All articles - Hematology
Number of articles: 256
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Iron is an irreplaceable element, the cathode in the body is folded in biochemical processes. It haemoglobin, mioglobin, tsitoxromlar (including R450), peroksidaza, katalaza, other gems enzymes as well as enzymes like gems nikotinamidade-nin-dinuklsotiddsgidrogsnaza (NAD-dsgidrogsnaza), suktsinat-digsdrogsnaza, atsetil degidrogenaza koenzim A (atsetil-KoA degidrogenaza). A part of the iron is contained in the tukima-liquid, where the irreplaceable part of the catalytic RSA is formed. (For example: free radical processes, lipid peroxides, and PC.) The source of iron for the organism Kil serving bulib ovkat. Absorption is mainly due to the fact that flour is contained in the intestine of two fingers (in all parts of the intestine in anemia). Iron prsparats consist of various two or three bases of iron-containing salts. They are smeared in two according to the sending: for weight loss and for injections with a spout. These drugs increase the entry of iron into the orga-NISM. So they were laughing at the Iron Tank of the inner seal-Di. Farm -
APPROACHES TO MATHEMATICAL MODELING OF INTERACTIONS BETWEEN MATERNAL AND FETAL BLOOD FLOWStrategies of multiscale computational modeling, extending from the cellular to the organ level, are the primary tools for studying the dynamic interaction of factors involved in the development of placental dysfunction. Recent years have been marked by significant evolutionary achievements in understanding the physiology and pathophysiology of pregnancy using computational methods for assessing the vascular system not only of the uterus and placenta, but also of the mother and fetus as a whole. So. new approaches in the field of in vivo and ex vivo imaging have given scientists access to the creation of new multiscale models of the uterus and placenta. The multiscale of the models provides a new clinically significant understanding of the pathology of pregnancy and defines the facets on which various scientific disciplines, from cell biology to in vivo imaging, can be combined using computational approaches.
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Quality of life is an important metric for health performance, health and well-being. Kidney disease is one of the major health problems affecting quality of life. This study aimed to assess the quality of life in dialysis (CKD-D) and non-dialysis (CKD-ND) patients with chronic renal failure (CKD) using the short form Kidney Quality of Life (KDQOL-SF™) and to identify differences in the symptoms of the disease between the two groups. The study included 200 patients with CKD. Our results showed that the burden of some symptoms was higher in the non-dialysis group compared to the dialysis group, but most symptoms did not reach statistical significance. Likewise, our results show no difference in quality of life and symptoms between dialysis and non-dialysis CKD patients. -
The article is devoted to the assessment and improvement of treatment quality of vegeto-vascular dystonia (VVD) among adolescents of central multidisciplinary polyclinic of Samarkand region. With the aim of diagnostic of such pathology from the general population of the polyclinic it has been detected adolescents and medical examination of children at the age from 10 to 14 years of age. The amount of them was 138 people (34,5%). From them boys were 40 (29%) and girls were 98 (71%). During performing of examination of 138 children in 21 (15,2%) it has been determined clinical symptoms of vegeto-vascular dystonia (VVD). These patients due to the indexes of arterial pressure we divided them into 2 groups: patients with high blood pressure and patients with low blood pressure. The appropriate treatment has been carried out according to the determined types of VVD. In the hypertonic type of VVD antihypertensive medications (betta-blockers) have been prescribed. Procedures of physiotherapy (UVR). massage and phytotherapy have been recommended for the patients of the hypotonic type of the disease. -
CONDITION HEMODYNAMIC AND MORPHOLOGICAL PARALLELS WOMEN WITH PREMATURE GENUS IN ANAMNESIS68 pregnant women were examined, whose pregnancy ended with premature birth in the gestation period of 22-36 weeks. Changes in the mother-placenta-fetus system, changes in the placental system in the system, connection of morphological changes between the placenta and the endometrium of the uterus, as well as their comparative analysis, were examined.
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The purpose of lhe study: to evaluate the state of hem coagulation with its physiological course for predicting the risk of obstetric hemorrhage in terms of trimesters of pregnancy in its dynamics. Surveyed 65 women with physiological pregnancy. Of these, 30 women (group II) have risk factors; smoking patients during this pregnancy, overweight. taking oral contraceptives with the abolition of less than or 3 months before pregnancy. 35- Women without risk factors with a normal pregnancy. Clinical and hcmostasiologic studies were performed for periods of 10-12, 22-24, and 35-36 weeks of gestation. During gestation, there was an increase in spontaneous platelets, an increase in fibrinogen level. D-dimer. and a slowdown in fibrinolysis. -
CLINICAL AND MORPHOLOGICAL CHARACTERISTICS OF CHRONIC RECURRENT HEMATOGENOUS OSTEOMYELITISThe studied material of scanning and transmission electron microscopy were bone fragments of 40 patients obtained during surgery from various pathologically altered sections of the affected tubular bones. Morphological studies revealed microscopic foci of necrosis, leukocyte infiltrates and microabscesses both in the main focus and in other parts of the bone marrow canal. Microabscesses detected by microscopy represent the morphological basis of chronic hematogenous osteomyelitis, can be located at a considerable distance from the main necrotic purulent focus and, under appropriate conditions, cause a relapse of the disease. Morphological studies have shown that surgical debridement of the lesion with ultrasonic cavitation of the lesion and the medullar)' canal contributes to a significant reduction in the degree of microbial contamination, followed by a decrease in pathological changes in bone tissue.
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Chronic atrophic rhinitis among all diseases of the ENT organs occurs in 10% of cases. This process is very rarely diffuse and mainly from an ailment, the nasal cavity and nasopharynx are sometimes tracheal membranes. The aim of the study was to study the indicators of a general analysis of blood, iron and ferritin in the blood. A study was conducted of 20 people with a diagnosis of atrophic rhinitis. After the initial reaction, expressed in the form of increased bone marrow production, a significant predominance of lymphocytes sets in again. Based on this, it can be concluded that a degenerative shift with an increase in the number of lymphocytes should apparently indicate a chronic infectious irritant. -
Erythrocytes and microcirculation of the oral mucosa when using laser and led radiationTo study the form of red blood cells in prosthetic stomatitis and the dynamics of their changes in the course of treatment, peripheral blood was studied in 32 patients with prosthetic stomatitis and in 8 healthy do-nors. The calculations showed that the proportion of D in the peripheral blood obtained from the finger, is normally 89%, erythrocytes with a crest and echinocytes 8%, stomatocytes 2%, irreversible forms of erythro-cytes - 1%. The use of laser and LED technologies in dentistry in complex diagnostics and treatment is effective and promising.
Journal problems of biology and medicine -
Comparative study of evaluation methods of the thrombus for biosealants formationThe use of new forms of biosealants based on thrombus is perspective direction in medicine. Thrombus may be studied from the view point of natural policompositive biomaterial without any negative influence on the organism. Especially retractive thrombi faced these requirements. In connection with this fact methods of evaluation and investigation of thrombus retraction, the study of their physic-mechanical properties have been had large significance. Current research was performed with aim to compare exist indirect methods of throm- bus retraction evaluation with perspective direct methods that allow assess physic-mechanical properties of thrombi. The work was performed in cooperation with researchers of Physic-technical institute at Academy of Science RUz.
Journal problems of biology and medicine -
Systemic scleroderma (TSD) is an autoimmune disease based on the activity of fibrosis processes in the skin and internal organs, as well as general microangiopathy. In the initial bandages, the disease is manifested by uzini edema of the chest in the fingers and skin changes in the course of the rhinitis syndrome, but the patient may not have any manifestations of deterioration of the general condition or signs of damage to internal organs (dysphagia, iaphasic stenosis, etc.), so the patient can get an early referral to a doctor in In this regard, systemic scleroderma is diagnosed with a delayed diagnosis, after the appearance of irreversible pathological changes in the organs and finding the treatment ineffective in the body. According to Canadian researchers, a diagnosis of systemic sclerodermia in 408 bsmor was made after 6.0 years of uttering and 2.7 years of uttering of primary "skin manifestations" had appeared [21J. In Russia, systemic scleroderma is diagnosed when the disease is 2,0-2,7 years old from the syndrome of the Rhine, and in diffuse and limited forms of the disease 4,8-6,5 years old when the diagnosis is found burn, which is associated with a variety of degree of damage to internal organs, as well as with the speed of At the same time, the results of a large study show that the incidence of bsmor with this disease is 68 out of 1000 patients per year [36]. So the diagnosis of weight loss and systemic sclerodermia in uz vaccine is a complex, but very sparing task for the doctor. -
CLINICAL AND PATHOGENETIC SIGNIFICANCE OF HEMOSTATIC HOMEOSTASIS DISORDERS IN NEW CORONAVIRAL INFECTION (COVID-19)The value of D-dimcr coagulation (DD), prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT) and fibrinogen (Fg) in predicting the severity and prognosis of COVID-19 was studied. Blood clotting dysfunction occurred in almost everyone, more often in severe patients. Indicators of hemostatic homeostasis such as D-dimcr, prothrombin time, fibrinogen and APTT can be used as indicators of the severity of the disease in patients. From the foregoing, it follows that anticoagulant and antiplatelet drugs should be included in the treatment of coronavirus infection.
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In the progression of diabetic nephropathy, considerable attention is paid to the development of anemia. Л significant reason for the development of anemia in patients with diabetes mellitus (DM) with diabetic nephropathy is a decrease in the production of erythropoietin in the peritubular cells of the proximal nephron. Anemia predominates in patients with diabetic nephropathy, it is associated with cardiovascular disease, retinopathy. Anemia begins to develop long before the violation of the filtration function of the kidneys. -
Violation of the volume of circulating blood and coating system during a burning shockThe article focuses on the main issues relating to the state of the structure of the circulating blood vol-ume and coagulation system in 95 patients with deep burns from 10 to 35% of the body surface in the period of burn shock. It was revealed that with the deep burns in the overwhelming majority of patients a moderate de-gree of blood loss is observed, which is manifested with a BCC deficit of up to 30%, a violation of the volume of circulating plasma protein, a decrease in globular blood volume. When plasma losses in patients with extensive deep burns, there is a violation of blood coagulation and suppression of fibrinolytic activity, which correlates with the degree of burn shock
Journal problems of biology and medicine -
Acute myeloid leukemia (AML) is the most common acute leukemia in adults. The pathophysiology of this disease is only beginning to be understood at the cellular and molecular level, and cytogenetic markers are currently the most important for risk stratification and treatment of AML patients. However, with the advent of new technologies, the discovery of other molecular markers, such as point mutations, indicates that the disease is approaching. Recent data show that the identification of new biomarkers for AML contributes to a better understanding of the molecular basis of the disease, is significantly useful in screening, diagnosis, prognosis and monitoring of AML. as well as the ability to predict the response of each person to treatment. This review summarizes the most important molecular (genetic, epigenetic, and proteinaceous) biomarkers associated with acute myeloid leukemia and discusses their clinical relevance in terms of risk prediction, diagnosis, and prognosis. -
Characteristics of liver damage during intra-passenger car traumaIn the article the characteristic features of liver damage are shown in case of intra-passenger car trauma in the driver and front seat passenger. In this case, liver damage by location, shape, size, direction and nature is different in the driver and front seat passenger.
Journal problems of biology and medicine -
Relationship of coronary artery damage and the level of the lipid profile in Patients with ischemic heart diseasePurpose of the study. Study of the course of coronary heart disease in patients depending on the damage to the coronary arteries and the level of lipid profile. Materials and methods. A retrospective study was performed in 75 patients with damage to two or more coronary arteries according to the coronary angiographic study, who were hospitalized in the Department of Infectious Diseases in the course of 2019-2020. Results. A close feedback between the level of HDL cholesterol and the risk of developing coronary heart disease was obtained and confirmed. According to our data, differences in laboratory parameters are generally quite predictable in both groups and confirm previously known data on the cardioprotective function of high density lipoproteins [7] and the negative effect of increased atherogenici-ty on the course of HID. There is a direct relationship between the level of HDL and CFS. especially triglycerides and
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Relevance. Today, operations with a wide surgical approach prevail in the traditional surgical treatment of varicose veins. The recurrence rate of the disease reaches 50% within 5 years after surgery and can increase to 80% in the longer period. The aim of the study: optimization of surgical treatment of patients with CVI of the lower extremities by using methods of minimally invasive correction of venous hypertension. Materials and research methods. In the period from 2010 to 2019, 867 patients with varicose veins of the lower extremities were operated in the surgical department of the 1st clinic of SamMl. of which 71 (8.2%) had CVI type C-4 (34), C - 5 (17) and C - 6 (20). Research results. In the long-term period, 49 patients were observed. When examining patients, attention was paid to local clinical symptoms. Conclusions. The severity and duration of trophic disorders of the lower extremities have a direct correlation with the severity of horizontal reflux. Dissection of perforating veins and elimination of pathological reflux along the saphenous veins should be considered a pathogcnctically important component of the surgical treatment of decompensated CVI forms. -
The purpose of the work is to study the topographic anatomy and macroscopic structure of the gallbladder and biliary tract in newborns, children and adolescents. Material and research methods. The object of the study was 54 corpses of newborns, children and adolescents of both sexes up to 16 years old. with body weight from 3.0 kg to 55 kg, who died for reasons not related to pathology of the liver and bile ducts. Studied in detail the formation of the common bile duct, the options for its formation. Results, /\ge-related changes in the topography of the ducts concerned the length, diameter, depth, the number of branches and the severity of anastomoses between segmental branches and between the lobar ducts. The diameter of the common hepatic duct ranged from 1.1 mm to 5.0 mm, the right hepatic duct from 0.87 mm to 3.06 mm. and the left hepatic duct from 0.89 mm to 3.03 mm in different age groups. The length of the total hepatic duct is from 4.5 mm to 35.8 mm. When considering the angles of incidence between the common hepatic and left and right ducts varies. Conclusion. The results showed that in children of all age groups the formation of the common hepatic duct is variable; 2 to 5 intrahepatic ducts take part in its formation, while the number of ducts coming from the right lobe of the liver prevails. -
Determination of the immunoglobulins level in infants blood Serum depending on the nature of feedingThis article examines a survey of 115 children who were divided into 2 groups. Group I consisted of 37 children aged 15 days to 2 months, group II included 78 children aged 2 to 6 months. The predominant class of immunoglobulins in the blood serum of the examined children was immunoglobulin G. Its concentration in children of the first age group was 5.75 ± 0.26 g/1. The content of immunoglobulin M in the blood serum of the observed children (in group 1 -0.83 ± 0.05 g /1; in group 2-0.99 ± 0.05 g /1) was significantly higher than in healthy children (0.32 ± 0.14 g) g/1 and 0.48 ±0.16 g/1. The same changes were observed in the concentration of class a immunoglobulin (in group 1, 26 ± 0.05 g / I, in group 2-0.39 ± 0.03 g/1, in healthy children, The IgA content was 0.07 ± 0.05 g/1 and 0.15 ± 0.10 g /1 for age groups.
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Republican Specialized Scientific and Practical Center of Phthisiology and Pulmonology, Tashkent, Uzbekistan The article presents an analytical analysis of studies on changes in the hemostatic system in patients with chronic obstructive pulmonary disease. Data obtained in the course of studies of coagulation and anticoagulation systems, as well as possible pathogenetic causes of these conditions in patients with chronic obstructive pulmonary disease are presented. The authors claim that establishing the causes of hypercoagulation in this category of patients will allowr to develop effective preventive measures for thrombotic complications. -
Immediate results of intra-regional auutoplasmic therapy in the Integrated treatment of local-distributed tongue cancer and bottom SideIn the article direct results of regional intraarterial and intraoperative autoplasmochemotherapy as a component of complex antitumoral treatment of cancer of the bottom of the oral cavity and tongue were studied. The obtained data testify to a sufficiently high efficiency, safe toxic profile and positive dynamics of immunoregulatory proteins in regional intraarterial and intraoperative autoplasmochemotherapy as a component of complex antitumor treatment in patients with cancer of the bottom of the mouth and tongue
Journal problems of biology and medicine -
In most cases, sepsis is caused by gram-positive flora. However, in patients without hematogenous dissemination, gram-negative microorganisms were microbiologically confirmed. Diagnosis of sepsis is a very difficult question. About 30% of sepsis cases remain without bacteriological confirmation. About 40-45% of sepsis cases are caused by staphylococci. However. 80% of cases of surgical infection is combined with an anaerobic infection. Surgical treatment of sepsis is considered to be the most relevant. Especially sepsis due to inflammatory diseases of soft tissues, treatment should begin with an urgent surgical intervention. -
Obstetric and gynecological anamnesis features of mothers with hemolytic disease newbornThe analysis of pregnant women's cards and the birth history of 50 women who gave birth to newborns with hemolytic disease was carried out. It is revealed that the most significant risk factors for the development of hemolytic disease of the newborn are: abortion, threatened miscarriage, anemia of pregnant women. A high correlative relationship was noted between the occurrence of GB due to Rhesus conflict with maternal parity, abortions, anemia of pregnant women, in newborns born to ABO of a conflict pregnancy with the first pregnancy of the mother.
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Профилактика венозных тромбоэмболических осложнений у беременных с варикозным расширением вен малого тазаThe use of 600 mg phlebodia in pregnant women with varicose veins of the pelvis is pathogenically grounded and effective. The reduction of the main clinical manifestations of this pathology in combination with the stabilization of the disturbed parameters of the blood coagulation system made it possible to prevent such formidable complications of pregnancy as venous thromboembolic complications in pregnant women at high risk
Journal problems of biology and medicine
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