All articles - Hematology
Number of articles: 256
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Frequensy of cognitive and non- cognitive disturbances in patients with young age with chronic cerebrovaslar diseases with conditioned arterial hypos and hypertensionCerebrovacular diseases can for a long time only be manifested by cognitive impairment. More than 1/3 of the examinations revealed discirculatory encephalopathy of the 1 st stage, mild and moderate cognitive im-pairment appeared in the first and second stages of discirculatory encephalopathy (DE). Symptoms of anxiety in patients with chronic cerebrovascular pathology in 92,8% of cases were observed in stage II stage discircu-latory encephalopathy due to arterial hypertension and in 89,6% with second stage discirculatory encephalo-pathy due to essential arterial hypertension(EAG)
Journal problems of biology and medicine -
Comparative clinic-laboratory indices in varions Forms of hemolytic disease in newbornsWe examined 16 children with hemolytic disease of newborns for Rh conflict and 14 for conflict with ABO system. It has been revealed that the state of birth in patients writh hemolytic disease of the fetus by Rh-factor is more severe compared to the disease by ABO system and are dependent on hematological indices detected in birth: red blood cells, hemoglobin, hematocrit.
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When a person has chronic illnesses, there are various unpleasant symptoms. Anemia in diseases of the kidneys is not uncommon, it arises in the late stages of the pathological process. A symptom is associated with a damaged kidney, which ceases to produce enough hormone responsible for the formation of red blood cells. For this reason, in the body, and especially in the kidneys, there is a shortage of red blood cells. When their number falls to a minimum, renal anemia is diagnosed -
The basis for the study was 371 patients with liver echinococcosis, admitted to the departments of surgery of the 1st and 2nd clinic of the Samarkand State Medical Institute. The optimal complex of medical-diagnostic and prophylactic measures developed has changed the quality of life of patients: excellent from 5.9% to 83.0%, good from 64.7% to 15.1%, satisfactory from 17.6% to 1, 9% and unsatisfactory - from 11.8% to 0%. -
Chronic viral hepatitis and tuberculosis are widespread as monoinfections. They are caused by the action of biological, socio-economic risk factors. In this article, we present materials on the epidemiological and clinical course of chronic viral hepatitis C and tuberculosis as a combination of infections, indicating an increase in the incidence, involvement in the epidemic process mainly of people of working age, and high mortality. -
The liver plays an important role in the implementation and regulation of many metabolic processes. A wide variety of functions of hepatocytes leads to the fact that in liver pathology, biochemical constants are disturbed, reflecting changes in many types of metabolism. The anatomical structure of the liver determines the features of the processes occurring in it. The structural components of the liver are: 1) parenchymal cells (hepatocytes); 2) epithelium of the bile ducts; 3) cells of the reticuloendothelial system (RES); 4) connective tissue. Connective tissue forms a capsule of the liver and it is not among the hepatocytes ordered into a lobed structure. Despite the many processes occurring in liver cells, changes in far from all of them are of diagnostic value [14]. The main pathological processes that form diagnostic signs are: 1) increased permeability of hepatocyte membranes; 2) reduction of synthetic processes in them; 3) an increase in the size of hepatocytes, compression of the bile ducts and impaired excretion of bile; 4) violation of the deposit process; 5) decrease in deactivation of toxic metabolites; 6) activation of mesenchymal tissue; 7) violation of immune responses. As a result of these processes, the following pathophysiological syndromes are formed: cytolysis, cholestasis, insufficiency of hepatocytes, inflammation. -
Organ-preserving operations m echinococcosis oi the liver arc accompanied by a slight trauma to the liver tissue. It is the cases when the invasiveness of access exceeds the invasiveness of the intervention itself on the operated organ are indications for the use of minimally invasive, video endoscopic technologies. Minimally invasive video endoscopic techniques for treating liver echinococcosis significantly improve patient outcomes. With the accumulation of experience in performing these operations for an increasing number of patients with echinococcosis, the approaches will become optimal for performing surgery. -
Differential - diagnostic approach of the etiology and clinical symptoms of prolonged neonatal hyperbilirubinemiaAnalysis of the literature data shows the relevance and significance of prolonged neonatal hyperbilirubinemia in the present. Excessive accumulation of bilirubin in the serum of a newborn can become negative in the growth and development of the individual as a whole. The particularly toxic effect of bilirubin leads to such negative consequences as damage to the central nervous system, after which paresis, paralysis and even death in the neonatal period can occur. The primary condition for solving this problem is a differential diagnostic approach of the etiology and clinical symptoms of prolonged neonatal hyperbilirubinemia.
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Cryoglobulinemia - importance in the development of extrahepatic manifestations in patients with viral hepatitis cCurrently, the association of chronic hepatitis C with various extrahepatic manifestations is becoming topical. The systemic generalized nature of the infection makes timely diagnosis and treatment more difficult. In the pathogenesis of extrahepatic manifestations, cryoglobulins arc crucial.
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Change of form of erythrocytes of peripheral blood in patients with obesity аfter laparoscopic sleeve gastrectomyUsing the express method of the «Thick drop», we studied the ratio of normal erythrocytes - discocytes and their pathological forms: stomatocytcs, cchinocytes, erythrocytes with a crest and others in patients with obesity before and at various times after bariatric surgery - laparoscopic sleeve gastrectomy. It has been shown that in patients with obesity, the ratio of the red blood cells to the discocytes/pathological forms does not differ from that observed in people with normal weight. Laparoscopic sleeve gastrectomy leads to significant changes in this ratio in the direction of increasing pathological forms of erythrocytes, which is especially pronounced 3 months after surgery.
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Investigation of physical and mechanical properties of thrombusThe study of the physico-mechanical properties of blood clots has recently become of increasing interest in practical medicine. The study of such physical parameters of a thrombus as adhesion force, density, porosity, elasticity, as well as changes in these properties of a thrombus over time, thrombus dynamics opens up new opportunities in hematology, surgery and other branches of medicine.
Journal problems of biology and medicine -
Mechanism of thrombus retraction and its evaluation in clinical practiceThe cascade of reactions in the process of blood coagulation is quite complex, in which platelets play an important role. They initiate it and further regulate it through biochemical and mechanical interactions. The coagulation process proceeds in 3 stages: platelet adhesion,aggregation, retraction. At present, the coagulation and anticoagulation systems of the blood have been studied quite well, however, there is still not enough information about the mechanisms underlying thrombus retraction (RT).
Journal problems of biology and medicine -
Prevalence of anemia in children, risk factors and their prophylaxisAnemia is the most common pathology in the world. Anemia is a clinical and hematological syndrome characterized by a decrease in the number of red blood cells and hemoglobin levels in one volume of blood. According to experts from the World Health Organization (WHO), from the point of view of public health, the assessment of the prevalence of anemia among the population is studied in 3 groups: weak - from 5% to 19.9%, medium - from 20% to 39.9%. %, high - 40% or more. With the prevalence of anemia among the population of more than 40%, the problem is not only medical, but also socio-economic in nature and requires measures to be taken at the state level [2, 5, 8, 11]. According to WHO, between 1993 and 2005, 1.62 billion people worldwide were diagnosed with anemia. This is 24.8% of the world's population.
Journal problems of biology and medicine -
Violation of vascular – platelet phase of hemostasis in patients with chronic hepatitis and liver cirrhosis of the viral etiologyThere are thrombocytopenia, infringement of adhesive and aggregating properties of thrombocites in liver cirrhosis of a viral etiology. The decrease activity of the vascular – platelet part of the coagulation system was more pronounced in patients with viral liver cirrhosis compared with non - viral liver cirrhosis. Cirrhosis of the C viral etiology was accompanied by more significant changes in the process of hemocytopoiesis in the bone marrow, but signs of hypersplenism prevailed in liver cirrhosis В or В+Д viral etiology
Journal problems of biology and medicine -
Features of coronary heart disease treatment in patients with iron deficiency anemia against the different severity levelsCurrently comorbidity is relevant in the outcome of many diseases [1]. In particular, we arc talking about 1HD, unstable angina and anemia of varying severity. In 30 patients with coronary artery disease in combination with anemia, 3-valence iron was changed, the drug Sufer (Yuria-Pharm Ukraine) at a dose of 5.0 ml iv for 5 days against the background of standard therapy. In examined patients, that an increase in hemoglobin levels contributes to the normalization of the vibros fraction reduce or disappear angina attacks, increased exercise tolerance [2,3].
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We have studied the effect of the severity of thermal trauma on the character of changes in the parame-ters of the coagulation system of blood in 55 patients aged 17 to 70 years in the period of burn shock. During the shock period, the study was conducted in three comparative groups of victims with varying degrees of se-verity of burn injury. The first group consisted of 15 patients with the Frank index up to 30, the second group consisted of 20 patients with the Frank index from 30 to 60 and the third group comprised 20 victims with a Franc index of more than 61. Burn shock, especially severe, causes significant disorders in the blood coagula-tion system . The state of hypercoagulability observed in the victims in the period of burn shock, require appro-priate correction for the prevention of thromboembolic complications -
Computer tomography in the diagnosis of tumor thrombosis of the renal and vena cava inferiorsThe article presents cases of the renal vein and inferior vena cava involvement by a tumor conglomerate, diagnosed by computed tomography. In all cases, patients were examined for complaints not related to the re-vealed underlying pathology and not presumed prior to the examination. Clinical diagnosis was determined with the help of detectable signs of massive expansion of the diameter of the main vessels. Thrombus was demonstrated in the vascular lumen with additional enhancement of CT after intravenous injection of uro-graphic contrast material.
Journal problems of biology and medicine -
Studies were performed on 98 rats in 14 series, 7 acute experiments in each series. We studied the change in pancreatic secretion with the introduction of CCK.-8 short-chain peptide and CCC-33 long-chain peptide in the presence of trypsin and contrical. It was concluded that the short-chain peptide CCK.-8 is utilized by the liver to a large extent, in comparison with the long-chain peptide CCK-33. Trypsin, when passing through the liver, reduces the ability of the liver to utilize CCK.-8, thereby stimulating the secretory function of the pancreas. When passing through the liver, the protease inhibitor increases the ability of the liver to utilize CCK.-8, thereby reducing the secretory function of the pancreas. Pancreatic hormone trypsin and its inhibitors may be involved in the modification of cholecystokinin mechanisms for regulating pancreatic function. -
Prognostic value of cytokines in women with varicose veins in case of placental insufficiencyChronic venous insufficiency and varicose veins are the most common group of extragenital pathology of the cardiovascular system in pregnant women and puerperas, according to various authors - in 30-50% of women. According to the authors, pregnant women with varicose veins have a rather high frequency of early toxicosis and gestosis (10%), chronic fetal hypoxia (10%), umbilical cord pathology (24-26%), untimely discharge of amniotic fluid (22-24%), and weakness of birth activity (15%), premature detachment of a normally located placenta (2%), bleeding in the postpartum and early postpartum periods (18%), postpartum endometritis (7%).
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Diagnosis of chronic venous insufficiency of lower extremitiesChronic venous insufficiency of the lower extremities (CVI) is of great social and economic importance in society due to the high prevalence, duration of treatment and loss of working capacity. One of the main reasons for its formation is varicose veins. The frequency of varicose veins is 25-33% among women and 10-20% among men [4, 11]. Diagnosis and treatment of the disease in the early stages, before the addition of trophic disorders that require long-term treatment and significant costs, are important. So, in the UK, about six hundred million pounds sterling is spent annually on the treatment of venous ulcers, and in the USA - more than a billion dollars. Currently, in European countries, there has been a tendency to reduce the frequency of common forms of the disease due to the introduction of a program for early diagnosis of the disease [18, 20]
Journal problems of biology and medicine -
The study of erythrocytes forms at patients with the arterial hypertensionUsing of express method of thick drop the proportion of the normal and pathological forms of erythro-cytes were studied. It was shown that in arterial hypertension the part of pathological forms of erythrocytes increases and the part of normal erythrocytes decreases. It is more obviously in second and third degrees of the arterial hypertension
Journal problems of biology and medicine -
Gastroduodenal bleeding complicates the course of the burn disease and in some cases may increase the likelihood of death in patients with severe thermal trauma. The analysis of 105 victims with severe thermal trauma (the area of deep burn 20-40%), who were on treatment from 2010 to 2017, in whom the course of the burn disease was complicated by the development of gastroduodenal bleeding. Studies have shown that the pathogenetically substantiated method of choice for the development of massive bleeding in burned patients is endoscopic arrest on the background of complex haemostatic, replacement and angioprotective therapy -
Evaluation of the risk of heredity and lifestyle of children and adolescents with obesity and arterial hypertensionData of a survey of 55 children and adolescents with obesity are given. It was found that the main risk factors for the development of various types of obesity in children, and hypertension are hypercaloric nutrition, inactivity, heredity in obesity and hypertension in both parents and diabetes maternal line, and smoking in families. Great importance in the progression of obesity and the manifestation of hypertension had a period of puberty.
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Changes of activity of neutrophils of blood at experimental bacterial and Immune periodontal disease and their correction by flavonolThe purpose of the study was to evaluate the activity of neutrophils in the blood under the condition of the experimental bacterial-immune periodontitis and to clarify the effect of flavonol quercetin on its parameters. The article presents the results of research on the indices of the spontaneous and activated test with nitrosin tetrazolium on the 14th day of the experimental bacterial-immune periodontitis and after correction with quercetin (in the same period of the experiment). In this case, data on the nature of changes in neutrophilic activity in the process of formation of inflammatory focus in the periodontal complex are given. The use of flavonol quercetin, which, acting on the immune processes, limited the inflammatory response in the periodontal tissues and led to a decrease in neutrophil activity relative to the rates of animals that did not receive the drug. As a result of the use of quercetin, the activity of neutrophils approached the values of the control group.
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Changes of lipid content in the blood of mother, fetus and placenta’s tissues at intrauterine hypothrophy of fetusDuring the study of peculiarities of lipid metabolism in mother- placenta-fetus system at hypotrophy it was determined that at growth retaliation of intrauterine fetus development the considerable changes take place, especially in NTFA (non terrified fatty acids), triglycerides,3-lipoproteides and phospholipids. By that the one directed character of changes in blood serum of the pregnant and their newborns, were determined at retardation of intrauterine fetus development there was value reduction of NTFA-triglycerides, reflecting the activity of lipolitic processes, being displayed with hyperlipidemia.
Journal problems of biology and medicine
