Introduction. Cervical cancer is one of the most serious threats to women's health. This is the fourth most common cancer in women around the world. According to the forecasts of international experts (taking into account population growth and an increase of life span expectancy), the increase in the incidence and prevalence of cervical cancer will have made up 40% in developing countries and in economically developed countries - 11% by 2020. In the case of non-conducting timely measures for the prevention and treatment of cervical cancer, malignant neoplasms of the cervix will affect up to 1 million women annually after 2050 in the world. Aim of the study is primary prevention of cervical cancer by introducing vaccination to 9 years old girls of the Republic of Uzbekistan. Material and methods. The Gardasil MK vaccine was imported to the Republic of Uzbekistan in 2019. From October 21 to November 30, 2019, the first dose was vaccinated to 9 years old girls in the republic; the introduction of the 2nd dose is planned in 6 months. Results and discussion. Vaccination rates significantly increased after the measures taken on November 30: in the city of Tashkent - 97%, in the Tashkent region - 90.8%, in Bukhara - 90.2%. Refusers made up 66.9% of unvaccinated girls. Temporary left who also did not receive vaccination made up 360 (4%). 1935 girls were not vaccinated by other reasons and they made up 21.4% of the total unvaccinated population. Conclusion. As a result of joint efforts by the Government of the Republic of Uzbekistan, the Ministry of Health with the support of international organizations from WHO and UNICEF, the first dose of the tetravalent HPV vaccine - Gardasil MK- was successfully administered to 9 years old girls all over the country. According to the data of Health Ministry of the Republic of Uzbekistan no adverse reactions were observed in 292,867 girls after vaccination.