent exudativly otitis media originality long- lasting selective deficit of IgA were discovered.
N Khushvakova, Sh Pirnazarov, N Khamrakulova, Sh Iskandarova
Summary of the first years of child in many aspect sare critical for language development, cognitive and social emotional skills, which leads to the paramount importance of early diagnosed hearing loss with problem which hearing. Factors such as, the age at which the of fense occured in the auditory the function, period de-tection of the degree hearing loss and time lines on meropryty to re-story auditory function.
M Nasretdinova, N Khushvakova, F Nurmukhamedov, A Kholbaev
The state of the immune status of patients with chronic rhinopharyngitis in various forms. The signs of tension humoral immunity, namely slgA. IgA. IgM, IgG. According immunoassay after the course c Amizona ahnost all patients there was an increase level of IgA to normal values in the case of bluetongue form of inflammation - 2.02 mg / dL (at p<0,05). ie to the upper limit of normal.
In recent years, there has been a significant increase in chronic rhinosinusitis (CRS) tn the structure ot diseases of the ENT organs. Chronic forms of rhinosinusitis arc one of the most common and often recurrent diseases of the nose and paranasal sinuses, the nature and mechanism of which have not been fully understood. The aim of this work is to study the main indicators of the neutrophilic link in phagocytosis in patients with chronic forms of rhinosinusitis. After the operative period, all patients underwent endonasal low-intensity laser therapy and recovery was observed in all patients. In conclusion, it should be noted that the use of endonasal low-intensity laser therapy after surgical treatment has shown some effective results compared with traditional treatment.
Sinusitis are common disease of childhood and observed in all age groups, starting with the first months of life. The study was performed in order to determine the features of the clinical course of sinusitis and the nature of the microflora in children suffering from diabetes mellitus (DM). The study involved 54 children. Defined microflora of the nasal cavity of children and their clinical course. In patients with DM purulent sinusitis is characterized by long, sluggish flow, involvement of other sinuses, the development of complications
As a result of the research, it was shown that complex treatment with the preparation of cytoflavin leads to an improvement in cerebral circulation and coronary blood flow activates metabolic processes in the central nervous system, contributes to a more pronounced regression of neurological symptoms in the mam group 2 to 3 times compared to the control group.
Summary: In recent years the possibility of isolating groups of free radical pathologies. High sensivity of test reflecting the metabolic reaction of the membrane level in chronic sinusitis that’s explains the composition of cell membranes and obtain more information for assessing the severity of pathologic process. There were showing and treating 48children at age from 5 to 15 with an exacerbation of various forms chronic sinusitis. Applying of drug aktovegen shows not only therapeutics effect but proof his antioxidant effect which show how relapse are down after applying therapy it make possibility for recommendation necessary in complex therapy